| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W-W Li, T-Z Guo, X Shi, Y Sun, T Wei, D J Clark, W S Kinger. Substance P spinal signaling induces glial activation and nociceptive sensitization after fracture. Neuroscience. vol 310. 2016-08-15. PMID:26386297. |
immunohistochemistry and pcr were used to evaluate microglial and astrocyte activation in the dorsal horn. |
2016-08-15 |
2023-08-13 |
rat |
| E E O'Brien, B A Smeester, K S Michlitsch, J-H Lee, A J Beit. Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor. Neuroscience. vol 301. 2016-04-18. PMID:26071956. |
secondly, this increase in mechanical hyperalgesia and cold allodynia is mirrored by significant increases in both spinal astrocyte activity and aromatase expression in the dorsal horn of fibrosarcoma-bearing mice. |
2016-04-18 |
2023-08-13 |
mouse |
| Hoon-Seong Choi, Dae-Hyun Roh, Seo-Yeon Yoon, Ji-Young Moon, Sheu-Ran Choi, Soon-Gu Kwon, Suk-Yun Kang, Ho-Jae Han, Hyun-Woo Kim, Alvin J Beitz, Seog-Bae Oh, Jang-Hern Le. Microglial interleukin-1β in the ipsilateral dorsal horn inhibits the development of mirror-image contralateral mechanical allodynia through astrocyte activation in a rat model of inflammatory pain. Pain. vol 156. issue 6. 2016-02-04. PMID:25749305. |
microglial interleukin-1β in the ipsilateral dorsal horn inhibits the development of mirror-image contralateral mechanical allodynia through astrocyte activation in a rat model of inflammatory pain. |
2016-02-04 |
2023-08-13 |
rat |
| Lorenzo Di Cesare Mannelli, Francesca Corti, Laura Micheli, Matteo Zanardelli, Carla Ghelardin. Delay of morphine tolerance by palmitoylethanolamide. BioMed research international. vol 2015. 2015-12-28. PMID:25874232. |
pea prevented both microglia and astrocyte cell number increase induced by morphine in the dorsal horn; on the contrary, the morphine-dependent increase of spinal tnf-α levels was not modified by pea. |
2015-12-28 |
2023-08-13 |
rat |
| Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepor. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. PloS one. vol 9. issue 9. 2015-12-21. PMID:25268642. |
persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. |
2015-12-21 |
2023-08-13 |
mouse |
| Jaime L Watson, Tamara J Hala, Rajarshi Putatunda, Daniel Sannie, Angelo C Lepor. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. PloS one. vol 9. issue 9. 2015-12-21. PMID:25268642. |
following injury, an increase in the number of neurons expressing Δfosb (a marker of chronic neuronal activation), persistent astrocyte activation and proliferation (as measured by gfap and ki67 expression), and a decrease in the expression of the astrocyte glutamate transporter glt1 are observed in the ipsilateral superficial dorsal horn of cervical spinal cord. |
2015-12-21 |
2023-08-13 |
mouse |
| Yan Lefèvre, Aurélie Amadio, Peggy Vincent, Amélie Descheemaeker, Stéphane H R Oliet, Radhouane Dallel, Daniel L Voisi. Neuropathic pain depends upon D-serine co-activation of spinal NMDA receptors in rats. Neuroscience letters. vol 603. 2015-11-23. PMID:26182881. |
immunocytochemistry showed that about 70% of serine racemase, the synthesizing enzyme of d-serine, was expressed in astrocyte processes in the superficial laminae of l5 dorsal horn. |
2015-11-23 |
2023-08-13 |
rat |
| Cayo Almeida, Aline DeMaman, Ricardo Kusuda, Flaviane Cadetti, Maria Ida Ravanelli, André L Queiroz, Thais A Sousa, Sonia Zanon, Leonardo R Silveira, Guilherme Luca. Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain. Pain. vol 156. issue 3. 2015-11-02. PMID:25687543. |
finally, prolonged swim exercise reversed astrocyte and microglia hyperactivity in the dorsal horn after nerve lesion, which remained normalized after training cessation. |
2015-11-02 |
2023-08-13 |
mouse |
| J Cui, W He, B Yi, H Zhao, K Lu, H Ruan, D M. mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model. Neuroscience. vol 275. 2015-10-15. PMID:24976516. |
mtor pathway is involved in adp-evoked astrocyte activation and atp release in the spinal dorsal horn in a rat neuropathic pain model. |
2015-10-15 |
2023-08-13 |
rat |
| Jastrow Canlas, Phillip Holt, Alexander Carroll, Shane Rix, Paul Ryan, Lorena Davies, Dusan Matusica, Stuart M Pitson, Claire F Jessup, Ian L Gibbins, Rainer V Haberberge. Sphingosine kinase 2-deficiency mediated changes in spinal pain processing. Frontiers in molecular neuroscience. vol 8. 2015-08-18. PMID:26283908. |
similarly, sphk2(-/-) mice showed in contrast to wild-type no cpi-dependent increase in areas of the dorsal horn immunoreactive for the microglia marker iba-1 and the astrocyte marker glial fibrillary acidic protein (gfap). |
2015-08-18 |
2023-08-13 |
mouse |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, glt1, in superficial dorsal horn. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
