| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kurt A Jellinge. Behavioral disorders in dementia with Lewy bodies: old and new knowledge. Journal of neural transmission (Vienna, Austria : 1996). 2024-09-05. PMID:39237792. |
neuroimaging studies displayed deficits in cholinergic brainstem nuclei and decreased metabolism in frontal, superior parietal regions, cingulate gyrus and amygdala in dlb. |
2024-09-05 |
2024-09-08 |
Not clear |
| Chao Zhang, R Michael Burge. Cholinergic modulation in the vertebrate auditory pathway. Frontiers in cellular neuroscience. vol 18. 2024-07-04. PMID:38962512. |
in this review, we highlight what is known about cholinergic function throughout the auditory system from the ear to the cortex, but with a particular emphasis on brainstem and midbrain auditory centers. |
2024-07-04 |
2024-07-10 |
Not clear |
| Takashi Shibata, Noriaki Hattori, Hisao Nishijo, Satoshi Kuroda, Kaoru Takakusak. Evolutionary origin of alpha rhythms in vertebrates. Frontiers in behavioral neuroscience. vol 18. 2024-04-23. PMID:38651071. |
the origin of posterior-dominant alpha rhythms observed in mammals in quiet and dark environments is not solely attributed to cholinergic pontine nuclei cells functioning as a 10 hz pacemaker in the brainstem. |
2024-04-23 |
2024-04-26 |
Not clear |
| Kim Alfred E Inting, Anthony N Pian. Irinotecan-Induced Transient Dysarthria in a Patient With Metastatic Colorectal Cancer: A Case Report. Cureus. vol 16. issue 2. 2024-03-21. PMID:38510900. |
the hypoglossal nucleus, responsible for the motor function of the tongue, is selectively affected due to dense innervation by muscarinic cholinergic receptors (in comparison to other brainstem nuclei). |
2024-03-21 |
2024-03-23 |
Not clear |
| Vincent Coulombe, Laurent Goetz, Manik Bhattacharjee, Peter V Gould, Stephan Saikali, Mohamad Ali Takech, Éric Philippe, André Parent, Martin Paren. Cholinergic and Nadph-δ neurons in the pedunculopontine and laterodorsal tegmental nuclei of human and nonhuman primates. The Journal of comparative neurology. 2023-12-18. PMID:38108576. |
stereological quantification reveals that 25.6% of chat+ neurons in the monkey ppn are devoid of nadph-δ staining, a finding that questions the reliability of nadph-δ as a marker for cholinergic neurons in primate brainstem. |
2023-12-18 |
2023-12-21 |
human |
| Jarrod A Gott, Sina Stücker, Philipp Kanske, Jan Haaker, Martin Dresle. Acetylcholine and metacognition during sleep. Consciousness and cognition. vol 117. 2023-12-02. PMID:38042119. |
additionally, acetylcholine is involved in the regulation of rem sleep: cholinergic neurons in the brainstem and basal forebrain project to and innervate wide areas of the cerebral cortex, and reciprocally interact with other neuromodulatory systems, to produce the sleep-wake cycle and different sleep stages. |
2023-12-02 |
2023-12-10 |
Not clear |
| Niels Okkels, Jacob Horsager, Tatyana D Fedorova, Karoline Knudsen, Casper Skjærbæk, Katrine B Andersen, Miguel Labrador-Espinosa, Karsten Vestergaard, Janne K Mortensen, Henriette Klit, Mette Møller, Erik H Danielsen, Erik L Johnsen, Goran Bekan, Kim V Hansen, Ole L Munk, Malene F Damholdt, Pernille L Kjeldsen, Allan K Hansen, Hanne Gottrup, Michel J Grothe, Per Borghamme. Impaired cholinergic integrity of the colon and pancreas in dementia with Lewy bodies. Brain : a journal of neurology. 2023-11-17. PMID:37975822. |
the findings also support that cholinergic denervation in the brainstem contributes to dysautonomia. |
2023-11-17 |
2023-11-20 |
human |
| Masarra Joda, Karen A Waters, Rita Machaalan. Choline-acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the human infant dorsal motor nucleus of the Vagus (DMNV), and alterations according to sudden infant death syndrome (SIDS) category. Neurobiology of disease. 2023-10-09. PMID:37813167. |
in the brainstem, the dorsal motor nucleus of the vagus (dmnv) has high cholinergic expression and is a region of interest in the neuropathology of sudden infant death syndrome (sids). |
2023-10-09 |
2023-10-15 |
human |
| Masarra Joda, Karen A Waters, Rita Machaalan. Choline-acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the human infant dorsal motor nucleus of the Vagus (DMNV), and alterations according to sudden infant death syndrome (SIDS) category. Neurobiology of disease. 2023-10-09. PMID:37813167. |
sids is the unexpected death of a seemingly healthy infant, but postmortem brainstem abnormalities suggesting altered cholinergic regulation have been found. |
2023-10-09 |
2023-10-15 |
human |
| Masarra Joda, Karen A Waters, Rita Machaalan. Choline-acetyltransferase (ChAT) and acetylcholinesterase (AChE) in the human infant dorsal motor nucleus of the Vagus (DMNV), and alterations according to sudden infant death syndrome (SIDS) category. Neurobiology of disease. 2023-10-09. PMID:37813167. |
these findings suggest altered cholinergic regulation in the brainstem of sids infants, with potential contribution of cigarette smoke exposure, presumably via the nicotinic acetylcholinergic receptor system. |
2023-10-09 |
2023-10-15 |
human |
