| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Golfo K Tzilos, Christina B Cintron, Jonas B R Wood, Norah S Simpson, Ashley D Young, Harrison G Pope, Deborah A Yurgelun-Tod. Lack of hippocampal volume change in long-term heavy cannabis users. The American journal on addictions. vol 14. issue 1. 2005-06-14. PMID:15804878. |
the effects of cannabis smoking on the morphology of the hippocampus are still unclear, especially because previous human studies have examined primarily younger, shorter-term users. |
2005-06-14 |
2023-08-12 |
human |
| Golfo K Tzilos, Christina B Cintron, Jonas B R Wood, Norah S Simpson, Ashley D Young, Harrison G Pope, Deborah A Yurgelun-Tod. Lack of hippocampal volume change in long-term heavy cannabis users. The American journal on addictions. vol 14. issue 1. 2005-06-14. PMID:15804878. |
moreover, hippocampal volume in cannabis users was not associated with age of onset of use not total lifetime episodes of use. |
2005-06-14 |
2023-08-12 |
human |
| Golfo K Tzilos, Christina B Cintron, Jonas B R Wood, Norah S Simpson, Ashley D Young, Harrison G Pope, Deborah A Yurgelun-Tod. Lack of hippocampal volume change in long-term heavy cannabis users. The American journal on addictions. vol 14. issue 1. 2005-06-14. PMID:15804878. |
these findings are consistent with recent literature suggesting that cannabis use is not associated with structural changes within the brain as a whole or the hippocampus in particular. |
2005-06-14 |
2023-08-12 |
human |
| Aaron B Ilan, Michael E Smith, Alan Gevin. Effects of marijuana on neurophysiological signals of working and episodic memory. Psychopharmacology. vol 176. issue 2. 2005-02-17. PMID:15502936. |
the primary psychoactive constituent of marijuana, delta9-thc, activates cannabinoid receptors, which are especially abundant in the frontal cortex and hippocampus. |
2005-02-17 |
2023-08-12 |
Not clear |
| Dana A Eldreth, John A Matochik, Jean L Cadet, Karen I Boll. Abnormal brain activity in prefrontal brain regions in abstinent marijuana users. NeuroImage. vol 23. issue 3. 2005-01-19. PMID:15528091. |
despite the lack of performance differences, the marijuana users showed hypoactivity in the left perigenual anterior cingulate cortex (acc) and the left lateral prefrontal cortex (lpfc) and hyperactivity in the hippocampus bilaterally, when compared to the comparison group. |
2005-01-19 |
2023-08-12 |
Not clear |
| Giovanni Diana, Massimiliano Malloni, Massimo Pier. Effects of the synthetic cannabinoid nabilone on spatial learning and hippocampal neurotransmission. Pharmacology, biochemistry, and behavior. vol 75. issue 3. 2004-04-08. PMID:12895676. |
cannabinoids, the active components of marijuana, affect memory and hippocampal neurotransmission. |
2004-04-08 |
2023-08-12 |
rat |
| Attila Losonczy, Agota A Biró, Zoltan Nusse. Persistently active cannabinoid receptors mute a subpopulation of hippocampal interneurons. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 5. 2004-03-09. PMID:14734812. |
here, we report that persistently active cannabinoid receptors, the site of action of endocannabinoids, and the psychostimulants marijuana and hashish, switch off the output (mute) of a unique class of hippocampal ins. |
2004-03-09 |
2023-08-12 |
Not clear |
| Robert I Block, Daniel S O'Leary, Richard D Hichwa, Jean C Augustinack, Laura L Boles Ponto, M M Ghoneim, Stephan Arndt, Richard R Hurtig, G Leonard Watkins, James A Hall, Peter E Nathan, Nancy C Andrease. Effects of frequent marijuana use on memory-related regional cerebral blood flow. Pharmacology, biochemistry, and behavior. vol 72. issue 1-2. 2003-10-21. PMID:11900794. |
memory-related blood flow in marijuana users, relative to control subjects, showed decreases in prefrontal cortex, increases in memory-relevant regions of cerebellum, and altered lateralization in hippocampus. |
2003-10-21 |
2023-08-12 |
human |
| X Wang, D Dow-Edwards, E Keller, Y L Hur. Preferential limbic expression of the cannabinoid receptor mRNA in the human fetal brain. Neuroscience. vol 118. issue 3. 2003-08-08. PMID:12710976. |
overall, the high cb1 mrna expression in the fetal hippocampus and amygdala indicates that these limbic structures might be most vulnerable to prenatal cannabis exposure. |
2003-08-08 |
2023-08-12 |
human |
| Marco Pistis, Luca Ferraro, Luigi Pira, Giovanna Flore, Sergio Tanganelli, Gian Luigi Gessa, Paola Devot. Delta(9)-tetrahydrocannabinol decreases extracellular GABA and increases extracellular glutamate and dopamine levels in the rat prefrontal cortex: an in vivo microdialysis study. Brain research. vol 948. issue 1-2. 2002-10-30. PMID:12383968. |
cannabinoid modulation of prefrontal cortex and hippocampus neuronal functioning has been correlated to the disruptive action of marijuana on memory tasks. |
2002-10-30 |
