| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu-Hong Wei, Xiao-Dong Na, Guang-Jie Liao, Qiu-Ying Chen, Yu Cui, Feng-Ying Chen, Yong-Yong Li, Ying Zang, Xian-Guo Li. The up-regulation of IL-6 in DRG and spinal dorsal horn contributes to neuropathic pain following L5 ventral root transection. Experimental neurology. vol 241. 2013-04-08. PMID:23261764. |
double immunofluorescence stainings revealed that in drgs the increased immunoreactivity (ir) of il-6 was almost restricted in neuronal cells, while in the spinal dorsal horn il-6-ir up-regulated in both glial cells (astrocyte and microglia) and neurons. |
2013-04-08 |
2023-08-12 |
Not clear |
| Yingxia Liang, Weijian Jiang, Zhiyu Zhang, Jianfeng Yu, Liang Tao, Shujin Zha. Behavioral and morphological evidence for the involvement of glial cells in the antinociceptive effect of najanalgesin in a rat neuropathic pain model. Biological & pharmaceutical bulletin. vol 35. issue 6. 2012-10-22. PMID:22687474. |
in addition, the astrocyte activation was attenuated following najanalgesin treatment in the dorsal horn of neuropathic rats, as assessed by immunohistology and western blotting. |
2012-10-22 |
2023-08-12 |
mouse |
| Jing Wang, Bin Geng, Hai-Li Shen, Xu Xu, Hong Wang, Cui-Fang Wang, Jing-Ling Ma, Zhi-Ping Wan. Amino acid transport system A is involved in inflammatory nociception in rats. Brain research. vol 1449. 2012-08-20. PMID:22373650. |
formalin (5%, 50μl) injected subcutaneously into the unilateral hindpaw pad induced typical biphase nociceptive behaviors, including licking/biting and flinching of the injected paw and an increase of glial fibrillary acid protein (gfap, an activated astrocyte marker) expression in spinal dorsal horn, and these effects could be attenuated by intrathecal injection of the competitive inhibitor of amino acid system a transporter, methylaminoisobutyric acid (meaib, 0.1, 0.3, 0.5, and 0.7mmol), in a dose-dependent manner. |
2012-08-20 |
2023-08-12 |
rat |
| Jeannine C Foley, Sally R McIver, Philip G Haydo. Gliotransmission modulates baseline mechanical nociception. Molecular pain. vol 7. 2012-08-06. PMID:22136202. |
under baseline conditions, immunostaining in the dorsal horn of the spinal cord showed astrocyte-specific transgene expression in dnsnare mice, and no difference in expression levels of the astrocyte marker gfap and the microglia marker iba1 relative to wild-type mice. |
2012-08-06 |
2023-08-12 |
mouse |
| Ya-Ni Huang, Ru-Yin Tsai, Shinn-Long Lin, Chih-Cheng Chien, Chen-Hwan Cherng, Ching-Tang Wu, Chun-Chang Yeh, Chih-Shung Won. Amitriptyline attenuates astrocyte activation and morphine tolerance in rats: role of the PSD-95/NR1/nNOS/PKCγ signaling pathway. Behavioural brain research. vol 229. issue 2. 2012-07-17. PMID:22309983. |
co-administration of amitriptyline with morphine not only preserved the antinociceptive effect of morphine, but also attenuated astrocyte activation in the rat spinal cord dorsal horn. |
2012-07-17 |
2023-08-12 |
rat |
| Ming Gu, Kan Miyoshi, Ronald Dubner, Wei Guo, Shiping Zou, Ke Ren, Koichi Noguchi, Feng We. Spinal 5-HT(3) receptor activation induces behavioral hypersensitivity via a neuronal-glial-neuronal signaling cascade. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 36. 2011-10-31. PMID:21900561. |
we found that there was neuron-to-microglia signaling via chemokine fractalkine, microglia to astrocyte signaling via the cytokine il-18, astrocyte to neuronal signaling by il-1β, and enhanced activation of glun (nmda) receptors in the spinal dorsal horn. |
