| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nimish Sidhpura, Peter Redfern, Helen Rowley, David Heal, Susan Wonnacot. Comparison of the effects of bupropion and nicotine on locomotor activation and dopamine release in vivo. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17678630. |
nicotine delivered during the response to bupropion resulted in enhanced dopamine overflow of 294 +/- 50%, also consistent with the actions of the two drugs being additive. |
2007-11-06 |
2023-08-12 |
rat |
| Linda P Dwoskin, B Matthew Joyce, Guangrong Zheng, Nichole M Neugebauer, Vamshi K Manda, Paul Lockman, Roger L Papke, Michael T Bardo, Peter A Crook. Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17727820. |
one strategy is to develop subtype-selective nicotinic receptor (nachr) antagonists that inhibit nicotine-evoked dopamine (da) release, the primary neurotransmitter involved in nicotine reward. |
2007-11-06 |
2023-08-12 |
rat |
| Huibert D Mansvelder, Zara M Fagen, Ben Chang, Robert Mitchum, Daniel S McGehe. Bupropion inhibits the cellular effects of nicotine in the ventral tegmental area. Biochemical pharmacology. vol 74. issue 8. 2007-11-06. PMID:17868653. |
many drugs of abuse, including nicotine, stimulate dopamine (da) release in the mesoaccumbens reward system. |
2007-11-06 |
2023-08-12 |
Not clear |
| Hans Rollema, Jotham W Coe, Leslie K Chambers, Raymond S Hurst, Stephen M Stahl, Kathryn E William. Rationale, pharmacology and clinical efficacy of partial agonists of alpha4beta2 nACh receptors for smoking cessation. Trends in pharmacological sciences. vol 28. issue 7. 2007-11-05. PMID:17573127. |
such agents are expected to exhibit a dual action by sufficiently stimulating alpha(4)beta(2)-nachr-mediated dopamine release to reduce craving when quitting and by inhibiting nicotine reinforcement when smoking. |
2007-11-05 |
2023-08-12 |
Not clear |
| Leslie K Jacobsen, W Einar Mencl, R Todd Constable, Michael Westerveld, Kenneth R Pug. Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokers. Psychopharmacology. vol 193. issue 4. 2007-10-23. PMID:17505817. |
work in rodents has shown that exposure to nicotine during adolescence leads to nicotine withdrawal emergent alterations in cortical and subcortical dopamine neurotransmission. |
2007-10-23 |
2023-08-12 |
Not clear |
| Marsha M Dopheide, Russell E Morgan, Kelli R Rodvelt, Todd R Schachtman, Dennis K Mille. Modafinil evokes striatal [(3)H]dopamine release and alters the subjective properties of stimulants. European journal of pharmacology. vol 568. issue 1-3. 2007-10-19. PMID:17477916. |
in neurochemical experiments, modafinil (100-300 microm) evoked [(3)h]overflow from rat striatal slices preloaded with [(3)h]dopamine in a concentration-dependent manner; however, modafinil was less potent and efficacious than amphetamine and nicotine. |
2007-10-19 |
2023-08-12 |
rat |
| Jessika Urbanavicius, Margot Ferreira, Gustavo Costa, Juan Andrés Abin-Carriquiry, Susan Wonnacott, Federico Daja. Nicotine induces tyrosine hydroxylase plasticity in the neurodegenerating striatum. Journal of neurochemistry. vol 102. issue 3. 2007-10-15. PMID:17437548. |
it has been shown that nicotine prevents the loss of dopamine (da) in the corpus striatum (cs) after 6-hydroxydopamine injection in the substantia nigra. |
2007-10-15 |
2023-08-12 |
Not clear |
| M H Skowronek, M Laucht, E Hohm, K Becker, M H Schmid. Interaction between the dopamine D4 receptor and the serotonin transporter promoter polymorphisms in alcohol and tobacco use among 15-year-olds. Neurogenetics. vol 7. issue 4. 2007-09-12. PMID:16819620. |
both alcohol and nicotine stimulate the dopamine (da) and the serotonin (5-ht) systems. |
2007-09-12 |
2023-08-12 |
human |
| Andrew J Montgomery, Anne R Lingford-Hughes, Alice Egerton, David J Nutt, Paul M Grasb. The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study. Synapse (New York, N.Y.). vol 61. issue 8. 2007-09-12. PMID:17492764. |
the effect of nicotine on striatal dopamine release in man: a [11c]raclopride pet study. |
2007-09-12 |
2023-08-12 |
Not clear |
| David C Perry, Danyan Mao, Allison B Gold, J Michael McIntosh, John C Pezzullo, Kenneth J Kella. Chronic nicotine differentially regulates alpha6- and beta3-containing nicotinic cholinergic receptors in rat brain. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17446303. |
we investigated the effects of chronic nicotine on alpha6- and beta3-containing nicotinic acetylcholine receptors (nachrs) in two rat brain regions using three methodological approaches: radioligand binding, immunoprecipitation, and nicotine-stimulated synaptosomal release of dopamine. |
