| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vanessa Chilunda, Tina M Calderon, Pablo Martinez-Aguado, Joan W Berma. The impact of substance abuse on HIV-mediated neuropathogenesis in the current ART era. Brain research. vol 1724. 2020-10-29. PMID:31473221. |
this review will focus on how substances of abuse, with an emphasis on methamphetamine (meth), cocaine, and opioids, impact blood brain barrier (bbb) integrity and transmigration of hiv-infected and uninfected monocytes across the bbb, as well as their effects on monocytes/macrophages, microglia, and astrocytes within the cns. |
2020-10-29 |
2023-08-13 |
human |
| K E Linker, M Gad, P Tawadrous, M Cano, K N Green, M A Wood, F M Lesli. Microglial activation increases cocaine self-administration following adolescent nicotine exposure. Nature communications. vol 11. issue 1. 2020-04-07. PMID:31949158. |
here, we report reactive microglia are critical regulators of nicotine-induced increases in adolescent cocaine self-administration. |
2020-04-07 |
2023-08-13 |
Not clear |
| Huynh Nhu Mai, Lan Thuy Ty Nguyen, Eun-Joo Shin, Dae-Joong Kim, Ji Hoon Jeong, Yoon Hee Chung, Xin Gen Lei, Naveen Sharma, Choon-Gon Jang, Toshitaka Nabeshima, Hyoung-Chun Ki. Astrocytic mobilization of glutathione peroxidase-1 contributes to the protective potential against cocaine kindling behaviors in mice via activation of JAK2/STAT3 signaling. Free radical biology & medicine. vol 131. 2019-12-20. PMID:30592974. |
genetic overexpression of gpx-1 significantly attenuated proliferation of iba-1-labeled microglia induced by cocaine in mice. |
2019-12-20 |
2023-08-13 |
mouse |
| Hilary R Smith, Thomas J R Beveridge, Susan H Nader, Michael A Nader, Linda J Porrin. Regional elevations in microglial activation and cerebral glucose utilization in frontal white matter tracts of rhesus monkeys following prolonged cocaine self-administration. Brain structure & function. vol 224. issue 4. 2019-11-21. PMID:30747315. |
in rodents, and possibly humans, cocaine exposure activates microglia. |
2019-11-21 |
2023-08-13 |
monkey |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
the current study assessed the effects of intravenous cocaine self-administration on microglial activation, and mecp2 and bdnf expression in reward regions of the brain in vivo, as well as determined specific effects of cocaine exposure on mecp2 and bdnf expression in human primary neurons and microglia. |
2019-09-06 |
2023-08-13 |
human |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
the results from this study highlight a distinct molecular pathway in microglia through which cocaine increases bdnf, including the phosphorylation of mecp2 its subsequent translocation from the nucleus to the cytosol, which frees the bdnf promoter and permits its transcriptional activation. |
2019-09-06 |
2023-08-13 |
human |
| Bianca Cotto, Hongbo Li, Ronald F Tuma, Sara Jane Ward, Dianne Langfor. Cocaine-mediated activation of microglia and microglial MeCP2 and BDNF production. Neurobiology of disease. vol 117. 2019-09-06. PMID:29859319. |
results from these studies show for the first time that cocaine self-administration increases microglial activation, and that microglial mecp2 is a sensitive target of cocaine resulting in increased release of bdnf from microglia, and possibly contributing to cocaine-induced synaptic plasticity. |
2019-09-06 |
2023-08-13 |
human |
| Marta Rodríguez-Arias, Sandra Montagud-Romero, Ana María Guardia Carrión, Carmen Ferrer-Pérez, Ana Pérez-Villalba, Eva Marco, Meritxell López Gallardo, María-Paz Viveros, José Miñarr. Social stress during adolescence activates long-term microglia inflammation insult in reward processing nuclei. PloS one. vol 13. issue 10. 2019-04-03. PMID:30365534. |
in addition to an increase in the conditioned rewarding effects of cocaine, our results showed that rsd in adolescence produced inflammatory reactivity in microglia that is prolonged into adulthood, affecting astrocytes and neurons of two reward-processing areas of the brain (the prelimbic cortex, and the nucleus accumbens core). |
2019-04-03 |
2023-08-13 |
Not clear |
| Palsamy Periyasamy, Ke Liao, Yeon Hee Kook, Fang Niu, Shannon E Callen, Ming-Lei Guo, Shilpa Buc. Cocaine-Mediated Downregulation of miR-124 Activates Microglia by Targeting KLF4 and TLR4 Signaling. Molecular neurobiology. vol 55. issue 4. 2019-02-26. PMID:28478506. |
cocaine is known to activate microglia both in vitro and in vivo. |
2019-02-26 |
2023-08-13 |
mouse |
| A Belin-Rauscent, J Lacoste, O Hermine, A Moussy, B J Everitt, David Beli. Decrease of cocaine, but not heroin, self-administration and relapse by the tyrosine kinase inhibitor masitinib in male Sprague Dawley rats. Psychopharmacology. vol 235. issue 5. 2019-02-20. PMID:29520592. |
