| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Chung-Yin Lin, Chiung-Mei Che. Dysregulation of choline metabolism and therapeutic potential of citicoline in Huntington's disease. Aging cell. 2024-08-15. PMID:39143698. |
both r6/2 mice and hd patients exhibited reduced expression of glycerophosphocholine phosphodiesterase 1 (gpcpd1), a key enzyme in choline metabolism, in the striatum and cortex. |
2024-08-15 |
2024-08-17 |
mouse |
| Dahye Yoon, Seon Min Oh, Hyeon Seon Na, Bo-Ram Choi, Kwan-Woo Kim, Young-Seob Lee, Dong-Ryung Lee, Dae Young Le. Metabolomics study to reveal cognitive improvement with treatment of Scrophularia buergeriana. Scientific reports. vol 14. issue 1. 2024-07-23. PMID:39043762. |
niacinamide, tyrosine, uridine, and valine in the cortex and gaba, choline, creatine, formate, fumarate, hypoxanthine, leucine, myo-inositol, pyroglutamate, and taurine in the hippocampus were identified as biomarker candidates for recovering cognitive impairment. |
2024-07-23 |
2024-07-26 |
mouse |
| Thomas A Bellio, Jessenia Y Laguna-Torres, Mary S Campion, Jay Chou, Sheila Yee, Jan K Blusztajn, Tiffany J Mellot. Perinatal choline supplementation prevents learning and memory deficits and reduces brain amyloid Aβ42 deposition in AppNL-G-F Alzheimer's disease model mice. PloS one. vol 19. issue 2. 2024-02-06. PMID:38315685. |
perinatal choline supplementation reduced aβ42 deposition in the amygdala, cortex, and hippocampus of appnl-g-f mice. |
2024-02-06 |
2024-02-09 |
mouse |
| Evan M Paules, Jorge A Silva-Gomez, Walter B Friday, Steve H Zeisel, Isis Trujillo-Gonzale. Choline Regulates SOX4 through miR-129-5p and Modifies H3K27me3 in the Developing Cortex. Nutrients. vol 15. issue 12. 2023-06-28. PMID:37375678. |
choline regulates sox4 through mir-129-5p and modifies h3k27me3 in the developing cortex. |
2023-06-28 |
2023-08-14 |
Not clear |
| Evan M Paules, Jorge A Silva-Gomez, Walter B Friday, Steve H Zeisel, Isis Trujillo-Gonzale. Choline Regulates SOX4 through miR-129-5p and Modifies H3K27me3 in the Developing Cortex. Nutrients. vol 15. issue 12. 2023-06-28. PMID:37375678. |
choline availability regulates neural progenitor cell proliferation and differentiation in the developing cerebral cortex. |
2023-06-28 |
2023-08-14 |
Not clear |
| Meaghan V Perdue, Marilena M DeMayo, Tiffany K Bell, Elodie Boudes, Mercedes Bagshawe, Ashley D Harris, Catherine Lebe. Changes in brain metabolite levels across childhood. NeuroImage. 2023-04-20. PMID:37080345. |
we examined the developmental changes of key metabolites (total n-acetylaspartate, tnaa; total choline, tcho; total creatine, tcr; glutamate+glutamine, glx; and myo-inositol, mi) using short echo-time magnetic resonance spectroscopy (mrs) in the anterior cingulate cortex (acc) and the left temporo-parietal cortex (ltp) using a mixed cross-sectional/longitudinal design in children aged 2-11 years (acc: n=101 children, 112 observations; ltp: n=95 children, 318 observations). |
2023-04-20 |
2023-08-14 |
human |
| Emma Muñoz-Moreno, Rui Vasco Simões, Raúl Tudela, Xavier López-Gil, Guadalupe Sori. Spatio-temporal metabolic rewiring in the brain of TgF344-AD rat model of Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-10-10. PMID:36216838. |
thus, in cortex, strong couplings of n-acetylaspartate and creatine with myo-inositol in wt, but with taurine in tgf344-ad rats were observed; whereas in the hippocampus, myo-inositol, taurine and choline compounds levels were highly correlated in wt but not in tgf344-ad animals. |
2022-10-10 |
2023-08-14 |
rat |
