| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chaohui Wang, Xiaoying Liu, Xi Sun, Yun Li, Xiaojun Yang, Yanli Li. Dietary betaine supplementation improved egg quality and gut microbes of laying hens under dexamethasone-induced oxidative stress. Poultry science. vol 103. issue 11. 2024-08-18. PMID:39154612. |
more importantly, dietary betaine addition significantly increased the levels of pantothenic acid, gamma-aminobutyric acid, equol and choline, all of which were related to antioxidant and anti-inflammatory properties. |
2024-08-18 |
2024-08-21 |
Not clear |
| Dahye Yoon, Seon Min Oh, Hyeon Seon Na, Bo-Ram Choi, Kwan-Woo Kim, Young-Seob Lee, Dong-Ryung Lee, Dae Young Le. Metabolomics study to reveal cognitive improvement with treatment of Scrophularia buergeriana. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043762. |
niacinamide, tyrosine, uridine, and valine in the cortex and gaba, choline, creatine, formate, fumarate, hypoxanthine, leucine, myo-inositol, pyroglutamate, and taurine in the hippocampus were identified as biomarker candidates for recovering cognitive impairment. |
2024-07-23 |
2024-07-26 |
mouse |
| Sharon K Hunter, M Camille Hoffman, Angelo D'Alessandro, Robert Freedma. Developmental Windows for Effects of Choline and Folate on Excitatory and Inhibitory Neurotransmission During Human Gestation. Developmental psychobiology. vol 66. issue 2. 2024-04-22. PMID:38646069. |
at different periods during gestation, choline stimulation of α7-nicotinic receptors facilitates conversion of γ-aminobutyric acid (gaba) receptors from excitatory to inhibitory and recruitment of glur1-r2 receptors for faster excitatory responses to glutamate. |
2024-04-22 |
2024-04-24 |
human |
| Alice R Thomson, Hannah Hwa, Duanghathai Pasanta, Benjamin Hopwood, Helen J Powell, Ross Lawrence, Zeus G Tabuenca, Tomoki Arichi, Richard A E Edden, Xiaoqian Chai, Nicolaas A Put. The developmental trajectory of 1H-MRS brain metabolites from childhood to adulthood. Cerebral cortex (New York, N.Y. : 1991). vol 34. issue 3. 2024-03-02. PMID:38430105. |
we find significant non-linear trajectories for gaba+ (gaba plus macromolecules), glx (glutamate + glutamine), total choline (tcho) and total creatine (tcr) concentrations. |
2024-03-02 |
2024-03-04 |
human |
| Kazuo Okanari, Hitoshi Teranishi, Ryohei Umeda, Kenshiro Shikano, Masanori Inoue, Toshikatsu Hanada, Kenji Ihara, Reiko Hanad. Behavioral and neurotransmitter changes on antiepileptic drugs treatment in the zebrafish pentylenetetrazol-induced seizure model. Behavioural brain research. 2024-02-25. PMID:38403178. |
to investigate the effects of aeds such as levetiracetam (lev), carbamazepine (cbz), and fenfluramine (ffr) on key neurotransmitters in the pentylenetetrazol (ptz)-induced seizures in adult zebrafish, we examined the changes in glutamic acid, gamma-aminobutyric acid (gaba), serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), choline, acetylcholine, norepinephrine, dopamine (da), 3,4-dihydroxyphenylacetic acid (dopac), and adenosine. |
2024-02-25 |
2024-02-28 |
zebrafish |
| Lauren Revie, Claudia Metzler-Baddele. Age-related fornix decline predicts conservative response strategy-based slowing in perceptual decision-making. Aging brain. vol 5. 2024-02-06. PMID:38318456. |
estimates of metabolite concentrations [n-acetyl aspartate (naa), glutamate (glx), and γ-aminobutyric acid (gaba), creatine (cr), choline (cho), myoinositol (mi)] were measured from occipital (occ), anterior cingulate (acc) and posterior parietal cortices (ppc). |
2024-02-06 |
2024-02-09 |
Not clear |
| Molly Charney, Sheryl Foster, Vishwa Shukla, Wufan Zhao, Sam H Jiang, Kasia Kozlowska, Alexander Li. Neurometabolic alterations in children and adolescents with functional neurological disorder. NeuroImage. Clinical. vol 41. 2024-01-14. PMID:38219534. |
metabolites assessed included n-acetyl aspartate (naa), a marker of neuron function; myo-inositol (mi), a glial-cell marker; choline (cho), a membrane marker; glutamate plus glutamine (glx), a marker of excitatory neurotransmission; γ-aminobutyric acid (gaba), a marker of inhibitor neurotransmission; and creatine (cr), an energy marker. |