furthermore, dysregulation of extracellular glutamate homeostasis and chronic astrocyte activation play important underlying roles in persistent hyperexcitability of these superficial dorsal horn neurons. |
2015-05-21 |
2023-08-13 |
rat |
| Rajarshi Putatunda, Tamara J Hala, Jeannie Chin, Angelo C Lepor. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain research. vol 1581. 2015-05-21. PMID:24833066. |
finally, persistent astrocyte activation and significantly reduced expression of the major cns glutamate transporter, glt1, in superficial dorsal horn astrocytes are associated with both excitability changes in stt neurons and the neuropathic pain behavioral phenotype. |
2015-05-21 |
2023-08-13 |
rat |
| Byung-Soo Ahn, Seong-Kyu Kim, Ha Neul Kim, Ji-Hye Lee, Ji-Hwan Lee, Deog Sang Hwang, Hyunsu Bae, Byung-Il Min, Sun Kwang Ki. Gyejigachulbu-Tang Relieves Oxaliplatin-Induced Neuropathic Cold and Mechanical Hypersensitivity in Rats via the Suppression of Spinal Glial Activation. Evidence-based complementary and alternative medicine : eCAM. vol 2014. 2014-12-16. PMID:25505922. |
immunoreactivities of glial fibrillary acidic protein (gfap, astrocyte marker) and ox-42 (microglia marker) in the spinal dorsal horn were significantly increased by an oxaliplatin injection, which were restored by gbt administration. |
2014-12-16 |
2023-08-13 |
rat |
| Wei Luo, Runqing Fu, Yu Tan, Bing Fang, Zhi Yan. Chemokine CCL2 up-regulated in the medullary dorsal horn astrocytes contributes to nocifensive behaviors induced by experimental tooth movement. European journal of oral sciences. vol 122. issue 1. 2014-12-03. PMID:24206110. |
to test the hypothesis that the astrocytic chemokine (c-c motif) ligand 2 (ccl2) plays an important role in nocifensive behaviors after experimental tooth movement (etm), the expression and cellular localization of ccl2 and astrocyte activation in the medullary dorsal horn (mdh) were determined by immunohistochemistry in rats. |
2014-12-03 |
2023-08-12 |
rat |
| Yoki Nakamura, Norimitsu Morioka, Hiromi Abe, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Keyue Liu, Masahiro Nishibori, Yoshihiro Nakat. Neuropathic pain in rats with a partial sciatic nerve ligation is alleviated by intravenous injection of monoclonal antibody to high mobility group box-1. PloS one. vol 8. issue 8. 2014-06-15. PMID:23991202. |
markers of astrocyte (glial fibrillary acidic protein (gfap)), microglia (ionized calcium binding adaptor molecule 1 (iba1)) and spinal neuron (cfos) activity were greatly increased in the ipsilateral dorsal horn side compared to the sham-operated side 21 days after psnl. |
2014-06-15 |
2023-08-12 |
rat |
| Jaekwang Lee, Oleg V Favorov, Mark Tommerdahl, C Justin Lee, Barry L Whitse. Attenuated Glial K(+) Clearance Contributes to Long-Term Synaptic Potentiation Via Depolarizing GABA in Dorsal Horn Neurons of Rat Spinal Cord. Experimental neurobiology. vol 23. issue 1. 2014-04-16. PMID:24737940. |
it is proposed that a transient impairment of astrocyte energy production can trigger the cascade of dorsal horn mechanisms that underlies hyperalgesia and persistent pain. |
2014-04-16 |
2023-08-13 |
rat |
| J Morgenweck, R B Griggs, R R Donahue, J E Zadina, B K Taylo. PPARγ activation blocks development and reduces established neuropathic pain in rats. Neuropharmacology. vol 70. 2013-11-26. PMID:23415633. |
intraperitoneal pioglitazone significantly reduced the nerve injury-induced up-regulation of cd11b, gfap, and p-p38 in the dorsal horn, indicating a mechanism of action involving spinal microglia and/or astrocyte activation. |
2013-11-26 |
2023-08-12 |
rat |
| Lisa C Loram, Frederick R Taylor, Keith A Strand, Steven F Maier, Jason D Speake, Kristen G Jordan, John W James, Steven P Wene, Robert C Pritchard, Heather Green, Katherine Van Dyke, Anatoly Mazarov, Sharon R Letchworth, Linda R Watkin. Systemic administration of an alpha-7 nicotinic acetylcholine agonist reverses neuropathic pain in male Sprague Dawley rats. The journal of pain. vol 13. issue 12. 2013-09-05. PMID:23182225. |
spinal cords were collected after 2 weeks and processed for microglial and astrocyte activation markers within the ipsilateral l4-l6 dorsal horn. |
2013-09-05 |
2023-08-12 |
rat |
| Shi-Ying Huang, Nan-Fu Chen, Wu-Fu Chen, Han-Chun Hung, Hsin-Pai Lee, Yen-You Lin, Hui-Min Wang, Ping-Jyun Sung, Jyh-Horng Sheu, Zhi-Hong We. Sinularin from indigenous soft coral attenuates nociceptive responses and spinal neuroinflammation in carrageenan-induced inflammatory rat model. Marine drugs. vol 10. issue 9. 2013-04-24. PMID:23118711. |
further, s.c. sinularin (80 mg/kg) significantly inhibited carrageenan-induced microglial and astrocyte activation as well as upregulation of inos in the dorsal horn of the lumbar spinal cord. |
2013-04-24 |
2023-08-12 |
rat |