| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Agustin Zapata, Carl R Lupic. Lateral habenula cannabinoid CB1 receptor involvement in drug-associated impulsive behavior. Neuropharmacology. vol 192. 2021-07-12. PMID:33965396. |
however, the brain areas where cannabinoids might control impulsivity or cocaine seeking are largely unknown. |
2021-07-12 |
2023-08-13 |
human |
| Radhouene Doggui, Wafaa Elsawy, Aldo Alberto Conti, Alex Baldacchin. Association between chronic psychoactive substances use and systemic inflammation: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 125. 2021-06-28. PMID:33639179. |
to meet the required inclusion criteria, all studies had to describe human participants with an age ≥18y., experiencing chronic psychostimulant (nicotine, amphetamine, cocaine), sedative (benzodiazepine, opioids) and/or cannabinoid use. |
2021-06-28 |
2023-08-13 |
human |
| Elizabeth M Doncheck, Gage T Liddiard, Chaz D Konrath, Xiaojie Liu, Laikang Yu, Luke A Urbanik, Matthew R Herbst, Margot C DeBaker, Nicholas Raddatz, Erik C Van Newenhizen, Jacob Mathy, Marieke R Gilmartin, Qing-Song Liu, Cecilia J Hillard, John R Mantsc. Sex, stress, and prefrontal cortex: influence of biological sex on stress-promoted cocaine seeking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 45. issue 12. 2021-06-23. PMID:32303052. |
we previously demonstrated that a stressor (footshock) can potentiate cocaine seeking in male rats via glucocorticoid-dependent cannabinoid type-1 receptor (cb1r)-mediated actions in the prelimbic prefrontal cortex (prl-pfc). |
2021-06-23 |
2023-08-13 |
rat |
| Lan-Yuan Zhang, Yue-Qing Zhou, Zhi-Peng Yu, Xiao-Qin Zhang, Jie Shi, Hao-Wei She. Restoring glutamate homeostasis in the nucleus accumbens via endocannabinoid-mimetic drug prevents relapse to cocaine seeking behavior in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 46. issue 5. 2021-06-23. PMID:33514875. |
these results demonstrate that enhancing endocannabinoid signaling is a potential pathway to restore glutamate homeostasis and may represent a promising therapeutic strategy for preventing cocaine relapse. |
2021-06-23 |
2023-08-13 |
rat |
| Megan Farley, Helena Tran, Steven Towler, Jirair Gevorkyan, Sue Pearring, Luke N Rodd. A Single Method for 127 Recommended and Additional DUID Drugs in Blood and Urine by LC-MS/MS. Journal of analytical toxicology. 2021-06-23. PMID:34159389. |
assessed in blood quantitatively, and urine qualitatively, is 127 target drug and metabolite analytes including cannabinoids (12), amphetamines (11), cocaine and metabolites (6), benzodiazepines (36), z-drugs (5), opioids (27), anticonvulsants (3), first-generation antihistamines (6), muscle relaxants (2), dissociatives and hallucinogens (6), barbiturates (10), and miscellaneous substances (3). |
2021-06-23 |
2023-08-13 |
Not clear |
| David Fabregat-Safont, Juan V Sancho, Félix Hernández, María Ibáñe. The key role of mass spectrometry in comprehensive research on new psychoactive substances. Journal of mass spectrometry : JMS. vol 56. issue 7. 2021-06-17. PMID:33155376. |
new psychoactive substances (nps) are a wide group of compounds that try to mimic the effects produced by the 'classical' illicit drugs, including cannabis (synthetic cannabinoids), cocaine and amphetamines (synthetic cathinones) or heroin (synthetic opioids), and which health effects are still unknown for most of them. |
2021-06-17 |
2023-08-13 |
Not clear |
| Francisco Navarrete, María Salud García-Gutiérrez, Ani Gasparyan, Amaya Austrich-Olivares, Jorge Manzanare. Role of Cannabidiol in the Therapeutic Intervention for Substance Use Disorders. Frontiers in pharmacology. vol 12. 2021-06-08. PMID:34093179. |
