| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G L Gessa, M A Casu, G Carta, M S Masci. Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A. European journal of pharmacology. vol 355. issue 2-3. 1998-12-11. PMID:9760025. |
the effect of delta9-tetrahydrocannabinol, the psychoactive principle of marijuana, and [r-(+)-(2,3-dihydro-5-methyl-3-[[4-morpholinylmethyl]pyrol[1,2,3-d e-]-1,4-benzoxazin-6y)(1-naphthalenyl)methanone monomethanesulfonate] (win 55,212-2), a synthetic cannabinoid receptor agonist, on the acetylcholine output in the medial-prefrontal cortex and hippocampus was studied by microdialysis in freely moving rats. |
1998-12-11 |
2023-08-12 |
human |
| G L Gessa, M A Casu, G Carta, M S Masci. Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A. European journal of pharmacology. vol 355. issue 2-3. 1998-12-11. PMID:9760025. |
since the inhibitory effect of delta9-tetrahydrocannabinol is produced by doses within those relevant to human use of marijuana, our results suggest that the negative effects of the latter on cognitive processes may be explained by its ability to reduce acetylcholine release in the medial-prefrontal cortex and hippocampus. |
1998-12-11 |
2023-08-12 |
human |
| G C Chan, T R Hinds, S Impey, D R Stor. Hippocampal neurotoxicity of Delta9-tetrahydrocannabinol. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 18. issue 14. 1998-07-27. PMID:9651215. |
here we report that delta9-tetrahydrocannabinol (thc), the major psychoactive component of marijuana, is toxic for hippocampal neurons. |
1998-07-27 |
2023-08-12 |
Not clear |
| E Schlicker, J Timm, J Zentner, M Göther. Cannabinoid CB1 receptor-mediated inhibition of noradrenaline release in the human and guinea-pig hippocampus. Naunyn-Schmiedeberg's archives of pharmacology. vol 356. issue 5. 1998-02-19. PMID:9402037. |
in conclusion, cannabinoid receptors of the cb1 subtype occur in the human hippocampus, where they may contribute to the psychotropic effects of cannabis, and in the guinea-pig hippocampus, cerebellum, cerebral cortex and hypothalamus. |
1998-02-19 |
2023-08-12 |
mouse |
| C J Heyser, R E Hampson, S A Deadwyle. Effects of delta-9-tetrahydrocannabinol on delayed match to sample performance in rats: alterations in short-term memory associated with changes in task specific firing of hippocampal cells. The Journal of pharmacology and experimental therapeutics. vol 264. issue 1. 1993-02-23. PMID:8380864. |
these findings strongly suggest that performance of the dmts task was selectively impaired by the lack of sample phase discharge of hippocampal neurons during the dmts trial, and that this effect could serve as the basis for the well characterized short-term memory and other cognitive deficits reported in humans after smoking marijuana. |
1993-02-23 |
2023-08-12 |
rat |
| A C Scalle. Neurotoxicology of cannabis and THC: a review of chronic exposure studies in animals. Pharmacology, biochemistry, and behavior. vol 40. issue 3. 1992-05-14. PMID:1666926. |
several laboratories have reported that chronic exposure to delta-9-tetrahydrocannabinol (thc) or marijuana extracts persistently altered the structure and function of the rat hippocampus, a paleocortical brain region involved with learning and memory processes in both rats and humans. |
1992-05-14 |
2023-08-11 |
human |
| J C Eldridge, P W Landfiel. Cannabinoid interactions with glucocorticoid receptors in rat hippocampus. Brain research. vol 534. issue 1-2. 1991-04-18. PMID:1963558. |
binding of [3h]dexamethasone (dex) to hippocampal cytosol, in vitro, was inhibited partially, but not completely, by 100-fold excess unlabeled thc and cannabidiol (cbd), a non-psychoactive cannabinoid. |
1991-04-18 |
2023-08-11 |
rat |
| R R Holson, S F Ali, A C Scallet, W Slikker, M G Paul. Benzodiazepine-like behavioral effects following withdrawal from chronic delta-9-tetrahydrocannabinol administration in rats. Neurotoxicology. vol 10. issue 3. 1990-04-12. PMID:2576305. |
chronic exposure to cannabis extract or delta-9-tetrahydrocannabinol (thc) has been reported to produce hippocampal neuropathology in rats, as well as classical "hippocampal" behavioral deficits. |
1990-04-12 |
2023-08-11 |
rat |
| A C Scallet, E Uemura, A Andrews, S F Ali, D E McMillan, M G Paule, R M Brown, W Slikke. Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC). Brain research. vol 436. issue 1. 1988-02-16. PMID:2825925. |
persistent behavioral effects resembling those of hippocampal brain lesions have been reported following chronic administration of marijuana or its major psychoactive constituent, delta-9-tetrahydrocannabinol (thc) to rats. |
1988-02-16 |
2023-08-11 |
rat |
| A C Scallet, E Uemura, A Andrews, S F Ali, D E McMillan, M G Paule, R M Brown, W Slikke. Morphometric studies of the rat hippocampus following chronic delta-9-tetrahydrocannabinol (THC). Brain research. vol 436. issue 1. 1988-02-16. PMID:2825925. |
