| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuan Zhu, Xiang Li, Siyi Liu, Yun-Han Zhao, Xue-Ru Liu, Xing-Yu Liu, Rongrong Yao, Lixia Tian, Xin-Qi Liu, Fanjun Meng, Lingli Lian. Enhanced interleukin-16-CD4 signaling in CD3 T cell mediates neuropathic pain via activating astrocytes in female mice. Neuropharmacology. 2024-08-13. PMID:39137872. |
additionally, il-16 induced astrocyte activation but not microglial activation in the spinal dorsal horn of female mice. |
2024-08-13 |
2024-08-16 |
mouse |
| Yuan Peng, Yuxin Zhang, Wei Wang, Biying Liu, Zuojing Zhang, Zhihao Gong, Xiaoxuan Zhang, Yuefeng Xia, Xingji You, Jingxiang W. Potential Role of Remimazolam in Alleviating Bone Cancer Pain in Mice via Modulation of Translocator Protein in Spinal Astrocytes. European journal of pharmacology. 2024-07-28. PMID:39068975. |
the results showed that bcp induced an upregulation of tspo and astrocyte activation in the spinal dorsal horn, alongside increased extracellular signal-regulated kinase (erk) signaling and inflammatory cytokine expression. |
2024-07-28 |
2024-08-02 |
mouse |
| Yifan Li, Bingyu Zhang, Jie Xu, Xiao Jiang, Liang Jing, Yanghua Tian, Kai Wang, Juanjuan Zhan. Inhibiting the JNK Signaling Pathway Attenuates Hypersensitivity and Anxiety-Like Behavior in a Rat Model of Non-specific Chronic Low Back Pain. Journal of molecular neuroscience : MN. vol 74. issue 3. 2024-07-24. PMID:39046556. |
astrocyte activation in the spinal cord plays an important role in the maintenance of latent sensitization of dorsal horn neurons in lbp. |
2024-07-24 |
2024-07-26 |
rat |
| Tang Li, Lingyue Hu, Chao Qin, Yuanjie Li, Zhenhua Song, Yang Jiao, Chunyan Wang, Wei Cui, Linlin Zhan. Annexin 1 Reduces Dermatitis-Induced Itch and Cholestatic Itch through Inhibiting Neuroinflammation and Iron Overload in the Spinal Dorsal Horn of Mice. Brain sciences. vol 14. issue 5. 2024-05-25. PMID:38790419. |
strikingly, ac2-26 therapy inhibits transferrin receptor 1 over-expression, iron accumulation, cytokine il-17 release and the production of its receptor il-17r, as well as astrocyte activation in the dorsal horn of spinal cord in mouse with dermatitis and cholestasis. |
2024-05-25 |
2024-05-27 |
mouse |
| Noémi Bencze, Bálint Scheich, Éva Szőke, Imola Wilhelm, Sándor Körmöndi, Bálint Botz, Zsuzsanna Helye. Osteosarcoma-Induced Pain Is Mediated by Glial Cell Activation in the Spinal Dorsal Horn, but Not Capsaicin-Sensitive Nociceptive Neurons: A Complex Functional and Morphological Characterization in Mice. Cancers. vol 16. issue 10. 2024-05-25. PMID:38791867. |
microglia activation was shown by the increased ionized calcium-binding adapter molecule 1 (iba1) immunopositivity on day 14 and astrocyte activation by the enhanced glial fibrillary acidic protein (gfap)-positive cell density on day 28 in the ipsilateral spinal dorsal horn. |
2024-05-25 |
2024-05-27 |
mouse |
| Xiao Luo, Tong Wan, Zhuofeng Ding, Xinran Hou, Jian Wang, Qulian Guo, Zongbin Son. Activation of A1 reactive astrocytes in the medullary dorsal horn of rats participates in the chronification of trigeminal neuralgia. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 49. issue 1. 2024-04-13. PMID:38615162. |
this study aims to observe the activation of a1 reactive astrocytes in the medullary dorsal horn in the rat model of trigeminal neuralgia, and to explore the mechanism of central sensitization caused by a1 reactive astrocyte. |
2024-04-13 |
2024-04-16 |
rat |
| Liqiong He, Shengyun Ma, Zijin Ding, Zhifeng Huang, Yu Zhang, Caiyun Xi, Kailu Zou, Qingwei Deng, Wendy Jia Men Huang, Qulian Guo, Changsheng Huan. Inhibition of NFAT5-Dependent Astrocyte Swelling Alleviates Neuropathic Pain. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-01-10. PMID:38195869. |
