| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Allison K Warner, Lauren Iskander, Kristen Allen, Isabella Quatela, Hannah Borrelli, Benjamin D Sach. The Effects of Brain Serotonin Deficiency on the Behavioral and Neurogenesis-Promoting Effects of Voluntary Exercise in Tryptophan Hydroxylase 2 (R439H) Knock-in Mice. Neuropharmacology. 2024-07-15. PMID:39009217. |
complete loss of function of the brain 5-ht synthesis enzyme (tryptophan hydroxylase 2, tph2) has been reported to prevent exercise-induced increases in neurogenesis and to block a subset of antidepressant-like responses to selective serotonin reuptake inhibitors (ssris), but whether partial loss of tph2 function blocks the behavioral and neurogenic effects of exercise has not been established. |
2024-07-15 |
2024-07-18 |
mouse |
| A B Arefieva, P D Komleva, M Gubina, A V Kuliko. Effect of (R)-2-Amino-6-(1R,2S)-1,2-Dihydroxypropyl)-5,6,7,8-Tetrahydropterin-4(3H)-One and Its Structural Analogues on the Temperature Stability of Tryptophan Hydroxylase 2 with the P447R Mutation. Bulletin of experimental biology and medicine. 2024-06-26. PMID:38922549. |
the enzyme tryptophan hydroxylase 2 (tph2) catalyzes the hydroxylation of l-tryptophan to l-5-hydroxytryptophan (5-htp), the first and the key step in 5-ht synthesis in the mammalian brain. |
2024-06-26 |
2024-06-29 |
human |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
both in vivo and in vitro, np group showed a decrease in the expression levels of erβ, tryptophan hydroxylase (tph1), and tryptophan hydroxylase-2 (tph2) genes and proteins, and reduced levels of da, ne, and 5-hydroxytryptophan (5-ht) neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
the expression levels of erβ, tph1, tph2, 5-ht and 5-hitt proteins were decreased in the np group, suggesting np-induced depression-like behaviours as well as disturbances in the secretion of serum hormones and monoamine neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| S E P Bruzzone, B Ozenne, P M Fisher, G Ortega, P S Jensen, V H Dam, C Svarer, G M Knudsen, K P Lesch, V G Frokjae. No association between peripheral serotonin-gene-related DNA methylation and brain serotonin neurotransmission in the healthy and depressed state. Clinical epigenetics. vol 16. issue 1. 2024-05-28. PMID:38802956. |
here, we evaluated the association between whole-blood-derived methylation of four cpg sites in the serotonin transporter (slc6a4) and six cpg sites of the tryptophan hydroxylase 2 (tph2) gene and in-vivo brain levels of serotonin transporter (5-htt) and serotonin 4 receptor (5-ht |
2024-05-28 |
2024-06-03 |
Not clear |
| Ying Zhu, Lifeng Yin, Qing Liu, Yaoxing Guan, Shuang Nie, Yongheng Zhu, Fengfeng M. Tryptophan metabolic pathway plays a key role in the stress-induced emotional eating. Current research in food science. vol 8. 2024-05-13. PMID:38736909. |
tryptophan supplementation improved the abnormal expression of appetite regulators (e.g., agrp, ox1r, mc4r), and tryptophan supplementation also increased the tryptophan hydroxylase 2 (tph2) and 5-ht receptors in the hypothalamus of cms mice, which indicates that the 5-ht metabolic pathway influences feeding behavior. |
2024-05-13 |
2024-05-27 |
mouse |
| Hayet Kouchi, Jonathon Smith, Béatrice Georges, Freya Cracknell, Laurent Bezin, Sylvain Rheim. Serotonin 2C receptor in a rat model of temporal lobe epilepsy: From brainstem expression to pharmacological blockade in relation to ventilatory function. Epilepsia. 2024-05-13. PMID:38738911. |
