| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
both in vivo and in vitro, np group showed a decrease in the expression levels of erβ, tryptophan hydroxylase (tph1), and tryptophan hydroxylase-2 (tph2) genes and proteins, and reduced levels of da, ne, and 5-hydroxytryptophan (5-ht) neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| Jie Yu, Yujie Zhang, Hao Yao, Ziping Zhang, Xiao Yang, Wei Zhu, Jie X. ERβ activation improves nonylphenol-induced depression and neurotransmitter secretion disruption via the TPH2/5-HT pathway. Ecotoxicology and environmental safety. vol 280. 2024-06-08. PMID:38850708. |
the expression levels of erβ, tph1, tph2, 5-ht and 5-hitt proteins were decreased in the np group, suggesting np-induced depression-like behaviours as well as disturbances in the secretion of serum hormones and monoamine neurotransmitters. |
2024-06-08 |
2024-06-11 |
rat |
| Sena L Field, Everardo Anta Galvan, Laura L Hernandez, Jimena Laport. Exploring the contribution of mammary-derived serotonin on liver and pancreas metabolism during lactation. PloS one. vol 19. issue 6. 2024-06-05. PMID:38837989. |
to investigate this, we utilized c57/bl6j mice with a lactation and mammary-specific deletion of the gene coding for the rate-limiting enzyme in serotonin synthesis (tph1, wap-cre x tph1fl/fl) to understand the metabolic contributions of mammary-derived serotonin during lactation. |
2024-06-05 |
2024-06-08 |
mouse |
| Teresa Zelante, Giuseppe Paolicelli, Francesca Fallarino, Marco Gargaro, Gianluca Vascelli, Marco De Zuani, Jan Fric, Petra Laznickova, Marcela Hortova Kohoutkova, Antonio Macchiarulo, Daniela Dolciami, Giuseppe Pieraccini, Lorenzo Gaetani, Giulia Scalisi, Caterina Trevisan, Barbara Frossi, Carlo Pucillo, Antonella De Luca, Emilia Nunzi, Roberta Spaccapelo, Marilena Pariano, Monica Borghi, Francesca Boscaro, Riccardo Romoli, Andrea Mancini, Lucia Gentili, Giorgia Renga, Claudio Costantini, Matteo Puccetti, Stefano Giovagnoli, Maurizio Ricci, Martina Antonini, Paolo Calabresi, Paolo Puccetti, Massimiliano Di Filippo, Luigina Roman. A microbially produced AhR ligand promotes a Tph1-driven tolerogenic program in multiple sclerosis. Scientific reports. vol 14. issue 1. 2024-03-21. PMID:38509264. |
as a result, in peripheral lymph nodes, microbial 3-iald, affected mast-cell tryptophan metabolism, forcing mast cells to produce serotonin via tph1. |
2024-03-21 |
2024-03-23 |
Not clear |
| Karisa M Renteria, Ethan Constantine, Chin May Teoh, Analynn Cooper, Nissi Lozano, Spenser Bauer, Gar Yee Ko. Combination of vitamin D Nutrition research (New York, N.Y.). vol 125. 2024-03-03. PMID:38432179. |
colonic vd receptor was elevated in vf-treated mice in both sexes, compared with ctr, which was positively correlated to colonic tph1, a rate-limiting enzyme for serotonin synthesis. |
2024-03-03 |
2024-03-06 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
furthermore, compared to the control group, the metal mixture exposure group showed a significantly lower expression level of tyrosine hydroxylase (th) and significantly higher expression levels of dopamine transporter (dat), tryptophan hydroxylase 1 (tph1), and serotonin reuptake transporter (sert). |
2023-12-01 |
2023-12-10 |
mouse |
| Sarita Pyatha, Haesoo Kim, Daeun Lee, Kisok Ki. Co-exposure to lead, mercury, and cadmium induces neurobehavioral impairments in mice by interfering with dopaminergic and serotonergic neurotransmission in the striatum. Frontiers in public health. vol 11. 2023-12-01. PMID:38026429. |