| Chen Zhang, Miao-Miao Zhou, Tian-Tian Zhang, Pei-Xu Cong, Jie Xu, Chang-Hu Xue, Teruyoshi Yanagita, Zi-Hao Wei, Yu-Ming Wan. Effects of Dietary Supplementation with EPA-enriched Phosphatidylcholine and Phosphatidylethanolamine on Glycerophospholipid Profile in Cerebral Cortex of SAMP8 Mice fed with High-fat Diet. Journal of oleo science. vol 70. issue 2. 2021-06-17. PMID:33456004. |
results demonstrated that dietary supplementation with epa-pe and epa pc for 8 weeks significantly increased the amount of choline plasmalogen (ppc) and lyso phosphatidylethanolamine (lpe) in the cerebral cortex of samp8 mice fed with high fat diet. |
2021-06-17 |
2023-08-13 |
mouse |
| Ryoki Sasaki, Naofumi Otsuru, Shota Miyaguchi, Sho Kojima, Hiraku Watanabe, Ken Ohno, Noriko Sakurai, Naoki Kodama, Daisuke Sato, Hideaki Onish. Influence of Brain-Derived Neurotrophic Factor Genotype on Short-Latency Afferent Inhibition and Motor Cortex Metabolites. Brain sciences. vol 11. issue 3. 2021-04-13. PMID:33804682. |
furthermore, the considerable inter-individual variability in inhibitory network activity typically measured by tms may be affected not only by gaba but also by other pathways, including glutamatergic and cholinergic activities; therefore, we used 3-t magnetic resonance spectroscopy (mrs) to measure the dynamics of glutamate plus glutamine (glx) and choline concentrations in the left m1, left somatosensory cortex, and right cerebellum. |
2021-04-13 |
2023-08-13 |
human |
| Elizabeth K Neumann, Lukasz G Migas, Jamie L Allen, Richard M Caprioli, Raf Van de Plas, Jeffrey M Spraggin. Spatial Metabolomics of the Human Kidney using MALDI Trapped Ion Mobility Imaging Mass Spectrometry. Analytical chemistry. vol 92. issue 19. 2021-02-16. PMID:32668145. |
through this improved sensitivity, we have found >40 low molecular weight metabolites in human kidney tissue, such as argininic acid, acetylcarnitine, and choline that localize to the cortex, medulla, and renal pelvis, respectively. |
2021-02-16 |
2023-08-13 |
human |
| Anderson Ribeiro-Carvalho, Carla S Lima, Ana C Dutra-Tavares, Fernanda Nunes, André L Nunes-Freitas, Cláudio C Filgueiras, Alex C Manhães, Armando Meyer, Yael Abreu-Villaç. Mood-related behavioral and neurochemical alterations in mice exposed to low chlorpyrifos levels during the brain growth spurt. PloS one. vol 15. issue 10. 2020-11-24. PMID:33007016. |
at pn10, cpf female mice showed increased serotonin and choline transporter binding in cerebral cortex. |
2020-11-24 |
2023-08-13 |
mouse |
| R Chinthu, T R Anju, C S Paulos. Cholinergic receptor alterations in the cerebral cortex of spinal cord injured rat. Biochemistry and biophysics reports. vol 10. 2020-09-30. PMID:29114569. |
the gene expression of key enzymes in cholinergic pathway - acetylcholine esterase and choline acetyl transferase showed significant upregulation in the cerebral cortex of spinal cord injured group compared to control with the fold increase in expression of acetylcholine esterase prominently higher than cholineacetyl transferase. |
2020-09-30 |
2023-08-13 |
rat |
| Shankar Tumati, Esther M Opmeer, Jan-Bernard C Marsman, Sander Martens, Fransje E Reesink, Peter P De Deyn, André Alema. Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:29706886. |
lower choline and myo-inositol in temporo-parietal cortex is associated with apathy in amnestic mci. |
2020-09-30 |
2023-08-13 |
Not clear |
| Austin T Mudd, Caitlyn M Getty, Ryan N Dilge. Maternal Dietary Choline Status Influences Brain Gray and White Matter Development in Young Pigs. Current developments in nutrition. vol 2. issue 6. 2020-09-29. PMID:29955727. |