in a rat model of temporal lobe epilepsy (epi rats), in which we previously reported interictal respiratory dysfunctions and a reduction of brainstem 5-ht tone, quantitative reverse transcriptase polymerase chain reaction showed overexpression of tph2 (5-ht synthesis enzyme), sert (5-ht reuptake transporter), and 5-ht2c transcript levels in the brainstem of epi rats, and of rna-specific adenosine deaminase (adar1, adar2) involved in the production of 5-ht2c isoforms. |
2024-05-13 |
2024-05-27 |
rat |
| Hui-Min Zhu, Bo Wang, Tao Wang, Jing Shao, Hui-Ru Chen, Chi Zhang, Li-Hua Xu, Jing-Jing Li, Min Wang, De-Xiang Xu, Xiu-Hong Men. Prenatal exposure to fenvalerate causes depressive-like behavior in adulthood by inhibiting brain-derived 5-HT synthesis. Environmental pollution (Barking, Essex : 1987). 2024-05-13. PMID:38740245. |
tryptophan hydroxylase 2 (tph2), a key enzyme for 5-ht synthesis, was downregulated in the midbrain of fenvalerate-exposed gd18 fetuses. |
2024-05-13 |
2024-05-27 |
mouse |
| Lucille Alonso, Polina Peeva, Tania Fernández-Del Valle Alquicira, Narda Erdelyi, Ángel Gil Nolskog, Michael Bader, York Winter, Natalia Alenina, Marion Rivala. Poor Decision Making and Sociability Impairment Following Central Serotonin Reduction in Inducible TPH2-Knockdown Rats. International journal of molecular sciences. vol 25. issue 9. 2024-05-11. PMID:38732220. |
using a novel rat model of inducible serotonin depletion via the genetic knockdown of tryptophan hydroxylase 2 (tph2), we achieved a 20% decrease in serotonin levels in the hypothalamus after three weeks of non-invasive oral doxycycline administration. |
2024-05-11 |
2024-05-27 |
rat |
| Helen M Collins, L Sophie Gullino, Dersu Ozdemir, Caroline Lazarenco, Yulia Sudarikova, Elizabeth Daly, Fuencisla Pilar Cuéllar, Raquel Pinacho, David M Bannerman, Trevor Shar. Rebound activation of 5-HT neurons following SSRI discontinuation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024-04-12. PMID:38609530. |
next, immunohistochemistry experiments found that paroxetine discontinuation increased c-fos expression in midbrain 5-ht (tph2 positive) neurons, adding further evidence for a hyperexcitable 5-ht system. |
2024-04-12 |
2024-04-15 |
mouse |
| Hanfei Wang, Yanrong Sun, Wenjuan Wang, Xiangqiu Wang, Jinglin Zhang, Yu Bai, Ke Wang, Liju Luan, Junhao Yan, Lihua Qi. Mapping the 5-HTergic neural pathways in perimenopausal mice and elucidating the role of oestrogen receptors in 5-HT neurotransmission. Heliyon. vol 10. issue 6. 2024-03-21. PMID:38510058. |
this study clarified that the expression of oestrogen receptor decreased in perimenopause, which regulated the transcription levels of tph2 and maoa, and ultimately led to the reduction of 5-ht content, providing a new target for clinical diagnosis and treatment of perimenopausal diseases. |
2024-03-21 |
2024-03-23 |
mouse |
| L Sophie Gullino, Cara Fuller, Poppy Dunn, Helen M Collins, Salah El Mestikawy, Trevor Shar. Evidence for a Role of 5-HT-glutamate Co-releasing Neurons in Acute Stress Mechanisms. ACS chemical neuroscience. 2024-02-20. PMID:38377469. |
acute, uncontrollable swim stress increased c-fos immunoreactivity in neurons co-expressing vglut3 and the 5-ht marker tryptophan hydroxylase 2 (tph2) in the dorsal raphe nucleus (drn). |
2024-02-20 |
2024-02-23 |
mouse |
| Jie Gu, Liguo Guo, Chen Chen, Guixiang Ji, Lei Wan. Neurobehavioral toxic effects and mechanisms of 2-aminobenzothiazole exposure on zebrafish. The Science of the total environment. 2023-12-24. PMID:38142985. |
furthermore, the real-time pcr results indicated a significant suppression of genes related to exposure to nth, specifically those in the gaba synthesis pathway (gabrg2, gad2, gad1b, and abat) and the 5-ht synthesis pathway (tph2, tph1b, pet1, and htr1aa). |
2023-12-24 |
2023-12-27 |
