All Relations between trem2 and microglial cell

Publication Sentence Publish Date Extraction Date Species
Jan Traub, Niklas Beyersdorf, Roxanne Sell, Stefan Frantz, Stefan Störk, Guido Stoll, Anna Fre. Plasma levels of soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) in chronic heart failure - predictors and prognostic relevance. American journal of physiology. Heart and circulatory physiology. 2025-02-07. PMID:39918245. trem2 (triggering receptor expressed on myeloid cells 2) is a transmembrane protein expressed on myeloid cells, including macrophages and microglia, and is involved in modulating inflammation and lipid metabolism. 2025-02-07 2025-02-09 Not clear
Kelley C Larson, Frederick W Gergits, Abigail J Renoux, Elizabeth J Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G McLaren, Berkley A Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Miresc. Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism. Journal of neuroinflammation. vol 22. issue 1. 2025-02-01. PMID:39891235. similar functions have also been ascribed to triggering receptor expressed on myeloid cells 2 (trem2), which shares an analogous microglia enrichment profile and converging intracellular signaling pathway mediated by spleen associated tyrosine kinase (syk) and phosphoinositide-3-kinase (pi3k). 2025-02-01 2025-02-04 mouse
Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang, Dan Lei, Yingxue Ren, Keiji Kawatani, Skylar C Starling, Ralph B Perkerson, Bhaskar Roy, Astrid C Quintero, Tammee M Parsons, Yining Pan, Zonghua Li, Minghui Wang, Hanmei Bao, Xianlin Han, Guojun Bu, Rudolph E Tanzi, Takahisa Kanekiy. Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice. Neurobiology of disease. 2025-01-29. PMID:39880319. in addition, we observed that abca7-a696s substitution disturbs the induction of proinflammatory cytokines interleukin 1β and interferon γ in the brains of 5xfad mice, although some disease-associated microglia gene expression, including trem2 and tyrobp, are upregulated. 2025-01-29 2025-02-01 mouse
Sarbani Mishra, Preety Sthutika Swain, Sanghamitra Pati, Budheswar Dehur. Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations. Heliyon. vol 11. issue 1. 2025-01-27. PMID:39866401. the myeloid-specific triggering receptors expressed on myeloid cells 2 (trem2) is a group of class i receptors expressed in brain microglia plays a decisive role in neurodegenerative diseases such as alzheimer's disease (ad) and nasu hakola disease (nhd). 2025-01-27 2025-01-29 Not clear
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d'Azz. Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation. Cell reports. vol 44. issue 1. 2025-01-16. PMID:39817909. neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of trem2 sialylation. 2025-01-16 2025-01-19 Not clear
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d'Azz. Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation. Cell reports. vol 44. issue 1. 2025-01-16. PMID:39817909. here, we examine how neu1 influences microglia by modulating the sialylation of full-length trem2 (trem2-fl), a multifunctional receptor that regulates microglial survival, phagocytosis, and cytokine production. 2025-01-16 2025-01-19 Not clear
Jessica A Greven, Joshua R Wydra, Rory A Greer, Cynthia Zhi, David A Price, Jordyn D Svoboda, Christopher L M Camitta, Mya Washington, Daisy W Leung, Yuhua Song, Jen Alexander-Brett, Tom J Bret. Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands. Molecular neurodegeneration. vol 20. issue 1. 2025-01-10. PMID:39789647. trem2 is a signaling receptor expressed on microglia that has emerged as an important drug target for alzheimer's disease and other neurodegenerative diseases. 2025-01-10 2025-01-13 Not clear
Yuchen Yao, Liru Hu, Danni Li, Yuhao Wang, Jian Pan, Dan Fa. Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke. Frontiers in neuroscience. vol 18. 2025-01-06. PMID:39758888. perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia trem2 via pi3k/akt pathway in mouse model of ischemic stroke. 2025-01-06 2025-01-08 mouse
