| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Li, Fang Hu, Hai-Jing Chen, Yi-Juan Du, Zhi-Ying Xie, Ying Zhang, Jun Wang, Yun Wan. LIMK-dependent actin polymerization in primary sensory neurons promotes the development of inflammatory heat hyperalgesia in rats. Science signaling. vol 7. issue 331. 2015-02-19. PMID:24962708. |
inflammatory stimuli stimulated actin polymerization and enhanced the response of the cation channel trpv1 (transient receptor potential v1) to capsaicin in drg neurons, effects that were reversed by the knockdown of limk or preventing cofilin phosphorylation. |
2015-02-19 |
2023-08-13 |
rat |
| Matthew P Rowan, Sonya M Bierbower, Michael A Eskander, Kalina Szteyn, Elaine D Por, Ruben Gomez, Nicholas Veldhuis, Nigel W Bunnett, Nathaniel A Jesk. Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk. PloS one. vol 9. issue 4. 2015-02-02. PMID:24695785. |
the transient receptor potential family v1 channel (trpv1) is activated by multiple stimuli, including capsaicin, acid, endovanilloids, and heat (>42c). |
2015-02-02 |
2023-08-13 |
Not clear |
| Seyoung Ahn, Jungyun Park, Inkyung An, Sung Jun Jung, Jungwook Hwan. Transient receptor potential cation channel V1 (TRPV1) is degraded by starvation- and glucocorticoid-mediated autophagy. Molecules and cells. vol 37. issue 3. 2014-12-12. PMID:24658385. |
transient receptor potential cation channel v1 (trpv1) is degraded by starvation- and glucocorticoid-mediated autophagy. |
2014-12-12 |
2023-08-12 |
Not clear |
| Chihiro Mogi, Takashi Nakakura, Fumikazu Okajim. Role of extracellular proton-sensing OGR1 in regulation of insulin secretion and pancreatic β-cell functions. Endocrine journal. vol 61. issue 2. 2014-11-04. PMID:24088601. |
in addition to ionotropic ion channels, such as transient receptor potential v1 (trpv1) and acid-sensing ion channels (asics), metabotropic proton-sensing g protein-coupled receptors (gpcrs) have also been identified recently as proton-sensing machineries. |
2014-11-04 |
2023-08-12 |
mouse |
| C Brenneis, K Kistner, M Puopolo, S Jo, Dp Roberson, M Sisignano, D Segal, E J Cobos, B J Wainger, S Labocha, N Ferreirós, C von Hehn, J Tran, G Geisslinger, P W Reeh, B P Bean, C J Wool. Bupivacaine-induced cellular entry of QX-314 and its contribution to differential nerve block. British journal of pharmacology. vol 171. issue 2. 2014-08-26. PMID:24117225. |
selective nociceptor fibre block is achieved by introducing the cell membrane impermeant sodium channel blocker lidocaine n-ethyl bromide (qx-314) through transient receptor potential v1 (trpv1) channels into nociceptors. |
2014-08-26 |
2023-08-12 |
Not clear |
| Mark A Birrell, Sara J Bonvini, Eric Dubuis, Sarah A Maher, Michael A Wortley, Megan S Grace, Kristof Raemdonck, John J Adcock, Maria G Belvis. Tiotropium modulates transient receptor potential V1 (TRPV1) in airway sensory nerves: A beneficial off-target effect? The Journal of allergy and clinical immunology. vol 133. issue 3. 2014-05-02. PMID:24506933. |
tiotropium modulates transient receptor potential v1 (trpv1) in airway sensory nerves: a beneficial off-target effect? |
2014-05-02 |
2023-08-12 |
Not clear |
| Zizhen Wu, Qing Yang, Robyn J Crook, Roger G O'Neil, Edgar T Walter. TRPV1 channels make major contributions to behavioral hypersensitivity and spontaneous activity in nociceptors after spinal cord injury. Pain. vol 154. issue 10. 2014-05-01. PMID:23811042. |
many nociceptors express transient receptor potential v1 (trpv1) channels, and in a preceding study most dissociated drg neurons exhibiting sa were excited by the trpv1 activator, capsaicin. |
2014-05-01 |
2023-08-12 |
Not clear |
| Yosuke Amagai, Hiroshi Matsuda, Akane Tanak. Abnormalities in itch sensation and skin barrier function in atopic NC/Tnd mice. Biological & pharmaceutical bulletin. vol 36. issue 8. 2014-02-21. PMID:23902968. |
particularly, in conventional nc/tnd mice with ad, stimulation against transient receptor potential (trp) v1 reduced the scratching behavior, suggesting the possibility of a trpv1 modulator in the treatment of atopic itch. |
2014-02-21 |
2023-08-12 |
mouse |
| Khoa Dang, Klaus Bielefeldt, G F Gebhar. Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons. Journal of neurophysiology. vol 110. issue 2. 2014-01-29. PMID:23636721. |
using patch-clamp techniques, we studied the plasticity of acid-sensing ion channels (asic) and transient receptor potential v1 (trpv1) channel function in dorsal root ganglia (drg) neurons retrogradely labeled from the bladder. |
2014-01-29 |
2023-08-12 |
rat |
| Dayna R Loyd, Xiaoling X Sun, Erin E Locke, Margaux M Salas, Kenneth M Hargreave. Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp. Pain. vol 153. issue 10. 2013-03-06. PMID:22819536. |
trigeminal pain can be evoked by the transient receptor potential v1 channel (trpv1), which is expressed by nociceptive trigeminal neurons and induces release of proinflammatory calcitonin gene-related peptide (cgrp). |
2013-03-06 |
2023-08-12 |
human |
