All Relations between Nicotine and acetylcholine

Publication Sentence Publish Date Extraction Date Species
Melody C Iacino, Elizabeth G Pitts, Amelia G Bonsib, Lacey L Sexton, Mark J Ferri. Long-term effects of adolescent versus adult nicotine self-administration on cholinergic modulation of dopamine in the nucleus accumbens core. Drug and alcohol dependence. vol 268. 2025-01-30. PMID:39881470. investigating α6-versus non-α6-containing nicotinic acetylcholine receptors (nachrs) revealed differential modulatory effects in adults and adolescents self-administering nicotine relative to respective saline controls. 2025-01-30 2025-02-01 rat
Taufik Muhammad Fakih, Aden Dhana Rizkita, Sintia Ayu Dewi, Muchtaridi Muchtarid. In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment. Current research in structural biology. vol 9. 2025-01-27. PMID:39867106. in silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nachrs) for nicotine addiction treatment. 2025-01-27 2025-01-29 human
Taufik Muhammad Fakih, Aden Dhana Rizkita, Sintia Ayu Dewi, Muchtaridi Muchtarid. In silico approaches for developing sesquiterpene derivatives as antagonists of human nicotinic acetylcholine receptors (nAChRs) for nicotine addiction treatment. Current research in structural biology. vol 9. 2025-01-27. PMID:39867106. an intriguing discovery is that sesquiterpene compounds originating from cinnamomum possess the capacity to function as antagonists for human nicotinic acetylcholine receptors (nachrs), specifically the nachrÿ3 subtype, rendering them potential candidates for nicotine replacement therapy (nrt) to aid active smokers. 2025-01-27 2025-01-29 human
Ranjithkumar Chellian, Azin Behnood-Rod, Adriaan W Bruijnzee. The role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the ICSS procedure in male and female rats. Drug and alcohol dependence. vol 267. 2025-01-03. PMID:39752924. the role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the icss procedure in male and female rats. 2025-01-03 2025-01-06 rat
Nia A Davies, Julanta Carriere, Aneesha Gopal, Annie Rajan, Melisa J Wallace, Aidan Seele. The inhibitory effect of nicotine on Lumbriculus variegatus stereotypical movements and locomotor activity. Pharmacology, biochemistry, and behavior. 2024-12-24. PMID:39719160. herein, we demonstrate the presence of endogenous acetylcholine and cholinesterase activity within l. variegatus and show the time-dependent effects on the sensitivity of l. variegatus to nicotine. 2024-12-24 2024-12-27 caenorhabditis_elegans
Christine Li Mei Lee, Claire J Brabander, Yoko Nomura, Yasunari Kanda, Sachiko Yoshid. Embryonic exposure to acetamiprid insecticide induces CD68-positive microglia and Purkinje cell arrangement abnormalities in the cerebellum of neonatal rats. Toxicology and applied pharmacology. 2024-12-24. PMID:39719252. ace, which is structurally similar to nicotine, acts as an agonist of nicotinic acetylcholine receptors (nachrs) and resists degradation by acetylcholinesterase. 2024-12-24 2024-12-27 rat
Soyemi Toluwalashe, Olusola Aremu, Olabode Ekerin, Abdulqudus Lawal, Faniyi Oluwatobi, Victor Adebayo, Adewunmi Akingbola, Simon Olaniyan, Agboola Progress, Abdullahi Tunde Aborod. Seizure Susceptibility in E-cigarette Users: Navigating the Clinical Management and Public Health Considerations. Substance use : research and treatment. vol 18. 2024-12-02. PMID:39618920. using recent case reports, epidemiological studies, and experimental research, we highlight the role of likely etiological mechanisms such as how nicotine's convulsive effects are linked to α7- nicotinic acetylcholine receptors (nachrs), the varied clinical presentations, and the potential nicotine toxicity linked to seizures. 2024-12-02 2024-12-06 Not clear
Titilayomi A Otenaike, Oluwabukola M Farodoye, Monica M de Silva, Julia S Loreto, Adeola O Adedara, Matheus M Dos Santos, Alessandro S de Prestes, Nilda V Barbosa, João B T da Rocha, Luiz E Lobo, Roger Wagner, Amos O Abolaji, Elgion L S Loret. Nicotine and Vape: Drugs of the Same Profile Flock Together. Journal of biochemical and molecular toxicology. vol 38. issue 12. 2024-11-27. PMID:39601203. nicotine, the addictive component present in tobacco products and electronic cigarettes (e-cigarettes, vape), can bind to nicotinic acetylcholine receptors in the brain to trigger a dopamine release that reinforces smoking. 2024-11-27 2024-11-29 drosophila_melanogaster
Brandon J Henderson, Lauren E Young, Nathan A Olszewski, Samuel Tetteh-Quarshie, Sarah K Maddox, M Alex Simpkins, Mathew C Dudich, M Sage McGlauglin, Zoie C Weinsweig, Skylar Y Coope. Age-dependent effects of vaping on the prefrontal cortex, ventral tegmental area, and nucleus accumbens. Communications biology. vol 7. issue 1. 2024-11-21. PMID:39572675. in the ventral tegmental area (vta), we observed that upregulation of nicotinic acetylcholine receptors (nachrs) only correlated with nicotine self-administration in adult and not adolescent-exposed mice. 2024-11-21 2024-11-24 mouse
