| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jingjing Yang, Hongjuan Wang, Huan Chen, Hongwei Hou, Qingyuan H. The association of genetic polymorphisms within the dopaminergic system with nicotine dependence: A narrative review. Heliyon. vol 10. issue 12. 2024-07-18. PMID:39021905. |
nicotine acts on the limbic dopamine reward loop in the midbrain by binding to nicotinic acetylcholine receptors, promoting the release of dopamine, and resulting in a rewarding effect or satisfaction. |
2024-07-18 |
2024-07-20 |
Not clear |
| Ranjithkumar Chellian, Azin Behnood-Rod, Adriaan W Bruijnzee. The Role of Glucocorticoid and Nicotinic Acetylcholine Receptors in the Reward-Enhancing Effects of Nicotine in the ICSS Procedure in Male and Female Rats. bioRxiv : the preprint server for biology. 2024-07-15. PMID:39005409. |
the role of glucocorticoid and nicotinic acetylcholine receptors in the reward-enhancing effects of nicotine in the icss procedure in male and female rats. |
2024-07-15 |
2024-07-18 |
rat |
| Silvio Uhlig, Bergitte Pearl Olderbø, Jan Tore Samuelsen, Solveig Uvsløkk, Lada Ivanova, Camille Vanderstraeten, Lene Aiko Grutle, Oscar Daniel Rangel-Huert. Mass spectrometry-based metabolomics study of nicotine exposure in THP-1 monocytes. Scientific reports. vol 14. issue 1. 2024-06-28. PMID:38942832. |
the tobacco alkaloid nicotine is known for its activation of neuronal nicotinic acetylcholine receptors. |
2024-06-28 |
2024-07-01 |
human |
| Yujie Shen, Qiang Huang, Xiaohui Yuan, Hongli Gong, Chengzhi Xu, Huaidong Du, Chi-Yao Hsueh, Liang Zho. Nicotine-induced activation of cholinergic receptor nicotinic alpha 5 subunit mediates the malignant behaviours of laryngeal squamous epithelial cells by interacting with RABL6. Cell death discovery. vol 10. issue 1. 2024-06-15. PMID:38879667. |
nicotine, a crucial constituent of tobacco smoke, can bind to and activate nicotinic acetylcholine receptors (nachrs), thereby regulating various biological functions. |
2024-06-15 |
2024-06-18 |
Not clear |
| Andrew M Lombardi, Helen Wong, Myra E Bower, Ryan Milstead, Curtis Borski, Emily Schmitt, Mina Griffioen, Lauren LaPlante, Marissa A Ehringer, Jerry Stitzel, Charles A Hoeffe. AKT2 modulates astrocytic nicotine responses bioRxiv : the preprint server for biology. 2024-06-10. PMID:38854016. |
nicotine binds and activates two astrocyte-expressed nicotinic acetylcholine receptors (nachrs), α4β2 and α7. |
2024-06-10 |
2024-06-14 |
Not clear |
| Khalil Hajiasgharzadeh, Parviz Shahabi, Elham Karimi-Sales, Mohammad Reza Alipou. Nicotine promotes development of bile duct ligation-induced liver fibrosis by increasing expression of nicotinic acetylcholine receptors in rats. Clinical and experimental hepatology. vol 10. issue 1. 2024-05-21. PMID:38765906. |
nicotine promotes development of bile duct ligation-induced liver fibrosis by increasing expression of nicotinic acetylcholine receptors in rats. |
2024-05-21 |
2024-05-27 |
rat |
| Khalil Hajiasgharzadeh, Parviz Shahabi, Elham Karimi-Sales, Mohammad Reza Alipou. Nicotine promotes development of bile duct ligation-induced liver fibrosis by increasing expression of nicotinic acetylcholine receptors in rats. Clinical and experimental hepatology. vol 10. issue 1. 2024-05-21. PMID:38765906. |
nicotine, as an agonist of nicotinic acetylcholine receptors (nachrs), induces many downstream signaling pathways. |
