| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshihisa Komor. Regulation of bone development and extracellular matrix protein genes by RUNX2. Cell and tissue research. vol 339. issue 1. 2010-03-23. PMID:19649655. |
during osteoblast differentiation, runx2 upregulates the expression of bone matrix protein genes including col1a1, spp1, ibsp, bglap, and fn1 in vitro and activates many promoters including those of col1a1, col1a2, spp1, bglap, and mmp13. |
2010-03-23 |
2023-08-12 |
mouse |
| Sujin Chae, Hyoung-Oh Jun, Eun Gyo Lee, Suk-Jin Yang, Dong Chul Lee, Joon Ki Jung, Kyung Chan Park, Young Il Yeom, Kyu-Won Ki. Osteopontin splice variants differentially modulate the migratory activity of hepatocellular carcinoma cell lines. International journal of oncology. vol 35. issue 6. 2010-01-08. PMID:19885563. |
osteopontin (opn, spp1) is a secretory extracellular matrix protein that has been implicated in cancer-associated mechanisms such as metastasis, invasion and angiogenesis. |
2010-01-08 |
2023-08-12 |
Not clear |
| I C Dunn, N T Joseph, M Bain, A Edmond, P W Wilson, P Milona, Y Nys, J Gautron, M Schmutz, R Preisinger, D Waddingto. Polymorphisms in eggshell organic matrix genes are associated with eggshell quality measurements in pedigree Rhode Island Red hens. Animal genetics. vol 40. issue 1. 2009-03-12. PMID:18828860. |
novel and traditional eggshell quality measurements were made from up to 2000 commercial pedigree hens for a candidate gene association analysis with organic eggshell matrix genes: ovocleidin-116, osteopontin (spp1), ovocalyxin-32 (rarres1), ovotransferrin (ltf), ovalbumin and ovocalyxin-36, as well as key genes in the maintenance and function of the shell gland [estrogen receptor (esr1) and carbonic anhydrase ii (caii)]. |
2009-03-12 |
2023-08-12 |
Not clear |
| Fabiana Yasuhara, Gisele Renata Oliveira Gomes, Erica Rosanna Siu, Cláudia Igushi Suenaga, Elisabeth Maróstica, Catarina Segreti Porto, Maria Fatima Magalhaes Lazar. Effects of the antiestrogen fulvestrant (ICI 182,780) on gene expression of the rat efferent ductules. Biology of reproduction. vol 79. issue 3. 2008-11-26. PMID:18495684. |
matrix metalloproteinase 7 (mmp7), osteopontin (spp1), and neuronal pentraxin 1 (nptx1) were among the most altered genes in this category. |
2008-11-26 |
2023-08-12 |
rat |
| Natalie J Hannan, Lois A Salamonse. CX3CL1 and CCL14 regulate extracellular matrix and adhesion molecules in the trophoblast: potential roles in human embryo implantation. Biology of reproduction. vol 79. issue 1. 2008-10-06. PMID:18367676. |
real-time rt-pcr quantitation revealed significant changes in the mrna transcripts of alpha-catenin (ctnna1), extracellular matrix protein 1 (ecm1), osteopontin (spp1), integrin alpha 6 (itga6), matrix metalloproteinase 12 (mmp12), and integrin beta 5 (itgb5) following chemokine treatment. |
2008-10-06 |
2023-08-12 |
human |
| Shizhong Han, Joel M Guthridge, Isaac T W Harley, Andrea L Sestak, Xana Kim-Howard, Kenneth M Kaufman, Bahram Namjou, Harshal Deshmukh, Gail Bruner, Luis R Espinoza, Gary S Gilkeson, John B Harley, Judith A James, Swapan K Nat. Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction. PloS one. vol 3. issue 3. 2008-08-08. PMID:18335026. |
osteopontin (spp1) is an important bone matrix mediator found to have key roles in inflammation and immunity. |
2008-08-08 |
2023-08-12 |
human |
| Massimiliano De Bortoli, Robert C Castellino, Darlene G Skapura, Jianhe J Shen, Jack M Su, Heidi V Russell, M John Hicks, Tsz-Kwong Man, John Y H Ki. Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases. European journal of cancer (Oxford, England : 1990). vol 43. issue 8. 2007-08-20. PMID:17467979. |
overexpressed genes include secreted phosphoprotein 1 (spp1, osteopontin), and matrix metalloproteinases-2 and -14 (mmp2 and mmp14). |
2007-08-20 |
2023-08-12 |
mouse |
| Jian-Ming Li, Xueqing Zhang, Peter R Nelson, Paul R Odgren, Janice D Nelson, Calin Vasiliu, Jane Park, Marvin Morris, Jane Lian, Bruce S Cutler, Peter E Newburge. Temporal evolution of gene expression in rat carotid artery following balloon angioplasty. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17171642. |
