All Relations between trem2 and microglial cell

Publication Sentence Publish Date Extraction Date Species
Mihyun Hwang, Cornelia C Bergman. Neurotropic murine coronavirus mediated demyelination: Factors dampening pathogenesis. Journal of neuroimmunology. vol 393. 2024-06-08. PMID:38850674. we specifically discuss the role of immune dampening factors programmed cell death ligand 1 (pd-l1) and interleukin (il)-10, as well as microglia and triggering receptor expressed on myeloid cells 2 (trem2), in limiting demyelination independent of viral persistence. 2024-06-08 2024-06-11 mouse
Yi Tian, Rong Ai, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Xiaoping Zh. Mechanism of the effect of TREM2 on cognitive function in autistic mice. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 6. 2024-06-05. PMID:38836680. trem2 overexpression and knockdown viruses were given to autism spectrum disorder (asd) mice and bv2 microglia cell line. 2024-06-05 2024-06-07 mouse
Michela Matteol. The role of microglial TREM2 in development: A path toward neurodegeneration? Glia. 2024-06-05. PMID:38837837. among the microglial genes, trem2 is a key player, controlling the functional state of microglia and being at the forefront of many processes that require interaction between microglia and other brain components, such as neurons and oligodendrocytes. 2024-06-05 2024-06-08 Not clear
Ainhoa Etxeberria, Yun-An A Shen, Steve Vito, Sean Silverman, Jose Imperio, Guita Lalehzadeh, Allison Soung, Changchun Du, Luke Xie, Man Kin Choy, Yi-Chun Hsiao, Hai Ngu, Chang Hoon Cho, Soumitra Ghosh, Gloriia Novikova, Mitchell G Rezzonico, Rebecca Leahey, Martin Weber, Alvin Gogineni, Justin Elstrott, Monica Xiong, Jacob J Greene, Kimberly L Stark, Pamela Chan, Gillie A Roth, Max Adrian, Qingling Li, Meena Choi, Weng Ruh Wong, Wendy Sandoval, Oded Foreman, Alicia A Nugent, Brad A Friedman, Shraddha Sadekar, Isidro Hötzel, David V Hansen, Ben Chih, Tracy J Yuen, Robby M Weimer, Amy Easton, William J Meilandt, Christopher J Bohle. Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer's Disease and Multiple Sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-03. PMID:38830764. for mice bearing amyloid-β (aβ) pathology (ps2app) or combined aβ and tau pathology (taups2app), chronic trem2 agonist antibody treatment had limited impact on microglia engagement with pathology, overall pathology burden, or downstream neuronal damage. 2024-06-03 2024-06-06 mouse
Xueting Wang, Yuqi Xie, Xiaoyang Fan, Xiaomei Wu, Dan Wang, Li Zh. Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease. Alzheimer's research & therapy. vol 16. issue 1. 2024-06-03. PMID:38831312. intermittent hypoxia training enhances aβ endocytosis by plaque associated microglia via vps35-dependent trem2 recycling in murine alzheimer's disease. 2024-06-03 2024-06-06 Not clear
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Elida Gomero, Alessandra d'Azz. Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826426. neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of trem2. 2024-06-03 2024-06-05 Not clear
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Elida Gomero, Alessandra d'Azz. Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826426. here we examined how neu1 influences microglia by modulating the sialylation of full-length trem2 (trem2-fl), a multifunctional receptor that regulates microglial survival, phagocytosis, and cytokine production. 2024-06-03 2024-06-05 Not clear
Hanjie Liu, Hui Yang, Shuqing Liu, Siyu Li, Wen Yang, Anwar Ayesha, Xin Tan, Cen Jiang, Yi Liu, Lushuang Xi. Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles. Journal of visualized experiments : JoVE. issue 207. 2024-06-03. PMID:38829108. protein-protein interaction network (ppi) identified mt3, calm2, dlg2, kcnd2, pakacb, camk2d, and nlgn4y in astrocytes, trem2, fos, apoe, app, and nlgn4y in microglia, and grin2a, itpr2, gnas, and nlgn4y in oligodendrocytes as key genes. 2024-06-03 2024-06-05 Not clear
Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. microglia and trem2. 2024-05-31 2024-06-02 human
Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. trem2 is a membrane receptor solely expressed on microglia in normal brain. 2024-05-31 2024-06-02 human
Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. in this review we outline recent advances in trem2 biology and its implications for microglial function, with particular emphasis on findings from ipsc-derived microglia (img) expressing trem2 loss-of-function mutations. 2024-05-31 2024-06-02 human
Erpan Ahat, Zanyu Shi, Shaoyou Chu, Hai Hoang Bui, Emily R Mason, Disha M Soni, Kenneth D Roth, Michael James Chalmers, Adrian L Oblak, Jie Zhang, Jesus A Gutierrez, Timothy Richardso. SHIP1 modulation and proteome characterization of microglia. Journal of proteomics. 2024-05-22. PMID:38777089. understanding microglial states in the aging brain has become crucial, especially with the discovery of numerous alzheimer's disease (ad) risk and protective variants in genes such as inpp5d and trem2, which are essential to microglia function in ad. 2024-05-22 2024-05-27 mouse
Qian Shi, Raul A Gutierrez, Manzoor A Bha. Microglia, Trem2, and Neurodegeneration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-05-21. PMID:38769824. microglia, trem2, and neurodegeneration. 2024-05-21 2024-05-27 human
Qian Shi, Raul A Gutierrez, Manzoor A Bha. Microglia, Trem2, and Neurodegeneration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-05-21. PMID:38769824. microglia express trem2, which serves as a receptor for a multitude of ligands enhancing their phagocytic activity. 2024-05-21 2024-05-27 human
Yunji Yan, Shengwei Bai, Hongxi Han, Junqiang Dai, Liang Niu, Hongyu Wang, Qiang Dong, Hang Yin, Guoqiang Yuan, Yawen Pa. Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways. Cell communication and signaling : CCS. vol 22. issue 1. 2024-05-15. PMID:38750472. knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the jak2/stat3 and nf-κb pathways. 2024-05-15 2024-05-27 Not clear
Andrew R Gomez, Hyae Ran Byun, Shaogen Wu, Akm Ghulam Mohammad, Jasmine Ikbariyeh, Jaelin Chen, Alek Muro, Lin Li, Ken E Bernstein, Richard Ainsworth, Warren G Tourtellott. Angiotensin Converting Enzyme (ACE) expression in microglia reduces amyloid β deposition and neurodegeneration by increasing SYK signaling and endolysosomal trafficking. bioRxiv : the preprint server for biology. 2024-05-07. PMID:38712251. ace-expressing microglia show enhanced aβ phagocytosis and endolysosomal trafficking, increased clustering around amyloid plaques, and increased syk tyrosine kinase activation downstream of the major aβ receptors, trem2 and clec7a. 2024-05-07 2024-05-27 mouse
Yue Wang, Wen Niu, Shan Zhu, Jianyu Sun, Jianrui Lv, Ning Wang, Huijuan Zhang, Zhenni Zhang, Meijuan Wang, Lingli Cao, Shuwei Li, Qian Zhai, Lei M. STING Agonist cGAMP Attenuates Sleep Deprivation-Induced Neuroinflammation and Cognitive Deficits via TREM2 Up-Regulation. Inflammation. 2024-04-26. PMID:38668837. trem2 upregulation induced by cgamp regulated the microglia from pro-inflammatory state to anti-inflammatory state, thereby relieving neuroinflammation in csr mice. 2024-04-26 2024-04-28 mouse
Zhao Li, Shenghui Yu, Lin Li, Chao Zhou, Lin Wang, Shuang Tang, Nina Gu, Zhaosi Zhang, Zhijian Huang, Hong Chen, Wei Tang, Yingwen Wang, Xiaomin Yang, Xiaochuan Sun, Jin Ya. TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia. Clinical and translational medicine. vol 14. issue 4. 2024-04-22. PMID:38649789. trem2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of dhcr24/lxr pathway in microglia. 2024-04-22 2024-04-26 mouse
Sujun Jiang, Guoen Cai, Zhimin Yang, Haoyuan Shi, Huajie Zeng, Qinyong Ye, Zhiyuan Hu, Zihua Wan. Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer's Disease. ACS nano. 2024-04-22. PMID:38649866. specifically, an upregulation of trem2 expression can reprogram microglia from a pro-inflammatory m1 phenotype to an anti-inflammatory m2 phenotype while also restoring its capacity to phagocytose aβ and its nerve repair function. 2024-04-22 2024-04-26 mouse
Noa Rachmian, Sedi Medina, Ulysse Cherqui, Hagay Akiva, Daniel Deitch, Dunya Edilbi, Tommaso Croese, Tomer Meir Salame, Javier Maria Peralta Ramos, Liora Cahalon, Valery Krizhanovsky, Michal Schwart. Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain. Nature neuroscience. 2024-04-18. PMID:38637622. microglia, and specifically those expressing the ad risk gene trem2, are considered important players in ad, but their exact contribution to pathology remains unclear. 2024-04-18 2024-04-21 mouse