Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
hypocretin receptor 1 blockade early in abstinence prevents incubation of cocaine seeking and normalizes dopamine transmission. |
2024-12-09 |
2024-12-12 |
rat |
Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
while the mechanisms underlying incubation of cocaine seeking remain elusive, considerable evidence suggests that abstinence from cocaine promotes mesolimbic dopamine adaptations that contribute to exaggerated cocaine seeking. |
2024-12-09 |
2024-12-12 |
rat |
Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
consequently, preventing these dopamine adaptations may reduce incubation of cocaine seeking and thereby reduce the likelihood of relapse. |
2024-12-09 |
2024-12-12 |
rat |
Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
in the present studies, we first examined if incubation of cocaine seeking was associated with aberrant dopamine transmission in the nucleus accumbens after seven days of abstinence from intermittent access to cocaine. |
2024-12-09 |
2024-12-12 |
rat |
Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
given the extensive evidence that hypocretins/orexins regulate motivation for cocaine, we then examined to what extent hypocretin receptor 1 antagonism on the first day of abstinence prevented incubation of cocaine seeking and dopamine adaptations later in abstinence. |
2024-12-09 |
2024-12-12 |
rat |
Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
we also observed aberrant dopamine transmission, but only in rats that displayed incubation of cocaine seeking. |
2024-12-09 |
2024-12-12 |
rat |
Philip J Clark, Volodar M Migovich, Sanjay Das, Wei Xi, Sandhya Kortagere, Rodrigo A Españ. Hypocretin Receptor 1 Blockade Early in Abstinence Prevents Incubation of Cocaine Seeking and Normalizes Dopamine Transmission. bioRxiv : the preprint server for biology. 2024-12-09. PMID:39651183. |
further, we showed that a single injection of the hypocretin receptor 1 antagonist, rtiox-276, on the first day of abstinence prevented incubation of cocaine seeking and aberrant dopamine transmission. |
2024-12-09 |
2024-12-12 |
rat |
Mary R Lee, Ehsan Shokri Kojori, William Dieckmann, Erick Singley, Julie A Mattison, Peter Herscovitch, Lorenzo Leggi. Oxytocin reduces methylphenidate-induced dorsal striatal dopamine release in male rhesus macaques. The international journal of neuropsychopharmacology. 2024-12-03. PMID:39626021. |
we investigated the effect of oxytocin on striatal dopamine release stimulated by methylphenidate whose mechanism of action is analogous to that of cocaine. |
2024-12-03 |
2024-12-06 |
Not clear |
Mia I Allen, Emory A Lewis, Jianjing Cao, Amy Hauck Newman, Michael A Nade. Selective dopamine D3 receptor partial agonist (±)VK4-40 reduces the reinforcing strength of d-amphetamine but not cocaine in rhesus monkeys responding under a progressive-ratio schedule of reinforcement. Drug and alcohol dependence. vol 265. 2024-11-11. PMID:39527868. |
selective dopamine d3 receptor partial agonist (±)vk4-40 reduces the reinforcing strength of d-amphetamine but not cocaine in rhesus monkeys responding under a progressive-ratio schedule of reinforcement. |
2024-11-11 |
2024-11-17 |
monkey |
Mia I Allen, Emory A Lewis, Jianjing Cao, Amy Hauck Newman, Michael A Nade. Selective dopamine D3 receptor partial agonist (±)VK4-40 reduces the reinforcing strength of d-amphetamine but not cocaine in rhesus monkeys responding under a progressive-ratio schedule of reinforcement. Drug and alcohol dependence. vol 265. 2024-11-11. PMID:39527868. |
one potential treatment target is the dopamine d3 receptor (d3r) and studies in rodents have suggested that the novel d3r partial agonist (±)vk4-40 may be effective at decreasing cocaine self-administration. |
2024-11-11 |
2024-11-17 |
monkey |
Tate A Pollock, Alexander V Margetts, Samara J Vilca, Luis M Tuest. Cocaine taking and craving produce distinct transcriptional profiles in dopamine neurons. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416214. |
cocaine taking and craving produce distinct transcriptional profiles in dopamine neurons. |