2024-01-14 |
2024-01-17 |
Not clear |
| Megha Kumari, Yasha Hasija, Richa Trived. Acute and sub-acute metabolic change in different brain regions induced by moderate blunt traumatic brain injury. Neuroreport. 2023-12-08. PMID:38064354. |
taurine, gamma amino butyric acid (gaba), choline, and alpha keto-glutarate levels were found to be significantly altered in striatal tissues at days 1 and 3pi. |
2023-12-08 |
2023-12-17 |
rat |
| Sudthirak Wongkhieo, Wanthongchai Tangmesupphaisan, Jeeraprapa Siriwaseree, Yaovapa Aramsirirujiwet, Prissana Wiriyajitsomboon, Tharnrat Kaewgrajang, Saifa Pumloifa, Atchara Paemanee, Buabarn Kuaprasert, Kiattawee Choowongkomon, Adrian H Chester, Napachanok M Swainso. In vitro cholesterol lowering activity of Ganoderma australe mycelia based on mass spectrometry, synchrotron Fourier-transform infrared analysis and liver-spheroid bioactivity. Scientific reports. vol 13. issue 1. 2023-08-21. PMID:37604902. |
this revealed the presence of lovastatin and tentative compounds including p-coumaric, nicotinamide, gamma-aminobutyric acid, choline, nucleosides, amino acids, and saccharides. |
2023-08-21 |
2023-09-07 |
Not clear |
| Jun Tan, Yue Li, Dekun Gao, Lianhua Sun, Qiang Song, Jun Yan. A liquid chromatography-mass spectroscopy-based untargeted metabolomic study of the rat cochlear nucleus at various stages of maturity. Hearing research. vol 426. 2022-11-08. PMID:36347123. |
n-acetylaspartylglutamic acid (naag), γ-aminobutyric acid (gaba), taurine, adenosine monophosphate (amp), and choline were significantly upregulated at pd60. |
2022-11-08 |
2023-08-14 |
rat |
| Susen Becker, Anja Schulz, Sophia Kreyer, Jan Dreßler, Angelika Richter, Christin Helmschrod. Sensitive and simultaneous quantification of 16 neurotransmitters and metabolites in murine microdialysate by fast liquid chromatography-tandem mass spectrometry. Talanta. vol 253. 2022-10-08. PMID:36208557. |
the quantitative analysis of 16 neurotransmitters and metabolites, including serotonin (5-ht), 5-hydroxyindoleacetic acid (5-hiaa), melatonin (me), dopamine (da), levodopa (l-dopa), 3-methoxytyramine (3-mt), norepinephrine (ne), epinephrine (ep), homovanillinic acid (hva), acetylcholine (ach), deoxy carnitine (iso-ach), choline (ch), and ɣ-aminobutyric acid (gaba), adenosine (ade), glutamine (gln), and glutamic acid (glu) was achieved within a chromatographic separation time of 6.5 min by the application of a biphenyl column coupled to an api-qtrap 5500 (ab sciex) mass spectrometer. |
2022-10-08 |
2023-08-14 |
mouse |
| Fengrong Chen, Yu Xu, Kai Shi, Zunyue Zhang, Zhenrong Xie, Hongjin Wu, Yuru Ma, Yong Zhou, Cheng Chen, Jiqing Yang, Yuan Wang, Trevor W Robbins, Kunhua Wang, Juehua Y. Multi-omics study reveals associations among neurotransmitter, extracellular vesicle-derived microRNA and psychiatric comorbidities during heroin and methamphetamine withdrawal. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 155. 2022-09-22. PMID:36137407. |
using weighted gene co-expression network analysis, a series of known, conserved, and novel exosomal mirnas were identified as being associated with the severity of anxiety and depression, as well as the concentrations of neurotransmitters gaba, choline, and serotonin. |
2022-09-22 |
2023-08-14 |
human |
| Ricardo P Martinho, Mukul G Jain, Lucio Frydma. High field ex vivo and in vivo 2D NMR spectroscopy in mice brain: Resolving and exploring the molecular environments. NMR in biomedicine. 2022-09-17. PMID:36114827. |
cross-peaks from main brain biomolecules including choline, creatine, gaba, naa, glutamine and glutamate showed enhancements in several of these various features, opening interesting vistas about metabolite compartmentalization as viewed by these 2d nmr experiments. |
2022-09-17 |
2023-08-14 |
mouse |
| Soomin Jeong, Soogyeong Jang, Seong Soon Kim, Myung Ae Bae, Junnyung Shin, Ki-Baek Lee, Ki-Tae Ki. Size-dependent seizurogenic effect of polystyrene microplastics in zebrafish embryos. Journal of hazardous materials. vol 439. 2022-09-15. PMID:36104895. |