2024-05-21 |
2024-05-27 |
rat |
| Mackenna Wollet, Abram Hernandez, Kaila Nip, Jason Pugh, Jun Hee Ki. Impacts of Perinatal Nicotine Exposure on nAChR Expression and Glutamatergic Synaptic Transmission in the Mouse Auditory Brainstem. bioRxiv : the preprint server for biology. 2024-05-20. PMID:38765998. |
this study investigated the effects of chronic nicotine exposure during a critical developmental period on the functional expression of nicotinic acetylcholine receptors (nachrs), glutamatergic synaptic transmission, and auditory processing in the mouse auditory brainstem. |
2024-05-20 |
2024-05-27 |
mouse |
| Mingyu Zhu, Lili Cui, Guanglin Liu, Pengpeng Yu, Qingyuan Hu, Huan Chen, Hongwei Ho. UHPLC-MS/MS combined with microdialysis for simultaneous determination of nicotine and neurotransmitter metabolites in the rat hippocampal brain region: application to pharmacokinetic and pharmacodynamic study. Analytical methods : advancing methods and applications. 2024-05-13. PMID:38738307. |
nicotine crosses the blood-brain barrier and interacts with nicotinic acetylcholine receptors, initiating a cascade of neurotransmitter effects with potential therapeutic implications for neurodegenerative conditions such as alzheimer's and parkinson's disease. |
2024-05-13 |
2024-05-27 |
rat |
| Ahmad Joukhan, Veno Kononenko, Marija Sollner Dolenc, Matej Hočevar, Tom Turk, Damjana Drobn. Modulation of the Effect of Cisplatin on Nicotine-Stimulated A549 Lung Cancer Cells Using Analog of Marine Sponge Toxin Loaded in Gelatin Nanoparticles. Nanomaterials (Basel, Switzerland). vol 14. issue 9. 2024-05-12. PMID:38727371. |
nicotine activates nicotinic acetylcholine receptors (nachrs), which are overexpressed in numerous cancer types, leading to signaling pathways that increase lung cancer invasiveness and resistance to chemotherapeutic agents. |
2024-05-12 |
2024-05-27 |
human |
| Nancy A Rigotti, Neal L Benowitz, Judith J Prochaska, Daniel F Cain, Julie Ball, Anthony Clarke, Brent A Blumenstein, Cindy Jacob. Cytisinicline for Vaping Cessation in Adults Using Nicotine E-Cigarettes: The ORCA-V1 Randomized Clinical Trial. JAMA internal medicine. 2024-05-06. PMID:38709500. |
cytisinicline, a plant-based alkaloid, targets nicotinic acetylcholine receptors, reduces nicotine dependence, and helps adults to stop smoking cigarettes. |
2024-05-06 |
2024-05-08 |
Not clear |
| Ahmad Joukhan, Veno Kononenko, Tadeja Bele, Marija Sollner Dolenc, Steve Peigneur, Ernesto Lopes Pinheiro-Junior, Jan Tytgat, Tom Turk, Igor Križaj, Damjana Drobn. Attenuation of Nicotine Effects on A549 Lung Cancer Cells by Synthetic α7 nAChR Antagonists APS7-2 and APS8-2. Marine drugs. vol 22. issue 4. 2024-04-26. PMID:38667764. |
nicotine binds to nicotinic acetylcholine receptors (nachrs) that are overexpressed in different cancer cells, promoting tumor growth and resistance to chemotherapy. |
2024-04-26 |
2024-04-28 |
human |
| Lois S Akinola, Jada Gonzales, Belle Buzzi, Hunter L Mathews, Roger L Papke, Jerry A Stitzel, M Imad Dama. Investigating the role of nicotinic acetylcholine receptors in menthol's effects in mice. Drug and alcohol dependence. vol 257. 2024-03-16. PMID:38492255. |
the widespread use of menthol can be attributed to its unique sensory characteristics; however, emerging evidence suggests that menthol also alters sensitivity to nicotine through modulation of nicotinic acetylcholine receptors (nachrs). |
