| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| D E Dluzen, L I Anderso. The effects of nicotine on dopamine and DOPAC output from rat striatal tissue. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489852. |
the effects of varying doses of nicotine infusion upon spontaneous (basal) and subsequent potassium chloride-stimulated dopamine and 3,4-dihydroxyphenylacetic acid (dopac) output from superfused corpus striatal tissue fragments of male rats were tested. |
1998-04-29 |
2023-08-12 |
rat |
| D E Dluzen, L I Anderso. The effects of nicotine on dopamine and DOPAC output from rat striatal tissue. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489852. |
spontaneous dopamine and dopac outputs were increased in response to 1, 5 and 10, but not to 0.1 and 0 (control) microm concentrations of nicotine. |
1998-04-29 |
2023-08-12 |
rat |
| D E Dluzen, L I Anderso. The effects of nicotine on dopamine and DOPAC output from rat striatal tissue. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489852. |
interestingly, the subsequent k+-stimulated (30 mm) dopamine output was completely abolished in preparations infused with the 5 and 10 microm nicotine, but not with the 1 or 0.1 microm nicotine. |
1998-04-29 |
2023-08-12 |
rat |
| D E Dluzen, L I Anderso. The effects of nicotine on dopamine and DOPAC output from rat striatal tissue. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489852. |
in experiment 2, the effects of an initial infusion of amphetamine (10 microm), potassium chloride (30 mm), nicotine (10 microm) or normal superfusion medium (control) were compared upon subsequent k+-evoked dopamine release. |
1998-04-29 |
2023-08-12 |
rat |
| D E Dluzen, L I Anderso. The effects of nicotine on dopamine and DOPAC output from rat striatal tissue. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489852. |
the amount of dopamine released in response to the second (subsequent) infusion of k+ was significantly greater in the potassium chloride and control conditions versus the nicotine and amphetamine stimulated groups. |
1998-04-29 |
2023-08-12 |
rat |
| D E Dluzen, L I Anderso. The effects of nicotine on dopamine and DOPAC output from rat striatal tissue. European journal of pharmacology. vol 341. issue 1. 1998-04-29. PMID:9489852. |
the augmented levels of dopac output along with the abolition of the k+-stimulated dopamine release in response to the 5 and 10 microm nicotine doses suggest that these doses may simultaneously produce an activation of intraneuronal metabolism of dopamine to dopac along with an activation of release and inhibition of uptake to diminish stores available for subsequent responses to k+ stimulation. |
1998-04-29 |
2023-08-12 |
rat |
| B Schilström, G G Nomikos, M Nisell, P Hertel, T H Svensso. N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483535. |
systemic nicotine enhances burst firing of dopamine neurons in the ventral tegmental area and dopamine release in the nucleus accumbens, mainly via stimulation of nicotinic acetylcholine receptors in the ventral tegmental area. |
1998-04-09 |
2023-08-12 |
rat |
| B Schilström, G G Nomikos, M Nisell, P Hertel, T H Svensso. N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483535. |
given that both the neuronal activity of mesolimbic dopamine neurons and terminal dopamine release are regulated by excitatory amino acid inputs to the ventral tegmental area and that nicotine facilitates glutamatergic transmission in brain, we investigated the putative role of ionotropic glutamate receptors within the ventral tegmental area for the effects of nicotine on dopamine release in the nucleus accumbens using microdialysis, with one probe implanted in the ventral tegmental area for drug application and another in the ipsilateral nucleus accumbens for measuring dopamine, in awake rats. |
1998-04-09 |
2023-08-12 |
rat |
| B Schilström, G G Nomikos, M Nisell, P Hertel, T H Svensso. N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483535. |
systemic nicotine (0.5 mg/kg, s.c.) and infusion of nicotine (1.0 mm) into the ventral tegmental area increased dopamine output in the nucleus accumbens. |
1998-04-09 |
2023-08-12 |
rat |
| B Schilström, G G Nomikos, M Nisell, P Hertel, T H Svensso. N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483535. |
infusion of either antagonist (0.3 or 1.0 mm) into the ventral tegmental area did not affect basal dopamine levels, whereas infusion of 2-amino-5-phosphonopentanoic acid, but not 6-cyano-7-nitroquinoxaline-2,3-dione, starting 40 min before nicotine injection dose-dependently attenuated the nicotine-induced increase in accumbal dopamine release. |
