| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu-Dong Cha, Qing-Yun Zou, Feng-Zhen Li, Tian-Yu Wang, Sheng-Lei Wang, Bo-Yu Cai, Zhi-Wen Cao, Zhen-Hua Ji, Hai-Bin Liu, Wen-Wen Wang, Teng-Fei Li, Cai-Quan Liang, Wen-Wen Ren, Huan-Hai Li. SIRT5 exacerbates eosinophilic chronic rhinosinusitis through promoting polarization of M2 macrophage. The Journal of allergy and clinical immunology. 2024-05-18. PMID:38761998. |
previous study implied that local m2 polarization of macrophage promoted mucosal edema and exacerbates th2 type inflammation in chronic rhinosinusitis with nasal polyps (crswnp). |
2024-05-18 |
2024-05-27 |
Not clear |
| Xianhai Zeng, Juanjuan Li, Jiangqi Liu, Lihua Mo, Yu Liu, Aizhi Zhang, Pingchang Yang, Hui Kon. Nasal mucosal fibroblasts produce IL-4 to induce Th2 response. Innate immunity. 2024-05-10. PMID:38725177. |
nasal mucosal fibroblasts produce il-4 to induce th2 response. |
2024-05-10 |
2024-05-27 |
Not clear |
| Xianhai Zeng, Juanjuan Li, Jiangqi Liu, Lihua Mo, Yu Liu, Aizhi Zhang, Pingchang Yang, Hui Kon. Nasal mucosal fibroblasts produce IL-4 to induce Th2 response. Innate immunity. 2024-05-10. PMID:38725177. |
this study aims to elucidate the role of nasal mucosal fibroblast-derived il-4 in the induction of th2 responses. |
2024-05-10 |
2024-05-27 |
Not clear |
| Weiliang Bai, Hui Su, Shengqun Xu, Zhao Gao, Ziwen Chang, Xun Sun, Tiancong Li. Cyp2e1 protects against OVA-induced allergic rhinitis through the inhibition of Th2 cell activation and differentiation: Mediated by MAFB. International immunopharmacology. vol 132. 2024-04-11. PMID:38603858. |
cyp2e1 inhibited th2 immune response by decreasing the expression and secretion of il-4, il-5, and il-13 as well as the expression of gata-3 in nalf or nasal mucosa. |
2024-04-11 |
2024-04-14 |
mouse |
| Xiaoyan Hu, Shuang Liu, Zhang Jing, Yuxiao He, Gang Qin, Liang Jian. Immunomodulation in allergic rhinitis: Insights from Th2 cells and NLRP3/IL-18 pathway. Cell biochemistry and function. vol 42. issue 3. 2024-03-31. PMID:38555506. |
following ova stimulation, increased nasal symptoms were observed in the ova group along with augmented gata3 expression and elevated il-4 and il-1b levels, indicative of th2 polarization and cellular pyroptosis involvement. |
2024-03-31 |
2024-04-02 |
mouse |
| Junhyoung Byun, Junhu Tai, Byoungjae Kim, Jaehyeong Kim, Semyung Jung, Juhyun Lee, Youn Woo Song, Jaemin Shin, Tae Hoon Ki. Identification of Hit Compounds Using Artificial Intelligence for the Management of Allergic Diseases. International journal of molecular sciences. vol 25. issue 4. 2024-02-24. PMID:38396957. |
in an ova-induced allergic rhinitis mouse model, we measured serum levels of total ige and ova-specific ige, performed real-time pcr on nasal mucosa samples to quantify th2 cytokines and ifn-γ expression, and conducted immunohistochemistry to analyze eosinophil levels. |
2024-02-24 |
2024-02-26 |
mouse |
| Min Wang, Haiyang Meng, Nan Zhang, Jian Jiao, Yifei Wang, Mengdi Liu, Ying Li, Xiangdong Wang, Luo Zhang, Claus Bacher. Associations of tenascin C with Th2 response, edema degree, and disease severity in patients with chronic rhinosinusitis with nasal polyps. Allergy. 2024-01-17. PMID:38230820. |
associations of tenascin c with th2 response, edema degree, and disease severity in patients with chronic rhinosinusitis with nasal polyps. |
2024-01-17 |
2024-01-19 |
Not clear |
