All Relations between tph2 and serotonin

Publication Sentence Publish Date Extraction Date Species
Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. both in vivo and in vitro, np group showed a decrease in the expression levels of erβ, tryptophan hydroxylase (tph1), and tryptophan hydroxylase-2 (tph2) genes and proteins, and reduced levels of da, ne, and 5-hydroxytryptophan (5-ht) neurotransmitters. 2024-06-08 2024-06-11 rat
Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. the expression levels of erβ, tph1, tph2, 5-ht and 5-hitt proteins were decreased in the np group, suggesting np-induced depression-like behaviours as well as disturbances in the secretion of serum hormones and monoamine neurotransmitters. 2024-06-08 2024-06-11 rat
S E P Bruzzone, B Ozenne, P M Fisher, G Ortega, P S Jensen, V H Dam, C Svarer, G M Knudsen, K P Lesch, V G Frokjae. No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state. Clinical epigenetics. vol 16. issue 1. 2024-05-28. PMID:38802956. here, we evaluated the association between whole-blood-derived methylation of four cpg sites in the serotonin transporter (slc6a4) and six cpg sites of the tryptophan hydroxylase 2 (tph2) gene and in-vivo brain levels of serotonin transporter (5-htt) and serotonin 4 receptor (5-ht 2024-05-28 2024-06-03 Not clear
Ying Zhu, Lifeng Yin, Qing Liu, Yaoxing Guan, Shuang Nie, Yongheng Zhu, Fengfeng M. Tryptophan metabolic pathway plays a key role in the stress-induced emotional eating. Current research in food science. vol 8. 2024-05-13. PMID:38736909. tryptophan supplementation improved the abnormal expression of appetite regulators (e.g., agrp, ox1r, mc4r), and tryptophan supplementation also increased the tryptophan hydroxylase 2 (tph2) and 5-ht receptors in the hypothalamus of cms mice, which indicates that the 5-ht metabolic pathway influences feeding behavior. 2024-05-13 2024-05-27 mouse
Hayet Kouchi, Jonathon Smith, Béatrice Georges, Freya Cracknell, Laurent Bezin, Sylvain Rheim. Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function. Epilepsia. 2024-05-13. PMID:38738911. in a rat model of temporal lobe epilepsy (epi rats), in which we previously reported interictal respiratory dysfunctions and a reduction of brainstem 5-ht tone, quantitative reverse transcriptase polymerase chain reaction showed overexpression of tph2 (5-ht synthesis enzyme), sert (5-ht reuptake transporter), and 5-ht2c transcript levels in the brainstem of epi rats, and of rna-specific adenosine deaminase (adar1, adar2) involved in the production of 5-ht2c isoforms. 2024-05-13 2024-05-27 rat
Hui-Min Zhu, Bo Wang, Tao Wang, Jing Shao, Hui-Ru Chen, Chi Zhang, Li-Hua Xu, Jing-Jing Li, Min Wang, De-Xiang Xu, Xiu-Hong Men. Prenatal exposure to fenvalerate causes depressive-like behavior in adulthood by inhibiting brain-derived 5-HT synthesis. Environmental pollution (Barking, Essex : 1987). 2024-05-13. PMID:38740245. tryptophan hydroxylase 2 (tph2), a key enzyme for 5-ht synthesis, was downregulated in the midbrain of fenvalerate-exposed gd18 fetuses. 2024-05-13 2024-05-27 mouse
Lucille Alonso, Polina Peeva, Tania Fernández-Del Valle Alquicira, Narda Erdelyi, Ángel Gil Nolskog, Michael Bader, York Winter, Natalia Alenina, Marion Rivala. Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732220. using a novel rat model of inducible serotonin depletion via the genetic knockdown of tryptophan hydroxylase 2 (tph2), we achieved a 20% decrease in serotonin levels in the hypothalamus after three weeks of non-invasive oral doxycycline administration. 2024-05-11 2024-05-27 rat
Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. 2024-04-12 2024-04-15 mouse
Hanfei Wang, Yanrong Sun, Wenjuan Wang, Xiangqiu Wang, Jinglin Zhang, Yu Bai, Ke Wang, Liju Luan, Junhao Yan, Lihua Qi. Mapping the 5-HTergic neural pathways in perimenopausal mice and elucidating the role of oestrogen receptors in 5-HT neurotransmission. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38510058. this study clarified that the expression of oestrogen receptor decreased in perimenopause, which regulated the transcription levels of tph2 and maoa, and ultimately led to the reduction of 5-ht content, providing a new target for clinical diagnosis and treatment of perimenopausal diseases. 2024-03-21 2024-03-23 mouse