| Daxiang Na, Jingyuan Zhang, Holly J Beaulac, Dorota Piekna-Przybylska, Paige R Nicklas, Amy E Kiernan, Patricia M Whit. Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis. Frontiers in neuroscience. vol 17. 2023-06-12. PMID:37304021. |
overall, we conclude that auditory alterations in amyloidosis mouse models correlate with amyloid deposits in the auditory brainstem and may be reversed initially through enhanced cholinergic signaling. |
2023-06-12 |
2023-08-14 |
mouse |
| Niels Okkels, Jacob Horsager, Miguel Labrador-Espinosa, Pernille L Kjeldsen, Malene F Damholdt, Janne Mortensen, Karsten Vestergård, Karoline Knudsen, Katrine B Andersen, Tatyana D Fedorova, Casper Skjærbæk, Hanne Gottrup, Allan K Hansen, Michel J Grothe, Per Borghamme. Severe cholinergic terminal loss in newly diagnosed dementia with Lewy bodies. Brain : a journal of neurology. 2023-06-06. PMID:37279796. |
patients with dementia showed spatially distinct reductions in cholinergic terminals across the cerebral cortex, limbic system, thalamus, and brainstem. |
2023-06-06 |
2023-08-14 |
human |
| Peilin Zhao, Tao Jiang, Huading Wang, Xueyan Jia, Anan Li, Hui Gong, Xiangning L. Upper brainstem cholinergic neurons project to ascending and descending circuits. BMC biology. vol 21. issue 1. 2023-06-06. PMID:37280580. |
upper brainstem cholinergic neurons project to ascending and descending circuits. |
2023-06-06 |
2023-08-14 |
Not clear |
| Peilin Zhao, Tao Jiang, Huading Wang, Xueyan Jia, Anan Li, Hui Gong, Xiangning L. Upper brainstem cholinergic neurons project to ascending and descending circuits. BMC biology. vol 21. issue 1. 2023-06-06. PMID:37280580. |
cholinergic neurons in the upper brainstem have extensive collateralizations in both ascending and descending circuits; however, their single-cell projection patterns remain unclear because of the lack of comprehensive characterization of individual neurons. |
2023-06-06 |
2023-08-14 |
Not clear |
| Mohammad Shabani, Mehran Ilaghi, Reyhaneh Naderi, Moazamehosadat Razavinasa. The hyperexcitability of laterodorsal tegmentum cholinergic neurons accompanies adverse behavioral and cognitive outcomes of prenatal stress. Scientific reports. vol 13. issue 1. 2023-04-12. PMID:37045899. |
laterodorsal tegmentum (ldt) is a part of the brainstem cholinergic system that is believed to play a pivotal role in the stress-associated progression of anxiety, memory impairment, and addictive behaviors. |
2023-04-12 |
2023-08-14 |
mouse |
| Raviye Ozen Koca, Z Isik Solak Gormus, Hatice Solak, Aynur Koc, İbrahim Kılınc, Mehmet Sinan İyisoy, Selim Kutl. How does neurokinin 3 receptor agonism affect pathological and cognitive impairments in an Alzheimer's disease-like rat model? Amino acids. 2023-02-06. PMID:36745246. |
cholinergic mechanism analysis from hippocampus-cortex tissues was performed by elisa and catecholamine analysis from brain stem tissue were performed by hplc method. |
2023-02-06 |
2023-08-14 |
rat |
| Sung-Gyoon Oh, Eun-Yeup Lee, Hyun-Sook Le. Projections from LIM homeobox 6 (Lhx6) + zona incerta neurons to the cholinergic or monoaminergic nuclei of the rat. Anatomical record (Hoboken, N.J. : 2007). 2022-12-30. PMID:36583474. |
thus, the present study was designed to examine whether lhx6-expressing neurons (in parallel to intermingled mch-expressing ones) may send efferent projections to cholinergic and/or monoaminergic nuclei from basal forebrain (bf) to brainstem (bs). |
2022-12-30 |
2023-08-14 |
rat |
| Erkan Kilinc, Ibrahim Ethem Torun, Yasemin Baranoglu Kilin. Meningeal mast cell-mediated mechanisms of cholinergic system modulation in neurogenic inflammation underlying the pathophysiology of migraine. The European journal of neuroscience. 2022-12-09. PMID:36485173. |
these results ensure for a first time direct evidence that endogenous acetylcholine contributes to migraine pathology mainly by activating meningeal mast cells while muscarinic receptors are involved in cgrp release from trigeminal ganglion and brainstem, without excluding the possible role of nicotinic cholinergic receptors. |
2022-12-09 |
2023-08-14 |
rat |
| Lindsay J Agostinelli, Scott C Seaman, Clifford B Saper, Dustin Fykstra, Marco M Hefti, Timothy R Koscik, Brian J Dlouhy, Alexander G Bassu. Human Brainstem and Cerebellum Atlas- Chemoarchitecture and Cytoarchitecture Paired to MRI. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2022-11-28. PMID:36442999. |
here, we report a high resolution (200 μm) 7t mri of a cadaveric male human brainstem and cerebellum paired with detailed, coregistered histology (at 2 μm single cell resolution) of the immunohistochemically stained cholinergic, serotonergic, and catecholaminergic (dopaminergic noradrenergic and adrenergic) neurons, in relationship to each other and to the cerebellum. |
2022-11-28 |
2023-08-14 |
human |
| Niloufar Kamalkhani, Mojtaba Zare. Distinct atrophy of septal nuclei in Parkinson's disease. Clinical parkinsonism & related disorders. vol 7. 2022-11-07. PMID:36338824. |
septal nuclei have extensive cholinergic connections with thalamus and brain stem nuclei. |
2022-11-07 |
2023-08-14 |
Not clear |