1998-04-09 |
2023-08-12 |
rat |
| B Schilström, G G Nomikos, M Nisell, P Hertel, T H Svensso. N-methyl-D-aspartate receptor antagonism in the ventral tegmental area diminishes the systemic nicotine-induced dopamine release in the nucleus accumbens. Neuroscience. vol 82. issue 3. 1998-04-09. PMID:9483535. |
concurrent intrategmental infusion of 2-amino-5-phosphonopentanoic acid and nicotine decreased nicotine-induced dopamine release in the nucleus accumbens. |
1998-04-09 |
2023-08-12 |
rat |
| M Bencherif, J D Schmitt, B S Bhatti, P Crooks, W S Caldwell, M E Lovette, K Fowler, L Reeves, P M Lippiell. The heterocyclic substituted pyridine derivative (+/-)-2-(-3-pyridinyl)-1-azabicyclo[2.2.2]octane (RJR-2429): a selective ligand at nicotinic acetylcholine receptors. The Journal of pharmacology and experimental therapeutics. vol 284. issue 3. 1998-04-09. PMID:9495846. |
it also is a potent partial agonist at nachrs mediating dopamine release from rat synaptosomal preparations (ec50 = 2 +/- 1 nm; emax = 40%; epibatidine and nicotine have ec50 values of 0.4 and 100 nm, respectively). |
1998-04-09 |
2023-08-12 |
human |
| C Lerman, N Caporaso, D Main, J Audrain, N R Boyd, E D Bowman, P G Shield. Depression and self-medication with nicotine: the modifying influence of the dopamine D4 receptor gene. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. vol 17. issue 1. 1998-04-02. PMID:9459071. |
depression and self-medication with nicotine: the modifying influence of the dopamine d4 receptor gene. |
1998-04-02 |
2023-08-12 |
Not clear |
| C Lerman, N Caporaso, D Main, J Audrain, N R Boyd, E D Bowman, P G Shield. Depression and self-medication with nicotine: the modifying influence of the dopamine D4 receptor gene. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. vol 17. issue 1. 1998-04-02. PMID:9459071. |
these preliminary results suggest that the rewarding effects of smoking and the beneficial effects of nicotine replacement therapy for depressed smokers may depend, in part, on genetic factors involved in dopamine transmission. |
1998-04-02 |
2023-08-12 |
Not clear |
| B E Hildebrand, G G Nomikos, P Hertel, B Schilström, T H Svensso. Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain research. vol 779. issue 1-2. 1998-04-02. PMID:9473676. |
reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. |
1998-04-02 |
2023-08-12 |
rat |
| B E Hildebrand, G G Nomikos, P Hertel, B Schilström, T H Svensso. Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain research. vol 779. issue 1-2. 1998-04-02. PMID:9473676. |
mesolimbocortical dopamine (da) neurotransmission is important in the mediation of the dependence-producing actions of nicotine and other drugs of abuse. |
1998-04-02 |
2023-08-12 |
rat |
| B E Hildebrand, G G Nomikos, P Hertel, B Schilström, T H Svensso. Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome. Brain research. vol 779. issue 1-2. 1998-04-02. PMID:9473676. |
this study examined putative changes in the extracellular levels of dopamine and its metabolites dihydroxyphenylacetic acid (dopac) and homovanillic acid (hva) in the nac and in the pfc of rats displaying behavioral signs of nicotine withdrawal. |
1998-04-02 |
2023-08-12 |
rat |
| H Takahashi, Y Takada, N Nagai, T Urano, A Takad. Effects of nicotine and footshock stress on dopamine release in the striatum and nucleus accumbens. Brain research bulletin. vol 45. issue 2. 1998-02-26. PMID:9443833. |
effects of nicotine and footshock stress on dopamine release in the striatum and nucleus accumbens. |
1998-02-26 |
2023-08-12 |
rat |
| H Takahashi, Y Takada, N Nagai, T Urano, A Takad. Effects of nicotine and footshock stress on dopamine release in the striatum and nucleus accumbens. Brain research bulletin. vol 45. issue 2. 1998-02-26. PMID:9443833. |
we have used a microdialysis technique to analyze the effects of nicotine administration on the release of dopamine in the striatum and the nucleus accumbens (nac) in rats under footshock stress. |
1998-02-26 |
2023-08-12 |
rat |
| H Takahashi, Y Takada, N Nagai, T Urano, A Takad. Effects of nicotine and footshock stress on dopamine release in the striatum and nucleus accumbens. Brain research bulletin. vol 45. issue 2. 1998-02-26. PMID:9443833. |
in the striatum, neither chronic systemic nicotine administration alone nor stress alone changed the extent of dopamine release. |
1998-02-26 |
2023-08-12 |
rat |