| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shilpa Buch, Honghong Yao, Minglei Guo, Tomohisa Mori, Blaise Mathias-Costa, Vijeta Singh, Pankaj Seth, John Wang, Tsung-Ping S. Cocaine and HIV-1 interplay in CNS: cellular and molecular mechanisms. Current HIV research. vol 10. issue 5. 2012-12-31. PMID:22591366. |
in the astroglia and microglia, cocaine exposure leads to up-regulation of pro-inflammatory mediators such as cytokines and chemokines. |
2012-12-31 |
2023-08-12 |
Not clear |
| Honghong Yao, Yanjing Yang, Kee Jun Kim, Crystal Bethel-Brown, Nan Gong, Keiko Funa, Howard E Gendelman, Tsung-Ping Su, John Q Wang, Shilpa Buc. Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. vol 115. issue 23. 2010-07-19. PMID:20354174. |
we now demonstrate that cocaine induces mcp-1 in rodent microglia through translocation of the sigma receptor to the lipid raft microdomains of the plasma membrane. |
2010-07-19 |
2023-08-12 |
mouse |
| Karley Y Little, Eric Ramssen, Ryan Welchko, Vitaly Volberg, Courtney J Roland, Bader Cassi. Decreased brain dopamine cell numbers in human cocaine users. Psychiatry research. vol 168. issue 3. 2009-09-17. PMID:19233481. |
both activated macrophages and activated microglia were significantly increased among cocaine users. |
2009-09-17 |
2023-08-12 |
human |
| David M Thomas, Paul D Walker, Joyce A Benjamins, Timothy J Geddes, Donald M Kuh. Methamphetamine neurotoxicity in dopamine nerve endings of the striatum is associated with microglial activation. The Journal of pharmacology and experimental therapeutics. vol 311. issue 1. 2004-12-15. PMID:15163680. |
dopamine transporter antagonists (cocaine, win 35,428 [(-)-2-beta-carbomethoxy-3-beta-(4-fluorophenyl)tropane 1,5-naphthalenedisulfonate], and nomifensine), selective d1 (skf 82958 [(+/-)-6-chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepine hydrobromide]), d2 (quinpirole), or mixed d1/d2 receptor agonists (apomorphine) do not mimic the effect of methamphetamine on microglia. |
2004-12-15 |
2023-08-12 |
mouse |
| Genya Gekker, Shuxian Hu, Mark P Wentland, Jean M Bidlack, James R Lokensgard, Phillip K Peterso. Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. The Journal of pharmacology and experimental therapeutics. vol 309. issue 2. 2004-06-21. PMID:14757849. |
because kappa-opioid receptor (kor) agonists have been shown to suppress neurochemical and neurobehavioral responses to cocaine and to inhibit hiv-1 expression in microglial cell cultures, we also postulated that kor ligands would inhibit cocaine-induced potentiation of hiv-1 expression. |
2004-06-21 |
2023-08-12 |
human |
| Genya Gekker, Shuxian Hu, Mark P Wentland, Jean M Bidlack, James R Lokensgard, Phillip K Peterso. Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. The Journal of pharmacology and experimental therapeutics. vol 309. issue 2. 2004-06-21. PMID:14757849. |
consistent with the hypotheses, treatment of microglia with cocaine promoted hiv-1 expression (maximal enhancement of 54%), and pretreatment of microglia with these kor agonists as well as with the kor-selective antagonist nor-binaltorphimine abrogated cocaine-induced potentiation of viral expression. |
2004-06-21 |
2023-08-12 |
human |