| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Toshihisa Komor. Roles of Runx2 in Skeletal Development. Advances in experimental medicine and biology. vol 962. 2017-09-26. PMID:28299652. |
it regulates the expression of sp7, the protein of which is a crucial transcription factor for osteoblast differentiation, as well as that of bone matrix genes including spp1, ibsp, and bglap2. |
2017-09-26 |
2023-08-13 |
Not clear |
| A Ellert-Miklaszewska, P Wisniewski, M Kijewska, P Gajdanowicz, D Pszczolkowska, P Przanowski, M Dabrowski, M Maleszewska, B Kaminsk. Tumour-processed osteopontin and lactadherin drive the protumorigenic reprogramming of microglia and glioma progression. Oncogene. vol 35. issue 50. 2017-08-30. PMID:27041573. |
using constructs encoding functional mutants of osteopontin, we demonstrated sequential processing of spp1 by thrombin and matrix metalloproteinase-3 and/or -7 (mmp-3 and/or -7) in glioma cells, which generates a microglia-activating form devoid of the inflammatory activity, while retaining the m2 reprogramming potential. |
2017-08-30 |
2023-08-13 |
human |
| Hadas Lavi, Miri Assayag, Assaf Schwartz, Nissim Arish, Zvi G Fridlender, Neville Berkma. The association between osteopontin gene polymorphisms, osteopontin expression and sarcoidosis. PloS one. vol 12. issue 3. 2017-08-24. PMID:28253271. |
osteopontin (spp1, opn) is an extra cellular matrix glycoprotein and cytokine with a known role in granuloma formation and in autoimmune and inflammatory diseases. |
2017-08-24 |
2023-08-13 |
Not clear |
| Yuji Inagaki, Katsuya Shiraki, Kazushi Sugimoto, Takazumi Yada, Masahiko Tameda, Suguru Ogura, Norihiko Yamamoto, Yoshiyuki Takei, Masaaki It. Epigenetic regulation of proliferation and invasion in hepatocellular carcinoma cells by CBP/p300 histone acetyltransferase activity. International journal of oncology. vol 48. issue 2. 2016-09-27. PMID:26676548. |
the level of matrix metallopeptidase 15 (mmp15) mrna expression was significantly reduced, whereas the level of laminin alpha 3 (lama3) and secreted phosphoprotein 1 (spp1) mrna expression was significantly increased in huh7 cells following exposure to c646. |
2016-09-27 |
2023-08-13 |
Not clear |
| Quan Zhang, Feng Zhu, Long Liu, Chuan Wei Zheng, De He Wang, Zhuo Cheng Hou, Zhong Hua Nin. Integrating transcriptome and genome re-sequencing data to identify key genes and mutations affecting chicken eggshell qualities. PloS one. vol 10. issue 5. 2016-02-04. PMID:25974068. |
some important matrix proteins, such as oc-116, ltf and spp1, were also expressed differentially between two groups. |
2016-02-04 |
2023-08-13 |
human |
| Francesca Veronesi, Stefania Pagani, Elena Della Bella, Gianluca Giavaresi, Milena Fin. Estrogen deficiency does not decrease the in vitro osteogenic potential of rat adipose-derived mesenchymal stem cells. Age (Dordrecht, Netherlands). vol 36. issue 3. 2015-07-15. PMID:24687841. |
in addition, clonogenicity, osteopontin (spp1) gene expression, alkaline phosphatase (alp) activity at 2 weeks of culture, total collagen (coll), osteocalcin (bglap) gene expression and production, and matrix mineralization were significantly higher in ovx than in sham adscs. |
2015-07-15 |
2023-08-12 |
rat |
| B Schminke, F Vom Orde, R Gruber, H Schliephake, R Bürgers, N Miosg. The pathology of bone tissue during peri-implantitis. Journal of dental research. vol 94. issue 2. 2015-03-27. PMID:25406169. |
the levels of typical bone matrix molecules, including spp1, bglap, and col9a1, in patients with peri-implantitis were reduced, while the inflammation marker interleukin 8 (il8) was highly expressed. |
