| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luara A Batista, Pedro H Gobira, Thercia G Viana, Daniele C Aguiar, Fabricio A Moreir. Inhibition of endocannabinoid neuronal uptake and hydrolysis as strategies for developing anxiolytic drugs. Behavioural pharmacology. vol 25. issue 5-6. 2015-03-31. PMID:25083569. |
the endocannabinoid system comprises the cb1 and cb2 receptors (the targets of the cannabis sativa compound delta-9-tetrahydrocannabinol), the endogenous ligands (endocannabinoids) arachidonoyl ethanolamide (anandamide) and 2-arachidonoyl glycerol, their synthesizing machinery and membrane transport system, and the hydrolyzing enzymes fatty acid amide hydrolase (faah) and monoacylglycerol lipase (magl), respectively. |
2015-03-31 |
2023-08-13 |
Not clear |
| Olivier Cottencin, Benjamin Rolland, Laurent Karil. New designer drugs (synthetic cannabinoids and synthetic cathinones): review of literature. Current pharmaceutical design. vol 20. issue 25. 2015-03-30. PMID:24001292. |
synthetic cannabinoids are psychoactive herbal and chemical products that mimic the effects of cannabis when used. |
2015-03-30 |
2023-08-12 |
human |
| Piotr Karabowicz, Emilia Grzęda, Marta Baranowska-Kuczko, Barbara Malinowsk. [Role of endocannabinoid 2-arachidonoylglycerol in the physiology and pathophysiology of the cardiovascular system]. Postepy higieny i medycyny doswiadczalnej (Online). vol 68. 2015-03-25. PMID:24934539. |
cannabinoids, the active ingredients of cannabis sativa var. |
2015-03-25 |
2023-08-13 |
Not clear |
| Mark E Gerich, Robert W Isfort, Bryan Brimhall, Corey A Siege. Medical marijuana for digestive disorders: high time to prescribe? The American journal of gastroenterology. vol 110. issue 2. 2015-03-25. PMID:25199471. |
along with growing interest in marijuana use has come an understanding of marijuana's effects on normal physiology and disease, primarily through elucidation of the human endocannabinoid system. |
2015-03-25 |
2023-08-13 |
human |
| Maria Haustein, Robert Ramer, Michael Linnebacher, Katrin Manda, Burkhard Hin. Cannabinoids increase lung cancer cell lysis by lymphokine-activated killer cells via upregulation of ICAM-1. Biochemical pharmacology. vol 92. issue 2. 2015-03-20. PMID:25069049. |
cannabidiol (cbd), a non-psychoactive cannabinoid, enhanced the susceptibility of cancer cells to adhere to and subsequently be lysed by lak cells, with both effects being reversed by a neutralizing icam-1 antibody. |
2015-03-20 |
2023-08-13 |
Not clear |
| Darrell G Boychuk, Greg Goddard, Giovanni Mauro, Maria F Orellan. The effectiveness of cannabinoids in the management of chronic nonmalignant neuropathic pain: a systematic review. Journal of oral & facial pain and headache. vol 29. issue 1. 2015-03-20. PMID:25635955. |
to carry out a systematic review to assess the effectiveness of cannabis extracts and cannabinoids in the management of chronic nonmalignant neuropathic pain. |
2015-03-20 |
2023-08-13 |
Not clear |
| Giovanni Battistella, Eleonora Fornari, Jean-Marie Annoni, Haithem Chtioui, Kim Dao, Marie Fabritius, Bernard Favrat, Jean-Frédéric Mall, Philippe Maeder, Christian Girou. Long-term effects of cannabis on brain structure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 9. 2015-03-02. PMID:24633558. |
the dose-dependent toxicity of the main psychoactive component of cannabis in brain regions rich in cannabinoid cb1 receptors is well known in animal studies. |
