| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiao-Liang Xu, Hui Liu, Ying Zhang, Su-Xin Zhang, Zhong Chen, Yang Bao, Tian-Ke L. SPP1 and FN1 are significant gene biomarkers of tongue squamous cell carcinoma. Oncology letters. vol 22. issue 4. 2021-08-31. PMID:34457068. |
the top 11 candidate hub genes were acquired, namely plasminogen activator urokinase (plau), signal transducer and activator of transcription 1, c-x-c motif chemokine ligand 12, matrix metallopeptidase (mmp) 13, secreted phosphoprotein 1 (spp1), periostin, mmp1, mmp3, fibronectin 1 (fn1), serpin family e member 1 and snail family transcriptional repressor 2. |
2021-08-31 |
2023-08-13 |
Not clear |
| Zhikai Lin, Cristina Nica, Anton Sculean, Maria B Asparuhov. Positive Effects of Three-Dimensional Collagen-Based Matrices on the Behavior of Osteoprogenitors. Frontiers in bioengineering and biotechnology. vol 9. 2021-08-10. PMID:34368101. |
in contrast to genes encoding the bone matrix proteins collagen type i (col1a1) and osteopontin (spp1) induced by all matrices, the expression of the osteogenic differentiation markers runx2, alpl, dlx5, ibsp, bglap2, and phex was significantly increased in cells grown on hadm and ccm only. |
2021-08-10 |
2023-08-13 |
Not clear |
| Michael P Whyte, S Deepak Amalnath, William H McAlister, Marc D McKee, Deborah J Veis, Margaret Huskey, Shenghui Duan, Vinieth N Bijanki, Suhas Alur, Steven Mum. Hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of DMP1 encoding dentin matrix protein 1 and SPP1 encoding osteopontin: The first digenic SIBLING protein osteopathy? Bone. vol 132. 2021-06-17. PMID:31843680. |
hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of dmp1 encoding dentin matrix protein 1 and spp1 encoding osteopontin: the first digenic sibling protein osteopathy? |
2021-06-17 |
2023-08-13 |
Not clear |
| Michael P Whyte, S Deepak Amalnath, William H McAlister, Marc D McKee, Deborah J Veis, Margaret Huskey, Shenghui Duan, Vinieth N Bijanki, Suhas Alur, Steven Mum. Hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of DMP1 encoding dentin matrix protein 1 and SPP1 encoding osteopontin: The first digenic SIBLING protein osteopathy? Bone. vol 132. 2021-06-17. PMID:31843680. |
the siblings are a subfamily of the secreted calcium-binding phosphoproteins and comprise five small integrin-binding ligand n-linked glycoproteins [dentin matrix protein-1 (dmp1), secreted phosphoprotein-1 (spp1) also called osteopontin (opn), integrin-binding sialoprotein (ibsp) also called bone sialoprotein (bsp), matrix extracellular phosphoglycoprotein (mepe), and dentin sialophosphoprotein (dspp)]. |
2021-06-17 |
2023-08-13 |
Not clear |
| Margareta Žlajpah, Nina Hauptman, Emanuela Boštjančič, Nina Zida. Differential expression of extracellular matrix‑related genes DCN, EPHA4, FN1, SPARC, SPON2 and SPP1 in colorectal carcinogenesis. Oncology reports. vol 42. issue 4. 2021-04-26. PMID:31524274. |
the present study validated the diagnostic and prognostic significance of 6 components of the extracellular matrix (ecm) that were identified in the previous bioinformatics analysis [decorin (dcn), erythropoietin‑producing hepatoma receptor a4 (epha4), fibronectin 1 (fn1), secreted protein acidic and cysteine rich (sparc), spondin 2 (spon2) and secreted phosphoprotein 1 (spp1)], by analyzing their gene and protein expression levels in all samples. |
2021-04-26 |
2023-08-13 |
Not clear |
| Chaoran Yu, Jie Chen, Junjun Ma, Lu Zang, Feng Dong, Jing Sun, Minhua Zhen. Identification of Key Genes and Signaling Pathways Associated with the Progression of Gastric Cancer. Pathology oncology research : POR. vol 26. issue 3. 2021-04-06. PMID:31848941. |
the ppi network-derived hub genes included collagen type i alpha 1 chain (col1a1), tissue inhibitor of the metalloproteinases (timp1), secreted phosphoprotein 1 (spp1), somatostatin (sst), neuropeptide y (npy), biglycan (bgn), matrix metallopeptidase 3 (mmp3), apolipoprotein e (apoe), atpase h+/k+ transporting alpha subunit (atp4a), lysyl oxidase (lox). |
