| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Masayuki Hashimoto, Masao Koda, Takeo Furuya, Atsushi Murata, Masashi Yamazaki, Kazuhisa Takahash. Intrathecal Noggin administration in rats temporally ameliorates mechanical allodynia induced by a chronic constriction injury. eNeurologicalSci. vol 4. 2020-10-01. PMID:29430541. |
fluorescence immunohistochemistry indicated that noggin administration decreased astrocyte accumulation in the dorsal horn compared with pbs after administration for one week. |
2020-10-01 |
2023-08-13 |
rat |
| Constanza Stefania Meneses, Heine Yacob Müller, Daniel Eduardo Herzberg, Benjamín Uberti, Hedie Almagro Bustamante, Marianne Patricia Werne. Immunofluorescence characterization of spinal cord dorsal horn microglia and astrocytes in horses. PeerJ. vol 5. 2020-09-30. PMID:29085760. |
evaluation of shape, area, cell diameter, cell process length and thickness was performed on dorsal horn microglia and astrocyte. |
2020-09-30 |
2023-08-13 |
human |
| Yu Zhong, Jialin Chen, Jing Chen, Yanhua Chen, Li Li, Yubo Xi. Crosstalk between Cdk5/p35 and ERK1/2 signalling mediates spinal astrocyte activity via the PPARγ pathway in a rat model of chronic constriction injury. Journal of neurochemistry. vol 151. issue 2. 2020-06-11. PMID:31314915. |
here, we quantified pain behaviour after cci; detected the localization of p35, cdk5, phosphorylated erk1/2 (perk1/2), phosphorylated peroxisome proliferator-activated receptor γ (ppparγ), neuronal nuclei (a neuronal marker), glial fibrillary acidic protein (gfap, an activated astrocyte marker) and ionized calcium binding adaptor molecule 1 (a microglial marker) in the dorsal horn using immunofluorescence; measured the protein levels of cdk5, p35, perk1/2, ppparγ and gfap using western blot analysis; and gauged the enzyme activity of cdk5/p35 kinase using a cdk5/p35 kinase activity assay kit. |
2020-06-11 |
2023-08-13 |
rat |
| Ágnes Hunyady, Zsófia Hajna, Tímea Gubányi, Bálint Scheich, Ágnes Kemény, Balázs Gaszner, Éva Borbély, Zsuzsanna Helye. Hemokinin-1 is an important mediator of pain in mouse models of neuropathic and inflammatory mechanisms. Brain research bulletin. vol 147. 2020-04-06. PMID:30664920. |
microglia, but not astrocyte activation was observed 14 days after psl in the ipsilateral spinal dorsal horn of wildtype, but not hk-1-deficient mice. |
2020-04-06 |
2023-08-13 |
mouse |
| Zsuzsanna Helyes, Valéria Tékus, Nikolett Szentes, Krisztina Pohóczky, Bálint Botz, Tamás Kiss, Ágnes Kemény, Zsuzsanna Környei, Krisztina Tóth, Nikolett Lénárt, Hajnalka Ábrahám, Emmanuel Pinteaux, Sheila Francis, Serena Sensi, Ádám Dénes, Andreas Goebe. Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1-induced mechanisms. Proceedings of the National Academy of Sciences of the United States of America. vol 116. issue 26. 2020-04-06. PMID:31182576. |
after a short-lasting paw inflammatory response in all groups, crps igg-injected mice displayed sustained, profound microglia and astrocyte activation in the dorsal horn of the spinal cord and pain-related brain regions, indicating central sensitization. |
2020-04-06 |
2023-08-13 |
mouse |
| Ke-Yu Xie, Qiang Wang, De-Jun Cao, Jia Liu, Xian-Feng Xi. Spinal astrocytic FGFR3 activation leads to mechanical hypersensitivity by increased TNF-α in spared nerve injury. International journal of clinical and experimental pathology. vol 12. issue 8. 2020-03-25. PMID:31934126. |
increased gfap expression in dorsal horn of the spinal cord indicated the participation of astrocyte in npp. |
2020-03-25 |
2023-08-13 |
Not clear |
| Wenqian Yang, Qulian Guo, Zhigang Cheng, Yunjiao Wang, Nianyue Bai, Zhenghua H. [mTOR signaling pathway of spinal cord is involved in peripheral nerve injury-induced hyperalgesia in rats]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 4. 2019-05-30. PMID:31113912. |
the gfap immunohistochemistry positive area and absorbance value in the dorsal horn of the lumbar spinal cord in the cci rats were decreased in the cci+early rapa group compared with the cci+early dmso group (p<0.05 or p<0.01), and which were also decreased in the cci+later rapa group compared with the cci+later dmso group (p<0.05 or p<0.01).
