Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
Jan Traub, Niklas Beyersdorf, Roxanne Sell, Stefan Frantz, Stefan Störk, Guido Stoll, Anna Fre. Plasma levels of soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) in chronic heart failure - predictors and prognostic relevance. American journal of physiology. Heart and circulatory physiology. 2025-02-07. PMID:39918245. |
trem2 (triggering receptor expressed on myeloid cells 2) is a transmembrane protein expressed on myeloid cells, including macrophages and microglia, and is involved in modulating inflammation and lipid metabolism. |
2025-02-07 |
2025-02-09 |
Not clear |
Kelley C Larson, Frederick W Gergits, Abigail J Renoux, Elizabeth J Weisman, Borislav Dejanovic, Liyue Huang, Bhaumik Pandya, Donald G McLaren, Berkley A Lynch, Richard Fisher, Evan Thackaberry, David Gray, Francois Gaudreault, Christian Miresc. Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism. Journal of neuroinflammation. vol 22. issue 1. 2025-02-01. PMID:39891235. |
similar functions have also been ascribed to triggering receptor expressed on myeloid cells 2 (trem2), which shares an analogous microglia enrichment profile and converging intracellular signaling pathway mediated by spleen associated tyrosine kinase (syk) and phosphoinositide-3-kinase (pi3k). |
2025-02-01 |
2025-02-04 |
mouse |
Xiaoye Ma, Dmitry Prokopenko, Ni Wang, Tomonori Aikawa, Younjung Choi, Can Zhang, Dan Lei, Yingxue Ren, Keiji Kawatani, Skylar C Starling, Ralph B Perkerson, Bhaskar Roy, Astrid C Quintero, Tammee M Parsons, Yining Pan, Zonghua Li, Minghui Wang, Hanmei Bao, Xianlin Han, Guojun Bu, Rudolph E Tanzi, Takahisa Kanekiy. Alzheimer's disease risk ABCA7 p.A696S variant disturbs the microglial response to amyloid pathology in mice. Neurobiology of disease. 2025-01-29. PMID:39880319. |
in addition, we observed that abca7-a696s substitution disturbs the induction of proinflammatory cytokines interleukin 1β and interferon γ in the brains of 5xfad mice, although some disease-associated microglia gene expression, including trem2 and tyrobp, are upregulated. |
2025-01-29 |
2025-02-01 |
mouse |
Sarbani Mishra, Preety Sthutika Swain, Sanghamitra Pati, Budheswar Dehur. Extracellular domain of TREM2 possess two distinct ligand recognition sites: Insights from machine-learning guided docking and all-atoms molecular dynamics simulations. Heliyon. vol 11. issue 1. 2025-01-27. PMID:39866401. |
the myeloid-specific triggering receptors expressed on myeloid cells 2 (trem2) is a group of class i receptors expressed in brain microglia plays a decisive role in neurodegenerative diseases such as alzheimer's disease (ad) and nasu hakola disease (nhd). |
2025-01-27 |
2025-01-29 |
Not clear |
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d'Azz. Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation. Cell reports. vol 44. issue 1. 2025-01-16. PMID:39817909. |
neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of trem2 sialylation. |
2025-01-16 |
2025-01-19 |
Not clear |
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d'Azz. Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation. Cell reports. vol 44. issue 1. 2025-01-16. PMID:39817909. |
here, we examine how neu1 influences microglia by modulating the sialylation of full-length trem2 (trem2-fl), a multifunctional receptor that regulates microglial survival, phagocytosis, and cytokine production. |
2025-01-16 |
2025-01-19 |
Not clear |
Jessica A Greven, Joshua R Wydra, Rory A Greer, Cynthia Zhi, David A Price, Jordyn D Svoboda, Christopher L M Camitta, Mya Washington, Daisy W Leung, Yuhua Song, Jen Alexander-Brett, Tom J Bret. Biophysical mapping of TREM2-ligand interactions reveals shared surfaces for engagement of multiple Alzheimer's disease ligands. Molecular neurodegeneration. vol 20. issue 1. 2025-01-10. PMID:39789647. |
trem2 is a signaling receptor expressed on microglia that has emerged as an important drug target for alzheimer's disease and other neurodegenerative diseases. |
2025-01-10 |
2025-01-13 |
Not clear |
Yuchen Yao, Liru Hu, Danni Li, Yuhao Wang, Jian Pan, Dan Fa. Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke. Frontiers in neuroscience. vol 18. 2025-01-06. PMID:39758888. |
perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia trem2 via pi3k/akt pathway in mouse model of ischemic stroke. |
2025-01-06 |
2025-01-08 |
mouse |
