| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Roberta Amoriello, Clara Ballerin. Immunofluorescence Staining of Murine Spinal Cord Sections to Evaluate Microglial Activation and Astrogliosis. Methods in molecular biology (Clifton, N.J.). vol 2857. 2024-09-30. PMID:39348064. |
aging impacts microglia and astrocytes by promoting the production of pro-inflammatory cytokines, impairing microglial phagocytosis and motility and astrocyte glutamate uptake. |
2024-09-30 |
2024-10-02 |
mouse |
| Anze Testen, Jonathan W VanRyzin, Tania J Bellinger, Ronald Kim, Han Wang, Matthew J Gastinger, Emily A Witt, Janay P Franklin, Haley A Vecchiarelli, Katherine Picard, Marie-Ève Tremblay, Kathryn J Reissne. Abstinence from cocaine self-administration promotes microglia pruning of astrocytes which drives cocaine-seeking behavior. bioRxiv : the preprint server for biology. 2024-09-30. PMID:39345569. |
rodent drug self-administration leads to compromised ability of astrocytes to maintain glutamate homeostasis within the brain's reward circuitry, as well as reductions in surface area, volume, and synaptic colocalization of astrocyte membranes. |
2024-09-30 |
2024-10-02 |
Not clear |
| Xiangyang Zang, Jingting Zhang, Jingping Hu, Xingying Mo, Tingwei Zheng, Jiaming Ji, Jibin Xing, Chaojin Chen, Shaoli Zho. Electroconvulsive therapy combined with esketamine improved depression through PI3K/AKT/GLT-1 pathway. Journal of affective disorders. 2024-09-12. PMID:39265873. |
glutamate transporter-1 (glt-1) expressed in astrocyte is responsible for glutamate clearance to maintain glutamate balance. |
2024-09-12 |
2024-09-15 |
rat |
| Xin-Hao Jiao, Jie Wan, Wei-Feng Wu, Lin-Hui Ma, Chen Chen, Wei Dong, Yi-Qi Liu, Chun-Hui Jin, Ao Sun, Yue Zhou, Zi-Yi Li, Qiang Liu, Yu-Qing Wu, Cheng-Hua Zho. GLT-1 downregulation in hippocampal astrocytes induced by type 2 diabetes contributes to postoperative cognitive dysfunction in adult mice. CNS neuroscience & therapeutics. vol 30. issue 9. 2024-09-02. PMID:39218798. |
astrocyte glutamate transporter 1 (glt-1) plays a crucial role in regulating neuron excitability. |
2024-09-02 |
2024-09-04 |
mouse |
| Henri Chahinian, Nouara Yahi, Jacques Fantin. Glutamate, Gangliosides, and the Synapse: Electrostatics at Work in the Brain. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201269. |
this electric field controls the flow of glutamate in the tripartite synapse involving pre- and post-synaptic neurons and the astrocyte. |
2024-08-29 |
2024-09-01 |
Not clear |
| Sarah Amato, Monica Averna, Elisa Farsetti, Diego Guidolin, Marco Pedrazzi, Elena Gatta, Simona Candiani, Guido Maura, Luigi Francesco Agnati, Chiara Cervetto, Manuela Marcol. Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes. International journal of molecular sciences. vol 25. issue 16. 2024-08-29. PMID:39201299. |
by biophysical and functional approaches, we focused our attention on the existence of an a2a-d2-otr high-order receptor complex and its role in modulating cytosolic calcium levels and endogenous glutamate release, when striatal astrocyte processes were stimulated with 4-aminopyridine. |
2024-08-29 |
2024-09-01 |
Not clear |
| Sophie Schröder, Ulrike Fuchs, Verena Gisa, Tonatiuh Pena, Dennis M Krüger, Nina Hempel, Susanne Burkhardt, Gabriela Salinas, Anna-Lena Schütz, Ivana Delalle, Farahnaz Sananbenesi, Andre Fische. PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease. Acta neuropathologica. vol 148. issue 1. 2024-08-29. PMID:39207536. |
in line with this, knockdown of prdm16-dt and prdm16os revealed its critical role in maintaining astrocyte homeostasis and supporting neuronal function by regulating genes essential for glutamate uptake, lactate release, and neuronal spine density through interactions with the re1-silencing transcription factor (rest) and polycomb repressive complex 2 (prc2). |
2024-08-29 |
2024-09-04 |
human |
| Sen Shang, Leilei Wang, Xiaoyun L. β-Hydroxybutyrate enhances astrocyte glutamate uptake through EAAT1 expression regulation. Molecular and cellular neurosciences. 2024-08-23. PMID:39179164. |
β-hydroxybutyrate enhances astrocyte glutamate uptake through eaat1 expression regulation. |
2024-08-23 |
2024-08-27 |
mouse |
| Sam S Critzer, Taylor J Bosch, Kelene A Fercho, Jamie L Scholl, Lee A Baug. Water and Brain Function - Effects of Hydration Status on Neurostimulation with Transcranial Magnetic Stimulation. Journal of neurophysiology. 2024-07-31. PMID:39081213. |
compared to dehydration, we expected rehydration to show signs of macroscopic and microscopic volume changes including decreased scalp-cortex distance (brain closer to stimulator) and astrocyte swelling-induced glutamate release. |
2024-07-31 |
2024-08-02 |
Not clear |
| Cheng-Lin Lu, Jing Ren, Xiong Ca. An astroglial basis of major depressive disorder: Molecular, Cellular, and Circuit Features. Biological psychiatry. 2024-07-31. PMID:39084500. |
accumulated evidence indicates that the astrocyte is an important contributor to the pathophysiology of mdd including blood-brain barrier (bbb) integrity, gap junctions, gliotransmission, glutamate homeostasis, and energy metabolism. |