conclusion: mtor signaling pathway may be involved in hyperalgesia induced by peripheral nerve injury via spinal astrocyte activation in the dorsal horn of the spinal cord. |
2019-05-30 |
2023-08-13 |
rat |
| Arden G Vanderwall, Shahani Noor, Melody S Sun, Jacob E Sanchez, Xuexian O Yang, Lauren L Jantzie, Nikolaos Mellios, Erin D Milliga. Effects of spinal non-viral interleukin-10 gene therapy formulated with d-mannose in neuropathic interleukin-10 deficient mice: Behavioral characterization, mRNA and protein analysis in pain relevant tissues. Brain, behavior, and immunity. vol 69. 2019-04-15. PMID:29113923. |
similarly, dm/pdna-il-10 treatment decreases immunoreactivity for the astrocyte activation marker gfap in lumbar spinal cord dorsal horn. |
2019-04-15 |
2023-08-13 |
mouse |
| Hiroshi Ueda, Hiroyuki Neyama, Jun Nagai, Yosuke Matsushita, Tamotsu Tsukahara, Ryoko Tsukahar. Involvement of lysophosphatidic acid-induced astrocyte activation underlying the maintenance of partial sciatic nerve injury-induced neuropathic pain. Pain. vol 159. issue 11. 2019-02-19. PMID:29939962. |
the involvement of lpa receptors in astrocyte activation in vivo was evidenced by the findings that ki-16425 treatments abolished the upregulation of cxcl1 in activated astrocytes in the spinal dorsal horn of mice at day 14 after the psnl, and that ki-16425 reversed the lpa-induced upregulation of several chemokine gene expressions in primary cultured astrocytes. |
2019-02-19 |
2023-08-13 |
mouse |
| Z Alshelh, F Di Pietro, E P Mills, E R Vickers, C C Peck, G M Murray, L A Henderso. Altered regional brain T2 relaxation times in individuals with chronic orofacial neuropathic pain. NeuroImage. Clinical. vol 19. 2019-01-30. PMID:30035014. |
preclinical and post-mortem human studies have revealed that neuropathic pain is associated with prolonged astrocyte activation in the dorsal horn and we have suggested that this may result in altered gliotransmission, which results in altered resting neural rhythm in the ascending pain pathway. |
2019-01-30 |
2023-08-13 |
human |
| Z Alshelh, F Di Pietro, E P Mills, E R Vickers, C C Peck, G M Murray, L A Henderso. Altered regional brain T2 relaxation times in individuals with chronic orofacial neuropathic pain. NeuroImage. Clinical. vol 19. 2019-01-30. PMID:30035014. |
evidence of astrocyte activation above the level of the dorsal horn in living humans is lacking and direct measurement of astrocyte activation in living humans is not possible, however, there is evidence that regional alterations in t2 relaxation times are indicative of astrogliosis. |
2019-01-30 |
2023-08-13 |
human |
| Ryan S Tonkin, Callum Bowles, Chamini J Perera, Brooke A Keating, Preet G S Makker, Samuel S Duffy, Justin G Lees, Collin Tran, Anthony S Don, Thomas Fath, Lu Liu, Simon J O'Carroll, Louise F B Nicholson, Colin R Green, Catherine Gorrie, Gila Moalem-Taylo. Attenuation of mechanical pain hypersensitivity by treatment with Peptide5, a connexin-43 mimetic peptide, involves inhibition of NLRP3 inflammasome in nerve-injured mice. Experimental neurology. vol 300. 2018-10-03. PMID:29055716. |
peptide5 treatment resulted in significantly reduced cx43, and microglial and astrocyte activity in the dorsal horn of the spinal cord, as compared to control saline-treated cci mice. |
2018-10-03 |
2023-08-13 |
mouse |
| Lorenzo Di Cesare Mannelli, Laura Micheli, Mario Maresca, Giancarlo Cravotto, Maria Bellumori, Marzia Innocenti, Nadia Mulinacci, Carla Ghelardin. Anti-neuropathic effects of Rosmarinus officinalis L. terpenoid fraction: relevance of nicotinic receptors. Scientific reports. vol 6. 2018-08-20. PMID:27713514. |