2021-04-06 |
2023-08-13 |
Not clear |
| Yewen Shi, Dongmin Chang, Wenhan Li, FengYu Zhao, Xiaoyong Ren, Bin Ho. Identification of core genes and clinical outcomes in tumors originated from endoderm (gastric cancer and lung carcinoma) via bioinformatics analysis. Medicine. vol 100. issue 12. 2021-04-05. PMID:33761685. |
twelve candidate genes with positive statistical significance (p < .01), comp cthrc1 col1a1 spp1 col11a1 col10a1 cxcl13 cldn3 cldn1 matrix metalloproteinases 7 adam12 plau, were picked out to further analysis. |
2021-04-05 |
2023-08-13 |
Not clear |
| Yao Peng, Xin-Huan Wang, Chao-Nan Su, Wei-Wei Qiao, Qian Gao, Xue-Fei Sun, Liu-Yan Men. RNA-seq analysis of palatal transcriptome changes in all-trans retinoic acid-induced cleft palate of mice. Environmental toxicology and pharmacology. vol 80. 2021-02-10. PMID:32569741. |
in addition, gene oncology analysis showed that transcriptional changes of genes from extracellular matrix (ecm) components, such as spp1, and crystallin family might play important role in palatal shelves elevation (e13.5-e14.5). |
2021-02-10 |
2023-08-13 |
mouse |
| Guoqiang Xu, Jianing Wei, Bing Huangfu, Jiping Gao, Xiaotang Wang, Lanfei Xiao, Ruijing Xuan, Zhaoyang Chen, Guohua Son. Animal model and bioinformatics analyses suggest the TIMP1/MMP9 axis as a potential biomarker in oral squamous cell carcinoma. Molecular carcinogenesis. vol 59. issue 11. 2020-12-01. PMID:33006223. |
gepia and ppi network analysis revealed that spp1, tnc, and acta1 were significantly related to tumor staging; spp1, tissue inhibitors of matrix metallopeptidases (mmps) 1 (timp1), and acta1 were closely related to prognosis. |
2020-12-01 |
2023-08-13 |
Not clear |
| Xiaocong Pang, Ran Xie, Zhuo Zhang, Qianxin Liu, Shiliang Wu, Yimin Cu. Identification of SPP1 as an Extracellular Matrix Signature for Metastatic Castration-Resistant Prostate Cancer. Frontiers in oncology. vol 9. 2020-09-30. PMID:31620371. |
identification of spp1 as an extracellular matrix signature for metastatic castration-resistant prostate cancer. |
2020-09-30 |
2023-08-13 |
Not clear |
| Laura González-González, Javier Alons. Periostin: A Matricellular Protein With Multiple Functions in Cancer Development and Progression. Frontiers in oncology. vol 8. 2020-09-29. PMID:29946533. |
many components of this family such as periostin (postn), osteopontin (spp1), or the cnn family of proteins have been shown to regulate key aspect of tumor biology, including proliferation, invasion, matrix remodeling, and dissemination to pre-metastatic niches in distant organs. |
2020-09-29 |
2023-08-13 |
Not clear |
| Irina Kramerova, Chino Kumagai-Cresse, Natalia Ermolova, Ekaterina Mokhonova, Masha Marinov, Joana Capote, Diana Becerra, Mattia Quattrocelli, Rachelle H Crosbie, Ellen Welch, Elizabeth M McNally, Melissa J Spence. Spp1 (osteopontin) promotes TGFβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases. Human molecular genetics. vol 28. issue 20. 2020-09-21. PMID:31411676. |
spp1 (osteopontin) promotes tgfβ processing in fibroblasts of dystrophin-deficient muscles through matrix metalloproteinases. |
2020-09-21 |
2023-08-13 |
mouse |
| G Beltramini, A Russillo, C Baserga, A Pellati, A Piva, V Candott. Collagenated heterologous cortico-cancelleus bone mix stimulated dental pulp derived stem cells. Journal of biological regulators and homeostatic agents. vol 34. issue 1 Suppl. 2. 2020-06-26. PMID:32270661. |
the obtained results demonstrated that chccbm enhance stem cells differentiation and deposition of matrix by the activation of osteoblast related genes sp7, fosl1 and spp1. |
2020-06-26 |
2023-08-13 |
human |