these findings suggest that the key proteins involved in the synthesis and reuptake of dopamine (th and dat, respectively), as well as in the synthesis and reuptake of serotonin (tph1 and sert, respectively), play crucial roles in the neurotoxic effects associated with exposure to metal mixtures. |
2023-12-01 |
2023-12-10 |
mouse |
| Amanda Marie Vanslette, Pernille Baumann Toft, Mari Lilith Lund, Thomas Moritz, Tulika Aror. Serotonin receptor 4 agonism prevents high fat diet induced reduction in GLP-1 in mice. European journal of pharmacology. 2023-11-05. PMID:37926275. |
in this study, we found that two weeks of high fat diet (hfd) feeding reduced rna expression of gut hormones, including proglucagon (gcg) gene encoding glp-1 and tryptophan hydroxylase1 (tph1) gene encoding rate limiting enzyme in 5-ht synthesis, specifically in the colon and reduced plasma glp-1 levels. |
2023-11-05 |
2023-11-08 |
mouse |
| Takanori Ikenaga, Tastufumi Nakamura, Tatsushi Tajiri, Minaki Tsuji, Dai-Ichiro Kato, Toshinao Ineno, Yasuhisa Kobayashi, Naoaki Tsutsui, Sadao Kiyohar. Diversity and evolution of serotonergic cells in taste buds of elasmobranchs and ancestral actinopterygian fish. Cell and tissue research. 2023-10-18. PMID:37851111. |
mrna of tryptophan hydroxylase 1 (tph1), a rate-limiting enzyme of the serotonin synthesis, is expressed in both the elongated and basal cells of stingray taste buds, indicating that these cells synthesize the serotonin by themselves. |
2023-10-18 |
2023-11-08 |
Not clear |
| Mieszko Wieckiewicz, Helena Martynowicz, Gilles Lavigne, Frank Lobbezoo, Takafumi Kato, Efraim Winocur, Joanna Wezgowiec, Dariusz Danel, Anna Wojakowska, Grzegorz Mazur, Joanna Smard. An exploratory study on the association between serotonin and sleep breathing disorders. Scientific reports. vol 13. issue 1. 2023-07-21. PMID:37479853. |
peripheral blood samples were collected to estimate the serum levels of serotonin, tryptophan hydroxylase 1 (tph1), and aromatic l-amino acid decarboxylase (aadc). |
2023-07-21 |
2023-08-14 |
Not clear |
| Mieszko Wieckiewicz, Helena Martynowicz, Gilles Lavigne, Frank Lobbezoo, Takafumi Kato, Efraim Winocur, Joanna Wezgowiec, Dariusz Danel, Anna Wojakowska, Grzegorz Mazur, Joanna Smard. An exploratory study on the association between serotonin and sleep breathing disorders. Scientific reports. vol 13. issue 1. 2023-07-21. PMID:37479853. |
a tendency to sleep-disordered breathing seemed to co-occur with lower blood serotonin and higher tph1 levels.clinical trial registration : www.clinicaltrials.gov , identifier nct04214561. |
2023-07-21 |
2023-08-14 |
Not clear |
| Gabriela Souza Rodrigues Queiroz, Juliana Carron, Ligia Traldi Macedo, Carmen Silvia Passos Lima, Gustavo Jacob Lourenç. Influence of variants in serotonin modulating genes on the risk, aggressiveness, and prognosis of oropharynx cancer. Head & neck. 2023-05-09. PMID:37158249. |
single-nucleotide variations (snvs) in tph1 rs623580 (t>a), tph2 rs4570625 (g>t), and htr1d rs674386 (g>a) may affect 5-ht levels. |
2023-05-09 |
2023-08-14 |
Not clear |
| Dane H Tow, Catherine G Tran, Luis C Borbon, Maclain Ridder, Guiying Li, Courtney A Kaemmer, Ellen Abusada, Aswanth Harish Mahalingam, Anguraj Sadanandam, Chandrikha Chandrasekaran, Joseph Dillon, Douglas R Spitz, Dawn E Quelle, Carlos H F Chan, Andrew Bellizzi, James R Howe, Po Hien Ea. Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066322. |