Brian C Reed, Maureen O Grissom, Michelle A Carroll Turpin, Steven M Stark. Addiction Medicine: Tobacco Use Disorder. FP essentials. vol 546. 2024-11-18. PMID:39556472. nicotine is the highly addictive component of tobacco that releases dopamine when it binds to alpha-4 beta-2 nicotinic acetylcholine receptors in the brain. 2024-11-18 2024-11-22 Not clear
T Mutoh, Y Niimi, Akihiro Ued. Activation of α7 Nicotinic Acetylcholine Receptor Augments Nerve Growth Factor Action on PCtrk Cells. Toxicology. 2024-11-06. PMID:39505136. although cigarette smoking is known to be a critical risk factor for various organ systems and cancers, accumulating evidence indicates that nicotine - a main constituent of cigarette smoking - can exert neuroprotective effects on neuronal cells through nicotinic acetylcholine receptors (nachrs). 2024-11-06 2024-11-09 Not clear
Alison Cartereau, Zakaria Bouchouireb, Sara Kaaki, François Héricourt, Emiliane Taillebois, Jean-Yves Le Questel, Steeve H Than. Pharmacology and molecular modeling studies of sulfoxaflor, flupyradifurone and neonicotinoids on the human neuronal α7 nicotinic acetylcholine receptor. Toxicology and applied pharmacology. 2024-10-11. PMID:39393466. specifically, the charged fragments of acetylcholine and nicotine, used as reference ligands, and their neonicotinoid homologs were found to be surrounded by aromatic residues, with key interactions with trp171 and y210. 2024-10-11 2024-10-14 human
Jitender Kumar Bhardwaj, Anshu Siwach, Som Nath Sachdev. Nicotine as a female reproductive toxicant-A review. Journal of applied toxicology : JAT. 2024-09-26. PMID:39323358. nicotine exerts its effect by modulating the expression of transmembrane ligand-gated ion channels called nicotinic acetylcholine receptors. 2024-09-26 2024-09-28 Not clear
Noah B Walker, Brenton R Tucker, Leanne N Thomas, Andrew E Tapp, Dylan R Drenan, Ryan M Drena. Expression of sensitized β2 nAChR subunits in VTA neurons enhances intravenous nicotine self-administration in male rats. Neuropharmacology. 2024-09-19. PMID:39299573. ventral tegmental area (vta) nicotinic acetylcholine receptors (nachrs) are important for nicotine reinforcement. 2024-09-19 2024-09-22 rat
Yoshiatsu Aomine, Yuto Shimo, Koki Sakurai, Mayuka Abe, Tom Macpherson, Takaaki Ozawa, Takatoshi Hikid. Sex-dependent differences in the ability of nicotine to modulate discrimination learning and cognitive flexibility in mice. Journal of neurochemistry. 2024-09-17. PMID:39289039. nicotine, an addictive compound found in tobacco, functions as an agonist of nicotinic acetylcholine receptors (nachrs) in the brain. 2024-09-17 2024-09-20 mouse
Chhatrapal Patel, Richa Patel, Anuradha Kesharwani, Laxmi Rao, Nishant Sudhir Jai. Central cholinergic transmission modulates endocannabinoid-induced marble-burying behavior in mice. Behavioural brain research. 2024-09-15. PMID:39278464. with various cholinergic agents like acetylcholine (ach), acetylcholinesterase inhibitor (achei), neostigmine, nicotine, machr antagonist, atropine, and nachr antagonist, mecamylamine. 2024-09-15 2024-09-18 mouse
Dooti Kundu, Srijan Acharya, Shujie Wang, Kyeong-Man Ki. Unveiling the intracellular dynamics of α4β2 nAChR-mediated ERK activation through the interplay of arrestin, Gβγ, and PKCβII. Life sciences. 2024-08-20. PMID:39163903. in contrast to g protein-coupled receptors or receptor tyrosine kinases, the mechanism underlying erk activation through nicotine acetylcholine receptors (nachrs), members of the ligand-gated ion channel family, remains poorly elucidated. 2024-08-20 2024-08-23 Not clear
Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan H. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. Heliyon. vol 10. issue 12. 2024-07-18. PMID:39021905. nicotine acts on the limbic dopamine reward loop in the midbrain by binding to nicotinic acetylcholine receptors, promoting the release of dopamine, and resulting in a rewarding effect or satisfaction. 2024-07-18 2024-07-20 Not clear
Ranjithkumar Chellian, Azin Behnood-Rod, Adriaan W Bruijnzee. The Role of Glucocorticoid and Nicotinic Acetylcholine Receptors in the Reward-Enhancing Effects of Nicotine in the ICSS Procedure in Male and Female Rats. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005409. the role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the icss procedure in male and female rats. 2024-07-15 2024-07-18 rat
Silvio Uhlig, Bergitte Pearl Olderbø, Jan Tore Samuelsen, Solveig Uvsløkk, Lada Ivanova, Camille Vanderstraeten, Lene Aiko Grutle, Oscar Daniel Rangel-Huert. Mass spectrometry-based metabolomics study of nicotine exposure in THP-1 monocytes. Scientific reports. vol 14. issue 1. 2024-06-28. PMID:38942832. the tobacco alkaloid nicotine is known for its activation of neuronal nicotinic acetylcholine receptors. 2024-06-28 2024-07-01 human