All Relations between Nicotine and acetylcholine

Publication Sentence Publish Date Extraction Date Species
Nancy A Rigotti, Neal L Benowitz, Judith J Prochaska, Daniel F Cain, Julie Ball, Anthony Clarke, Brent A Blumenstein, Cindy Jacob. Cytisinicline for Vaping Cessation in Adults Using Nicotine E-Cigarettes: The ORCA-V1 Randomized Clinical Trial. JAMA internal medicine. 2024-05-06. PMID:38709500. cytisinicline, a plant-based alkaloid, targets nicotinic acetylcholine receptors, reduces nicotine dependence, and helps adults to stop smoking cigarettes. 2024-05-06 2024-05-08 Not clear
Ahmad Joukhan, Veno Kononenko, Tadeja Bele, Marija Sollner Dolenc, Steve Peigneur, Ernesto Lopes Pinheiro-Junior, Jan Tytgat, Tom Turk, Igor Križaj, Damjana Drobn. Attenuation of Nicotine Effects on A549 Lung Cancer Cells by Synthetic α7 nAChR Antagonists APS7-2 and APS8-2. Marine drugs. vol 22. issue 4. 2024-04-26. PMID:38667764. nicotine binds to nicotinic acetylcholine receptors (nachrs) that are overexpressed in different cancer cells, promoting tumor growth and resistance to chemotherapy. 2024-04-26 2024-04-28 human
Lois S Akinola, Jada Gonzales, Belle Buzzi, Hunter L Mathews, Roger L Papke, Jerry A Stitzel, M Imad Dama. Investigating the role of nicotinic acetylcholine receptors in menthol's effects in mice. Drug and alcohol dependence. vol 257. 2024-03-16. PMID:38492255. the widespread use of menthol can be attributed to its unique sensory characteristics; however, emerging evidence suggests that menthol also alters sensitivity to nicotine through modulation of nicotinic acetylcholine receptors (nachrs). 2024-03-16 2024-03-19 mouse
Roger L Papk. The many enigmas of nicotine. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467485. this review discusses the diverse effects of nicotine on the various nicotinic acetylcholine receptors of the central and peripheral nervous system and how those effects may promote the usage and addiction to tobacco products. 2024-03-11 2024-03-14 Not clear
Yan Fu, Keyu Shen, Hao Wang, Shun Wang, Xufeng Wang, Le Zhu, Yan Zheng, Tiantian Zou, Hongfei Ci, Qiongzhu Dong, Lun-Xiu Qi. Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis. Signal transduction and targeted therapy. vol 9. issue 1. 2024-03-07. PMID:38453934. acetylcholine promoted icc metastasis through interacting with its receptor, alpha 5 nicotine acetylcholine receptor subunits (chrna5). 2024-03-07 2024-03-10 Not clear
Aden Dhana Rizkita, Sintia Ayu Dewi, Taufik Muhammad Fakih, Cheng-Chung Le. Effectiveness of sesquiterpene derivatives from Cinnamomum genus in nicotine replacement therapy through blocking acetylcholine nicotinate: a computational analysis. Journal of biomolecular structure & dynamics. 2024-01-25. PMID:38268238. effectiveness of sesquiterpene derivatives from cinnamomum genus in nicotine replacement therapy through blocking acetylcholine nicotinate: a computational analysis. 2024-01-25 2024-01-27 Not clear
Kumboyono Kumboyono, Indah N Chomsy, Nadya N Shalshabilla, Hidayat Sujuti, Arie Srihardyastutie, Cholid T Tjahjono, Teuku Heriansyah, Titin A Wihastut. Nicotine is associated with smoking dependence and vascular inflammation through cotinine: A mediation analysis. Tobacco induced diseases. vol 22. 2024-01-22. PMID:38250634. cotinine, a metabolite of nicotine, is capable of causing dependence effects through endless mechanisms modulated by the ion channel nicotinic acetylcholine receptors nachrs. 2024-01-22 2024-01-24 Not clear
Ashwini Wani, Bala Prabhakar, Pravin Shend. Competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-30. PMID:38159871. competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. 2023-12-30 2024-01-05 Not clear
Ashwini Wani, Bala Prabhakar, Pravin Shend. Competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-30. PMID:38159871. nicotine released in a sustained manner attaches to the nicotine acetylcholine receptors (nachr) to release dopamine for controlling the withdrawal challenges such as anxiety, irritability, cravings, disturbed sleep pattern, etc. 2023-12-30 2024-01-05 Not clear
Chhatrapal Patel, Richa Patel, Vaibhav Maturkar, Nishant Sudhir Jai. Central cholinergic transmission affects the compulsive-like behavior of mice in marble-burying test. Brain research. 2023-12-14. PMID:38097126. injection of acetylcholine (0.01 µg) (subeffective: 0.1 and 0.5 µg), cholinesterase inhibitor, neostigmine (0.1, 0.3, 0.5 µg/mouse) and neuronal nicotinic acetylcholine receptor agonist, nicotine (0.1, 2 µg/mouse) significantly attenuated the number of marbles buried by mice in mbb test without affecting basal locomotor activity. 2023-12-14 2023-12-17 mouse
Takemori Yamawak. [Nicotine, pesticides, and tobacco, in Three Act Tragedy]. Brain and nerve = Shinkei kenkyu no shinpo. vol 75. issue 12. 2023-12-14. PMID:38097217. when nicotine enters the body, it binds to acetylcholine receptors and causes various symptoms. 2023-12-14 2023-12-17 Not clear