sbnets express high levels of tryptophan hydroxylase 1 (tph1), a key enzyme in serotonin biosynthesis. |
2023-04-17 |
2023-08-14 |
Not clear |
| Dane H Tow, Catherine G Tran, Luis C Borbon, Maclain Ridder, Guiying Li, Courtney A Kaemmer, Ellen Abusada, Aswanth Harish Mahalingam, Anguraj Sadanandam, Chandrikha Chandrasekaran, Joseph Dillon, Douglas R Spitz, Dawn E Quelle, Carlos H F Chan, Andrew Bellizzi, James R Howe, Po Hien Ea. Inhibition of serotonin biosynthesis in neuroendocrine neoplasm suppresses tumor growth bioRxiv : the preprint server for biology. 2023-04-17. PMID:37066322. |
patients with high serotonin level may develop carcinoid syndrome, which can be treated with somatostatin analogues and the tph1 inhibitor telotristat ethyl in severe cases. |
2023-04-17 |
2023-08-14 |
Not clear |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
[alterations in the level of mrna of tph1, tph2 genes, tryptophan hydroxylase activity and serotonin metabolism in mouse brain five days after lipopolysaccharide administration]. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
tryptophan hydroxylases 1 and 2 (tph1 and tph2) play a key role in the synthesis of serotonin (5-ht), a hormone and neurotransmitter, in the peripheral organs and brain, respectively. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
in the frontal cortex, hippocampus, striatum, hypothalamus, and midbrain the concentrations of 5-ht and its main metabolite, 5-hydroxyindole acetic acid (5-hiaa), and tph activity were assayed using hplc, while tph1 and tph2 mrna were quantified using quantitative real-time rt-pcr. |
2023-03-31 |
2023-08-14 |
mouse |
| D V Sherbakov, A B Arefieva, P D Komleva, A E Iz'urov, N V Khotskin, D V Bazovkina, A V Kuliko. [Alterations in the Level of mRNA of TPH1, TPH2 Genes, Tryptophan Hydroxylase Activity and Serotonin Metabolism in Mouse Brain Five Days after Lipopolysaccharide Administration]. Molekuliarnaia biologiia. vol 57. issue 2. 2023-03-31. PMID:37000657. |
thus, tph1 gene expression in the mouse brain is too low to significantly affect 5-ht synthesis in normal conditions and during inflammation. |
2023-03-31 |
2023-08-14 |
mouse |
| Wei Du, Zhi Fei Zhang, Jia Ying Xiao, Ying Wang, Weng Yi Liu, Hui Ling Zhen. 5-hydroxytryptophan inhibits β-casein biosynthesis and promotes goat mammary epithelial cell apoptosis through the JAK2/STAT5a axis and the HTR7. Journal of animal science. 2023-03-25. PMID:36964762. |
tryptophan hydroxylase 1 (tph1) catalyzes the conversion of 5-hydroxytryptophan (5-htp) into l-tryptophan, which is then converted into 5-ht by monoamine-oxidase (mao-a). |
2023-03-25 |
2023-08-14 |
Not clear |
| Shalinda J A Fernando, Qian Wang, Debbie L Hay, Ross Bathgate, Peter R Shepherd, Kate L Le. Evidence that RXFP4 is located in enterochromaffin cells and can regulate production and release of serotonin. Bioscience reports. 2023-03-22. PMID:36947541. |
this was paralleled by a reduction in expression of mrna for tph1, the enzyme controlling the rate limiting step in the production of serotonin. overexpression of rxfp4 also attenuated the camp-induced release of serotonin from colo320 cells. together this demonstrates that serotonin producing enterochromaffin cells are the major site of rxfp4 expression in the gut and that rxfp4 can have inhibitory functional impacts on camp production as well as tph1 expression and serotonin release. |
2023-03-22 |
2023-08-14 |
mouse |