2007-08-30 |
2023-08-12 |
rat |
| David C Perry, Danyan Mao, Allison B Gold, J Michael McIntosh, John C Pezzullo, Kenneth J Kella. Chronic nicotine differentially regulates alpha6- and beta3-containing nicotinic cholinergic receptors in rat brain. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17446303. |
there was a small but significant decrease in total nicotine-stimulated dopamine release in striatal synaptosomes after nicotine exposure. |
2007-08-30 |
2023-08-12 |
rat |
| Yuichiro Inoue, Lina Yao, F Woodward Hopf, Peidong Fan, Zhan Jiang, Antonello Bonci, Ivan Diamon. Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17468300. |
nicotine and ethanol activate protein kinase a synergistically via g(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine d(1)/d(2) and adenosine a(2a) receptors. |
2007-08-30 |
2023-08-12 |
Not clear |
| Yuichiro Inoue, Lina Yao, F Woodward Hopf, Peidong Fan, Zhan Jiang, Antonello Bonci, Ivan Diamon. Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17468300. |
because dopamine receptors d(1) and d(2) are highly expressed on nacb neurons, nicotine could influence nacb neurons indirectly by activating vta neurons to release dopamine in the nacb. |
2007-08-30 |
2023-08-12 |
Not clear |
| Yuichiro Inoue, Lina Yao, F Woodward Hopf, Peidong Fan, Zhan Jiang, Antonello Bonci, Ivan Diamon. Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17468300. |
nicotine increased camp response element-mediated gene expression only in cocultures; this increase was blocked by nach or dopamine d(1) or d(2) receptor antagonists. |
2007-08-30 |
2023-08-12 |
Not clear |
| Yuichiro Inoue, Lina Yao, F Woodward Hopf, Peidong Fan, Zhan Jiang, Antonello Bonci, Ivan Diamon. Nicotine and ethanol activate protein kinase A synergistically via G(i) betagamma subunits in nucleus accumbens/ventral tegmental cocultures: the role of dopamine D(1)/D(2) and adenosine A(2A) receptors. The Journal of pharmacology and experimental therapeutics. vol 322. issue 1. 2007-08-30. PMID:17468300. |
these results suggest that nicotine activated vta neurons, causing the release of dopamine, which in turn stimulated both d(1) and d(2) receptors on nacb neurons. |
2007-08-30 |
2023-08-12 |
Not clear |
| Hongwen Zhu, MoonSook Lee, Soh Agatsuma, Noboru Hiro. Pleiotropic impact of constitutive fosB inactivation on nicotine-induced behavioral alterations and stress-related traits in mice. Human molecular genetics. vol 16. issue 7. 2007-08-28. PMID:17468183. |
in wild-type mice, repeated nicotine injections, but not a single acute injection, increased the expression of fosb and its truncated variant deltafosb in the targets but not at the origins of the mesolimbic and nigrostriatal dopamine pathways; no detectable level of fosb/deltafosb was found in ko mice. |
2007-08-28 |
2023-08-12 |
mouse |
| Neil E Paterson, David J Balfour, Athina Marko. Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561823. |
chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. |
2007-08-17 |
2023-08-12 |
human |
| Neil E Paterson, David J Balfour, Athina Marko. Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561823. |
to explore the hypothesis that bupropion ameliorates nicotine withdrawal partly by a dopamine-dependent mechanism, we investigated the effects of chronic bupropion on potassium-stimulated dopamine overflow in the nucleus accumbens shell in nicotine-withdrawing rats. |
2007-08-17 |
2023-08-12 |
human |
| Neil E Paterson, David J Balfour, Athina Marko. Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561823. |
cessation of nicotine administration in non-bupropion-treated rats elevated reward thresholds reflecting a reward deficit, increased somatic signs and diminished potassium-evoked dopamine overflow in the nucleus accumbens shell. |
2007-08-17 |
2023-08-12 |
human |
| Neil E Paterson, David J Balfour, Athina Marko. Chronic bupropion attenuated the anhedonic component of nicotine withdrawal in rats via inhibition of dopamine reuptake in the nucleus accumbens shell. The European journal of neuroscience. vol 25. issue 10. 2007-08-17. PMID:17561823. |
chronic bupropion lowered reward thresholds and increased potassium-evoked dopamine release regardless of previous nicotine exposure, possibly by inhibition of dopamine reuptake, and thus attenuated the anhedonic and neurochemical effects of nicotine withdrawal. |
2007-08-17 |
2023-08-12 |
human |