this study elucidates the pivotal role of the nuclear factor of activated t-cells 5 (nfat5) emerges as a master regulator of astrocyte swelling in the spinal dorsal horn (sdh) during neuropathic pain. |
2024-01-10 |
2024-01-13 |
Not clear |
| Siyi Liu, Shuting Yang, Xuan Zhu, Xiang Li, Xi Zhang, Xiaoqiong Zhou, Hong Cheng, Fu-Quan Huo, Qingxiang Mao, Lingli Lian. Spinal apolipoprotein E is involved in inflammatory pain via regulating lipid metabolism and glial activation in the spinal dorsal horn. Biology direct. vol 18. issue 1. 2023-12-09. PMID:38071369. |
inflammation and nerve injury promote astrocyte activation, which regulates the development and resolution of pain, in the spinal dorsal horn. |
2023-12-09 |
2023-12-17 |
mouse |
| Jee Youn Lee, Chan Sol Park, Kyung Jin Seo, In Yi Kim, Sungmin Han, Inchan Youn, Tae Young Yun. IL-6/JAK2/STAT3 axis mediates neuropathic pain by regulating astrocyte and microglia activation after spinal cord injury. Experimental neurology. 2023-10-20. PMID:37863306. |
in particular, ag490 treatment inhibited both microglial and astrocyte activation in the lumbar (l) 4-5 dorsal horn and significantly decreased levels of p-p38mapk, p-erk and p-jnk, which are known to be activated in microglia (p-p38mapk and p-erk) and astrocyte (p-jnk). |
2023-10-20 |
2023-11-08 |
rat |
| Andrea Angeli, Laura Micheli, Rita Turnaturi, Lorella Pasquinucci, Carmela Parenti, Vincenzo Alterio, Anna Di Fiore, Giuseppina De Simone, Simona Maria Monti, Fabrizio Carta, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Claudiu T Supura. Discovery of a novel series of potent carbonic anhydrase inhibitors with selective affinity for μ Opioid receptor for Safer and long-lasting analgesia. European journal of medicinal chemistry. vol 260. 2023-09-07. PMID:37678143. |
by means of repeated treatment of 3 daily administrations for 17 days, fentanyl (0.1 mg/kg, subcutaneously) led to tolerance development, pain threshold alterations and withdrawal symptoms in cd-1 mice, as well as astrocyte and microglia activation in the dorsal horn of the lumbar spinal cord. |
2023-09-07 |
2023-10-07 |
mouse |
| Mengchan Ou, Yali Chen, Jin Liu, Donghang Zhang, Yaoxin Yang, Jiefei Shen, Changhong Miao, Shao-Jun Tang, Xin Liu, Daniel K Mulkey, Tao Zhu, Cheng Zho. Spinal Astrocytic MeCP2 Regulates Kir4.1 for the Maintenance of Chronic Hyperalgesia in Neuropathic Pain. Progress in neurobiology. 2023-03-17. PMID:36931588. |
astrocyte activation in the spinal dorsal horn may play an important role in the development of chronic neuropathic pain, but the mechanisms involved in astrocyte activation and their modulatory effects remain unknown. |
2023-03-17 |
2023-08-14 |
Not clear |
| Xiaona Zhao, Xinxin Li, Huiling Guo, Panmei Liu, Minyu Ma, Yanping Wan. Resolvin D1 Attenuates Mechanical Allodynia after Burn Injury: Involvement of Spinal Glia, p38 MAPK, and BDNF/TrkB signaling. Molecular pain. 2023-02-11. PMID:36765459. |
pain behavior and the expression levels of spinal dorsal horn iba-1 (microglia marker), gfap (astrocyte marker), p-p38 mitogen-activated protein kinase (mapk), brain-derived neurotrophic factor (bdnf), and tropomyosin-related kinase b (trkb) were detected by behavioral and immunocytochemical assays. |
2023-02-11 |
2023-08-14 |
rat |
| Miyuki Kurabe, Mika Sasaki, Kenta Furutani, Hidemasa Furue, Yoshinori Kamiya, Hiroshi Bab. Structural and functional properties of spinal dorsal horn neurons after peripheral nerve injury change overtime via astrocyte activation. iScience. vol 25. issue 12. 2022-11-29. PMID:36444301. |