zebrafish |
| I E Sorokin, V S Evsyukova, A B Arefieva, V V Sachkova, P A Kulikov, A V Kuliko. Effect of Prolonged Exposure to Short Daylight and a Tryptophan Hydroxylase Inhibitor on the Behavior and Brain Serotonin System in Danio rerio. Bulletin of experimental biology and medicine. 2023-11-18. PMID:37979022. |
on day 31, the fish behavior in the "novel tank diving" test, their sex and body weight were determined, and the levels of pcpa, 5-ht, and its metabolite 5-hiaa were measured by hplc; the levels of the key genes encoding metabolism enzymes (tph1a, tph1b, tph2, and mao) and receptors of 5-ht (htr1aa, htr2aa) were assessed by real-time pcr with reverse transcription. |
2023-11-18 |
2023-11-20 |
zebrafish |
| Neha Sawant, Sudhir Kshirsagar, P Hemachandra Reddy, Arubala P Redd. Protective effects of SSRI, Citalopram in mutant APP and mutant Tau expressed dorsal raphe neurons in Alzheimer's disease. Biochimica et biophysica acta. Molecular basis of disease. 2023-11-06. PMID:37931714. |
we then assessed mrna and protein levels of p-tau, total tau, serotonin related proteins such as tph2, sert, and 5htr1a, synaptic proteins and cytoskeletal structure. |
2023-11-06 |
2023-11-08 |
Not clear |
| Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. |
the potentiation of synaptic plasticity and serotonin generation by brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 2 (tph2) is well characterized to facilitate rapid and long-lasting antidepressant actions. |
2023-11-02 |
2023-11-08 |
mouse |
| Nuo Chen, Ming Zhao, Yaxin Guo, Nan Wu, Baihui Cao, Bing Zhan, Tian Zhou, Yubin Li, Faliang Zhu, WanJun Chen, Yan Li, Lining Zhan. D-mannose is a rapid inducer of ACSS2 to trigger rapid and long-lasting antidepressant responses through augmenting BDNF and TPH2 levels. Translational psychiatry. vol 13. issue 1. 2023-11-02. PMID:37914710. |
we show here that a lack of acetyl-coa synthetase short-chain family member 2 (acss2) causes impairments in bdnf-dependent synaptic plasticity and tryptophan hydroxylase 2 (tph2)-mediated serotonin generation, thereby contributing to spontaneous and chronic restraint stress (crs)-induced depressive-like behavior in mice. |
2023-11-02 |
2023-11-08 |
mouse |
| Alla B Arefieva, Polina D Komleva, Vladimir S Naumenko, Nikita V Khotskin, Alexander V Kuliko. In Vitro and In Vivo Chaperone Effect of (R)-2-amino-6-(1R, 2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropterin-4(3H)-one on the C1473G Mutant Tryptophan Hydroxylase 2. Biomolecules. vol 13. issue 10. 2023-10-30. PMID:37892138. |
tryptophan hydroxylase 2 (tph2) is the key and rate-limiting enzyme of serotonin (5-ht) synthesis in the mammalian brain. |
2023-10-30 |
2023-11-08 |
mouse |
| Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. |
a central serotonin regulating gene polymorphism (tph2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. |
2023-09-04 |
2023-09-07 |
Not clear |
| Congcong Liu, Keshuang Li, Meina Fu, Yingying Zhang, Cornelia Sindermann, Christian Montag, Xiaoxiao Zheng, Hongxing Zhang, Shuxia Yao, Zheng Wang, Bo Zhou, Keith M Kendrick, Benjamin Becke. A central serotonin regulating gene polymorphism (TPH2) determines vulnerability to acute tryptophan depletion-induced anxiety and ventromedial prefrontal threat reactivity in healthy young men. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 77. 2023-09-04. PMID:37666184. |
the present study aimed to investigate whether individual variations in the tryptophan hydroxylase 2 (tph2) genetics influence susceptibility for behavioral and neural threat reactivity dysregulations during transiently decreased 5-ht signaling. |
2023-09-04 |
2023-09-07 |
Not clear |