2024-07-31 |
2024-08-03 |
Not clear |
| Rong Luo, Xiaojun Hu, Xin Li, Fan Lei, Ping Liao, Limei Yi, Xia Zhang, Bin Zhou, Ruotian Jian. Dysfunctional astrocyte glutamate uptake in the hypothalamic paraventricular nucleus contributes to visceral pain and anxiety-like behavior in mice with chronic pancreatitis. Glia. 2024-07-24. PMID:39046219. |
dysfunctional astrocyte glutamate uptake in the hypothalamic paraventricular nucleus contributes to visceral pain and anxiety-like behavior in mice with chronic pancreatitis. |
2024-07-24 |
2024-07-26 |
mouse |
| Ana Isabel Silva, Renato Socodato, Carolina Pinto, Ana Filipa Terceiro, Teresa Canedo, João Bettencourt Relvas, Margarida Saraiva, Teresa Summaviell. IL-10 and Cdc42 modulate astrocyte-mediated microglia activation in methamphetamine-induced neuroinflammation. Glia. 2024-05-23. PMID:38780232. |
our findings reveal that the presence of recombinant il-10 (ril-10) counteracts meth-induced excessive glutamate release in astrocyte cultures, which significantly reduces microglial activation. |
2024-05-23 |
2024-05-27 |
Not clear |
| Lu Chen, Wenqian Yang, Fei Yang, Tingwan Xu, Yanying Yu, Qian Wu, Yanbing Ha. Astrocyte mitochondria: Potential therapeutic targets for epilepsy. Heliyon. vol 10. issue 9. 2024-05-18. PMID:38756598. |
in this review, we mainly summarize the regulatory role of astrocyte mitochondria in glutamate, calcium ion, and adenosine triphosphate (atp) homeostasis and outline the protective role of astrocyte mitochondria in nervous system diseases, revealing a new target for epilepsy treatment. |
2024-05-18 |
2024-05-27 |
Not clear |
| Xiaoying Tan, Elizabeth M Neslund, Khawla Fentis, Zheng-Ming Din. Fluorocitrate inhibition of astrocytes reduces nicotine self-administration and alters extracellular levels of glutamate and dopamine within the nucleus accumbens in male Wistar rats. Neuropharmacology. 2024-05-16. PMID:38750804. |
these results indicate that nicotine reinforcement upregulates the astrocyte marker gfap expression in the naccr, metabolic inhibition of astrocytes attenuates nicotine reinforcement and relapse, and metabolic inhibition of astrocytes disrupts extracellular dopamine and glutamate transmission. |
2024-05-16 |
2024-05-27 |
rat |
| Elena Dossi, Lou Zonca, Helena Pivonkova, Giampaolo Milior, Julien Moulard, Lydia Vargova, Oana Chever, David Holcman, Nathalie Rouac. Astroglial gap junctions strengthen hippocampal network activity by sustaining afterhyperpolarization via KCNQ channels. Cell reports. vol 43. issue 5. 2024-05-09. PMID:38722742. |
here, using astroglial connexin-deficient mice, in which astrocytes are disconnected and neuronal bursting patterns are abnormal, we show that astrocyte networks strengthen bursting activity via dynamic regulation of extracellular potassium levels, independently of glutamate homeostasis or metabolic support. |
2024-05-09 |
2024-05-27 |
mouse |
| Duo Li, Sihui Li, Min Pan, Qiang Li, Jiangling Song, Rui Zhan. The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence. Cognitive neurodynamics. vol 18. issue 2. 2024-05-03. PMID:38699615. |
however, there lacks of investigation regarding the role of extracellular glutamate homeostasis dysregulated by astrocyte in neuronal epileptic discharges. |
2024-05-03 |
2024-05-05 |
Not clear |
| Duo Li, Sihui Li, Min Pan, Qiang Li, Jiangling Song, Rui Zhan. The role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence. Cognitive neurodynamics. vol 18. issue 2. 2024-05-03. PMID:38699615. |
the role of extracellular glutamate homeostasis dysregulated by astrocyte in epileptic discharges: a model evidence. |
2024-05-03 |
2024-05-05 |
Not clear |
| Lizbeth García-Velázquez, Reem Alobayan, Denisse Morales-Moreno, Evangelina Ávila-Muñoz, Clorinda Aria. Differential changes in Wnt7 and Dkk1 levels in astrocytes exposed to glutamate or TNFα. Neuroreport. 2024-04-10. PMID:38597273. |
primary astrocyte cultures from rat cerebral cortices were exposed to glutamate or tnfα. |
2024-04-10 |
2024-04-12 |
rat |
| Dongxiao Li, Yufeng Wang, Yansu Guo, Weiping Wan. Bioinformatics analysis reveals multiple functional changes in astrocytes in temporal lobe epilepsy. Brain research. 2024-02-28. PMID:38417653. |
the correlation between the expression of these hub genes and seizure frequency, as well as epilepsy-related factors, including inflammatory mediators, complement factors, glutamate excitotoxicity and astrocyte reactivity, were analyzed. |
2024-02-28 |
2024-03-02 |
human |
| Jiawei Yang, Ying Wang, Yuyan Xia, Yajie Ren, Zhi Wang, Xin Meng, Shuangyue Li, Xiaohui Liu, Jing Sha. PFOS Elicits Cytotoxicity in Neuron Through Astrocyte-Derived CaMKII-DLG1 Signaling In Vitro Rat Hippocampal Model. Neurochemical research. 2024-02-23. PMID:38393622. |
the application of pfos showed a decreased cell viability, synapse length and glutamate transporter 1 (glt-1) expression, but an increased camkii, dlg1 and cyclic amp response element binding protein (creb) expression in primary cultured astrocyte. |
2024-02-23 |
2024-02-25 |
rat |