research in animal models suggests that perinatal choline deficiency influences neuron development in the hippocampus and cortex, yet these observations require invasive techniques. |
2020-09-29 |
2023-08-13 |
Not clear |
| Anna L Cranston, Adrianna Wysocka, Marta Steczkowska, Maciej Zadrożny, Ewelina Palasz, Charles R Harrington, Franz Theuring, Claude M Wischik, Gernot Riedel, Grazyna Niewiadomsk. Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer's disease and frontotemporal lobar degeneration. Brain communications. vol 2. issue 1. 2020-09-28. PMID:32954291. |
a significant lowering of choline acetyltransferase-positive neurons and p75-positive neurons in the basal forebrain of line 1 at 3, 6 and 9 months was observed in two independent studies, alongside a significant decrease in acetylcholinesterase staining in the cortex and hippocampus. |
2020-09-28 |
2023-08-13 |
mouse |
| F Dittman. The effect of ooplasmic pH regulation on the formation of yolk spheres in the telotrophic ovariole of Dysdercus intermedius. Journal of insect physiology. vol 43. issue 2. 2019-11-20. PMID:12769922. |
6) monensin induced ooplasmic proton loading was reversible when 40mm choline were replaced by 40mm na(+).vitellogenesis was demonstrated by the accumulation of fluorescence labelled hemolymph proteins in yolk spheres in the cortex of the oocyte: 1) yolk formation continued in potassium-free medium. |
2019-11-20 |
2023-08-12 |
Not clear |
| Isis Trujillo-Gonzalez, Yanyan Wang, Walter B Friday, Kasey C Vickers, Cynthia L Toth, Lorian Molina-Torres, Natalia Surzenko, Steven H Zeise. MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 3. 2019-11-12. PMID:30521373. |
microrna-129-5p is regulated by choline availability and controls egf receptor synthesis and neurogenesis in the cerebral cortex. |
2019-11-12 |
2023-08-13 |
Not clear |
| Isis Trujillo-Gonzalez, Yanyan Wang, Walter B Friday, Kasey C Vickers, Cynthia L Toth, Lorian Molina-Torres, Natalia Surzenko, Steven H Zeise. MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 3. 2019-11-12. PMID:30521373. |
for the first time, to our knowledge, we have identified the molecular links that explain how a change in the availability of the diet metabolite choline impacts the essential cellular processes underlying brain development.-trujillo-gonzalez, i., wang, y., friday, w. b., vickers, k. c., toth, c. l., molina-torres, l., surzenko, n., zeisel, s. h. microrna-129-5p is regulated by choline availability and controls egf receptor synthesis and neurogenesis in the cerebral cortex. |
2019-11-12 |
2023-08-13 |
Not clear |
| Isis Trujillo-Gonzalez, Yanyan Wang, Walter B Friday, Kasey C Vickers, Cynthia L Toth, Lorian Molina-Torres, Natalia Surzenko, Steven H Zeise. MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 3. 2019-11-12. PMID:30521373. |
choline availability modulates neurogenesis and cerebral cortex development through the regulation of neural progenitor cell (npc) proliferative and differentiation capacity. |
2019-11-12 |
2023-08-13 |
Not clear |
| N N Shusharina, M V Patrushev, E V Silina, V A Stupin, P F Litvitsky, A S Orlov. [Expression of genes for neurotransmitter transporters in astrocytes in different brain regions in experiment]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. vol 118. issue 6. 2019-05-17. PMID:30040802. |
to investigate the expression of transporters of different neurotransmitters (glutamate, aspartate, lactate, choline) in the culture of astrocytes isolated from different regions of the brain (cortex, hippocampus and brainstem) in 3- and 11-day rats. |
2019-05-17 |
2023-08-13 |
rat |