the most significant signature of the induced neointimal profile is enrichment of genes functionally related to angiogenesis and extracellular matrix (ecm) remodeling (e.g., spp1 (secreted phosphoprotein 1), cd44 (cd44 antigen), and cxcl12 (chemokine (c-x-c motif) ligand 12 (stromal cell-derived factor 1)). |
2007-07-24 |
2023-08-12 |
rat |
| J-W Kim, J P Simme. Hereditary dentin defects. Journal of dental research. vol 86. issue 5. 2007-06-06. PMID:17452557. |
a major surprise in the characterization of genes underlying inherited dentin defects is the apparent lack of roles played by the genes encoding the less-abundant non-collagenous proteins in dentin, such as dentin matrix protein 1 (dmp1), integrin-binding sialoprotein (ibsp), matrix extracellular phosphoglycoprotein (mepe), and secreted phosphoprotein-1, or osteopontin (spp1, opn). |
2007-06-06 |
2023-08-12 |
Not clear |
| Karl D Murray, Prabhakara V Choudary, Edward G Jone. Nucleus- and cell-specific gene expression in monkey thalamus. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 6. 2007-03-22. PMID:17261798. |
examples included the transcription factor tcf7l2, localized exclusively to excitatory neurons; a calmodulin-binding protein pcp4; the bone extracellular matrix molecules spp1 and sparc; and other genes involved in axon outgrowth and cell matrix interactions. |
2007-03-22 |
2023-08-12 |
monkey |
| Brent C Taylor, Pamela J Schreiner, Terence M Doherty, Myriam Fornage, J Jeffrey Carr, Steve Sidne. Matrix Gla protein and osteopontin genetic associations with coronary artery calcification and bone density: the CARDIA study. Human genetics. vol 116. issue 6. 2005-07-12. PMID:15744522. |
our aim has been to investigate whether matrix gla protein (mgp) t-138c, osteopontin (spp1) t-443c, and asp94asp single nucleotide polymorphisms are associated with the development of arterial calcification and bone density. |
2005-07-12 |
2023-08-12 |
Not clear |
| A V Skamrov, M A Nechaenko, L E Goryunova, E S Feoktistova, G L Khaspekov, D A Kovalevsky, L I Vinnitsky, G F Sheremeteva, R Sh Beabealashvill. Gene expression analysis to identify mRNA markers of cardiac myxoma. Journal of molecular and cellular cardiology. vol 37. issue 3. 2005-03-18. PMID:15350845. |
mia, spp1, fibromodulin are modulators or participants of the interaction between extracellular matrix proteins and their cell surface receptors. |
2005-03-18 |
2023-08-12 |
human |
| Shunichi Shibata, Kenji Fukada, Shoichi Suzuki, Takuya Ogawa, Yasuo Yamashit. In situ hybridization and immunohistochemistry of bone sialoprotein and secreted phosphoprotein 1 (osteopontin) in the developing mouse mandibular condylar cartilage compared with limb bud cartilage. Journal of anatomy. vol 200. issue Pt 3. 2002-07-12. PMID:12033735. |
in this study we used in situ hybridization and immunohistochemistry to investigate whether the formation of primary (tibial) and secondary (condylar) cartilage also differs with respect to the expression of two major non-collagenous glycoproteins of bone matrix, bone sialoprotein (bsp) and secreted phosphoprotein 1 (spp1, osteopontin). |
2002-07-12 |
2023-08-12 |
mouse |
| P S Rowe, P A de Zoysa, R Dong, H R Wang, K E White, M J Econs, C L Oude. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics. vol 67. issue 1. 2001-01-11. PMID:10945470. |
this new gene has been named mepe (matrix extracellular phosphoglycoprotein) and has major similarities to a group of bone-tooth mineral matrix phospho-glycoproteins (osteopontin (opn; hgmw-approved symbol spp1), dentin sialo phosphoprotein (dspp), dentin matrix protein 1 (dmp1), bone sialoprotein ii (ibsp), and bone morphogenetic proteins (bmp). |
2001-01-11 |
2023-08-12 |
human |
| M MacDougal. Refined mapping of the human dentin sialophosphoprotein (DSPP) gene within the critical dentinogenesis imperfecta type II and dentin dysplasia type II loci. European journal of oral sciences. vol 106 Suppl 1. 1998-05-29. PMID:9541230. |
human genomic dspp clones were isolated, and gene content mapping performed with specific primers for dentin matrix protein 1 (dmp1), bone sialoprotein (bsp) and osteopontin (secreted phosphoprotein 1, spp1). |
1998-05-29 |
2023-08-12 |
human |