2011-10-31 |
2023-08-12 |
rat |
| Gregory Fischer, Sandra Kostic, Hiroyuki Nakai, Frank Park, Damir Sapunar, Hongwei Yu, Quinn Hoga. Direct injection into the dorsal root ganglion: technical, behavioral, and histological observations. Journal of neuroscience methods. vol 199. issue 1. 2011-10-03. PMID:21540055. |
only minimal astrocyte activation in the spinal dorsal horn was evident after drg saline injections. |
2011-10-03 |
2023-08-12 |
rat |
| Damir Sapunar, Katarina Vukojević, Sandra Kostić, Livia Pulja. Attenuation of pain-related behavior evoked by injury through blockade of neuropeptide Y Y2 receptor. Pain. vol 152. issue 5. 2011-08-23. PMID:21376464. |
exacerbation of pain-related behavior following npy injection was accompanied by astrocyte activation in ipsilateral dorsal horn and with satellite cells activation in the drg proximal to injury. |
2011-08-23 |
2023-08-12 |
Not clear |
| Azusa Kobayashi, Masamichi Shinoda, Barry J Sessle, Kuniya Honda, Yoshiki Imamura, Suzuro Hitomi, Yoshiyuki Tsuboi, Akiko Okada-Ogawa, Koichi Iwat. Mechanisms involved in extraterritorial facial pain following cervical spinal nerve injury in rats. Molecular pain. vol 7. 2011-06-22. PMID:21310020. |
nocifensive behavior, phosphorylated extracellular signal-regulated kinase (perk) expression and astroglial cell activation in the trigeminal spinal subnucleus caudalis (vc) and upper cervical spinal dorsal horn (c1-c2) neurons were analyzed in rats with upper cervical spinal nerve transection (cnx). |
2011-06-22 |
2023-08-12 |
rat |
| Christina A Christianson, Maripat Corr, Gary S Firestein, Anahita Mobargha, Tony L Yaksh, Camilla I Svensso. Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis. Pain. vol 151. issue 2. 2011-02-14. PMID:20739123. |
the superficial dorsal horn of arthritic mice displayed increased staining of microglia at early and late time points, but astrocyte staining increased only during the inflammatory phase. |
2011-02-14 |
2023-08-12 |
mouse |
| Peter M Grace, Mark R Hutchinson, Jim Manavis, Andrew A Somogyi, Paul E Rola. A novel animal model of graded neuropathic pain: utility to investigate mechanisms of population heterogeneity. Journal of neuroscience methods. vol 193. issue 1. 2011-01-21. PMID:20817038. |
astrocyte gfap expression was positively associated with graded allodynia in the ipsilateral dorsal horn (p=0.18, r(2)>0.6) and ipsilateral dlf (p<0.05, r(2)>0.9). |
2011-01-21 |
2023-08-12 |
rat |
| H Nie, H Zhang, H R Wen. Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats. Neuroscience. vol 170. issue 3. 2011-01-11. PMID:20678556. |
the effects of minocycline treatments on the dorsal horn expression of glial gts and astrocyte marker glial fibrillary acidic protein (gfap) were analyzed by immunohistochemistry. |
2011-01-11 |
2023-08-12 |
rat |
| Yong-Jing Gao, Ru-Rong J. Light touch induces ERK activation in superficial dorsal horn neurons after inflammation: involvement of spinal astrocytes and JNK signaling in touch-evoked central sensitization and mechanical allodynia. Journal of neurochemistry. vol 115. issue 2. 2010-11-22. PMID:20722971. |
collectively, these data suggest that (i) erk can be activated in superficial dorsal horn neurons by low-threshold mechanical stimulation under pathological condition and (ii) erk activation by light touch is associated with mechanical allodynia and requires an astrocyte network. |
2010-11-22 |
2023-08-12 |
Not clear |
