| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
we found that microglia exposed to cocaine exhibited significant induction of nlrp3 and mature il-1β expression. |
2021-11-18 |
2023-08-13 |
mouse |
| Ernest T Chivero, Annadurai Thangaraj, Ashutosh Tripathi, Palsamy Periyasamy, Ming-Lei Guo, Shilpa Buc. NLRP3 Inflammasome Blockade Reduces Cocaine-Induced Microglial Activation and Neuroinflammation. Molecular neurobiology. vol 58. issue 5. 2021-11-18. PMID:33417223. |
collectively, these findings suggest that cocaine activates microglia involving the nlrp3 inflammasome pathway, thereby contributing to neuroinflammation. |
2021-11-18 |
2023-08-13 |
mouse |
| Maria Carolina Machado da Silva, Giovanni Freitas Gomes, Heliana de Barros Fernandes, Aristóbolo Mendes da Silva, Antônio Lúcio Teixeira, Fabrício A Moreira, Aline Silva de Miranda, Antônio Carlos Pinheiro de Oliveir. Inhibition of CSF1R, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine. Scientific reports. vol 11. issue 1. 2021-11-15. PMID:34362959. |
inhibition of csf1r, a receptor involved in microglia viability, alters behavioral and molecular changes induced by cocaine. |
2021-11-15 |
2023-08-13 |
mouse |
| Ernest T Chivero, Susmita Sil, Seema Singh, Annadurai Thangaraj, Lila Gordon, Grace B Evah-Nzoughe, Natasha Ferguson, Shannon Callen, Shilpa Buc. Protective Role of Lactobacillus rhamnosus Probiotic in Reversing Cocaine-Induced Oxidative Stress, Glial Activation and Locomotion in Mice. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 2021-10-10. PMID:34628571. |
in cocaine administered mice, there was increased activation of both microglia and astrocytes in the striatum and cortex of the brain as shown by enhanced expression of cd11b and gfap, respectively. |
2021-10-10 |
2023-08-13 |
mouse |
| Ernest T Chivero, Ke Liao, Fang Niu, Ashutosh Tripathi, Changhai Tian, Shilpa Buch, Guoku H. Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia. Frontiers in cell and developmental biology. vol 8. 2021-09-14. PMID:32850781. |
psychostimulants such as cocaine have been shown to activate microglia by downregulating mir-124, leading, in turn, to neuroinflammation. |
2021-09-14 |
2023-08-13 |
mouse |
| Ernest T Chivero, Ke Liao, Fang Niu, Ashutosh Tripathi, Changhai Tian, Shilpa Buch, Guoku H. Engineered Extracellular Vesicles Loaded With miR-124 Attenuate Cocaine-Mediated Activation of Microglia. Frontiers in cell and developmental biology. vol 8. 2021-09-14. PMID:32850781. |
mouse primary microglia (mpm) were treated with purified engineered evs loaded with either cy5-mir-124 or cy5-scrambled mirna oligos in the presence or absence of cocaine followed by assessing ev uptake and microglial activation. |
2021-09-14 |
2023-08-13 |
mouse |
| Sanjay Kumar, Brennetta J Crenshaw, Sparkle D Williams, Courtnee' R Bell, Qiana L Matthews, Brian Sim. Cocaine-Specific Effects on Exosome Biogenesis in Microglial Cells. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33559104. |
cocaine can have direct effects on all cell types in the brain, including microglia. |
2021-09-14 |
2023-08-13 |
Not clear |
| Sanjay Kumar, Brennetta J Crenshaw, Sparkle D Williams, Courtnee' R Bell, Qiana L Matthews, Brian Sim. Cocaine-Specific Effects on Exosome Biogenesis in Microglial Cells. Neurochemical research. vol 46. issue 4. 2021-09-14. PMID:33559104. |
however, how cocaine regulates microglia and the influence of cocaine on microglial-derived exosomes remains unknown. |
2021-09-14 |
2023-08-13 |
Not clear |
| María Amparo Assis, Pedro Gabriel Carranza, Emilio Ambrosi. A "Drug-Dependent" Immune System Can Compromise Protection against Infection: The Relationships between Psychostimulants and HIV. Viruses. vol 13. issue 5. 2021-08-18. PMID:33919273. |
immune receptors, like toll-like receptors (tlrs) on microglia, are modulated by cocaine and amphetamine exposure. |
2021-08-18 |
2023-08-13 |
Not clear |
| Marina Aksenova, Justin Sybrandt, Biyun Cui, Vitali Sikirzhytski, Hao Ji, Diana Odhiambo, Matthew D Lucius, Jill R Turner, Eugenia Broude, Edsel Peña, Sofia Lizarraga, Jun Zhu, Ilya Safro, Michael D Wyatt, Michael Shtutma. Inhibition of the Dead Box RNA Helicase 3 Prevents HIV-1 Tat and Cocaine-Induced Neurotoxicity by Targeting Microglia Activation. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. vol 15. issue 2. 2021-05-27. PMID:31802418. |