2023-08-12 |
rat |
| F Nava, G Carta, G Colombo, G L Gess. Effects of chronic Delta(9)-tetrahydrocannabinol treatment on hippocampal extracellular acetylcholine concentration and alternation performance in the T-maze. Neuropharmacology. vol 41. issue 3. 2001-12-04. PMID:11522331. |
delta(9)-tetrahydrocannabinol (delta(9)-thc), the psychoactive ingredient of cannabis sativa, reduces both extracellular hippocampal acetylcholine concentration and correct alternation tasks in the t-maze. |
2001-12-04 |
2023-08-12 |
Not clear |
| E Acquas, A Pisanu, P Marrocu, S R Goldberg, G Di Chiar. Delta9-tetrahydrocannabinol enhances cortical and hippocampal acetylcholine release in vivo: a microdialysis study. European journal of pharmacology. vol 419. issue 2-3. 2001-11-01. PMID:11426837. |
we report here that the active ingredient of cannabis preparations, delta9-tetrahydrocannabinol, administered at 10, 37.5, 75 and 150 microg/kg, dose dependently stimulated acetylcholine release from rat prefrontal cortex and hippocampus estimated by means of in vivo brain microdialysis with vertical concentric probes. |
2001-11-01 |
2023-08-12 |
rat |
| F Nava, G Carta, A M Battasi, G L Gess. D(2) dopamine receptors enable delta(9)-tetrahydrocannabinol induced memory impairment and reduction of hippocampal extracellular acetylcholine concentration. British journal of pharmacology. vol 130. issue 6. 2000-09-13. PMID:10903956. |
our findings suggest that impairment of working memory and inhibition of hippocampal extracellular acetylcholine concentration are mediated by the concomitant activation of d(2) dopamine and cb(1) cannabinoid receptors, and that d(2) dopamine receptor antagonists may be useful in the treatment of the cognitive deficits induced by marijuana. |
2000-09-13 |
2023-08-12 |
rat |
| A F Hoffman, C R Lupic. Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 7. 2000-05-16. PMID:10729327. |
the localization of cannabinoid (cb) receptors to gabaergic interneurons in the hippocampus indicates that cbs may modulate gabaergic function and thereby mediate some of the disruptive effects of marijuana on spatial memory and sensory processing. |
2000-05-16 |
2023-08-12 |
rat |
| G A Bohme, M Laville, C Ledent, M Parmentier, A Imperat. Enhanced long-term potentiation in mice lacking cannabinoid CB1 receptors. Neuroscience. vol 95. issue 1. 2000-01-31. PMID:10619457. |
marijuana is known to affect learning and memory in humans, and cannabinoids block long-term potentiation in the hippocampus, a model for the synaptic changes that are believed to underlie memory at the cellular level. |
2000-01-31 |
2023-08-12 |
mouse |
| J M Sulliva. Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons. Journal of neurophysiology. vol 82. issue 3. 1999-11-01. PMID:10482747. |
cannabinoids, such as marijuana, are known to impair learning and memory perhaps through their actions in the hippocampus where cannabinoid receptors are expressed at high density. |
1999-11-01 |
2023-08-12 |
Not clear |
| D L Misner, J M Sulliva. Mechanism of cannabinoid effects on long-term potentiation and depression in hippocampal CA1 neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 16. 1999-09-01. PMID:10436037. |
to investigate the possible contribution of cannabinoid receptor-mediated deficits in hippocampal function to the learning and memory impairments produced by marijuana, we studied the effects of cannabinoid receptor activation on two models of learning and memory, long-term potentiation (ltp) and long-term depression (ltd), in hippocampal slices. |
1999-09-01 |
2023-08-12 |
Not clear |
| A Amer. The effects of cannabinoids on the brain. Progress in neurobiology. vol 58. issue 4. 1999-07-22. PMID:10368032. |
the toxicity of marijuana has been underestimated for a long time, since recent findings revealed delta9-thc-induced cell death with shrinkage of neurons and dna fragmentation in the hippocampus. |
1999-07-22 |
2023-08-12 |
Not clear |
| R E Hampson, S A Deadwyle. Role of cannabinoid receptors in memory storage. Neurobiology of disease. vol 5. issue 6 Pt B. 1999-05-06. PMID:9974179. |
studies have shown that delta 9-tetrahydrocannabinol, the principal psychoactive ingredient in marijuana, produces memory deficits similar to those produced by neurochemical lesions of the hippocampus. |
1999-05-06 |
2023-08-12 |
Not clear |
| G Carta, F Nava, G L Gess. Inhibition of hippocampal acetylcholine release after acute and repeated Delta9-tetrahydrocannabinol in rats. Brain research. vol 809. issue 1. 1998-12-16. PMID:9795096. |
the effects of acute and repeated administration of delta9-tetrahydrocannabinol (delta9-thc), the psychoactive principle of marijuana, on acetylcholine release in the hippocampus was studied in freely moving rats by microdialysis. |
1998-12-16 |
2023-08-12 |
rat |