| Shivani Ruparel, Dustin Green, Paul Chen, Kenneth M Hargreave. The cytochrome P450 inhibitor, ketoconazole, inhibits oxidized linoleic acid metabolite-mediated peripheral inflammatory pain. Molecular pain. vol 8. 2013-02-14. PMID:23006841. |
oxidized linoleic acid metabolites (olams) are a class of endogenous agonists to the transient receptor potential v1 (trpv1) receptor. |
2013-02-14 |
2023-08-12 |
Not clear |
| Hans Jürgen Solinski, Susanna Zierler, Thomas Gudermann, Andreas Brei. Human sensory neuron-specific Mas-related G protein-coupled receptors-X1 sensitize and directly activate transient receptor potential cation channel V1 via distinct signaling pathways. The Journal of biological chemistry. vol 287. issue 49. 2013-02-07. PMID:23074220. |
the transient receptor potential cation channel v1 (trpv1) is also expressed in primary sensory neurons and detects painful stimuli such as protons and heat. |
2013-02-07 |
2023-08-12 |
human |
| Alec Okun, Ping Liu, Peg Davis, Jiyang Ren, Bethany Remeniuk, Triza Brion, Michael H Ossipov, Jennifer Xie, Gregory O Dussor, Tamara King, Frank Porrec. Afferent drive elicits ongoing pain in a model of advanced osteoarthritis. Pain. vol 153. issue 4. 2012-09-12. PMID:22387095. |
systemic amg9810, a transient receptor potential v1 channel (trpv1) antagonist, effectively blocked thermal hypersensitivity, but failed to block high-dose mia-induced weight asymmetry or ongoing pain. |
2012-09-12 |
2023-08-12 |
rat |
| Urszula Grabiec, Marco Koch, Sonja Kallendrusch, Robert Kraft, Kerstin Hill, Claudia Merkwitz, Chalid Ghadban, Beat Lutz, Alex Straiker, Faramarz Dehghan. The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)). Neuropharmacology. vol 62. issue 4. 2012-07-27. PMID:22186081. |
to identify the responsive receptor type of nada mediated neuroprotection, we applied the cannabinoid (cb) receptor 1 (cb(1)) inverse agonist/antagonist am251, cb(2) inverse agonist/antagonist am630, abnormal-cannabidiol (abn-cbd)-sensitive receptor antagonist o-1918, transient receptor potential channel v1 (trpv1) antagonist 6-iodonordihydrocapsaicin and a1 (trpa1) antagonist hc-030031. |
2012-07-27 |
2023-08-12 |
mouse |
| D R Loyd, P B Chen, K M Hargreave. Anti-hyperalgesic effects of anti-serotonergic compounds on serotonin- and capsaicin-evoked thermal hyperalgesia in the rat. Neuroscience. vol 203. 2012-07-19. PMID:22209919. |
peripherally released 5ht induces thermal hyperalgesia, possibly via modulation of the transient receptor potential v1 (trpv1) channel, which is gated by various noxious stimuli, including capsaicin. |
2012-07-19 |
2023-08-12 |
rat |
| Dayna R Loyd, Gabriela Weiss, Michael A Henry, Kenneth M Hargreave. Serotonin increases the functional activity of capsaicin-sensitive rat trigeminal nociceptors via peripheral serotonin receptors. Pain. vol 152. issue 10. 2012-06-25. PMID:21737202. |
trigeminal pain can be triggered by activation of the transient receptor potential v1 channel (trpv1), expressed by a subset of nociceptive trigeminal ganglia (tg) neurons and gated by capsaicin, noxious heat, and other noxious stimuli. |
2012-06-25 |
2023-08-12 |
rat |
| Seungsoo Chung, Young-Hwan Kim, Jin-Young Koh, Taick-Sang Nam, Duck-Sun Ah. Intracellular acidification evoked by moderate extracellular acidosis attenuates transient receptor potential V1 (TRPV1) channel activity in rat dorsal root ganglion neurons. Experimental physiology. vol 96. issue 12. 2012-03-22. PMID:21930676. |
intracellular acidification evoked by moderate extracellular acidosis attenuates transient receptor potential v1 (trpv1) channel activity in rat dorsal root ganglion neurons. |
2012-03-22 |
2023-08-12 |
rat |
| Seungsoo Chung, Young-Hwan Kim, Jin-Young Koh, Taick-Sang Nam, Duck-Sun Ah. Intracellular acidification evoked by moderate extracellular acidosis attenuates transient receptor potential V1 (TRPV1) channel activity in rat dorsal root ganglion neurons. Experimental physiology. vol 96. issue 12. 2012-03-22. PMID:21930676. |
transient receptor potential v1 (trpv1) has been suggested to play an important role in detecting decreases in extracellular ph (ph(o)). |
2012-03-22 |
2023-08-12 |
rat |
| Chul-Kyu Park, Ning Lü, Zhen-Zhong Xu, Tong Liu, Charles N Serhan, Ru-Rong J. Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 42. 2011-12-08. PMID:22016541. |
we investigated the role of trpv1 (transient receptor potential subtype v1) and tnf-α, two critical mediators for inflammatory pain, in regulating spinal cord synaptic transmission. |
2011-12-08 |
2023-08-12 |
mouse |
| Motoko Nakano, Shizuo Kitano, Masato Nanri, Mamoru Kiniw. Lafutidine, a unique histamine H2-receptor antagonist, inhibits distention-induced gastric acid secretion through an H2 receptor-independent mechanism. European journal of pharmacology. vol 658. issue 2-3. 2011-07-25. PMID:21349265. |
the antisecretory action of lafutidine under these conditions was partly reversed by the co-administration of the nitric oxide synthase inhibitor l-nmma, but was hardly affected by denervation with capsaicin or by the administration of the transient receptor potential channel v1 (trpv1) antagonist capsazepine. |
2011-07-25 |
2023-08-12 |
rat |