| Silvia Ruiz-Gaspà, Nuria Guañabens, Susana Jurado, Marta Dubreuil, Andres Combalia, Pilar Peris, Ana Monegal, Albert Paré. Bile acids and bilirubin effects on osteoblastic gene profile. Implications in the pathogenesis of osteoporosis in liver diseases. Gene. vol 725. 2020-01-06. PMID:31639434. |
several genes were up-regulated by lca, most of them pro-apoptotic (bax, bcl10, bcl2l13, bcl2l14), but also mgp (matrix gla protein), bglap (osteocalcin), spp1 (osteopontin) and cyp24a1, and down-regulated bone morphogenic protein genes (bmp3 and bmp4) and dkk1 (dickkopf-related protein 1). |
2020-01-06 |
2023-08-13 |
human |
| Nicola Chiarelli, Giulia Carini, Nicoletta Zoppi, Marco Ritelli, Marina Colomb. Molecular insights in the pathogenesis of classical Ehlers-Danlos syndrome from transcriptome-wide expression profiling of patients' skin fibroblasts. PloS one. vol 14. issue 2. 2019-11-12. PMID:30716086. |
transcriptome profiling revealed significant changes in the expression levels of different extracellular matrix (ecm)-related genes, such as spp1, postn, edil3, igfbp2, and c3, which encode both matricellular and soluble proteins that are mainly involved in cell proliferation and migration, and cutaneous wound healing. |
2019-11-12 |
2023-08-13 |
Not clear |
| Mourad Assidi, Wafaey Gomaa, Mohammad Jafri, Mehenaz Hanbazazh, Mahmoud Al-Ahwal, Peter Pushparaj, Asia Al-Harbi, Mohammed Al-Qahtani, Abdelbaset Buhmeida, Jaudah Al-Maghrab. Prognostic value of Osteopontin (SPP1) in colorectal carcinoma requires a personalized molecular approach. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 41. issue 9. 2019-09-16. PMID:31500540. |
osteopontin (spp1) is a key extracellular matrix protein involved in several pathophysiological processes including cancer progression and metastasis. |
2019-09-16 |
2023-08-13 |
Not clear |
| L B Buravkova, E R Andreeva, M V Lobanova, E V Cotnezova, A I Grigorie. The Differential Expression of Adhesion Molecule and Extracellular Matrix Genes in Mesenchymal Stromal Cells after Interaction with Cord Blood Hematopoietic Progenitors. Doklady. Biochemistry and biophysics. vol 479. issue 1. 2018-07-05. PMID:29779099. |
after 72 h of culturing, a downregulation of the genes encoding the majority of matrix molecules (spp1; col6a2,7a1; mmp1,3; timp1,3; and has1) and cell-matrix adhesion molecules (itgs) was revealed. |
2018-07-05 |
2023-08-13 |
human |
| Yu Li, Wei Du, Jian Han, Junbo G. LAMP3 promotes the invasion of osteosarcoma cells via SPP1 signaling. Molecular medicine reports. vol 16. issue 5. 2018-06-07. PMID:28849219. |
furthermore, knockdown of lamp3 increased the expression of secreted phosphoprotein 1 (spp1), cadherin 1, and keratin 19, while it decreased the expression of matrix metallopeptidase 2, collagen type iii α 1, twist family bhlh transcription factor 1 and cadherin 2. |
2018-06-07 |
2023-08-13 |
Not clear |
| AtLee T D Watson, Antonio Planchart, Carolyn J Mattingly, Christoph Winkler, David M Reif, Seth W Kullma. From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka, Oryzias latipes. Toxicological sciences : an official journal of the Society of Toxicology. vol 155. issue 2. 2018-04-26. PMID:28077779. |
endogenous expression of osteogenic regulators runt-related transcription factor 2 (runx2) and osterix (osx/sp7), and extracellular matrix genes osteopontin (spp1), collagen type i alpha i (col1), collagen type x alpha i (col10a1), and osteocalcin (bglap/osc) was significantly diminished at 20 dpf following tcdd exposure as compared with controls. |
2018-04-26 |
2023-08-13 |
human |
| Toshihisa Komor. Roles of Runx2 in Skeletal Development. Advances in experimental medicine and biology. vol 962. 2017-09-26. PMID:28299652. |
it regulates the expression of sp7, the protein of which is a crucial transcription factor for osteoblast differentiation, as well as that of bone matrix genes including spp1, ibsp, and bglap2. |
2017-09-26 |
2023-08-13 |
Not clear |