2015-03-02 |
2023-08-12 |
Not clear |
| Giovanni Battistella, Eleonora Fornari, Jean-Marie Annoni, Haithem Chtioui, Kim Dao, Marie Fabritius, Bernard Favrat, Jean-Frédéric Mall, Philippe Maeder, Christian Girou. Long-term effects of cannabis on brain structure. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 9. 2015-03-02. PMID:24633558. |
we provide evidence that regular cannabis use is associated with gray matter volume reduction in the medial temporal cortex, temporal pole, parahippocampal gyrus, insula, and orbitofrontal cortex; these regions are rich in cannabinoid cb1 receptors and functionally associated with motivational, emotional, and affective processing. |
2015-03-02 |
2023-08-12 |
Not clear |
| Daniela Muhl, Markus Kathmann, Carolin Hoyer, Laura Kranaster, Martin Hellmich, Christoph W Gerth, Johannes Faulhaber, Eberhard Schlicker, F Markus Lewek. Increased CB2 mRNA and anandamide in human blood after cessation of cannabis abuse. Naunyn-Schmiedeberg's archives of pharmacology. vol 387. issue 7. 2015-02-19. PMID:24788457. |
in previous studies, long-term cannabis use led to alterations of the endocannabinoid system including an increase in cb1 and/or cb2 receptor messenger rna (mrna) in blood cells and an increase in the serum level of the endocannabinoid 2-arachidonoyl glycerol. |
2015-02-19 |
2023-08-13 |
human |
| Jenny L Wiley, D Matthew Walentiny, M Jerry Wright, Patrick M Beardsley, James J Burston, Justin L Poklis, Aron H Lichtman, Robert E Van. Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents. European journal of pharmacology. vol 737. 2015-02-13. PMID:24858366. |
the mechanism through which marijuana produces its psychoactive effects is Δ(9)-tetrahydrocannabinol (thc)-induced activation of cannabinoid cb1 receptors. |
2015-02-13 |
2023-08-13 |
mouse |
| C J A Morgan, C Gardener, G Schafer, S Swan, C Demarchi, T P Freeman, P Warrington, I Rupasinghe, A Ramoutar, N Tan, G Wingham, S Lewis, H V Curra. Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being. Psychological medicine. vol 42. issue 2. 2015-02-09. PMID:21798112. |
sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being. |
2015-02-09 |
2023-08-12 |
Not clear |
| C J A Morgan, C Gardener, G Schafer, S Swan, C Demarchi, T P Freeman, P Warrington, I Rupasinghe, A Ramoutar, N Tan, G Wingham, S Lewis, H V Curra. Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being. Psychological medicine. vol 42. issue 2. 2015-02-09. PMID:21798112. |
cannabis varies considerably in levels of its two major constituent cannabinoids - (delta-9-tetrahydrocannabinol (thc) and cannabidiol (cbd). |
2015-02-09 |
2023-08-12 |
Not clear |
| Garry Milman, Mateus M Bergamaschi, Dayong Lee, Damodara R Mendu, Allan J Barnes, Ryan Vandrey, Marilyn A Huesti. Plasma cannabinoid concentrations during dronabinol pharmacotherapy for cannabis dependence. Therapeutic drug monitoring. vol 36. issue 2. 2015-02-09. PMID:24067260. |
plasma cannabinoid concentrations during dronabinol pharmacotherapy for cannabis dependence. |
2015-02-09 |
2023-08-12 |
Not clear |
| Garry Milman, Mateus M Bergamaschi, Dayong Lee, Damodara R Mendu, Allan J Barnes, Ryan Vandrey, Marilyn A Huesti. Plasma cannabinoid concentrations during dronabinol pharmacotherapy for cannabis dependence. Therapeutic drug monitoring. vol 36. issue 2. 2015-02-09. PMID:24067260. |