additionally, an increase in the levels of neurochemicals choline, betaine, dopamine, 3-methoxytyramine, and gamma-aminobutyric acid indicated that the observed hypoactivity and seizure-like behavior were associated with the dysregulation of the cholinergic, dopaminergic, and gabaergic systems. |
2022-09-15 |
2023-08-14 |
zebrafish |
| b' Katarina Simi\\xc4\\x87, Nina Todorovi\\xc4\\x87, Sne\\xc5\\xbeana Trifunovi\\xc4\\x87, Zoran Miladinovi\\xc4\\x87, Aleksandra Gavrilovi\\xc4\\x87, Silvana Jovanovi\\xc4\\x87, Nata\\xc5\\xa1a Avramovi\\xc4\\x87, Dejan Go\\xc4\\x91evac, Ljubodrag Vujisi\\xc4\\x87, Vele Te\\xc5\\xa1evi\\xc4\\x87, Ljubica Tasi\\xc4\\x87, Boris Mandi\\xc4\\x8. NMR Metabolomics in Serum Fingerprinting of Schizophrenia Patients in a Serbian Cohort. Metabolites. vol 12. issue 8. 2022-08-25. PMID:36005580.' |
thirteen metabolites (lactate/lactic acid, threonine, leucine, isoleucine, valine, glutamine, asparagine, alanine, gamma-aminobutyric acid, choline, glucose, glycine and tyrosine) that are common for three different ethnic and geographic origins (serbia, brazil and china) could be a good start point for the setup of a universal nmr serum biomarker set for schizophrenia. |
2022-08-25 |
2023-08-14 |
Not clear |
| Mona Guath, Johan Lundin Kleberg, Jan Weis, Ebba Widegren, Matilda Frick, Stefan Möller, Lisa Klevebrant, Barry Karlsson, David Fällmar, Johanna Mårtensson, Daniel S Pine, Karin Brocki, Malin Gingnell, Andreas Fric. Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents. Behavioural brain research. 2022-08-20. PMID:35987307. |
depressive symptoms are associated with altered pupillary responses during learning and reward prediction as well as with changes in neurometabolite levels, including brain concentrations of choline, glutamate and gamma-aminobutyric acid (gaba). |
2022-08-20 |
2023-08-14 |
human |
| Mona Guath, Johan Lundin Kleberg, Jan Weis, Ebba Widegren, Matilda Frick, Stefan Möller, Lisa Klevebrant, Barry Karlsson, David Fällmar, Johanna Mårtensson, Daniel S Pine, Karin Brocki, Malin Gingnell, Andreas Fric. Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents. Behavioural brain research. 2022-08-20. PMID:35987307. |
participants completed the revised child anxiety and depression scale (rcads) and underwent a reward learning task while measuring pupil dilation and a single voxel dorsal anterior cingulate cortex (dacc) mega-press magnetic resonance spectroscopy scan assessing choline, glutamate and gaba concentrations. |
2022-08-20 |
2023-08-14 |
human |
| Mona Guath, Johan Lundin Kleberg, Jan Weis, Ebba Widegren, Matilda Frick, Stefan Möller, Lisa Klevebrant, Barry Karlsson, David Fällmar, Johanna Mårtensson, Daniel S Pine, Karin Brocki, Malin Gingnell, Andreas Fric. Pupil dilation during negative prediction errors is related to brain choline concentration and depressive symptoms in adolescents. Behavioural brain research. 2022-08-20. PMID:35987307. |
dorsal acc choline was positively associated with depressive symptoms, whereas glutamate and gaba were not related to pe-pdr or depressive symptoms. |
2022-08-20 |
2023-08-14 |
human |
| Tiffany K Bell, Kate J Godfrey, Ashley L Ware, Keith Owen Yeates, Ashley D Harri. Harmonization of multi-site MRS data with ComBat. NeuroImage. 2022-05-26. PMID:35618196. |
analyses were performed using data acquired across 20 sites and included edited mrs for gaba+ (n=218) and macromolecule-suppressed gaba data (n=209), as well as standard press data to quantify naa, creatine, choline, and glutamate (n=190). |
2022-05-26 |
2023-08-13 |
Not clear |
| Mengying Wei, Yuanyuan Liu, Zifeng Pi, Kexin Yue, Shizhe Li, Mingxin Hu, Zhiqiang Liu, Fengrui Song, Zhongying Li. Investigation of plasma metabolomics and neurotransmitter dysfunction in the process of Alzheimer's disease rat induced by amyloid beta 25-35. RSC advances. vol 9. issue 32. 2022-05-06. PMID:35515227. |
the neurotransmitter dysfunction was mainly involved in γ-aminobutyric acid (gaba), acetyl choline (ach), glutamic acid (glu), 5-hydroxytryptamine (5-ht), dopamine (da) and norepinephrine (ne). |
2022-05-06 |
2023-08-13 |
rat |