Yuchen Yao, Liru Hu, Danni Li, Yuhao Wang, Jian Pan, Dan Fa. Perioperative enriched environment attenuates postoperative cognitive dysfunction by upregulating microglia TREM2 via PI3K/Akt pathway in mouse model of ischemic stroke. Frontiers in neuroscience. vol 18. 2025-01-06. PMID:39758888. |
however, we observed that an enriched environment (ee) could ameliorate this cognitive impairment by upregulating microglia trem2 expression in the hippocampus and suppressing neuroinflammation. |
2025-01-06 |
2025-01-08 |
mouse |
Jessica A Greven, Jennifer M Alexander-Brett, Thomas J Bret. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750848. |
understanding the molecular mechanisms underlying trem2 signaling in microglia will facilitate the development of specific, safe and efficacious therapies for ad that target trem2. |
2025-01-03 |
2025-01-05 |
Not clear |
Harry Crook, Malak Wahdan, Marie Emilie Tuil, Nicholas R Livingston, Sanara Raza, Joseph Nowell, Paul Ediso. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39750876. |
triggering receptor expressed on myeloid cells 2 (trem2) is crucial to microglial involvement in ad, mediating trem2-dependent activation and disease-associated microglia (dam) polarization. |
2025-01-03 |
2025-01-05 |
Not clear |
Shahnawaz A Bha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751305. |
following the genome-wide association studies (gwas) discovery of microglia-specific genes, particularly trem-2, ship-1, and cd33, significantly associated with higher alzheimer's disease (ad) risk, the microglia trem2 pathway has become central for regulating amyloid load, tissue damage, and limiting its spread. |
2025-01-03 |
2025-01-05 |
mouse |
Shahnawaz A Bha. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751305. |
these discoveries have opened up the exciting possibility of therapeutic microglia trem2 manipulation in ad. |
2025-01-03 |
2025-01-05 |
mouse |
Junyi Liang, Aditya Aditya Menon, Taylor Tomco, Lynn M Bekri. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751383. |
triggering receptor expressed on myeloid cells 2 (trem2) is increasingly recognized to play a central role in amyloid beta clearance and microglia activation in ad. |
2025-01-03 |
2025-01-05 |
Not clear |
Berta Sanz Morello, Elin Byman Shatri, Sofie Frandsen, Benjamin Schmid, Kenneth Thirstrup, Bjørn Hols. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751449. |
these activities are tightly regulated by microglia receptors cd33 and trem2. |
2025-01-03 |
2025-01-05 |
Not clear |
Masataka Kikuchi, Akinori Miyashita, Yu Hirota, Norikazu Hara, Mai Hasegawa, Yasufumi Sakakibara, Michiko Sekiya, Yuko Saito, Shigeo Murayama, Koichi M Iijima, Takeshi Ikeuch. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751567. |
however, reactive microglia are less likely to be induced in trem2 mutation carriers. |
2025-01-03 |
2025-01-05 |
Not clear |
Li Gan, Sarah Nagui. Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 20 Suppl 1. 2025-01-03. PMID:39751696. |
trem2 is required for the induction of a disease-associated microglia (dam) signature and microglial neurodegenerative phenotype (mgnd) in response to disease pathology, signatures which both include apoe upregulation. |
2025-01-03 |
2025-01-05 |
Not clear |
Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pococ. Amelioration of signaling deficits underlying metabolic shortfall in TREM2 The FEBS journal. 2024-12-27. PMID:39726135. |
amelioration of signaling deficits underlying metabolic shortfall in trem2 the microglial triggering receptor expressed on myeloid cells 2 (trem2) is required for diverse microglia responses in neurodegeneration, including immunometabolic plasticity, phagocytosis, and survival. |
2024-12-27 |
2024-12-29 |
Not clear |
Foteini Vasilopoulou, Thomas M Piers, Jingzhang Wei, John Hardy, Jennifer M Pococ. Amelioration of signaling deficits underlying metabolic shortfall in TREM2 The FEBS journal. 2024-12-27. PMID:39726135. |
we previously identified that patient ipsc-derived microglia (ips-mg) harboring the alzheimer's disease (ad) trem2 |
2024-12-27 |
2024-12-29 |
Not clear |
Yong-Chang Wang, Liang-Yu Huang, Hai-Hua Guo, Min Liu, Yu-Ying Zhang, Zi-Qi Zhang, Quan Hao, Chen-Chen Tan, Lan Ta. Higher CSF sTREM2 attenuates APOE ε4-related risk for amyloid pathology in cognitively intact adults: The CABLE study. Journal of neurochemistry. vol 169. issue 1. 2024-12-26. PMID:39725857. |
the triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane protein found in microglia within the brain, and its soluble form (strem2) has been shown to reduce amyloid deposition. |
2024-12-26 |
2024-12-29 |
human |