here we review preclinical and clinical reports regarding the effects of cbd on the regulation of the reinforcing, motivational and withdrawal-related effects of different drugs of abuse such as alcohol, opioids (morphine, heroin), cannabinoids, nicotine, and psychostimulants (cocaine, amphetamine). |
2021-06-08 |
2023-08-13 |
Not clear |
| Larissa Alencar Rodrigues, Mariana Emanuele Silva Caroba, Fernando Kengy Taba, Renato Filev, Andrea Donatti Gallass. Evaluation of the potential use of cannabidiol in the treatment of cocaine use disorder: A systematic review. Pharmacology, biochemistry, and behavior. vol 196. 2021-05-27. PMID:32645315. |
cannabinoids may have an important therapeutic potential for the treatment of dependence on crack cocaine. |
2021-05-27 |
2023-08-13 |
Not clear |
| Gianni Testino, Patrizia Balbinot, Rinaldo Pellican. Substances use disorders and liver injury: a concise review. Minerva gastroenterology. 2021-05-11. PMID:33971710. |
in this concise review, liver damage from amphetamines, cannabinoids, cocaine and opioids is analyzed and the need to identify a possible associated alcohol use disorder is also suggested. |
2021-05-11 |
2023-08-13 |
Not clear |
| Ewa Galaj, Guo-Hua Bi, Hong-Ju Yang, Zheng-Xiong X. Cannabidiol attenuates the rewarding effects of cocaine in rats by CB2, 5-HT Neuropharmacology. vol 167. 2021-04-23. PMID:31437433. |
strikingly, this reduction in both cocaine self-administration and bsr was blocked by am630 (a cannabinoid cb2 receptor antagonist), way100135 (a 5-ht |
2021-04-23 |
2023-08-13 |
rat |
| Guichang Zou, Xin Zuo, Kai Chen, Yushu Ge, Xiaoqun Wang, Guangwei Xu, Huan Wang, Chenjian Miao, Zhenyu Xu, Shuangshuang Tian, Zhen Wang, Yifeng Zhou, Wei Wei, Guangming Huang, Dan Liu, Wei Xion. Cannabinoids Rescue Cocaine-Induced Seizures by Restoring Brain Glycine Receptor Dysfunction. Cell reports. vol 30. issue 12. 2021-04-07. PMID:32209479. |
cannabinoids are reported to rescue cocaine-induced seizures (ciss), a severe complication in cocaine users. |
2021-04-07 |
2023-08-13 |
Not clear |
| Kuntheavy Ing Lorenzini, François Girardi. Direct-acting antiviral interactions with opioids, alcohol or illicit drugs of abuse in HCV-infected patients. Liver international : official journal of the International Association for the Study of the Liver. vol 40. issue 1. 2021-03-23. PMID:31654604. |
we discussed the pharmacokinetics (pks) and pharmacodynamics (pd) of currently prescribed direct antiviral agents (nsa5 inhibitors: daclatasvir, elbasvir, ledipasvir, pibrentasvir, velpatasvir; ns5b inhibitor: sofosbuvir; ns3/4a protease inhibitors: glecaprevir, grazoprevir, voxilaprevir) and most common substances of abuse (opioids: buprenorphine, fentanyl, heroin, methadone, morphine, oxycodone; stimulants: amphetamines, cathinones, cocaine; cannabinoids; ethanol). |
2021-03-23 |
2023-08-13 |
Not clear |
| Amvrosios Orfanidis, Helen G Gika, Georgios Theodoridis, Orthodoxia Mastrogianni, Nikolaos Raiko. A UHPLC-MS-MS Method for the Determination of 84 Drugs of Abuse and Pharmaceuticals in Blood. Journal of analytical toxicology. vol 45. issue 1. 2021-02-11. PMID:32369171. |
), some of the most important groups of drugs of abuse: opiates, cocaine, cannabinoids, amphetamines, benzodiazepines and new psychoactive substances. |
2021-02-11 |
2023-08-13 |
Not clear |
| Guido Pelletti, Francesca Rossi, Marco Garagnani, Rossella Barone, Raffaella Roffi, Paolo Fais, Susi Pelott. Optimization of cloned enzyme donor immunoassay cut-offs for drugs of abuse in post-mortem whole blood. Forensic science international. vol 312. 2021-02-01. PMID:32353744. |
in this study, semi-quantitative results on post-mortem whole blood samples obtained through cedia analysis (cannabinoids, cocaine, amphetamine compounds, opiates and methadone), were compared with results of confirmatory analysis obtained using gc-ms. |
2021-02-01 |
2023-08-13 |
Not clear |
