| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Janna Cousijn, Reinout W Wiers, K Richard Ridderinkhof, Wim van den Brink, Dick J Veltman, Anna E Goudriaa. Grey matter alterations associated with cannabis use: results of a VBM study in heavy cannabis users and healthy controls. NeuroImage. vol 59. issue 4. 2012-07-03. PMID:21982932. |
within the group of heavy cannabis users, grey matter volume in the amygdala and hippocampus correlated negatively with the amount of cannabis use or dependence. |
2012-07-03 |
2023-08-12 |
Not clear |
| Liana Palermo, Filippo Bianchini, Giuseppe Iaria, Antonio Tanzilli, Cecilia Guarigli. Assessing topographical orientation skills in cannabis users. TheScientificWorldJournal. vol 2012. 2012-05-16. PMID:22272167. |
indeed it has been showed that cannabis users have a reduced hippocampus and that the hippocampus is the brain region in which cannabis has the greatest effect since it contains the highest concentration of cannabinoid receptors. |
2012-05-16 |
2023-08-12 |
human |
| Jing Han, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges, Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes, Qingsong Liu, Guang Bai, Wei Wang, Lize Xiong, Wei Ren, Giovanni Marsicano, Xia Zhan. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. vol 148. issue 5. 2012-04-20. PMID:22385967. |
acute cannabinoids impair working memory through astroglial cb1 receptor modulation of hippocampal ltd. impairment of working memory is one of the most important deleterious effects of marijuana intoxication in humans, but its underlying mechanisms are presently unknown. |
2012-04-20 |
2023-08-12 |
mouse |
| Jing Han, Philip Kesner, Mathilde Metna-Laurent, Tingting Duan, Lin Xu, Francois Georges, Muriel Koehl, Djoher Nora Abrous, Juan Mendizabal-Zubiaga, Pedro Grandes, Qingsong Liu, Guang Bai, Wei Wang, Lize Xiong, Wei Ren, Giovanni Marsicano, Xia Zhan. Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD. Cell. vol 148. issue 5. 2012-04-20. PMID:22385967. |
we conclude that the impairment of working memory by marijuana and cannabinoids is due to the activation of astroglial cb(1)r and is associated with astroglia-dependent hippocampal ltd in vivo. |
2012-04-20 |
2023-08-12 |
mouse |
| Traute Demirakca, Alexander Sartorius, Gabriele Ende, Nadja Meyer, Helga Welzel, Gisela Skopp, Karl Mann, Derik Herman. Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol. Drug and alcohol dependence. vol 114. issue 2-3. 2012-02-13. PMID:21050680. |
diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol. |
2012-02-13 |
2023-08-12 |
Not clear |
| Traute Demirakca, Alexander Sartorius, Gabriele Ende, Nadja Meyer, Helga Welzel, Gisela Skopp, Karl Mann, Derik Herman. Diminished gray matter in the hippocampus of cannabis users: possible protective effects of cannabidiol. Drug and alcohol dependence. vol 114. issue 2-3. 2012-02-13. PMID:21050680. |
chronic cannabis use has been associated with memory deficits and a volume reduction of the hippocampus, but none of the studies accounted for different effects of tetrahydrocannabinol (thc) and cannabidiol (cbd). |
2012-02-13 |
2023-08-12 |
Not clear |
| Manzar Ashtari, Brian Avants, Laura Cyckowski, Kelly L Cervellione, David Roofeh, Philip Cook, James Gee, Serge Sevy, Sanjiv Kumr. Medial temporal structures and memory functions in adolescents with heavy cannabis use. Journal of psychiatric research. vol 45. issue 8. 2011-11-29. PMID:21296361. |
converging lines of evidence suggest an adverse effect of heavy cannabis use on adolescent brain development, particularly on the hippocampus. |
2011-11-29 |
2023-08-12 |
human |
| Manzar Ashtari, Brian Avants, Laura Cyckowski, Kelly L Cervellione, David Roofeh, Philip Cook, James Gee, Serge Sevy, Sanjiv Kumr. Medial temporal structures and memory functions in adolescents with heavy cannabis use. Journal of psychiatric research. vol 45. issue 8. 2011-11-29. PMID:21296361. |
in this preliminary study, we compared hippocampal morphology in 14 "treatment-seeking" adolescents (aged 18-20) with a history of prior heavy cannabis use (5.8 joints/day) after an average of 6.7 months of drug abstinence, and 14 demographically matched normal controls. |
2011-11-29 |
2023-08-12 |
human |
| Manzar Ashtari, Brian Avants, Laura Cyckowski, Kelly L Cervellione, David Roofeh, Philip Cook, James Gee, Serge Sevy, Sanjiv Kumr. Medial temporal structures and memory functions in adolescents with heavy cannabis use. Journal of psychiatric research. vol 45. issue 8. 2011-11-29. PMID:21296361. |
in controls, larger hippocampus volumes were observed to be significantly correlated with higher cvlt verbal learning and memory scores, but these relationships were not observed in cannabis users. |