Yuchen Yao, Liru Hu, Danni Li, Yuhao Wang, Jian Pan, Dan Fa. Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke. Frontiers in neuroscience. vol 18. 2025-01-06. PMID:39758888. however, we observed that an enriched environment (ee) could ameliorate this cognitive impairment by upregulating microglia trem2 expression in the hippocampus and suppressing neuroinflammation. 2025-01-06 2025-01-08 mouse
Jessica A Greven, Jennifer M Alexander-Brett, Thomas J Bret. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750848. understanding the molecular mechanisms underlying trem2 signaling in microglia will facilitate the development of specific, safe and efficacious therapies for ad that target trem2. 2025-01-03 2025-01-05 Not clear
Harry Crook, Malak Wahdan, Marie Emilie Tuil, Nicholas R Livingston, Sanara Raza, Joseph Nowell, Paul Ediso. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750876. triggering receptor expressed on myeloid cells 2 (trem2) is crucial to microglial involvement in ad, mediating trem2-dependent activation and disease-associated microglia (dam) polarization. 2025-01-03 2025-01-05 Not clear
Shahnawaz A Bha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751305. following the genome-wide association studies (gwas) discovery of microglia-specific genes, particularly trem-2, ship-1, and cd33, significantly associated with higher alzheimer's disease (ad) risk, the microglia trem2 pathway has become central for regulating amyloid load, tissue damage, and limiting its spread. 2025-01-03 2025-01-05 mouse
Shahnawaz A Bha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751305. these discoveries have opened up the exciting possibility of therapeutic microglia trem2 manipulation in ad. 2025-01-03 2025-01-05 mouse
Junyi Liang, Aditya Aditya Menon, Taylor Tomco, Lynn M Bekri. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751383. triggering receptor expressed on myeloid cells 2 (trem2) is increasingly recognized to play a central role in amyloid beta clearance and microglia activation in ad. 2025-01-03 2025-01-05 Not clear
Berta Sanz Morello, Elin Byman Shatri, Sofie Frandsen, Benjamin Schmid, Kenneth Thirstrup, Bjørn Hols. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751449. these activities are tightly regulated by microglia receptors cd33 and trem2. 2025-01-03 2025-01-05 Not clear
Masataka Kikuchi, Akinori Miyashita, Yu Hirota, Norikazu Hara, Mai Hasegawa, Yasufumi Sakakibara, Michiko Sekiya, Yuko Saito, Shigeo Murayama, Koichi M Iijima, Takeshi Ikeuch. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751567. however, reactive microglia are less likely to be induced in trem2 mutation carriers. 2025-01-03 2025-01-05 Not clear
Li Gan, Sarah Nagui. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751696. trem2 is required for the induction of a disease-associated microglia (dam) signature and microglial neurodegenerative phenotype (mgnd) in response to disease pathology, signatures which both include apoe upregulation. 2025-01-03 2025-01-05 Not clear
Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pococ. Amelioration of signaling deficits underlying metabolic shortfall in TREM2 The FEBS journal. 2024-12-27. PMID:39726135. amelioration of signaling deficits underlying metabolic shortfall in trem2 the microglial triggering receptor expressed on myeloid cells 2 (trem2) is required for diverse microglia responses in neurodegeneration, including immunometabolic plasticity, phagocytosis, and survival. 2024-12-27 2024-12-29 Not clear
Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pococ. Amelioration of signaling deficits underlying metabolic shortfall in TREM2 The FEBS journal. 2024-12-27. PMID:39726135. we previously identified that patient ipsc-derived microglia (ips-mg) harboring the alzheimer's disease (ad) trem2 2024-12-27 2024-12-29 Not clear
Yong-Chang Wang, Liang-Yu Huang, Hai-Hua Guo, Min Liu, Yu-Ying Zhang, Zi-Qi Zhang, Quan Hao, Chen-Chen Tan, Lan Ta. Higher CSF sTREM2 attenuates APOE ε4-related risk for amyloid pathology in cognitively intact adults: The CABLE study. Journal of neurochemistry. vol 169. issue 1. 2024-12-26. PMID:39725857. the triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane protein found in microglia within the brain, and its soluble form (strem2) has been shown to reduce amyloid deposition. 2024-12-26 2024-12-29 human