| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luca Ferraro, M C Tomasini, S Beggiato, S Gaetani, T Cassano, V Cuomo, S Amoroso, S Tanganelli, T Antonell. Short- and long-term consequences of prenatal exposure to the cannabinoid agonist WIN55,212-2 on rat glutamate transmission and cognitive functions. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 8. 2009-09-24. PMID:19533296. |
thus, although it is difficult and sometimes misleading to extrapolate findings obtained from animal models to humans, the possibility that an alteration of glutamate transmission might underlie, at least in part, some of the cognitive deficits affecting the offspring of marijuana users, is supported. |
2009-09-24 |
2023-08-12 |
rat |
| Kazuhide Hayakawa, Kenichi Mishima, Masanori Nozako, Mai Hazekawa, Keiichi Irie, Masayuki Fujioka, Kensuke Orito, Kohji Abe, Nobuyoshi Hasebe, Nobuaki Egashira, Katsunori Iwasaki, Michihiro Fujiwar. Delayed treatment with cannabidiol has a cerebroprotective action via a cannabinoid receptor-independent myeloperoxidase-inhibiting mechanism. Journal of neurochemistry. vol 102. issue 5. 2007-11-06. PMID:17437545. |
unlike delta(9)-thc, cannabidiol did not affect the excess release of glutamate in the cortex after occlusion. |
2007-11-06 |
2023-08-12 |
mouse |
| Carol Hamelink, Aidan Hampson, David A Wink, Lee E Eiden, Robert L Eska. Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity. The Journal of pharmacology and experimental therapeutics. vol 314. issue 2. 2005-09-30. PMID:15878999. |
because the nonpsychoactive cannabinoid cannabidiol (cbd) was previously shown in vitro to prevent glutamate toxicity through its ability to reduce oxidative stress, we evaluated cbd as a neuroprotectant in a rat binge ethanol model. |
2005-09-30 |
2023-08-12 |
rat |
| I Suárez, G Bodega, M Rubio, J J Fernández-Ruiz, J A Ramos, B Fernánde. Prenatal cannabinoid exposure down- regulates glutamate transporter expressions (GLAST and EAAC1) in the rat cerebellum. Developmental neuroscience. vol 26. issue 1. 2005-03-15. PMID:15509898. |
this study analyzed the expression of the glial (glast) and neuronal (eaac1) subtypes of glutamate transporter in the cerebellum of male and female offspring exposed pre- and postnatally to delta9-tetrahydrocannabinol (thc, the main component of marijuana). |
2005-03-15 |
2023-08-12 |
rat |
| Azza B El-Remessy, Ibrahim E Khalil, Suraporn Matragoon, Gamal Abou-Mohamed, Nai-Jer Tsai, Penny Roon, Ruth B Caldwell, Robert W Caldwell, Keith Green, Gregory I Lio. Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. The American journal of pathology. vol 163. issue 5. 2003-12-05. PMID:14578199. |
in this study, we test the hypothesis that glutamate causes apoptosis of retinal neurons via the excessive formation of peroxynitrite, and that the neuroprotective effect of the psychotropic delta9-tetrahydroxycannabinol (thc) or nonpsychotropic cannabidiol (cbd) is via the attenuation of this formation. |
2003-12-05 |
2023-08-12 |
rat |
| Maria Cristina Tomasini, Luca Ferraro, Berta Wonjie Bebe, Sergio Tanganelli, Tommaso Cassano, Vincenzo Cuomo, Tiziana Antonell. Delta(9)-tetrahydrocannabinol increases endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons: involvement of CB(1) receptors. Journal of neuroscience research. vol 68. issue 4. 2002-07-18. PMID:11992471. |
the effects of the principal psychoactive component of marijuana, delta(9)-tetrahydrocannabinol (delta(9)-thc), on endogenous extracellular glutamate levels in primary cultures of rat cerebral cortex neurons were investigated. |
2002-07-18 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, M Lolic, D Wink, R Rosenthal, J Axelro. Neuroprotective antioxidants from marijuana. Annals of the New York Academy of Sciences. vol 899. 2000-07-13. PMID:10863546. |
in a head to head trial of the abilities of various antioxidants to prevent glutamate toxicity, cannabidiol was superior to both alpha-tocopherol and ascorbate in protective capacity. |
2000-07-13 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, M Lolic, D Wink, R Rosenthal, J Axelro. Neuroprotective antioxidants from marijuana. Annals of the New York Academy of Sciences. vol 899. 2000-07-13. PMID:10863546. |
cannabidiol and other cannabinoids were examined as neuroprotectants in rat cortical neuron cultures exposed to toxic levels of the neurotransmitter, glutamate. |
2000-07-13 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
cannabidiol was more protective against glutamate neurotoxicity than either ascorbate or alpha-tocopherol, indicating it to be a potent antioxidant. |
1998-08-06 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
the neuroprotective actions of cannabidiol and other cannabinoids were examined in rat cortical neuron cultures exposed to toxic levels of the excitatory neurotransmitter glutamate. |
1998-08-06 |
2023-08-12 |
rat |
| A J Hampson, M Grimaldi, J Axelrod, D Win. Cannabidiol and (-)Delta9-tetrahydrocannabinol are neuroprotective antioxidants. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 14. 1998-08-06. PMID:9653176. |
glutamate toxicity was reduced by both cannabidiol, a nonpsychoactive constituent of marijuana, and the psychotropic cannabinoid (-)delta9-tetrahydrocannabinol (thc). |
1998-08-06 |
2023-08-12 |
rat |
| S Y Nah, D Saya, Z Voge. Cannabinoids inhibit agonist-stimulated formation of inositol phosphates in rat hippocampal cultures. European journal of pharmacology. vol 246. issue 1. 1993-09-17. PMID:8102606. |
addition of cannabinoids, such as delta 8-tetrahydrocannabinol, delta 9-tetrahydrocannabinol or the psychoinactive cannabidiol inhibited formation of inositol phosphates evoked by carbachol, glutamate or norepinephrine by 55-90%. |
1993-09-17 |
2023-08-12 |
rat |