2015-03-27 |
2023-08-13 |
human |
| Greg A Johnson, Robert C Burghardt, Fuller W Baze. Osteopontin: a leading candidate adhesion molecule for implantation in pigs and sheep. Journal of animal science and biotechnology. vol 5. issue 1. 2015-02-11. PMID:25671104. |
osteopontin (opn; also known as secreted phosphoprotein 1, spp1) is a secreted extra-cellular matrix (ecm) protein that binds to a variety of cell surface integrins to stimulate cell-cell and cell-ecm adhesion and communication. |
2015-02-11 |
2023-08-13 |
Not clear |
| Juan Xu, Bo Yu, Christine Hong, Cun-Yu Wan. KDM6B epigenetically regulates odontogenic differentiation of dental mesenchymal stem cells. International journal of oral science. vol 5. issue 4. 2014-04-03. PMID:24158144. |
additionally, mrna expression of odontogenic marker gene sp7 (osterix, osx), as well as extracellular matrix genes bglap (osteoclacin, ocn) and spp1 (osteopontin, opn), was suppressed by kdm6b depletion. |
2014-04-03 |
2023-08-12 |
Not clear |
| Ignacio Fernández, Daniel M Tiago, Vincent Laizé, M Leonor Cancela, Enric Gisber. Retinoic acid differentially affects in vitro proliferation, differentiation and mineralization of two fish bone-derived cell lines: different gene expression of nuclear receptors and ECM proteins. The Journal of steroid biochemistry and molecular biology. vol 140. 2014-03-25. PMID:24291400. |
expression of hormone receptor genes (rars and rxrs), and extracellular matrix-related genes such as matrix and bone gla proteins (mgp and bglap), osteopontin (spp1) and type i collagen (col1a1) were differentially regulated upon exposure to ra in proliferating, differentiating and mineralizing cultures of vsa13 and vsa16 cells. |
2014-03-25 |
2023-08-12 |
Not clear |
| Matthieu Pérard, Justine Le Clerc, Tanguy Watrin, Fleur Meary, Fabienne Pérez, Sylvie Tricot-Doleux, Pascal Pellen-Muss. Spheroid model study comparing the biocompatibility of Biodentine and MTA. Journal of materials science. Materials in medicine. vol 24. issue 6. 2014-01-06. PMID:23515903. |
we investigated the expression of genes involved in odontogenic differentiation (runx2), matrix secretion (col1a1, spp1) and mineralisation (alp). |
2014-01-06 |
2023-08-12 |
Not clear |
| Luciano de Souza Viana, Renato José Affonso, Sandra Regina Morini Silva, Marcos Vinicius Araujo Denadai, Delcio Matos, Carolina Salinas de Souza, Jaques Waisber. Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination. Oncology. vol 84. issue 2. 2013-02-21. PMID:23128103. |
relationship between the expression of the extracellular matrix genes sparc, spp1, fn1, itga5 and itgav and clinicopathological parameters of tumor progression and colorectal cancer dissemination. |
2013-02-21 |
2023-08-12 |
Not clear |
| Luciano de Souza Viana, Renato José Affonso, Sandra Regina Morini Silva, Marcos Vinicius Araujo Denadai, Delcio Matos, Carolina Salinas de Souza, Jaques Waisber. Relationship between the expression of the extracellular matrix genes SPARC, SPP1, FN1, ITGA5 and ITGAV and clinicopathological parameters of tumor progression and colorectal cancer dissemination. Oncology. vol 84. issue 2. 2013-02-21. PMID:23128103. |
to evaluate the relationship between the expression of the extracellular matrix (ecm) genes sparc, spp1, fn1, itga5 and itgav and the histopathologic parameters of neoplastic progression and colorectal carcinoma (crc) dissemination. |
2013-02-21 |
2023-08-12 |
Not clear |