graphical abstract rk-33, selective inhibitor of dead box rna helicase 3 (ddx3) protects neurons from combined tat and cocaine neurotoxicity by inhibition of microglia activation and production of proinflammatory cytokines. |
2021-05-27 |
2023-08-13 |
human |
| Maria E Burkovetskaya, Robert Small, Liyang Guo, Shilpa Buch, Ming-Lei Gu. Cocaine self-administration differentially activates microglia in the mouse brain. Neuroscience letters. vol 728. 2021-05-17. PMID:32278944. |
cocaine self-administration differentially activates microglia in the mouse brain. |
2021-05-17 |
2023-08-13 |
mouse |
| Maria E Burkovetskaya, Robert Small, Liyang Guo, Shilpa Buch, Ming-Lei Gu. Cocaine self-administration differentially activates microglia in the mouse brain. Neuroscience letters. vol 728. 2021-05-17. PMID:32278944. |
these findings indicate that microglia could be activated in the early stage of cocaine addiction directly supporting the rationale that dysregulation on neuroimmune signaling is inherently involved in the development of drug addiction. |
2021-05-17 |
2023-08-13 |
mouse |
| Ching Mei Wu, Ted Weita La. Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice. Brain research. vol 1761. 2021-03-21. PMID:33639199. |
cocaine and other addictive drugs are known to stimulate microglia, and microglia in turn have been shown to play roles in both the development and mitigation of drug dependence. |
2021-03-21 |
2023-08-13 |
mouse |
| Ching Mei Wu, Ted Weita La. Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice. Brain research. vol 1761. 2021-03-21. PMID:33639199. |
for instance, cocaine can directly bind to surface receptors on microglia and trigger their release of interleukin-1β, which promotes addictive behaviors; however, cocaine also indirectly stimulates microglia by elevating dopamine, which causes microglia to impair long-lasting neuronal changes related to cocaine use. |
2021-03-21 |
2023-08-13 |
mouse |
| Ching Mei Wu, Ted Weita La. Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice. Brain research. vol 1761. 2021-03-21. PMID:33639199. |
although cocaine treatment had little effect on microglial abundance, plx3397 treatment dramatically decreased the number of microglia in the nucleus accumbens and hippocampus in control mice and in mice subjected to cocaine sensitization. |
2021-03-21 |
2023-08-13 |
mouse |
| Ching Mei Wu, Ted Weita La. Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice. Brain research. vol 1761. 2021-03-21. PMID:33639199. |
importantly, loss of microglia did not appear to affect either the acute locomotor response to cocaine treatment or sensitization after repeated doses of cocaine. |
2021-03-21 |
2023-08-13 |
mouse |
| Ching Mei Wu, Ted Weita La. Microglia depletion by PLX3397 has no effect on cocaine-induced behavioral sensitization in male mice. Brain research. vol 1761. 2021-03-21. PMID:33639199. |
in conclusion, while our data do not contradict previous findings indicating that different microglial-derived factors can have seemingly opposite effects on behaviors associated with cocaine use, they suggest that microglia do not have a net effect on cocaine-induced long-lasting behavioral changes. |
2021-03-21 |
2023-08-13 |
mouse |
| Kinga Gawlińska, Małgorzata Frankowska, Dawid Gawliński, Marcin Piechota, Michał Korostyński, Małgorzata Fili. Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. International journal of molecular sciences. vol 21. issue 21. 2021-03-08. PMID:33120991. |
cocaine induces neuronal changes as well as non-neuronal (astrocytes, microglia, oligodendroglia) mechanisms, but these changes can also be modulated by various types of drug abstinence. |
2021-03-08 |
2023-08-13 |
rat |
| Annadurai Thangaraj, Palsamy Periyasamy, Ming-Lei Guo, Ernest T Chivero, Shannon Callen, Shilpa Buc. Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Autophagy. vol 16. issue 2. 2020-11-23. PMID:30990365. |
exposure of microglia to cocaine also resulted in increased expression of dnm1l and optn with a concomitant decrease in the rate of mitochondrial oxygen consumption as well as impaired mitochondrial functioning. |
2020-11-23 |
2023-08-13 |
mouse |
| Annadurai Thangaraj, Palsamy Periyasamy, Ming-Lei Guo, Ernest T Chivero, Shannon Callen, Shilpa Buc. Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Autophagy. vol 16. issue 2. 2020-11-23. PMID:30990365. |
additionally, in the presence of cocaine, microglia also exhibited upregulated expression of autophagosome markers, becn1, map1lc3b-ii, and sqstm1. |
2020-11-23 |
2023-08-13 |
mouse |