2011-11-29 |
2023-08-12 |
human |
| Manzar Ashtari, Brian Avants, Laura Cyckowski, Kelly L Cervellione, David Roofeh, Philip Cook, James Gee, Serge Sevy, Sanjiv Kumr. Medial temporal structures and memory functions in adolescents with heavy cannabis use. Journal of psychiatric research. vol 45. issue 8. 2011-11-29. PMID:21296361. |
in cannabis users, a smaller right hippocampus volume was correlated with a higher amount of cannabis use (r = -0.57, p < 0.03). |
2011-11-29 |
2023-08-12 |
human |
| Manzar Ashtari, Brian Avants, Laura Cyckowski, Kelly L Cervellione, David Roofeh, Philip Cook, James Gee, Serge Sevy, Sanjiv Kumr. Medial temporal structures and memory functions in adolescents with heavy cannabis use. Journal of psychiatric research. vol 45. issue 8. 2011-11-29. PMID:21296361. |
these data support a hypothesis that heavy cannabis use may have an adverse effect on hippocampus development. |
2011-11-29 |
2023-08-12 |
human |
| Manzar Ashtari, Brian Avants, Laura Cyckowski, Kelly L Cervellione, David Roofeh, Philip Cook, James Gee, Serge Sevy, Sanjiv Kumr. Medial temporal structures and memory functions in adolescents with heavy cannabis use. Journal of psychiatric research. vol 45. issue 8. 2011-11-29. PMID:21296361. |
alternatively, the observed hippocampal volumetric abnormalities may represent a risk factor for cannabis dependence. |
2011-11-29 |
2023-08-12 |
human |
| C J Ledgerwood, S M Greenwood, R R Brett, J A Pratt, T J Bushel. Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways. British journal of pharmacology. vol 162. issue 1. 2011-04-05. PMID:20825410. |
cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways. |
2011-04-05 |
2023-08-12 |
rat |
| K Zavitsanou, H Wang, V S Dalton, V Nguye. Cannabinoid administration increases 5HT1A receptor binding and mRNA expression in the hippocampus of adult but not adolescent rats. Neuroscience. vol 169. issue 1. 2011-03-04. PMID:20438810. |
the effects in the adult brain may compromise hippocampal function and could account for the cognitive deficits seen in habitual heavy cannabis users. |
2011-03-04 |
2023-08-12 |
rat |
| Nora Laaris, Cameron H Good, Carl R Lupic. Delta9-tetrahydrocannabinol is a full agonist at CB1 receptors on GABA neuron axon terminals in the hippocampus. Neuropharmacology. vol 59. issue 1-2. 2010-10-20. PMID:20417220. |
marijuana impairs learning and memory through actions of its psychoactive constituent, delta-9-tetrahydrocannabinol (delta(9)-thc), in the hippocampus, through activation of cannabinoid cb1 receptors (cb1r). |
2010-10-20 |
2023-08-12 |
mouse |
| Alexander F Hoffman, Nora Laaris, Masahito Kawamura, Susan A Masino, Carl R Lupic. Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 2. 2010-02-01. PMID:20071517. |
marijuana is a widely used drug that impairs memory through interaction between its psychoactive constituent, delta-9-tetrahydrocannabinol (delta(9)-thc), and cb(1) receptors (cb1rs) in the hippocampus. |
2010-02-01 |
2023-08-12 |
mouse |
| Alexander F Hoffman, Nora Laaris, Masahito Kawamura, Susan A Masino, Carl R Lupic. Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 30. issue 2. 2010-02-01. PMID:20071517. |
additionally, our data imply that caffeine may potentiate the effects of marijuana on hippocampal function. |
2010-02-01 |
2023-08-12 |
mouse |
| Laura E Wise, Andrew J Thorpe, Aron H Lichtma. Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 9. 2009-12-07. PMID:19322169. |
however, the degree to which cb(1) receptors in the hippocampus play a specific functional role in the memory disruptive effects of marijuana or its primary psychoactive constituent delta(9)-tetrahydrocannabinol (delta(9)-thc) is unknown. |
2009-12-07 |
2023-08-12 |
rat |
| Laura E Wise, Andrew J Thorpe, Aron H Lichtma. Hippocampal CB(1) receptors mediate the memory impairing effects of Delta(9)-tetrahydrocannabinol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 34. issue 9. 2009-12-07. PMID:19322169. |
these findings provide compelling evidence in support of the view that hippocampal cb(1) receptors play a necessary role in the memory disruptive effects of marijuana. |
2009-12-07 |
2023-08-12 |
rat |
| Liam Nestor, Gloria Roberts, Hugh Garavan, Robert Heste. Deficits in learning and memory: parahippocampal hyperactivity and frontocortical hypoactivity in cannabis users. NeuroImage. vol 40. issue 3. 2008-06-17. PMID:18296071. |
cannabis-related impairments in learning and memory in chronic cannabis users, it has been argued, are caused by the effects of cannabis on hippocampal functioning. |
2008-06-17 |
2023-08-12 |
human |