| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chun S Zuo, Katherine A Davis, Scott E Luka. Lower dACC glutamate in cannabis users during early phase abstinence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-04-28. PMID:35484401. |
dorsal anterior cingulate cortex (dacc) glutamate and γ-amino butyric acid (gaba) were measured with proton mrs at baseline and on abstinent days 7 and 21 in conjunction with measures of cannabis withdrawal and craving (mcq), sleep difficulties (psqi) and mood state. |
2022-04-28 |
2023-08-13 |
Not clear |
| Chun S Zuo, Katherine A Davis, Scott E Luka. Lower dACC glutamate in cannabis users during early phase abstinence. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2022-04-28. PMID:35484401. |
these findings provide preliminary evidence that dacc glutamate is associated with the cannabis withdrawal syndrome. |
2022-04-28 |
2023-08-13 |
Not clear |
| Chun S Zuo, Katherine A Davis, Madeline K Kuppe, M Kathryn Dahlgren, Staci Gruber, Garrett M Fitzmaurice, Scott E Luka. Elevated striatal glutamate + glutamine in recreational cannabis users during abstinence. Journal of psychiatric research. vol 146. 2022-01-09. PMID:34999370. |
elevated striatal glutamate + glutamine in recreational cannabis users during abstinence. |
2022-01-09 |
2023-08-13 |
human |
| Chun S Zuo, Katherine A Davis, Madeline K Kuppe, M Kathryn Dahlgren, Staci Gruber, Garrett M Fitzmaurice, Scott E Luka. Elevated striatal glutamate + glutamine in recreational cannabis users during abstinence. Journal of psychiatric research. vol 146. 2022-01-09. PMID:34999370. |
we hypothesize that cannabis withdrawal may be associated with a reset of regional γ-amino butyric acid (gaba) and glutamate concentrations secondary to changes in the endocannabinoid system during abstinence and conducted a study on this issue. |
2022-01-09 |
2023-08-13 |
human |
| Cora E Smiley, Heyam K Saleh, Katherine E Nimchuk, Constanza Garcia-Keller, Justin T Gas. Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli. Behavioural brain research. vol 415. 2021-11-04. PMID:34389427. |
additionally, exposure to cannabis, alcohol, and stress can induce alterations in glutamate regulation and homeostasis in the prefrontal cortex (pfc) that may lead to impairments in neuronal functioning and cognition. |
2021-11-04 |
2023-08-13 |
Not clear |
| Aisling O'Neill, Luciano Annibale, Grace Blest-Hopley, Robin Wilson, Vincent Giampietro, Sagnik Bhattacharyy. Cannabidiol modulation of hippocampal glutamate in early psychosis. Journal of psychopharmacology (Oxford, England). vol 35. issue 7. 2021-10-07. PMID:33860709. |
cannabidiol modulation of hippocampal glutamate in early psychosis. |
2021-10-07 |
2023-08-13 |
Not clear |
| Natasha L Mason, Eef L Theunissen, Nadia R P W Hutten, Desmond H Y Tse, Stefan W Toennes, Jacobus F A Jansen, Peter Stiers, Johannes G Ramaeker. Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users. Addiction biology. vol 26. issue 1. 2021-10-05. PMID:31865628. |
in occasional users, cannabis induced significant neurometabolic alterations in reward circuitry, namely, decrements in functional connectivity and increments in striatal glutamate concentrations, which were associated with increases in subjective high and decreases in performance on a sustained attention task. |
2021-10-05 |
2023-08-13 |
Not clear |
| Grace Blest-Hopley, Aisling O'Neill, Robin Wilson, Vincent Giampietro, David Lythgoe, Alice Egerton, Sagnik Bhattacharyy. Adolescent-onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31478302. |
adolescent-onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus. |
2021-09-28 |
2023-08-13 |
human |
| Grace Blest-Hopley, Aisling O'Neill, Robin Wilson, Vincent Giampietro, David Lythgoe, Alice Egerton, Sagnik Bhattacharyy. Adolescent-onset heavy cannabis use associated with significantly reduced glial but not neuronal markers and glutamate levels in the hippocampus. Addiction biology. vol 25. issue 6. 2021-09-28. PMID:31478302. |
we investigated the effect of persistent cannabis use on the brain levels of n-acetyl aspartate (naa) and myoinositol, the metabolite markers of neurons and glia, the site of the main central cannabinoid cb1 receptor, and the levels of glutamate, the neurotransmitter directly affected by cb1 modulation. |
2021-09-28 |
2023-08-13 |
human |
| James J Prisciandaro, William Mellick, Lindsay M Squeglia, Sara Hix, Lauren Arnold, Bryan K Tollive. Results from a randomized, double-blind, placebo-controlled, crossover, multimodal-MRI pilot study of gabapentin for co-occurring bipolar and cannabis use disorders. Addiction biology. 2021-08-14. PMID:34390300. |
primary analyses revealed that (1) gabapentin was well tolerated and adherence and retention were high, (2) gabapentin increased dorsal anterior cingulate cortex (dacc) and right basal ganglia (rbg) glutamate levels and (3) gabapentin increased activation to visual cannabis cues in the posterior midcingulate cortex (pmcc, a region involved in response inhibition to rewarding stimuli). |
2021-08-14 |
2023-08-13 |
human |