| Yunxiu Wang, He Zhao, Jing Yang, Zhiwei Cao, Liying Hao, Zhaowei G. Exposure of nonylphenol promoted NLRP3 inflammasome and GSDMD-mediated pyroptosis in allergic rhinitis mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2024-01-04. PMID:38176579. |
studies have confirmed that the intake of nonylphenol (np) can increase nasal symptoms, eosinophils, and th2 responses in allergic rhinitis (ar) mice. |
2024-01-04 |
2024-01-07 |
mouse |
| Lei Yu, Yi Wei, Tong Lu, Zhengqi Li, Shimin Lai, Yan Yan, Changhui Chen, Weiping We. The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback. Cell communication and signaling : CCS. vol 21. issue 1. 2023-12-01. PMID:38037054. |
h3k4me3 levels in the human nasal epithelium may change under th2-biased inflammatory conditions, resulting in exaggerated local nasal th2 responses via the regulation of naïve cd4 |
2023-12-01 |
2023-12-10 |
human |
| Said Ahmad Shah, Masayoshi Kobayash. Pathogenesis of chronic rhinosinusitis with nasal polyp and a prominent T2 endotype. Heliyon. vol 9. issue 9. 2023-09-07. PMID:37674852. |
stimulation of th2 cells, type-2 innate lymphoid cells, epithelial cell damage, staphylococcus aureus enterotoxins, and autoimmune antibodies have important roles in the enhancement of th2 cytokines and pathogenesis of chronic rhinosinusitis with nasal polyp. |
2023-09-07 |
2023-10-07 |
Not clear |
| Fang-Lin Liu, Ying Rong, Hui Zhou, Tong Yu, Luyao Liu, Qianwen Cao, Zhaolong Qin, Lingbo Qu, Xinglin Liao, Qiman Jiang, Nan Zhang, Xia X. Cineole inhibits the biosynthesis of leukotrienes and prostaglandins to alleviate allergic rhinitis: Insights from metabolomics. Journal of pharmaceutical and biomedical analysis. vol 234. 2023-07-23. PMID:37481900. |
it also inhibits the production of th2 cytokines and inflammatory cell infiltration, thereby alleviating symptoms such as nasal congestion and nasal leakage. |
2023-07-23 |
2023-08-14 |
mouse |
| Zhisheng Zheng, Ping Wan. Serum ATG5 concentration relates to Th2 cell, nasal symptoms and therapeutic outcomes in allergic rhinitis patients. Biomarkers in medicine. 2023-07-21. PMID:37477539. |
serum atg5 concentration relates to th2 cell, nasal symptoms and therapeutic outcomes in allergic rhinitis patients. |
2023-07-21 |
2023-08-14 |
Not clear |
| Mauro Maniscalco, Aikaterini Detoraki, Giovanni Sarnelli, Maria Nolano, Amato De Paulis, Giuseppe Spadaro, Elena Canton. A Multidisciplinary Approach for Type 2 Allergic Diseases: What Do Biologics Teach Us? Journal of personalized medicine. vol 13. issue 6. 2023-06-28. PMID:37373930. |
patients with atopic/allergic disorders, including atopic dermatitis (ad), allergic rhino-conjunctivitis (ar), chronic rhinosinusitis with/without nasal polyps (crswnp/crssnp), bronchial asthma, food allergy, and eosinophilic esophagitis (eoe), often share a common genetic background, a type th2 polarized immune response, and several environmental factors [...]. |
2023-06-28 |
2023-08-14 |
Not clear |
| Dariusz Jurkiewicz, Maciej Kupczyk, Eliza Brożek-Mądry, Piotr Rapiejk. Biologicals in the treatment of chronic rhinosinusitis with nasal polyps – position of the Polish Society of Otorhinolaryngologists –Head and Neck Surgeons and the Polish Society of Allergology experts Otolaryngologia polska = The Polish otolaryngology. vol 77. issue 2. 2023-06-26. PMID:37347975. |