| Jorge J Zacca, Gabriella H Giudice, Mônica P Souza, Luíza N B Caldas, Maurício L Vieira, Angelo H L Machad. Development and validation of analytical method for identification of new psychoactive substances using linear retention indexes and gas chromatography-mass spectrometry. Journal of chromatography. A. vol 1636. 2021-01-26. PMID:33340744. |
the method was optimized and validated for 22 different drugs covering ten categories: phenethylamines (amphetamine, mdma, methamphetamine, 25cnbome, 2-fa, 5-mapb), "classic" drugs (cocaine, ephedrine, thc, heroine), synthetic cannabinoids (jwh-081, am-2201, jwh-210, mam-2201), piperazines (o-cpp, p-cpp), tryptamines (5-meo-mipt), synthetic cathinones (n-ethylpentylone), synthetic opioids (u-47700), aminoindanes (5-iai), plant-based substances (salvinorin-a) and "other" (methiopropamine). |
2021-01-26 |
2023-08-13 |
Not clear |
| Timothée Joye, Katell Rocher, Julien Déglon, Jonathan Sidibé, Bernard Favrat, Marc Augsburger, Aurélien Thoma. Driving Under the Influence of Drugs: A Single Parallel Monitoring-Based Quantification Approach on Whole Blood. Frontiers in chemistry. vol 8. 2020-10-03. PMID:33005598. |
the method was fully validated for the quantification of the major classes of psychoactive substances associated with impaired-driving (cannabinoids, cocaine and its metabolites, amphetamines, opiates and opioids, and the major benzodiazepines and z-drugs). |
2020-10-03 |
2023-08-13 |
Not clear |
| Tsung-Ping S. Non-canonical Targets Mediating the Action of Drugs of Abuse: Cocaine at the Sigma-1 Receptor as an Example. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31396041. |
in addition to acting on traditionally recognized receptors or transporters on the plasma membrane, several drugs of abuse, including amphetamine, methamphetamine, nicotine, opioid, cocaine, ketamine, and cannabinoid, have been shown to exert their effects by acting on additional molecular targets either on the plasma membrane or inside a cell. |
2020-10-01 |
2023-08-13 |
Not clear |
| Osama A Alibrahim, Yusuf A Misau, Alkali Mohammed, Mohammad Bashir Faruk, Izzeldin S. Prevalence of hepatitis C viral infection among injecting drug users in a Saudi Arabian hospital: A point cross sectional survey. Journal of public health in Africa. vol 9. issue 1. 2020-09-30. PMID:30079162. |
there was statistically significant association between clinical assessments of the participants who were abusing drugs generally, dependent on drugs, specifically abusing cocaine, amphetamines, opioids, cannabinoids and alcohol with hcv antibodies seropositivity. |
2020-09-30 |
2023-08-13 |
human |
| Nadejda Korneeva, Urska Cvek, Anna Leskova, Kimberley Hutchinson, Avery Callahan, Gregory Patek, Marjan Trutschl, Phillip C S R Kilgore, Patrick McGauly, Nicolas Goeders, Thomas Arnol. Urine Drug Screen Trends from 1998 through 2011 Among Emergency Department Patients Treated in a University Teaching Hospital. Toxicology communications. vol 2. issue 1. 2020-09-29. PMID:30906915. |
samples were tested for the presence of amphetamines, barbiturates, benzodiazepines, cannabinoids, cocaine, 3,4-methylenedioxymethamphetamine (mdma), methadone, methamphetamine, opiates, phencyclidine, and propoxyphene. |
2020-09-29 |
2023-08-13 |
Not clear |
| Nadejda Korneeva, Urska Cvek, Anna Leskova, Kimberley Hutchinson, Avery Callahan, Gregory Patek, Marjan Trutschl, Phillip C S R Kilgore, Patrick McGauly, Nicolas Goeders, Thomas Arnol. Urine Drug Screen Trends from 1998 through 2011 Among Emergency Department Patients Treated in a University Teaching Hospital. Toxicology communications. vol 2. issue 1. 2020-09-29. PMID:30906915. |
the caucasian population predominated in positive tests for prescription drugs (opiates and benzodiazepines), while the african-american population predominated in results positive for illicit drugs (cannabinoids and cocaine). |
2020-09-29 |
2023-08-13 |
Not clear |