| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jong-Chan Park, Jong Won Han, Woochan Lee, Jieun Kim, Sang-Eun Lee, Dongjoon Lee, Hayoung Choi, Jihui Han, You Jung Kang, Yen N Diep, Hansang Cho, Rian Kang, Won Jong Yu, Jean Lee, Murim Choi, Sun-Wha Im, Jong-Il Kim, Inhee Mook-Jun. Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-07-09. PMID:38981007. |
microglia gravitate toward amyloid plaques surrounded by externalized phosphatidylserine via trem2. |
2024-07-09 |
2024-07-12 |
Not clear |
| Jong-Chan Park, Jong Won Han, Woochan Lee, Jieun Kim, Sang-Eun Lee, Dongjoon Lee, Hayoung Choi, Jihui Han, You Jung Kang, Yen N Diep, Hansang Cho, Rian Kang, Won Jong Yu, Jean Lee, Murim Choi, Sun-Wha Im, Jong-Il Kim, Inhee Mook-Jun. Microglia Gravitate toward Amyloid Plaques Surrounded by Externalized Phosphatidylserine via TREM2. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2024-07-09. PMID:38981007. |
microglia play a crucial role in synaptic elimination by engulfing dystrophic neurons via triggering receptors expressed on myeloid cells 2 (trem2). |
2024-07-09 |
2024-07-12 |
Not clear |
| Fardin Nabizadeh, Homa Seyedmirzaei, Shaghayegh Karam. Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study. Scientific reports. vol 14. issue 1. 2024-07-03. PMID:38961148. |
understanding the exact pathophysiological mechanisms underlying the involvement of triggering receptor expressed on myeloid cells 2 (trem2) related microglia activation is crucial for the development of clinical trials targeting microglia activation at different stages of alzheimer's disease (ad). |
2024-07-03 |
2024-07-08 |
human |
| Fardin Nabizadeh, Homa Seyedmirzaei, Shaghayegh Karam. Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer's disease: a longitudinal study. Scientific reports. vol 14. issue 1. 2024-07-03. PMID:38961148. |
given the contradictory findings in the literature, it is imperative to investigate the longitudinal alterations in cerebrospinal fluid (csf) soluble trem2 (strem2) levels as a marker for microglia activation, and its potential association with ad biomarkers, in order to address the current knowledge gap. |
2024-07-03 |
2024-07-08 |
human |
| Wenyu Ni, Yun Niu, Sitong Cao, Chunsun Fan, Jian Fan, Li Zhu, Xueting Wan. Intermittent hypoxia exacerbates anxiety in high-fat diet-induced diabetic mice by inhibiting TREM2-regulated IFNAR1 signaling. Journal of neuroinflammation. vol 21. issue 1. 2024-07-03. PMID:38956653. |
moreover, trem2 upregulation has been suggested to play a protective role in attenuating microglia activation and improving synaptic function in t2dm mice. |
2024-07-03 |
2024-07-06 |
mouse |
| Naser Gilani, Fatemeh Bitarafan, Mehmet Ozaslan, Sarah Åsheim, Morteza Heidari, Masoud Garshasb. Homozygous TREM2 c.549del; p.(Leu184Serfs*5) variant causing Nasu-Hakola disease in three siblings in a consanguineous Iraqi family: Case report and review of literature. Molecular genetics & genomic medicine. vol 12. issue 6. 2024-06-18. PMID:38888203. |
the triggering receptor expressed on myeloid cells 2 protein (trem2) plays a crucial role in various biological processes, including osteoclast differentiation, and disease-associated microglia (dam) activation to regulate neuroinflammation, and phagocytosis in the brain. |
2024-06-18 |
2024-06-21 |
Not clear |
| Mihyun Hwang, Cornelia C Bergman. Neurotropic murine coronavirus mediated demyelination: Factors dampening pathogenesis. Journal of neuroimmunology. vol 393. 2024-06-08. PMID:38850674. |
we specifically discuss the role of immune dampening factors programmed cell death ligand 1 (pd-l1) and interleukin (il)-10, as well as microglia and triggering receptor expressed on myeloid cells 2 (trem2), in limiting demyelination independent of viral persistence. |
2024-06-08 |
2024-06-11 |
mouse |
| Yi Tian, Rong Ai, Xiao Xiao, Weiliang Liu, Shanqing Cheng, Xiaoping Zh. Mechanism of the effect of TREM2 on cognitive function in autistic mice. Cellular and molecular biology (Noisy-le-Grand, France). vol 70. issue 6. 2024-06-05. PMID:38836680. |
trem2 overexpression and knockdown viruses were given to autism spectrum disorder (asd) mice and bv2 microglia cell line. |
2024-06-05 |
2024-06-07 |
mouse |
| Michela Matteol. The role of microglial TREM2 in development: A path toward neurodegeneration? Glia. 2024-06-05. PMID:38837837. |
among the microglial genes, trem2 is a key player, controlling the functional state of microglia and being at the forefront of many processes that require interaction between microglia and other brain components, such as neurons and oligodendrocytes. |
2024-06-05 |
2024-06-08 |
Not clear |