the generalized inflammatory process with the formation of nasal polyps and excess eosinophils in the mucosa of the paranasal sinuses is called type 2 inflammation, which is mediated by th2 lymphocytes – cells of the immune system responsible for chronic inflammatory processes. |
2023-06-26 |
2023-11-29 |
Not clear |
| Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo, Hyun Jik Ki. Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis. BMC microbiology. vol 23. issue 1. 2023-05-26. PMID:37237381. |
allergic rhinitis (ar) is characterized by airway inflammation in nasal mucosa from inhaled allergens and interleukin (il)-33 is the potent inducer of th2 inflammation in allergic nasal epithelium. |
2023-05-26 |
2023-08-14 |
human |
| Yung Jin Jeon, Chan Hee Gil, Jina Won, Ara Jo, Hyun Jik Ki. Symbiotic microbiome Staphylococcus epidermidis restricts IL-33 production in allergic nasal epithelium via limiting the cellular necroptosis. BMC microbiology. vol 23. issue 1. 2023-05-26. PMID:37237381. |
thus, we sought to characterize the mechanism of s. epidermidis regulating th2 inflammation and il-33 production in ar nasal mucosa. |
2023-05-26 |
2023-08-14 |
human |
| Anastasios K Goulioumis, Konstantinos Kourelis, Magioula Gkorpa, Vasilios Danielide. Pathogenesis of Nasal Polyposis: Current Trends. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India. vol 75. issue Suppl 1. 2023-05-19. PMID:37206761. |
th2 cytokines, subsequently, induce the accumulation of eosinophils and ige together with the remodeling of the stroma in the sub-epithelial layers leading, eventually, to the formation of nasal polyps. |
2023-05-19 |
2023-08-14 |
Not clear |
| R A Larin, P P Mokeeva, A S Grishi. [Experience of biological therapy in severe forms of chronic rhinosinusitis with nasal polyps in the conditions of regional healthcare]. Vestnik otorinolaringologii. vol 88. issue 2. 2023-05-15. PMID:37184555. |
recurrent chronic rhinosinusitis with nasal polyps (crswnp) with a predominant th2 endotype of inflammation, including associated with bronchial asthma and/or allergic rhinitis, aspirin triad, refers to diseases with an insufficient level of control, despite the use of a wide range of options for conservative and surgical treatment. |
2023-05-15 |
2023-08-14 |
Not clear |
| Nongping Zhong, Honghui Ai, Wei Zhong, Xiaoyan Huang, Kai Wang, Qing Luo, Jieqing Y. Effects of Pendrin Protein in Nasal Epithelial Cells on Mucin Production in the Context of Type 2 Inflammation. Journal of personalized medicine. vol 13. issue 3. 2023-03-29. PMID:36983684. |
the pathogenesis of chronic sinusitis is still unclear; however, the nasal cavity and paranasal sinuses are commonly affected by type 2 inflammation, which is caused by th2 cytokines such as interleukin (il)-5, il-4, and il-13. |
2023-03-29 |
2023-08-14 |
human |
| Naoto Uda, Sawako Ogata, Norimasa Yamasaki, Shuka Miura, Naohisa Hosomi, Akio Mori, Minoru Gotoh, Kento Miura, Osamu Kaminum. Re-evaluation of over-the-counter histamine H1-receptor antagonists based on their effects on murine models of allergen-induced nasal hyperresponsiveness. Journal of pharmacological sciences. vol 150. issue 4. 2022-11-07. PMID:36344050. |
regardless of the alleviation of stimulation-induced th2 cytokine expression by loratadine and desloratadine in vitro, allergen-induced nhr and nasal eosinophil infiltration in th2 cell-transferred mice were unaffected by loratadine in vivo. |
2022-11-07 |
2023-08-14 |
mouse |