| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Li Kuan, Maha Alfaidi, Catherine B Horne, Benjamin Vallin, Sarah Fox, Shaline V Fazal, Caroline H Williams-Gray, Roger A Barke. Selective neurodegeneration generated by intravenous α-synuclein pre-formed fibril administration is not associated with endogenous α-synuclein levels in the rat brain. Brain pathology (Zurich, Switzerland). 2022-11-02. PMID:36321260. |
our data demonstrated that a non-selective, transvascular delivery of α-synuclein pffs led to a time-dependent loss of specific populations of midbrain (but not olfactory) dopaminergic neurons, medullary (but not pontine) cholinergic neurons, and brainstem serotonergic neurons. |
2022-11-02 |
2023-08-14 |
rat |
| Prabesh Kanel, C Chauncey Spears, Stiven Roytman, Robert A Koeppe, Kirk A Frey, Peter J H Scott, Roger L Albin, Nicolaas I Bohne. Differential cholinergic systems' changes in progressive supranuclear palsy versus Parkinson's disease: an exploratory analysis. Journal of neural transmission (Vienna, Austria : 1996). 2022-10-12. PMID:36222971. |
prior studies indicate more severe brainstem cholinergic deficits in progressive supranuclear palsy (psp) compared to parkinson's disease (pd), but the extent and topography of subcortical deficits remains poorly understood. |
2022-10-12 |
2023-08-14 |
Not clear |
| Silvana G Cooper, Lucas A C Souza, Caleb J Worker, Ariana Julia B Gayban, Sophie Buller, Ryosuke Satou, Yumei Feng Earle. Renin-a in the Subfornical Organ Plays a Critical Role in the Maintenance of Salt-Sensitive Hypertension. Biomolecules. vol 12. issue 9. 2022-09-23. PMID:36139008. |
using rnascope, we report for the first time that renin mrna is expressed in several regions of the brain, including the subfornical organ (sfo), the paraventricular nucleus of the hypothalamus (pvn), and the brainstem, where it is found in glutamatergic, gabaergic, cholinergic, and tyrosine hydroxylase-positive neurons. |
2022-09-23 |
2023-08-14 |
mouse |
| Didier Le Ray, Sandrine S Bertrand, Réjean Dubu. Cholinergic Modulation of Locomotor Circuits in Vertebrates. International journal of molecular sciences. vol 23. issue 18. 2022-09-23. PMID:36142651. |
nicotinic cholinergic inputs increase the level of excitation of brainstem descending command neurons, the reticulospinal neurons (rsns), whereas muscarinic inputs activate a select group of hindbrain neurons that project to the rsns to boost their level of excitation. |
2022-09-23 |
2023-08-14 |
Not clear |
| Hao Yang, XiaoLi Yang, SiLu Yan, ZhongKui Su. Effect of acetylcholine deficiency on neural oscillation in a brainstem-thalamus-cortex neurocomputational model related with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-09-02. PMID:36056083. |
this work constructs a comprehensive neural mass model for cholinergic neuropathogenesis that involves brainstem, thalamus and cortex, wherein how acetylcholine deficiency in ad affects neural oscillation of the model output is systematically explored from the perspective of neurocomputation. |
2022-09-02 |
2023-08-14 |
Not clear |
| Hao Yang, XiaoLi Yang, SiLu Yan, ZhongKui Su. Effect of acetylcholine deficiency on neural oscillation in a brainstem-thalamus-cortex neurocomputational model related with Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-09-02. PMID:36056083. |
by decreasing synapse connectivity parameters in direct cholinergic pathway from brainstem to thalamus or in indirect glutamatergic synapse pathway from cortex to brainstem to mimic the pathological condition of reduced acetylcholine release in patients with ad, the property of neural oscillation in this model is numerically investigated by means of power spectrum in frequency domain and amplitude distribution in time domain. |
2022-09-02 |
2023-08-14 |
Not clear |
| Hernan Alvarez-Munoz, Sergio Vicencio-Jimenez, Pascal Jorratt, Paul H Delano, Gonzalo Terrero. Corticofugal and Brainstem Functions Associated With Medial Olivocochlear Cholinergic Transmission. Frontiers in neuroscience. vol 16. 2022-05-16. PMID:35573302. |
corticofugal and brainstem functions associated with medial olivocochlear cholinergic transmission. |
2022-05-16 |
2023-08-13 |
mouse |
| Adil El Boujdaini, Lorenzo Peluso, Amina Khaldi, Elisabetta Macchini, Andrea Minini, Elisa Gouvea Bogossian, Jacques Creteur, Fabio S Taccon. Prognostic role of automatic pupillometry in sepsis: a retrospective study. Minerva anestesiologica. 2022-02-22. PMID:35191640. |
cholinergic pathways and brainstem dysfunction may result in pupillary alterations. |
2022-02-22 |
2023-08-13 |
Not clear |
| Ke Chen, Xing Ge, Yue Da. Cholinergic modulation of persistent inward currents is mediated by activating muscarinic receptors of serotonergic neurons in the brainstem of ePet-EYFP mice. Experimental brain research. 2022-02-15. PMID:35166863. |
cholinergic modulation of persistent inward currents is mediated by activating muscarinic receptors of serotonergic neurons in the brainstem of epet-eyfp mice. |
2022-02-15 |
2023-08-13 |
mouse |
| Ke Chen, Xing Ge, Yue Da. Cholinergic modulation of persistent inward currents is mediated by activating muscarinic receptors of serotonergic neurons in the brainstem of ePet-EYFP mice. Experimental brain research. 2022-02-15. PMID:35166863. |
the whole-cell patch-clamp recordings were performed in the brainstem slices of epet-eyfp mice to investigate the electrophysiological properties of pics with cholinergic modulation. |