accumulating evidence shows that cocaine, and also heroin, influence several tyrosine kinases, expressed in neurons and in non-neuronal populations such as microglia, astrocytes and mast-cells. |
2019-02-20 |
2023-08-13 |
rat |
| Zi-Jun Wang, Jennifer A Martin, Amy M Gancarz, Danielle N Adank, Fraser J Sim, David M Diet. Activin A is increased in the nucleus accumbens following a cocaine binge. Scientific reports. vol 7. 2018-11-08. PMID:28272550. |
activin a levels in the nac were assessed via elisa and immunohistochemistry (in neurons, astrocytes, and microglia) following a cocaine binge paradigm. |
2018-11-08 |
2023-08-13 |
Not clear |
| Kyle T Brown, Sophia C Levis, Casey E O'Neill, Alexis L Northcutt, Timothy J Fabisiak, Linda R Watkins, Ryan K Bachtel. Innate immune signaling in the ventral tegmental area contributes to drug-primed reinstatement of cocaine seeking. Brain, behavior, and immunity. vol 67. 2018-07-11. PMID:28813640. |
although considerable attention has been directed at the consequences of neuronal changes following chronic cocaine taking, few studies have examined the role of microglia, the brain's resident immune cells, following chronic cocaine administration. |
2018-07-11 |
2023-08-13 |
rat |
| Gil M Lewitus, Sarah C Konefal, Andrew D Greenhalgh, Horia Pribiag, Keanan Augereau, David Stellwage. Microglial TNF-α Suppresses Cocaine-Induced Plasticity and Behavioral Sensitization. Neuron. vol 90. issue 3. 2017-08-22. PMID:27112496. |
here we show that repeated administration of cocaine activates striatal microglia and induces tnf-α production, which in turn depresses glutamatergic synaptic strength in the nac core and limits the development of behavioral sensitization. |
2017-08-22 |
2023-08-13 |
Not clear |
| Yu Cai, Lu Yang, Shannon Callen, Shilpa Buc. Multiple Faceted Roles of Cocaine in Potentiation of HAND. Current HIV research. vol 14. issue 5. 2017-08-10. PMID:27009095. |
ample evidence suggests that cocaine not only facilitates viral replication in macrophages and microglia, but also inflicts deleterious effects on various other cells of the cns, thereby contributing to the potentiation of hand. |
2017-08-10 |
2023-08-13 |
human |
| Ming-Lei Guo, Palsamy Periyasamy, Ke Liao, Yeon Hee Kook, Fang Niu, Shannon E Callen, Shilpa Buc. Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation. Epigenetics. vol 11. issue 11. 2017-05-23. PMID:27786595. |
cocaine, one of most commonly abused drugs, has been shown to activate microglia both in vitro and in vivo. |
2017-05-23 |
2023-08-13 |
mouse |
| Ming-Lei Guo, Palsamy Periyasamy, Ke Liao, Yeon Hee Kook, Fang Niu, Shannon E Callen, Shilpa Buc. Cocaine-mediated downregulation of microglial miR-124 expression involves promoter DNA methylation. Epigenetics. vol 11. issue 11. 2017-05-23. PMID:27786595. |
in the current study, we demonstrated that cocaine exposure decreased mir-124 levels in both bv-2 cells and rat primary microglia. |
2017-05-23 |
2023-08-13 |
mouse |
| Ke Liao, Minglei Guo, Fang Niu, Lu Yang, Shannon E Callen, Shilpa Buc. Cocaine-mediated induction of microglial activation involves the ER stress-TLR2 axis. Journal of neuroinflammation. vol 13. 2016-10-05. PMID:26860188. |
cocaine exposure has been demonstrated to mediate up-regulation of inflammatory mediators in in vitro cultures of microglia. |
2016-10-05 |
2023-08-13 |
human |
| Eun Young Jang, Yeon-Hee Ryu, Bong Hyo Lee, Su-Chan Chang, Mi Jin Yeo, Sang Hyun Kim, Ryan J Folsom, Nathan D Schilaty, Kwang Joong Kim, Chae Ha Yang, Scott C Steffensen, Hee Young Ki. Involvement of reactive oxygen species in cocaine-taking behaviors in rats. Addiction biology. vol 20. issue 4. 2016-02-29. PMID:24975938. |
increased oxidative stress was found mainly on neurons, but not astrocytes, microglia or oligodendrocytes, in nac of rats self-administering cocaine. |
2016-02-29 |
2023-08-13 |
rat |
| Frances Zenón, Annabell C Segarra, Mariangeline Gonzalez, Loyda M Melénde. Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 9. issue 5. 2015-06-23. PMID:25209871. |
recent evidence establishes that cocaine use promotes brain perivascular macrophage infiltration and microglia activation. |
2015-06-23 |
2023-08-13 |
Not clear |
| Blaise Mathias Costa, Honghong Yao, Lu Yang, Shilpa Buc. Role of endoplasmic reticulum (ER) stress in cocaine-induced microglial cell death. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 8. issue 3. 2014-02-11. PMID:23404095. |
herein we demonstrate that exposure of microglial cell line-bv2 or rat primary microglia to exogenous cocaine resulted in decreased cell viability as determined by mts and tunel assays. |
2014-02-11 |
2023-08-12 |
human |