L Sophie Gullino, Cara Fuller, Poppy Dunn, Helen M Collins, Salah El Mestikawy, Trevor Shar. Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms. ACS chemical neuroscience. 2024-02-20. PMID:38377469. acute, uncontrollable swim stress increased c-fos immunoreactivity in neurons co-expressing vglut3 and the 5-ht marker tryptophan hydroxylase 2 (tph2) in the dorsal raphe nucleus (drn). 2024-02-20 2024-02-23 mouse
Jie Gu, Liguo Guo, Chen Chen, Guixiang Ji, Lei Wan. Neurobehavioral toxic effects and mechanisms of 2-aminobenzothiazole exposure on zebrafish. The Science of the total environment. 2023-12-24. PMID:38142985. furthermore, the real-time pcr results indicated a significant suppression of genes related to exposure to nth, specifically those in the gaba synthesis pathway (gabrg2, gad2, gad1b, and abat) and the 5-ht synthesis pathway (tph2, tph1b, pet1, and htr1aa). 2023-12-24 2023-12-27 zebrafish
I E Sorokin, V S Evsyukova, A B Arefieva, V V Sachkova, P A Kulikov, A V Kuliko. Effect of Prolonged Exposure to Short Daylight and a Tryptophan Hydroxylase Inhibitor on the Behavior and Brain Serotonin System in Danio rerio. Bulletin of experimental biology and medicine. 2023-11-18. PMID:37979022. on day 31, the fish behavior in the "novel tank diving" test, their sex and body weight were determined, and the levels of pcpa, 5-ht, and its metabolite 5-hiaa were measured by hplc; the levels of the key genes encoding metabolism enzymes (tph1a, tph1b, tph2, and mao) and receptors of 5-ht (htr1aa, htr2aa) were assessed by real-time pcr with reverse transcription. 2023-11-18 2023-11-20 zebrafish
Neha Sawant, Sudhir Kshirsagar, P Hemachandra Reddy, Arubala P Redd. Protective effects of SSRI, Citalopram in mutant APP and mutant Tau expressed dorsal raphe neurons in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-11-06. PMID:37931714. we then assessed mrna and protein levels of p-tau, total tau, serotonin related proteins such as tph2, sert, and 5htr1a, synaptic proteins and cytoskeletal structure. 2023-11-06 2023-11-08 Not clear
Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. the potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 2 (tph2) is well characterized to facilitate rapid and long-lasting antidepressant actions. 2023-11-02 2023-11-08 mouse
Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. we show here that a lack of acetyl-coa synthetase short-chain family member 2 (acss2) causes impairments in bdnf-dependent synaptic plasticity and tryptophan hydroxylase 2 (tph2)-mediated serotonin generation, thereby contributing to spontaneous and chronic restraint stress (crs)-induced depressive-like behavior in mice. 2023-11-02 2023-11-08 mouse
Alla B Arefieva, Polina D Komleva, Vladimir S Naumenko, Nikita V Khotskin, Alexander V Kuliko. In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2. Biomolecules. vol 13. issue 10. 2023-10-30. PMID:37892138. tryptophan hydroxylase 2 (tph2) is the key and rate-limiting enzyme of serotonin (5-ht) synthesis in the mammalian brain. 2023-10-30 2023-11-08 mouse
Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. a central serotonin regulating gene polymorphism (tph2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. 2023-09-04 2023-09-07 Not clear
Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. the present study aimed to investigate whether individual variations in the tryptophan hydroxylase 2 (tph2) genetics influence susceptibility for behavioral and neural threat reactivity dysregulations during transiently decreased 5-ht signaling. 2023-09-04 2023-09-07 Not clear
Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. together the present findings suggest for the first time that individual variations in tph2 genetics render individuals susceptible to the anxiogenic and neural effects of a transient decrease in 5-ht signaling. 2023-09-04 2023-09-07 Not clear
Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Ki. Impact of the circadian nuclear receptor REV-ERBα in dorsal raphe 5-HT neurons on social interaction behavior, especially social preference. Experimental & molecular medicine. 2023-08-03. PMID:37537215. to investigate whether the circadian nuclear receptor rev-erbα, a transcriptional repressor of the rate-limiting enzyme tryptophan hydroxylase 2 (tph2) gene in 5-ht biosynthesis, may affect social interaction behaviors, we generated a conditional knockout (cko) mouse by targeting rev-erbα in dorsal raphe (dr) 5-ht neurons (5-ht 2023-08-03 2023-08-14 mouse