Niyati A Borkar, Michael A Thompson, Colleen M Bartman, Latifa Khalfaoui, Steven M Sine, Venkatachalem Sathish, Y S Prakash, Christina M Pabelic. Nicotinic Receptors in Airway Disease. American journal of physiology. Lung cellular and molecular physiology. 2023-12-12. PMID:38084408. there is now increasing evidence that alpha7 nicotinic acetylcholine receptors (α7nachrs) are critical players in nicotine effects on airways, but the mechanisms by which α7nachr influences different airway cell types have not been widely explored. 2023-12-12 2023-12-17 Not clear
Yuqin Xu, Juan Wang, Zihan He, Zihan Rao, Zhongwei Zhang, Jianming Zhou, Tong Zhou, Huai Wan. A review on the effect of COX-2-mediated mechanisms on development and progression of gastric cancer induced by nicotine. Biochemical pharmacology. 2023-12-11. PMID:38081368. nicotine, the principal tobacco alkaloid, would exert its role of contribution to gastric cancer development and progression through nicotinic acetylcholine receptors (nachrs) and β-adrenergic receptors (β-ars), which then promote cancer cell proliferation, migration and invasion. 2023-12-11 2023-12-17 Not clear
Hind Al Khashali, Ban Darweesh, Ravel Ray, Ben Haddad, Caroline Wozniak, Robert Ranzenberger, Stuti Goel, Jeneen Khalil, Jeffrey Guthrie, Deborah Heyl, Hedeel Guy Evan. Regulation of Vascular Endothelial Growth Factor Signaling by Nicotine in a Manner Dependent on Acetylcholine-and/or β-Adrenergic-Receptors in Human Lung Cancer Cells. Cancers. vol 15. issue 23. 2023-12-09. PMID:38067204. in addition to binding to nicotinic acetylcholine receptors (nachrs), nicotine is known to regulate the β-adrenergic receptors (β-ars) promoting oncogenic signaling. 2023-12-09 2023-12-17 human
Chuyue Pan, Jun Liu, Yingsheng Gao, Maohui Yang, Haiyang Hu, Chang Liu, Minyi Qian, Hai-Yang Yuan, Song Yang, Ming-Hua Zheng, Lirui Wan. Hepatocyte CHRNA4 mediates the MASH-promotive effects of immune cell-produced acetylcholine and smoking exposure in mice and humans. Cell metabolism. vol 35. issue 12. 2023-12-06. PMID:38056431. we further revealed that during mash development, acetylcholine released from immune cells or nicotine derived from smoking functioned as an agonist to activate hepatocyte-intrinsic chrna4, inducing calcium influx and activation of inflammatory signaling. 2023-12-06 2023-12-10 mouse
Niyati A Borkar, Michael A Thompson, Colleen M Bartman, Venkatachalem Sathish, Y S Prakash, Christina M Pabelic. Nicotine Affects Mitochondrial Structure and Function in Human Airway Smooth Muscle Cells. American journal of physiology. Lung cellular and molecular physiology. 2023-11-07. PMID:37933473. nicotine exerts its functional activity via nicotinic acetylcholine receptors (nachrs) and the alpha7 subtype (α7nachr) has recently been shown to adversely affect airway dynamics. 2023-11-07 2023-11-08 human
Julie A Mustard, Rachel Dobb, Geraldine A Wrigh. Chronic nicotine exposure influences learning and memory in the honey bee. Journal of insect physiology. 2023-11-02. PMID:37918514. in insects, nicotine activates nicotinic acetylcholine receptors, which are expressed throughout the central nervous system. 2023-11-02 2023-11-08 bee
Khalid Boussaine, Maria Taha, Cáinà Nìng, Alison Cartereau, Sabine Rakotobe, Lourdes Mateos-Hernandez, Emiliane Taillebois, Ladislav Šimo, Steeve H Than. Isolation and electrophysiological recording of Ixodes ricinus synganglion neurons. Journal of pharmacological and toxicological methods. 2023-10-22. PMID:37866797. method: we developed a simple protocol for synganglion neuron isolation and used a whole-cell patch clamp to measure ionic currents induced by acetylcholine, nicotine and muscarine. 2023-10-22 2023-11-08 Not clear
Gerald Wölkart, Alexander Kollau, Michael Russwurm, Doris Koesling, Astrid Schrammel, Bernd Maye. Varied effects of tobacco smoke and e-cigarette vapor suggest that nicotine does not affect endothelium-dependent relaxation and nitric oxide signaling. Scientific reports. vol 13. issue 1. 2023-09-22. PMID:37739972. at a dilution of 1:3, cse almost entirely inhibited the relaxation of rat aortas and porcine coronary arteries to acetylcholine and bradykinin, respectively, while undiluted eve, with a 15-fold higher nicotine concentration, had no significant effect. 2023-09-22 2023-10-07 rat
Markus M Hilscher, Sanja Mikulovic, Sharn Perry, Stina Lundberg, Klas Kullande. The alpha2 nicotinic acetylcholine receptor, a subunit with unique and selective expression in inhibitory interneurons associated with principal cells. Pharmacological research. 2023-08-31. PMID:37652281. nicotinic acetylcholine receptors (nachrs) play crucial roles in various human disorders, with the α7, α4, α6, and α3-containing nachr subtypes extensively studied in relation to conditions such as alzheimer's disease, parkinson's disease, nicotine dependence, mood disorders, and stress disorders. 2023-08-31 2023-09-07 human