| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| José Luiz Pedroso, Edson Bor-Seng-Shu, Pedro Braga-Neto, Rodrigo Souza Ribeiro, Márcio Luiz Escorcio Bezerra, Lucila B F do Prado, Ilza Rosa Batista, Helena Alessi, Manoel Jacobsen Teixeira, Gilberto Mastrocola Manzano, Gilmar Fernandes do Prado, Orlando Graziani Povoas Barsottin. Neurophysiological studies and non-motor symptoms prior to ataxia in a patient with machado-joseph disease: trying to understand the natural history of brain degeneration. Cerebellum (London, England). vol 13. issue 4. 2015-02-09. PMID:24604677. |
impairment of midbrain cholinergic and pontine noradrenergic systems, dysfunction of the pre-synaptic nigrostriatal system, changes in echogenicity of the substantia nigra, and damage to vestibulo-cervical pathways are supposed to occur previous to cerebellar involvement in machado-joseph disease. |
2015-02-09 |
2023-08-12 |
human |
| Robert P Machol. Loss of rostral brainstem cholinergic activity results in decreased ultrasonic vocalization behavior and altered sensorimotor gating. Behavioural brain research. vol 256. 2014-12-18. PMID:23810416. |
the parabigeminal (pbg), pedunculopontine (pptg), and laterodorsal tegmental (ldtg) nuclei located in the rostral brainstem are the primary sources of the neurotransmitter acetylcholine (ach) for the midbrain and thalamus, and as part of the ascending reticular activating system, these cholinergic signaling pathways regulate mouse behavioral responses to sensory stimuli. |
2014-12-18 |
2023-08-12 |
mouse |
| Martin Sarter, Roger L Albin, Aaron Kucinski, Cindy Lusti. Where attention falls: Increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function. Experimental neurology. vol 257. 2014-08-13. PMID:24805070. |
where attention falls: increased risk of falls from the converging impact of cortical cholinergic and midbrain dopamine loss on striatal function. |
2014-08-13 |
2023-08-13 |
Not clear |
| Christoph Straub, Nicolas X Tritsch, Nellwyn A Hagan, Chenghua Gu, Bernardo L Sabatin. Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948810. |
the motor and learning functions of the striatum are critically dependent on synaptic transmission from midbrain dopamine neurons and striatal cholinergic interneurons (cins). |
2014-08-12 |
2023-08-13 |
mouse |
| Christoph Straub, Nicolas X Tritsch, Nellwyn A Hagan, Chenghua Gu, Bernardo L Sabatin. Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 25. 2014-08-12. PMID:24948810. |
these findings imply that, in addition to their direct effects on striatal projection neurons, midbrain dopamine neurons indirectly modulate striatal output by dynamically controlling cholinergic tone. |
2014-08-12 |
2023-08-13 |
mouse |
| Kristi A Kohlmeie. Off the beaten path: drug addiction and the pontine laterodorsal tegmentum. ISRN neuroscience. vol 2013. 2014-06-24. PMID:24959564. |
the major cholinergic input to neurons in the midbrain which are instrumental in assessment of reward and assignment of salience to stimuli, including drugs of abuse, sources from acetylcholine- (ach-) containing pontine neurons of the laterodorsal tegmentum (ldt). |
2014-06-24 |
2023-08-13 |
Not clear |
| Kristi A Kohlmeie. Off the beaten path: drug addiction and the pontine laterodorsal tegmentum. ISRN neuroscience. vol 2013. 2014-06-24. PMID:24959564. |
excitatory ldt input, likely cholinergic, is critical in allowing behaviorally relevant neuronal firing patterns within midbrain reward circuitry. |
2014-06-24 |
2023-08-13 |
Not clear |
| Y Falkeborn, C Larsson, A Nordberg, P Slanin. A comparison of the regional ontogenesis of nicotine- and muscarine-like binding sites in mouse brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 1. issue 4-5. 2014-06-02. PMID:24875947. |