| Donald J Joseph, Papiya Choudhury, Amy B Macdermot. An in vitro assay system for studying synapse formation between nociceptive dorsal root ganglion and dorsal horn neurons. Journal of neuroscience methods. vol 189. issue 2. 2010-09-28. PMID:20385165. |
to address this issue, we have established an in vitro assay system consisting of separately purified drg neurons and dorsal horn neurons on astrocyte microislands. |
2010-09-28 |
2023-08-12 |
Not clear |
| Rita Bardoni, Alessia Ghirri, Micaela Zonta, Chiara Betelli, Giovanni Vitale, Valentina Ruggieri, Maurizio Sandrini, Giorgio Carmignot. Glutamate-mediated astrocyte-to-neuron signalling in the rat dorsal horn. The Journal of physiology. vol 588. issue Pt 5. 2010-06-02. PMID:20083514. |
by using patch-clamp and confocal microscope calcium imaging techniques in rat spinal cord slices, we monitored the activity of dorsal horn lamina ii neurons following astrocyte activation. |
2010-06-02 |
2023-08-12 |
rat |
| Camille J Olechowski, Janet J Truong, Bradley J Ker. Neuropathic pain behaviours in a chronic-relapsing model of experimental autoimmune encephalomyelitis (EAE). Pain. vol 141. issue 1-2. 2009-04-08. PMID:19084337. |
there is, however, a significant influx of cd3+ t cells and increased astrocyte and microglia/macrophage reactivity in the superficial dorsal horn of mice with mog(35-55) eae. |
2009-04-08 |
2023-08-12 |
mouse |
| Natasa Jokic, Yong Yong Ling, Rachael E Ward, Adina T Michael-Titus, John V Priestley, Andrea Malaspin. Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis. Journal of neurochemistry. vol 103. issue 5. 2008-01-03. PMID:17956549. |
the expression of rxrbeta in lamina ii neurons in the dorsal horn of transgenic and wild type (wt) animals was associated with extensive astrocyte staining in end-stage lumbar spinal cord from transgenic rats. |
2008-01-03 |
2023-08-12 |
rat |
| Minoru Narita, Takuya Yoshida, Mayumi Nakajima, Michiko Narita, Mayumi Miyatake, Tomoe Takagi, Yoshinori Yajima, Tsutomu Suzuk. Direct evidence for spinal cord microglia in the development of a neuropathic pain-like state in mice. Journal of neurochemistry. vol 97. issue 5. 2006-07-21. PMID:16606373. |
at 7 days after sciatic nerve ligation, the immunoreactivities (irs) of the specific astrocyte marker glial fibrillary acidic protein (gfap) and the specific microglial marker ox-42, but not the specific oligodendrocyte marker o4, were increased on the ipsilateral side of the spinal cord dorsal horn in nerve-ligated mice compared with that on the contralateral side. |
2006-07-21 |
2023-08-12 |
mouse |
| Linda S Sorkin, Karly Maruyama, David L Boyle, Li Yang, Martin Marsala, Gary S Firestei. Spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. Neuroscience letters. vol 340. issue 2. 2003-05-29. PMID:12668251. |
spinal adenosine agonist reduces c-fos and astrocyte activation in dorsal horn of rats with adjuvant-induced arthritis. |
2003-05-29 |
2023-08-12 |
rat |
| M J Schwei, P Honore, S D Rogers, J L Salak-Johnson, M P Finke, M L Ramnaraine, D R Clohisy, P W Manty. Neurochemical and cellular reorganization of the spinal cord in a murine model of bone cancer pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 24. 2000-01-06. PMID:10594070. |
in the spinal cord, ipsilateral to the cancerous bone, there was a massive astrocyte hypertrophy without neuronal loss, an expression of dynorphin and c-fos protein in neurons in the deep laminae of the dorsal horn. |
2000-01-06 |
2023-08-12 |
Not clear |