structural and functional properties of spinal dorsal horn neurons after peripheral nerve injury change overtime via astrocyte activation. |
2022-11-29 |
2023-08-14 |
Not clear |
| Yumeng Ding, Liye Hu, Xiaotong Wang, Qingyu Sun, Tingting Hu, Jing Liu, Danmin Shen, Yurui Zhang, Wen Chen, Chao Wei, Meng Liu, Dianxin Liu, Peipei Wang, Chenguang Zhang, Jiannan Zhang, Qian Li, Fei Yan. The contribution of spinal dorsal horn astrocytes in neuropathic pain at the early stage of EAE. Neurobiology of disease. 2022-11-04. PMID:36332813. |
in this study, we demonstrated that spinal dorsal horn astrocytes were activated in the pre-clinical stage of eae mice, and the inhibition of spinal cord astrocyte reactivity effectively alleviates pain symptoms in eae mice. |
2022-11-04 |
2023-08-14 |
mouse |
| Yonggang Xie, Zhen Li, Hongyu Xu, Jiahai Ma, Tao Li, Cunxian Shi, Jin Ji. Downregulation of Sp1 Inhibits the Expression of HDAC1/SOX10 to Alleviate Neuropathic Pain-like Behaviors after Spinal Nerve Ligation in Mice. ACS chemical neuroscience. 2022-04-14. PMID:35420781. |
immunofluorescence was performed to determine sp1, hdac1, and sox10 in the spinal dorsal horn neurons as well as the neuronal marker (neun), microglial marker (iba-1), and astrocyte marker (gfap). |
2022-04-14 |
2023-08-13 |
mouse |
| Wei Wei, Weili Liu, Shibin Du, Gokulapriya Govindarajalu, Antony Irungu, Alex Bekker, Yuan-Xiang Ta. A Compound Mitigates Cancer Pain and Chemotherapy-Induced Neuropathic Pain by Dually Targeting nNOS-PSD-95 Interaction and GABA Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021-11-19. PMID:34796458. |
this injection also decreased neuronal and astrocyte hyperactivities in the lumbar dorsal horn after rm-1 tibial inoculation or paclitaxel intraperitoneal injection. |
2021-11-19 |
2023-08-13 |
Not clear |
| Yuqiang Shi, Subo Yuan, Shao-Jun Tan. Reactive Oxygen Species (ROS) are Critical for Morphine Exacerbation of HIV-1 gp120-Induced Pain. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 16. issue 3. 2021-11-17. PMID:32827051. |
we found that repeated morphine treatment promoted astrocyte activation in the spinal dorsal horn (sdh) and up-regulation of pro-inflammatory cytokines il-1β and tnf-α. |
2021-11-17 |
2023-08-13 |
mouse |
| Huixing Wang, Xiaodong Huo, Chenyang Han, Jiang Ning, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Quanbo Li, Yonghao Yu, Kemei Sh. Ferroptosis is involved in the development of neuropathic pain and allodynia. Molecular and cellular biochemistry. vol 476. issue 8. 2021-09-06. PMID:33864570. |
taken together, our results showed that ferroptosis is involved in the development of np in male rats by blocking neuron and astrocyte activation in the spinal dorsal horn. |
2021-09-06 |
2023-08-13 |
rat |
| Yoshihiro Inami, Daisuke Uta, Tsugunobu Ando. Neuronal hyperexcitability and astrocyte activation in spinal dorsal horn of a dermatitis mouse model with cutaneous hypersensitivity. Neuroscience letters. vol 720. 2021-04-16. PMID:31987915. |
neuronal hyperexcitability and astrocyte activation in spinal dorsal horn of a dermatitis mouse model with cutaneous hypersensitivity. |
2021-04-16 |
2023-08-13 |
mouse |
| Ruijuan Guo, Yuqing Sun, Huili Li, Danxu Ma, Yun Wan. Upregulation of spinal glucose-dependent insulinotropic polypeptide receptor induces membrane translocation of PKCγ and synaptic target of AMPA receptor GluR1 subunits in dorsal horns in a rat model of incisional pain. Neurochemistry international. vol 134. 2021-02-23. PMID:31870892. |
the double-labeling immunofluorescence demonstrated that spinal gipr was expressed in dorsal horn neurons, but not in astrocyte or microglial cells. |
2021-02-23 |
2023-08-13 |
rat |