| Stephen W Mamber, Volkan Gurel, Ryan G Rhodes, John McMichae. Effects of streptolysin o on extracellular matrix gene expression in normal human epidermal keratinocytes. Dose-response : a publication of International Hormesis Society. vol 9. issue 4. 2012-10-02. PMID:22461761. |
downregulated genes of interest were mmp9 (encoding matrix metalloproteinase 9) and spp1 (encoding osteopontin). |
2012-10-02 |
2023-08-12 |
human |
| b' In\\xc3\\xaas Vinga, Catarina Baptista, Isabelle Auzat, Isabelle Petipas, Rudi Lurz, Paulo Tavares, M\\xc3\\xa1rio A Santos, Carlos S\\xc3\\xa3o-Jos\\xc3\\xa. Role of bacteriophage SPP1 tail spike protein gp21 on host cell receptor binding and trigger of phage DNA ejection. Molecular microbiology. vol 83. issue 2. 2012-05-01. PMID:22171743.' |
extracts from b. subtilis-infected cells applied to a yueb affinity matrix led to preferential capturing of gp21 from spp1. |
2012-05-01 |
2023-08-12 |
Not clear |
| Leping Ye, Binghai Zhao, Kaiming Yuan, Yanhui Chu, Changchong Li, Connie Zhao, Qing-Quan Lian, Ren-Shan G. Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure. Toxicology letters. vol 209. issue 3. 2012-04-16. PMID:22237054. |
the other genes were primarily included in the categories of cytoskeletal structure (tpm1, tnnt2, actn3, myoz2, tmod1, and mfap5), extracellular matrix (ckm, lum, tnnc1, art3, dcn, col17a1, aspn, ctsk, itm2a, spock2 and orm1), transporting (cox8h, cox6a2 and scnn1a) and secreted proteins (scgb3a1, nppb and spp1). |
2012-04-16 |
2023-08-12 |
rat |
| Jacqueline D Peacock, Danielle J Huk, Hasini N Ediriweera, Joy Lincol. Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046352. |
sox9 transcriptionally represses spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. |
2012-03-26 |
2023-08-12 |
mouse |
| Jacqueline D Peacock, Danielle J Huk, Hasini N Ediriweera, Joy Lincol. Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046352. |
in addition, sox9 knockdown in post natal mouse heart valve explants and rib chondrocyte cultures promotes spp1 expression and matrix mineralization, while attenuating expression of cartilage genes type ii collagen and cartilage link protein. |
2012-03-26 |
2023-08-12 |
mouse |
| Jacqueline D Peacock, Danielle J Huk, Hasini N Ediriweera, Joy Lincol. Sox9 transcriptionally represses Spp1 to prevent matrix mineralization in maturing heart valves and chondrocytes. PloS one. vol 6. issue 10. 2012-03-26. PMID:22046352. |
further, we show that spp1 is required for matrix mineralization induced by sox9 knockdown. |
2012-03-26 |
2023-08-12 |
mouse |
| Ignacio Fernández, Maria Darias, Karl B Andree, David Mazurais, Jose Luís Zambonino-Infante, Enric Gisber. Coordinated gene expression during gilthead sea bream skeletogenesis and its disruption by nutritional hypervitaminosis A. BMC developmental biology. vol 11. 2011-07-22. PMID:21306609. |
therefore, in order to gain further knowledge of fish larval development and its disruption by nutritional va imbalance, the relative expression of some rars and rxrs, as well as several genes involved in morpho- and skeletogenesis such as peroxisome proliferator-activated receptors (ppara, pparb and pparg); retinol-binding protein (rbp); insulin-like growth factors i and ii (igf1 and igf2, respectively); bone morphogenetic protein 2 (bmp2); transforming growth factor β-1 (tgfb1); and genes encoding different extracellular matrix (ecm) proteins such as matrix gla protein (mgp), osteocalcin (bglap), osteopontin (spp1), secreted protein acidic and rich in cysteine (sparc) and type i collagen α1 chain (col1a1) have been studied in gilthead sea bream. |
2011-07-22 |
2023-08-12 |
Not clear |