in the dorsal horn of the spinal cord, ure did not reduce astrocyte activation. |
2018-08-20 |
2023-08-13 |
rat |
| Jee Youn Lee, Hae Young Choi, Bong-Gun Ju, Tae Young Yun. Estrogen alleviates neuropathic pain induced after spinal cord injury by inhibiting microglia and astrocyte activation. Biochimica et biophysica acta. Molecular basis of disease. vol 1864. issue 7. 2018-08-06. PMID:29653184. |
both microglia and astrocyte activation in the lamina i and ii of l4-5 dorsal horn was also inhibited by 17β-estradiol. |
2018-08-06 |
2023-08-13 |
rat |
| Benoit Michot, Ronald Deumens, Emmanuel Herman. Immunohistochemical comparison of astrocytic mGluR5 upregulation in infraorbital nerve- versus sciatic nerve-ligated rat. Neuroscience letters. vol 653. 2018-04-30. PMID:28533177. |
seven days later, mglur5 and the astrocyte marker gfap (glial fibrillary acidic protein) were overexpressed and appeared localized mainly in the superficial lamina of the trigeminal nucleus in cci-ion and the spinal cord dorsal horn in cci-sn rats. |
2018-04-30 |
2023-08-13 |
rat |
| Dongmei Wang, Yaping Xue, Yanhua Yan, Minjie Lin, Jiajia Yang, Jianzhong Huang, Yanguo Hon. Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury. Neurobiology of disease. vol 91. 2018-02-20. PMID:27018398. |
the present study provides evidence that activation of mrgc receptors inhibits nerve injury-induced increase of pronociceptive molecules in drg neurons, suppressing astrocyte activation, the upregulation of excitatory mediators and phosphorylation of transcription factors in the spinal dorsal horn. |
2018-02-20 |
2023-08-13 |
rat |
| Igor V Manzhulo, Olga S Ogurtsova, Yuliya O Kipryushina, Nikolay A Latyshev, Sergey P Kasyanov, Inessa V Dyuizen, Anna A Tyrtyshnai. Neuron-astrocyte interactions in spinal cord dorsal horn in neuropathic pain development and docosahexaenoic acid therapy. Journal of neuroimmunology. vol 298. 2017-08-17. PMID:27609281. |
we characterized the dynamics of gfap-positive astrocyte, substance p (sp) and nnos-positive neurons activity in the spinal cord dorsal horn (scdh) superficial lamina. |
2017-08-17 |
2023-08-13 |
rat |
| Preet G S Makker, Samuel S Duffy, Justin G Lees, Chamini J Perera, Ryan S Tonkin, Oleg Butovsky, Susanna B Park, David Goldstein, Gila Moalem-Taylo. Characterisation of Immune and Neuroinflammatory Changes Associated with Chemotherapy-Induced Peripheral Neuropathy. PloS one. vol 12. issue 1. 2017-08-10. PMID:28125674. |
in the central nervous system, ptx induced significant astrocyte activation in the spinal cord dorsal horn, and both ptx and oxa caused reduction of p2ry12+ homeostatic microglia, with no measurable changes in iba-1+ microglia/macrophages in the dorsal and ventral horns. |
2017-08-10 |
2023-08-13 |
mouse |
| Sheu-Ran Choi, Dae-Hyun Roh, Seo-Yeon Yoon, Soon-Gu Kwon, Hoon-Seong Choi, Ho-Jae Han, Alvin J Beitz, Jang-Hern Le. Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice. Neuropharmacology. vol 111. 2017-07-11. PMID:27567941. |
a thoracic spinal cord hemisection significantly increased both astrocyte activation and cx43 expression in lumbar dorsal horn. |
2017-07-11 |
2023-08-13 |
mouse |
| B A Smeester, E E O'Brien, K S Michlitsch, J-H Lee, A J Beit. The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice. Neuroscience. vol 324. 2017-01-03. PMID:26995084. |
the decrease in mechanical hyperalgesia in ovx females was mirrored by significant decreases in spinal astrocyte activity in laminae i-ii, iii-iv, v-vi and x and aromatase expression in laminae v-vi and x in the dorsal horn of tumor-bearing animals. |
2017-01-03 |
2023-08-13 |
mouse |