the postnatal development of the cholinergic neurotransmitter system was studied in the cortex, hippocampus, midbrain and cerebellum of 3-, 7-, 12-, 17- and 30-day-old nmri mice. |
2014-06-02 |
2023-08-13 |
mouse |
| Natalie M Doig, Peter J Magill, Paul Apicella, J Paul Bolam, Andrew Sharot. Cortical and thalamic excitation mediate the multiphasic responses of striatal cholinergic interneurons to motivationally salient stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 34. issue 8. 2014-04-10. PMID:24553950. |
in primates, tonically active neurons (putative cholinergic interneurons) exhibit multiphasic responses to motivationally salient stimuli that mirror those of midbrain dopamine neurons and together these two systems mediate reward-related learning in basal ganglia circuits. |
2014-04-10 |
2023-08-12 |
rat |
| M R Williams, R Marsh, C D Macdonald, J Jain, R K B Pearce, S R Hirsch, O Ansorge, S M Gentleman, M Maie. Neuropathological changes in the nucleus basalis in schizophrenia. European archives of psychiatry and clinical neuroscience. vol 263. issue 6. 2014-03-21. PMID:23229688. |
the nucleus basalis is a collection of large cholinergic neurons in the basal forebrain receiving information from the midbrain and limbic system, projecting to the cortex and involved with attention, learning and memory, and receives regulation from serotonergic inputs. |
2014-03-21 |
2023-08-12 |
Not clear |
| Nichole M Neugebauer, Emily B Einstein, Maria B Lopez, Tristan D McClure-Begley, Yann S Mineur, Marina R Picciott. Morphine dependence and withdrawal induced changes in cholinergic signaling. Pharmacology, biochemistry, and behavior. vol 109. 2014-01-07. PMID:23651795. |
acetylcholinesterase (ache) activity and [³h]-epibatidine binding were evaluated in order to determine if morphine dependence and withdrawal induces alterations in cholinergic signaling or expression of high affinity nicotinic acetylcholine receptors (nachrs) in the midbrain (mb), medial habenula (mhb) and interpeduncular nucleus (ipn). |
2014-01-07 |
2023-08-12 |
mouse |
| Stephan Steidl, Esther Lee, David Wasserman, John S Yeoman. Acute food deprivation reverses morphine-induced locomotion deficits in M5 muscarinic receptor knockout mice. Behavioural brain research. vol 252. 2013-10-28. PMID:23742799. |
m5 muscarinic cholinergic receptors, expressed by midbrain dopamine neurons, are critical for the ability of morphine to increase nucleus accumbens dopamine levels and locomotion, and for morphine cpp. |
2013-10-28 |
2023-08-12 |
mouse |
| Tanja Hochstrasser, Lindsay A Hohsfield, Barbara Sperner-Unterweger, Christian Humpe. β-Amyloid induced effects on cholinergic, serotonergic, and dopaminergic neurons is differentially counteracted by anti-inflammatory drugs. Journal of neuroscience research. vol 91. issue 1. 2013-07-18. PMID:22996751. |
the aim of the present study was to investigate the effects of aβ(1-42) on cholinergic neurons of the nucleus basalis of meynert (which degenerate in ad), on serotonergic neurons of the dorsal raphe nucleus (which play a role in depression), and on dopaminergic neurons of the ventral mesencephalon (which degenerate in pd) in rat organotypic brain slices. |
2013-07-18 |
2023-08-12 |
rat |
| Manojkumar Valiyaveettil, Yonas A Alamneh, Stacey-Ann Miller, Rasha Hammamieh, Peethambaran Arun, Ying Wang, Yanling Wei, Samuel Oguntayo, Joseph B Long, Madhusoodana P Nambia. Modulation of cholinergic pathways and inflammatory mediators in blast-induced traumatic brain injury. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23159883. |