the hippocampal changes reported here may constitute a morphological basis for behavioral effects after chronic exposure to marijuana. |
1988-02-16 |
2023-08-11 |
rat |
| K A Campbell, T C Foster, R E Hampson, S A Deadwyle. delta 9-Tetrahydrocannabinol differentially affects sensory-evoked potentials in the rat dentate gyrus. The Journal of pharmacology and experimental therapeutics. vol 239. issue 3. 1987-01-30. PMID:3025423. |
the results demonstrate that low doses of delta 9-thc distort behaviorally relevant sensory information converging on the dentate gyrus and support the hypothesis that the psychoactive effects of marijuana may be mediated by action within the hippocampus. |
1987-01-30 |
2023-08-11 |
rat |
| A Stiglick, M E Llewellyn, H Kalan. Residual effects of prolonged cannabis treatment on shuttle-box avoidance in the rat. Psychopharmacology. vol 84. issue 4. 1985-03-25. PMID:6441947. |
these and other residual effects of chronic cannabis treatment are similar to the effects of hippocampal lesions. |
1985-03-25 |
2023-08-12 |
rat |
| P W Kujtan, P L Carlen, B M Kapu. delta 9-Tetrahydrocannabinol and cannabidiol: dose-dependent effects on evoked potentials in the hippocampal slice. Canadian journal of physiology and pharmacology. vol 61. issue 4. 1983-08-26. PMID:6305469. |
delta 9-tetrahydrocannabinol and cannabidiol: dose-dependent effects on evoked potentials in the hippocampal slice. |
1983-08-26 |
2023-08-12 |
Not clear |
| P W Kujtan, P L Carlen, B M Kapu. delta 9-Tetrahydrocannabinol and cannabidiol: dose-dependent effects on evoked potentials in the hippocampal slice. Canadian journal of physiology and pharmacology. vol 61. issue 4. 1983-08-26. PMID:6305469. |
the effects of (-) trans-delta 9-tetrahydrocannabinol (thc) and its metabolite cannabidiol (cbd) were investigated on evoked responses in the ca1 and dentate gyrus regions of the guinea pig transverse hippocampal slice. |
1983-08-26 |
2023-08-12 |
Not clear |
| A Stiglick, H Kalan. Residual effects of prolonged cannabis administration on exploration and DRL performance in rats. Psychopharmacology. vol 77. issue 2. 1982-12-02. PMID:6812129. |
these and other findings (impaired maze learning and facilitated two-way shuttle box avoidance) might mean that cannabis produces long-lasting hippocampal dysfunction in rats. |
1982-12-02 |
2023-08-12 |
human |
| W G Drew, C R Weet, S E De Rossett, J R Bat. Effects of hippocampal brain damage on auditory and visual recent memory: comparison with marijuana-intoxicated subjects. Biological psychiatry. vol 15. issue 6. 1981-04-24. PMID:6257312. |
results are discussed in terms of cannabinoid actions on hippocampal functioning and, in general, support the hypothesis that the action of marijuana in the brain may focus in the hippocampal region and produce behavioral changes similar to that resulting from traumatic injury or removal of the region. |
1981-04-24 |
2023-08-12 |
human |
| R G Heath, A T Fitzjarrell, C J Fontana, R E Gare. Cannabis sativa: effects on brain function and ultrastructure in rhesus monkeys. Biological psychiatry. vol 15. issue 5. 1980-12-18. PMID:6251929. |
after 2- to 3-months' exposure, the monkeys that were heavy- and moderate-smokers of active marijuana, and those administered delta-9-thc iv, developed chronic recording changes at deep brain sites, most marked in the septal region, hippocampus, and amygdala. |
1980-12-18 |
2023-08-12 |
human |
| C Lindamood, B K Colasant. Effects of delta 9-tetrahydrocannabinol and cannabidiol on sodium-dependent high affinity choline uptake in the rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6245205. |
effects of delta 9-tetrahydrocannabinol and cannabidiol on sodium-dependent high affinity choline uptake in the rat hippocampus. |
1980-06-27 |
2023-08-12 |
rat |
| C Lindamood, B K Colasant. Effects of delta 9-tetrahydrocannabinol and cannabidiol on sodium-dependent high affinity choline uptake in the rat hippocampus. The Journal of pharmacology and experimental therapeutics. vol 213. issue 2. 1980-06-27. PMID:6245205. |
doses of delta 9-tetrahydrocannabinol (delta 9-thc) and cannabidiol (cbd) affording the same degree of protection against seizures induced by maximal electroshock were compared for their effects on sodium-dependent high affinity choline uptake into six rat brain regions: cortex, striatum, medulla-pons, hypothalamus, midbrain and hippocampus. |
1980-06-27 |
2023-08-12 |
rat |
| I Izquierdo, A G Nasell. Effects of cannabidiol and of diphenylhydantoin on the hippocampus and on learning. Psychopharmacologia. vol 31. issue 2. 1973-10-05. PMID:4578907. |
effects of cannabidiol and of diphenylhydantoin on the hippocampus and on learning. |
1973-10-05 |
2023-08-11 |
Not clear |