| James J Prisciandaro, William Mellick, Lindsay M Squeglia, Sara Hix, Lauren Arnold, Bryan K Tollive. Results from a randomized, double-blind, placebo-controlled, crossover, multimodal-MRI pilot study of gabapentin for co-occurring bipolar and cannabis use disorders. Addiction biology. 2021-08-14. PMID:34390300. |
exploratory evaluation of clinical outcomes further found that in participants taking gabapentin versus placebo, (1) elevations of dacc gaba levels were associated with lower manic/mixed and depressive symptoms and (2) elevations of rbg glutamate levels and pmcc activation to cannabis cues were associated with lower cannabis use. |
2021-08-14 |
2023-08-13 |
human |
| J G Ramaekers, N L Mason, E L Theunisse. Blunted highs: Pharmacodynamic and behavioral models of cannabis tolerance. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 36. 2021-08-10. PMID:32014378. |
such neuroadaptions are absent in occasional users, who show strong increments of dopamine and glutamate levels in the striatum, a loss of functional connectivity within the mesolimbic circuit and neurocognitive impairments when exposed to cannabis. |
2021-08-10 |
2023-08-13 |
human |
| Musa Sami, Amanda Worker, Marco Colizzi, Luciano Annibale, Debasis Das, Marlene Kelbrick, Savitha Eranti, Tracy Collier, Chidimma Onyejiaka, Aisling O'Neill, David Lythgoe, Philip McGuire, Steve C R Williams, Matthew J Kempton, Sagnik Bhattacharyy. Association of cannabis with glutamatergic levels in patients with early psychosis: Evidence for altered volume striatal glutamate relationships in patients with a history of cannabis use in early psychosis. Translational psychiatry. vol 10. issue 1. 2021-06-18. PMID:32317625. |
association of cannabis with glutamatergic levels in patients with early psychosis: evidence for altered volume striatal glutamate relationships in patients with a history of cannabis use in early psychosis. |
2021-06-18 |
2023-08-13 |
human |
| Marco Colizzi, Nathalie Weltens, Philip McGuire, David Lythgoe, Steve Williams, Lukas Van Oudenhove, Sagnik Bhattacharyy. Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:30770892. |
in contrast, pre-clinical research suggests that cannabis may affect dopamine via modulation of glutamate signaling. |
2021-05-14 |
2023-08-13 |
human |
| Marco Colizzi, Nathalie Weltens, Philip McGuire, David Lythgoe, Steve Williams, Lukas Van Oudenhove, Sagnik Bhattacharyy. Delta-9-tetrahydrocannabinol increases striatal glutamate levels in healthy individuals: implications for psychosis. Molecular psychiatry. vol 25. issue 12. 2021-05-14. PMID:30770892. |
a double-blind, randomized, placebo-controlled, crossover design was used to investigate whether altered striatal glutamate, as measured using proton magnetic resonance spectroscopy, underlies the acute psychotomimetic effects of intravenously administered delta-9-tetrahydrocannabinol (Δ9-thc; 1.19 mg/2 ml), the key psychoactive ingredient in cannabis, in a set of 16 healthy participants (7 males) with modest previous cannabis exposure. |
2021-05-14 |
2023-08-13 |
human |
| Sharlene D Newman, Hu Cheng, Dae-Jin Kim, Ashley Schnakenberg-Martin, Ulrike Dydak, Shalmali Dharmadhikari, William Hetrick, Brian O'Donnel. An investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users. Brain imaging and behavior. vol 14. issue 5. 2021-04-13. PMID:31302844. |
an investigation of the relationship between glutamate and resting state connectivity in chronic cannabis users. |
2021-04-13 |
2023-08-13 |
human |
| Y Daniju, M G Bossong, K Brandt, P Alle. Do the effects of cannabis on the hippocampus and striatum increase risk for psychosis? Neuroscience and biobehavioral reviews. vol 112. 2021-03-26. PMID:32057817. |
there is limited evidence that cannabis use affects cortical and striatal glutamate levels, but there are currently too few studies to draw firm conclusions. |
2021-03-26 |
2023-08-13 |
Not clear |
| Maurício Dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Be. Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease. Frontiers in pharmacology. vol 11. 2021-01-30. PMID:33510643. |
tnf-α, on its own, promoted the synaptic release of glutamate in cortical neuronal cultures, whereas cannabidiol + capsazepine prevented this effect. |
2021-01-30 |
2023-08-13 |
mouse |
| Jeremy J Watts, Ranjini Garani, Tania Da Silva, Nittha Lalang, Sofia Chavez, Romina Mizrah. Evidence That Cannabis Exposure, Abuse, and Dependence Are Related to Glutamate Metabolism and Glial Function in the Anterior Cingulate Cortex: A Frontiers in psychiatry. vol 11. 2020-12-07. PMID:32973572. |
evidence that cannabis exposure, abuse, and dependence are related to glutamate metabolism and glial function in the anterior cingulate cortex: a there is evidence that long-term cannabis use is associated with alterations to glutamate neurotransmission and glial function. |
2020-12-07 |
2023-08-13 |
Not clear |
| Eva Ceskova, Petr Silha. Novel treatment options in depression and psychosis. Neuropsychiatric disease and treatment. vol 14. 2020-10-01. PMID:29559781. |
new treatment options not yet available include cannabidiol, glutamate modulators, and nicotine receptors agonists. |
2020-10-01 |
2023-08-13 |
Not clear |