| Ainhoa Etxeberria, Yun-An A Shen, Steve Vito, Sean Silverman, Jose Imperio, Guita Lalehzadeh, Allison Soung, Changchun Du, Luke Xie, Man Kin Choy, Yi-Chun Hsiao, Hai Ngu, Chang Hoon Cho, Soumitra Ghosh, Gloriia Novikova, Mitchell G Rezzonico, Rebecca Leahey, Martin Weber, Alvin Gogineni, Justin Elstrott, Monica Xiong, Jacob J Greene, Kimberly L Stark, Pamela Chan, Gillie A Roth, Max Adrian, Qingling Li, Meena Choi, Weng Ruh Wong, Wendy Sandoval, Oded Foreman, Alicia A Nugent, Brad A Friedman, Shraddha Sadekar, Isidro Hötzel, David V Hansen, Ben Chih, Tracy J Yuen, Robby M Weimer, Amy Easton, William J Meilandt, Christopher J Bohle. Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer's Disease and Multiple Sclerosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2024-06-03. PMID:38830764. |
for mice bearing amyloid-β (aβ) pathology (ps2app) or combined aβ and tau pathology (taups2app), chronic trem2 agonist antibody treatment had limited impact on microglia engagement with pathology, overall pathology burden, or downstream neuronal damage. |
2024-06-03 |
2024-06-06 |
mouse |
| Xueting Wang, Yuqi Xie, Xiaoyang Fan, Xiaomei Wu, Dan Wang, Li Zh. Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer's disease. Alzheimer's research & therapy. vol 16. issue 1. 2024-06-03. PMID:38831312. |
intermittent hypoxia training enhances aβ endocytosis by plaque associated microglia via vps35-dependent trem2 recycling in murine alzheimer's disease. |
2024-06-03 |
2024-06-06 |
Not clear |
| Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Elida Gomero, Alessandra d'Azz. Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826426. |
neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of trem2. |
2024-06-03 |
2024-06-05 |
Not clear |
| Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Elida Gomero, Alessandra d'Azz. Neuraminidase 1 regulates the cellular state of microglia by modulating the sialylation of Trem2. bioRxiv : the preprint server for biology. 2024-06-03. PMID:38826426. |
here we examined how neu1 influences microglia by modulating the sialylation of full-length trem2 (trem2-fl), a multifunctional receptor that regulates microglial survival, phagocytosis, and cytokine production. |
2024-06-03 |
2024-06-05 |
Not clear |
| Hanjie Liu, Hui Yang, Shuqing Liu, Siyu Li, Wen Yang, Anwar Ayesha, Xin Tan, Cen Jiang, Yi Liu, Lushuang Xi. Biomarker Identification for Gender Specificity of Alzheimer's Disease Based on the Glial Transcriptome Profiles. Journal of visualized experiments : JoVE. issue 207. 2024-06-03. PMID:38829108. |
protein-protein interaction network (ppi) identified mt3, calm2, dlg2, kcnd2, pakacb, camk2d, and nlgn4y in astrocytes, trem2, fos, apoe, app, and nlgn4y in microglia, and grin2a, itpr2, gnas, and nlgn4y in oligodendrocytes as key genes. |
2024-06-03 |
2024-06-05 |
Not clear |
| Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. |
microglia and trem2. |
2024-05-31 |
2024-06-02 |
human |
| Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. |
trem2 is a membrane receptor solely expressed on microglia in normal brain. |
2024-05-31 |
2024-06-02 |
human |
| Jennifer Pocock, Foteini Vasilopoulou, Elina Svensson, Katharina Coske. Microglia and TREM2. Neuropharmacology. 2024-05-31. PMID:38821351. |
in this review we outline recent advances in trem2 biology and its implications for microglial function, with particular emphasis on findings from ipsc-derived microglia (img) expressing trem2 loss-of-function mutations. |
2024-05-31 |
2024-06-02 |
human |
| Erpan Ahat, Zanyu Shi, Shaoyou Chu, Hai Hoang Bui, Emily R Mason, Disha M Soni, Kenneth D Roth, Michael James Chalmers, Adrian L Oblak, Jie Zhang, Jesus A Gutierrez, Timothy Richardso. SHIP1 modulation and proteome characterization of microglia. Journal of proteomics. 2024-05-22. PMID:38777089. |
understanding microglial states in the aging brain has become crucial, especially with the discovery of numerous alzheimer's disease (ad) risk and protective variants in genes such as inpp5d and trem2, which are essential to microglia function in ad. |
2024-05-22 |
2024-05-27 |
mouse |
| Qian Shi, Raul A Gutierrez, Manzoor A Bha. Microglia, Trem2, and Neurodegeneration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-05-21. PMID:38769824. |
microglia, trem2, and neurodegeneration. |
2024-05-21 |
2024-05-27 |
human |
| Qian Shi, Raul A Gutierrez, Manzoor A Bha. Microglia, Trem2, and Neurodegeneration. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 2024-05-21. PMID:38769824. |
microglia express trem2, which serves as a receptor for a multitude of ligands enhancing their phagocytic activity. |
2024-05-21 |
2024-05-27 |
human |