2024-10-17 |
2024-10-19 |
mouse |
Tate A Pollock, Alexander V Margetts, Samara J Vilca, Luis M Tuest. Cocaine taking and craving produce distinct transcriptional profiles in dopamine neurons. bioRxiv : the preprint server for biology. 2024-10-17. PMID:39416214. |
to bridge this gap, we have adapted a virus-based method for labeling and capture of dopamine nuclei, coupled with nuclear rna-sequencing, to study the transcriptional adaptations, specifically, of dopamine neurons in the ventral tegmental area (vta) during cocaine taking and cocaine craving, using a mouse model of cocaine intravenous self-administration (ivsa). |
2024-10-17 |
2024-10-19 |
mouse |
Valentin Mira, Christelle Baunez, Alexandre Eusebio, Tatiana Witjas, Eve Benchetrit, Jean-Philippe Azula. Cocaine and dopamine abuse improved by subthalamic nucleus deep brain stimulation in one Parkinsonian patient. Psychiatry and clinical neurosciences. 2024-10-01. PMID:39350435. |
cocaine and dopamine abuse improved by subthalamic nucleus deep brain stimulation in one parkinsonian patient. |
2024-10-01 |
2024-10-03 |
Not clear |
Mia I Allen, Omeed Rahimi, Bernard N Johnson, Jianjing Cao, Amy Hauck Newman, Michael A Nade. The Journal of pharmacology and experimental therapeutics. 2024-09-20. PMID:39304350. |
one strategy to mitigate cocaine craving and relapse is to elevate dopamine (da). |
2024-09-20 |
2024-09-23 |
Not clear |
Jocelyn A Ricard, Loïc Labache, Ashlea Segal, Elvisha Dhamala, Carrisa V Cocuzza, Grant Jones, Sarah W Yip, Sidhant Chopra, Avram J Holme. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D Communications biology. vol 7. issue 1. 2024-09-19. PMID:39300138. |
a shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine d the biological mechanisms that contribute to cocaine and other substance use disorders involve an array of cortical and subcortical systems. |
2024-09-19 |
2024-09-22 |
Not clear |
Jocelyn A Ricard, Loïc Labache, Ashlea Segal, Elvisha Dhamala, Carrisa V Cocuzza, Grant Jones, Sarah W Yip, Sidhant Chopra, Avram J Holme. A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D Communications biology. vol 7. issue 1. 2024-09-19. PMID:39300138. |
profiles of functional connectivity in cocaine use disorder reliably linked with spatial densities of dopamine d |
2024-09-19 |
2024-09-22 |
Not clear |
Sophia J Weber, Alex B Kawa, Madelyn M Beutler, Hayley M Kuhn, Alana L Moutier, Jonathan G Westlake, Lara M Koyshman, Cloe D Moreno, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-09-19. PMID:39300272. |
dopamine transmission at d1 and d2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. |
2024-09-19 |
2024-09-22 |
rat |
Sophia J Weber, Alex B Kawa, Madelyn M Beutler, Hayley M Kuhn, Alana L Moutier, Jonathan G Westlake, Lara M Koyshman, Cloe D Moreno, Amanda M Wunsch, Marina E Wol. Dopamine transmission at D1 and D2 receptors in the nucleus accumbens contributes to the expression of incubation of cocaine craving. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-09-19. PMID:39300272. |
however, despite the importance of dopaminergic signaling in the nacc for motivated behavior, little is known about the role that dopamine (da) plays in the incubation of cocaine craving. |
2024-09-19 |
2024-09-22 |
rat |
Dana M Smith, Mary M Torregross. The ventral tegmental area dopamine to basolateral amygdala projection supports acquisition of cocaine self-administration. Neuropharmacology. 2024-09-18. PMID:39293506. |
the ventral tegmental area dopamine to basolateral amygdala projection supports acquisition of cocaine self-administration. |
2024-09-18 |
2024-09-21 |
Not clear |
Dana M Smith, Mary M Torregross. The ventral tegmental area dopamine to basolateral amygdala projection supports acquisition of cocaine self-administration. Neuropharmacology. 2024-09-18. PMID:39293506. |
dopamine signaling in the amygdala is known to play a role in associative learning and memory, including the process of learning to associate environmental cues with the reinforcing properties of drugs like cocaine. |
2024-09-18 |
2024-09-21 |
Not clear |