cdna microarray analysis showed significant changes in the expression of cholinergic (muscarinic and nicotinic) and gammaaminobutyric acid and glutamate receptors in the midbrain region along with significant changes in multiple genes involved in inflammatory pathways in various regions of the brain. |
2013-05-28 |
2023-08-12 |
mouse |
| Kristi A Kohlmeier, Masaru Ishibashi, Jürgen Wess, Martha E Bickford, Christopher S Leonar. Knockouts reveal overlapping functions of M(2) and M(4) muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus. Journal of neurophysiology. vol 108. issue 10. 2013-04-30. PMID:22956788. |
cholinergic neurons in the laterodorsal tegmental (ldt) and peduncolopontine tegmental (ppt) nuclei regulate reward, arousal, and sensory gating via major projections to midbrain dopamine regions, the thalamus, and pontine targets. |
2013-04-30 |
2023-08-12 |
mouse |
| Irene Morganstern, Zhiy Ye, Sherry Liang, Shawn Fagan, Sarah F Leibowit. Involvement of cholinergic mechanisms in the behavioral effects of dietary fat consumption. Brain research. vol 1470. 2013-01-15. PMID:22765913. |
these findings suggest that the exploratory and novelty-seeking behaviors induced by dietary fat may be mediated by enhanced nicotinic cholinergic activity, which is accompanied by increased density of β2-nachrs in cortical and midbrain regions associated with impulsivity and locomotor activity and of α7-nachrs in hypothalamic regions associated with arousal and energy balance. |
2013-01-15 |
2023-08-12 |
rat |
| Elisha D W Mackey, Staci E Engle, Mi Ran Kim, Heidi C O'Neill, Charles R Wageman, Natalie E Patzlaff, Ying Wang, Sharon R Grady, J Michael McIntosh, Michael J Marks, Henry A Lester, Ryan M Drena. α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 30. 2012-10-29. PMID:22836257. |
the sc has emerged as a potential key brain area responsible for transmitting short-latency salience signals to thalamus and midbrain da neurons, and these results suggest that α6* nachrs may be important for nicotinic cholinergic sensitization of this pathway. |
2012-10-29 |
2023-08-12 |
mouse |
| T Kuriyama, J Taguchi, K Kuriyam. Functional alterations in striatal cholinergic and striato-nigral gabaergic neurons following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration. Neurochemistry international. vol 16. issue 3. 2012-10-02. PMID:20504575. |
neurochemical changes in cholinergic neurons in the striatum and ?-aminobutyric acid (gaba)ergic neurons in the midbrain, especially in the basal ganglia, have been examined following the intraperitoneal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), which is known to cause behavioral changes resembling those in parkinson's disease due to the destruction of nigro-striatal dopaminergic neurons. |
2012-10-02 |
2023-08-12 |
mouse |
| A D Taranalli, T C Cheeramkuzh. Influence of clitoria ternatea extracts on memory and central cholinergic activity in rats. Pharmaceutical biology. vol 38. issue 1. 2012-10-02. PMID:21214440. |
in order to delineate the possible mechanism through which c. ternatea elicits the anti-amnesic effects, we studied its influence on central cholinergic activity by estimating the acetylcholine content of the whole brain and acetylcholinesterase activity at different regions of the rat brain, viz., cerebral cortex, midbrain, medulla oblongata and cerebellum. |
2012-10-02 |
2023-08-12 |
rat |
| K Jah. [Gait disorders in the elderly: prospects for a symptomatic therapy]. Fortschritte der Neurologie-Psychiatrie. vol 80. issue 5. 2012-09-04. PMID:22566138. |
based on pathophysiology and uncontrolled studies, the most promising approaches are to support cholinergic neurotransmission in the midbrain and thalamus by central cholinesterase inhibitors and the regularisation of purkinje cell function by potassium channel blockers. |
2012-09-04 |
2023-08-12 |
human |