the present data describe cannabinoid pharmacokinetics in chronic, daily cannabis smokers who received high-dose oral thc pharmacotherapy and later a smoked cannabis challenge. |
2015-02-09 |
2023-08-12 |
Not clear |
| Shuso Takeda, Eriko Ikeda, Shengzhong Su, Mari Harada, Hiroyuki Okazaki, Yasushi Yoshioka, Hajime Nishimura, Hiroyuki Ishii, Kazuhiro Kakizoe, Aya Taniguchi, Miki Tokuyasu, Taichi Himeno, Kazuhito Watanabe, Curtis J Omiecinski, Hironori Aramak. Δ(9)-THC modulation of fatty acid 2-hydroxylase (FA2H) gene expression: possible involvement of induced levels of PPARα in MDA-MB-231 breast cancer cells. Toxicology. vol 326. 2015-02-09. PMID:25291031. |
we recently reported that Δ(9)-tetrahydrocannabinol (Δ(9)-thc), a major cannabinoid component in cannabis sativa (marijuana), significantly stimulated the expression of fatty acid 2-hydroxylase (fa2h) in human breast cancer mda-mb-231 cells. |
2015-02-09 |
2023-08-13 |
human |
| Zygmunt Zdrojewicz, Damian Pypno, Krzysztof Cabała, Bartosz Bugaj, Mateusz Warack. [Potential applications of marijuana and cannabinoids in medicine]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 37. issue 220. 2015-01-29. PMID:25518584. |
[potential applications of marijuana and cannabinoids in medicine]. |
2015-01-29 |
2023-08-13 |
Not clear |
| Zygmunt Zdrojewicz, Damian Pypno, Krzysztof Cabała, Bartosz Bugaj, Mateusz Warack. [Potential applications of marijuana and cannabinoids in medicine]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego. vol 37. issue 220. 2015-01-29. PMID:25518584. |
cannabinoids, psychoactive substances present in cannabis, have been known to mankind for hundreds of years. |
2015-01-29 |
2023-08-13 |
Not clear |
| Robert B Laprairie, Amina M Bagher, Melanie E M Kelly, Denis J Dupré, Eileen M Denovan-Wrigh. Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons. The Journal of biological chemistry. vol 289. issue 36. 2015-01-28. PMID:25037227. |
in the current study, we compared the functional selectivity of six cannabinoids, including two endocannabinoids (2-arachidonyl glycerol (2-ag) and anandamide (aea)), two synthetic cannabinoids (win55,212-2 and cp55,940), and two phytocannabinoids (cannabidiol (cbd) and Δ(9)-tetrahydrocannabinol (thc)) on arrestin2-, gα(i/o)-, gβγ-, gα(s)-, and gα(q)-mediated intracellular signaling in the mouse sthdh(q7/q7) cell culture model of striatal medium spiny projection neurons that endogenously express cb1. |
2015-01-28 |
2023-08-13 |
mouse |
| Delphine Ladarre, Alexandre B Roland, Stefan Biedzinski, Ana Ricobaraza, Zsolt Lenke. Polarized cellular patterns of endocannabinoid production and detection shape cannabinoid signaling in neurons. Frontiers in cellular neuroscience. vol 8. 2015-01-22. PMID:25610369. |
interestingly, somatodendritic 2-ag levels differently modified signaling responses to cb1r activation by Δ(9)-thc, the psychoactive compound of marijuana, and by the synthetic cannabinoids win55,212-2 and cp55,940. |
2015-01-22 |
2023-08-13 |
rat |
| Torbjörn U C Järbe, Brian J LeMay, Aneetha Halikhedkar, JodiAnne Wood, Subramanian K Vadivel, Alexander Zvonok, Alexandros Makriyanni. Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats. Psychopharmacology. vol 231. issue 3. 2015-01-07. PMID:24005529. |
the "subjective high" from marijuana ingestion is likely due to Δ(9)-tetrahydrocannabinol (thc) activating the central cannabinoid receptor type 1 (cb1r) of the endocannabinoid signaling system. |
2015-01-07 |
2023-08-12 |
rat |