2024-03-16 |
2024-03-19 |
mouse |
| Roger L Papk. The many enigmas of nicotine. Advances in pharmacology (San Diego, Calif.). vol 99. 2024-03-11. PMID:38467485. |
this review discusses the diverse effects of nicotine on the various nicotinic acetylcholine receptors of the central and peripheral nervous system and how those effects may promote the usage and addiction to tobacco products. |
2024-03-11 |
2024-03-14 |
Not clear |
| Yan Fu, Keyu Shen, Hao Wang, Shun Wang, Xufeng Wang, Le Zhu, Yan Zheng, Tiantian Zou, Hongfei Ci, Qiongzhu Dong, Lun-Xiu Qi. Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis. Signal transduction and targeted therapy. vol 9. issue 1. 2024-03-07. PMID:38453934. |
acetylcholine promoted icc metastasis through interacting with its receptor, alpha 5 nicotine acetylcholine receptor subunits (chrna5). |
2024-03-07 |
2024-03-10 |
Not clear |
| Aden Dhana Rizkita, Sintia Ayu Dewi, Taufik Muhammad Fakih, Cheng-Chung Le. Effectiveness of sesquiterpene derivatives from Cinnamomum genus in nicotine replacement therapy through blocking acetylcholine nicotinate: a computational analysis. Journal of biomolecular structure & dynamics. 2024-01-25. PMID:38268238. |
effectiveness of sesquiterpene derivatives from cinnamomum genus in nicotine replacement therapy through blocking acetylcholine nicotinate: a computational analysis. |
2024-01-25 |
2024-01-27 |
Not clear |
| Kumboyono Kumboyono, Indah N Chomsy, Nadya N Shalshabilla, Hidayat Sujuti, Arie Srihardyastutie, Cholid T Tjahjono, Teuku Heriansyah, Titin A Wihastut. Nicotine is associated with smoking dependence and vascular inflammation through cotinine: A mediation analysis. Tobacco induced diseases. vol 22. 2024-01-22. PMID:38250634. |
cotinine, a metabolite of nicotine, is capable of causing dependence effects through endless mechanisms modulated by the ion channel nicotinic acetylcholine receptors nachrs. |
2024-01-22 |
2024-01-24 |
Not clear |
| Ashwini Wani, Bala Prabhakar, Pravin Shend. Competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-30. PMID:38159871. |
competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. |
2023-12-30 |
2024-01-05 |
Not clear |
| Ashwini Wani, Bala Prabhakar, Pravin Shend. Competitive inhibition of nicotine acetylcholine receptors using microneedles of nicotine and varenicline for smoking withdrawal therapy. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2023-12-30. PMID:38159871. |
nicotine released in a sustained manner attaches to the nicotine acetylcholine receptors (nachr) to release dopamine for controlling the withdrawal challenges such as anxiety, irritability, cravings, disturbed sleep pattern, etc. |
2023-12-30 |
2024-01-05 |
Not clear |
| Chhatrapal Patel, Richa Patel, Vaibhav Maturkar, Nishant Sudhir Jai. Central cholinergic transmission affects the compulsive-like behavior of mice in marble-burying test. Brain research. 2023-12-14. PMID:38097126. |
injection of acetylcholine (0.01 µg) (subeffective: 0.1 and 0.5 µg), cholinesterase inhibitor, neostigmine (0.1, 0.3, 0.5 µg/mouse) and neuronal nicotinic acetylcholine receptor agonist, nicotine (0.1, 2 µg/mouse) significantly attenuated the number of marbles buried by mice in mbb test without affecting basal locomotor activity. |
2023-12-14 |
2023-12-17 |
mouse |