2022-02-15 |
2023-08-13 |
mouse |
| Jelena Radulovic, Sanja Ivkovic, Miroslav Adzi. From chronic stress and anxiety to neurodegeneration: Focus on neuromodulation of the axon initial segment. Handbook of clinical neurology. vol 184. 2022-01-17. PMID:35034756. |
it is grounded in findings demonstrating that the earliest pd pathologies occur in the stress-responsive, emotion regulation network of the brainstem, which provides the sn with dense aminergic and cholinergic innervation. |
2022-01-17 |
2023-08-13 |
Not clear |
| John F Smiley, Cynthia Bleiwas, Stefanie Canals-Baker, Sharifa Z Williams, Robert Sears, Catia M Teixeira, Donald A Wilson, Mariko Sait. Neonatal ethanol causes profound reduction of cholinergic cell number in the basal forebrain of adult animals. Alcohol (Fayetteville, N.Y.). vol 97. 2021-12-07. PMID:34464696. |
in contrast, cholinergic cells in the striatum were reduced only 12% by ethanol, and those of the brainstem pedunculopontine/lateral dorsal tegmental nuclei (ch5/ch6) were not significantly reduced. |
2021-12-07 |
2023-08-13 |
mouse |
| Lai-Wo Stan Leung, Tao Lu. Cholinergic Modulation of General Anesthesia. Current neuropharmacology. vol 19. issue 11. 2021-11-25. PMID:33882810. |
cholinergic neurons in the mesopontine brainstem and basal forebrain are important for activation of the cerebral cortex, which is characterized by the suppression of irregular slow waves, an increase in gamma (30- 100 hz) activity in the electroencephalogram, and the appearance of a hippocampal theta rhythm. |
2021-11-25 |
2023-08-13 |
human |
| Milton H Werner, C Warren Olano. Parkinson's Disease Modification through Abl Kinase Inhibition: An Opportunity. Movement disorders : official journal of the Movement Disorder Society. 2021-11-24. PMID:34816484. |
historically characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta, pd pathology is now known to be widespread and to affect serotonin, cholinergic and norepinephrine neurons as well as nerve cells in the olfactory system, cerebral hemisphere, brain stem, spinal cord, and peripheral autonomic nervous system. |
2021-11-24 |
2023-08-13 |
human |
| Conor Fearon, Andrew J Lees, John J McKinley, Allan McCarthy, Shane Smyth, Michael Farrell, Timothy Lync. On the Emergence of Tremor in Prodromal Parkinson's Disease. Journal of Parkinson's disease. vol 11. issue 1. 2021-11-12. PMID:33325397. |
the pvn is affected in pd and evidence from related phenomena suggest that the pvn could increase tremor either by increasing downstream cholinergic activity on brainstem nuclei such as the reticular formation or by stimulating the locus ceruleus to activate the cerebellothalamocortical network via the ventrolateral nucleus of the thalamus. |
2021-11-12 |
2023-08-13 |
Not clear |
| N Kezunovic, C Simon, J Hyde, K Smith, P Beck, A Odle, E Garcia-Ril. AROUSAL FROM SLICES TO HUMANS: Translational studies on sleep-wake control. Translational neuroscience. vol 1. issue 1. 2021-10-21. PMID:22639732. |
one element of the reticular activating system (ras) is the pedunculopontine nucleus (ppn), which is the cholinergic arm of the ras, and projects to the thalamus to trigger thalamocortical rhythms and to the brainstem to modulate muscle tone and locomotion. |
2021-10-21 |
2023-08-12 |
human |
| Jose M Ballesteros, Deborah A VAN DER List, Leo M Chalup. Formation of eye-specific retinogeniculate projections occurs prior to the innervation of the dorsal lateral geniculate nucleus by cholinergic fibers. Thalamus & related systems. vol 3. issue 2. 2021-10-20. PMID:19367340. |
we compared the developmental periods in the mouse when projections from the two eyes become segregated in the dorsal lateral geniculate nucleus with the time when this nucleus becomes innervated by cholinergic fibers from the brainstem. |
2021-10-20 |
2023-08-12 |
mouse |
| Jose M Ballesteros, Deborah A VAN DER List, Leo M Chalup. Formation of eye-specific retinogeniculate projections occurs prior to the innervation of the dorsal lateral geniculate nucleus by cholinergic fibers. Thalamus & related systems. vol 3. issue 2. 2021-10-20. PMID:19367340. |
immunocytochemical staining showed that cholinergic neurons are present in the parabrachial region of the brain stem on the day of birth. |
2021-10-20 |
2023-08-12 |
mouse |
| Jose M Ballesteros, Deborah A VAN DER List, Leo M Chalup. Formation of eye-specific retinogeniculate projections occurs prior to the innervation of the dorsal lateral geniculate nucleus by cholinergic fibers. Thalamus & related systems. vol 3. issue 2. 2021-10-20. PMID:19367340. |
these results indicate that segregation of eye-specific projections during normal development is unlikely to be regulated by cholinergic inputs from the brainstem. |
2021-10-20 |
2023-08-12 |
mouse |
| Andres Carrasco, Atsushi Tamura, Stefan Pommer, Julie A Chouinard, Kiyoto Kurima, Paolo Barzaghi, Jeffery R Wicken. Multiparametric assessment of the impact of opsin expression and anesthesia on striatal cholinergic neurons and auditory brainstem activity. The Journal of comparative neurology. vol 528. issue 5. 2021-09-27. PMID:31625606. |
multiparametric assessment of the impact of opsin expression and anesthesia on striatal cholinergic neurons and auditory brainstem activity. |
2021-09-27 |
2023-08-13 |
mouse |