| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tamar L Ben-Shaanan, Konrad Knöpper, Lihui Duan, Ruiqi Liu, Hanna Taglinao, Ying Xu, Jinping An, Maksim V Plikus, Jason G Cyste. Dermal TRPV1 innervations engage a macrophage- and fibroblast-containing pathway to activate hair growth in mice. Developmental cell. 2024-06-08. PMID:38851191. |
the neuropeptide cgrp and the extracellular matrix protein spp1 were required for the nociceptor-triggered hair growth. |
2024-06-08 |
2024-06-11 |
mouse |
| Xun Chen, Chaofeng Wang, Guolong Zhao, Zhong Li, Wentao Zhang, Tao Song, Congming Zhang, Ning Dua. Suppression of DNMT2/3 by proinflammatory cytokines inhibits CtBP1/2-dependent genes to promote the occurrence of atrophic nonunion. Cytokine. vol 173. 2023-11-18. PMID:37979214. |
increased ctbp1/2 acts as transcriptional corepressors that, along with histone acetyltransferase p300 and runt-related transcription factor 2 (runx2), suppress the expression levels of six genes involved in bone healing: bglap (bone gamma-carboxyglutamate protein), alpl (alkaline phosphatase), spp1 (secreted phosphoprotein 1), col1a1 (collagen 1a1), ibsp (integrin binding sialoprotein), and mmp13 (matrix metallopeptidase 13). |
2023-11-18 |
2023-11-20 |
mouse |
| Fatma F Mohamed, Betty Hoac, Aonjittra Phanrungsuwan, Michelle H Tan, Priscila Alves Giovani, Sana Ghiba, Monzur Murshed, Brian L Foster, Marc D McKe. Contributions of increased osteopontin and hypophosphatemia to dentoalveolar defects in osteomalacic Hyp mice. Bone. 2023-08-27. PMID:37634682. |
the mineralization-inhibiting, secreted extracellular matrix phosphoprotein osteopontin (opn, gene spp1) is a substrate for the phex enzyme whereby extensive and inactivating degradation of inhibitory opn by phex facilitates mineralization. |
2023-08-27 |
2023-09-07 |
mouse |
| Yu Wang, Di Li, Dan Li, Honglei Wang, Yu W. Integrated bioinformatics analysis for exploring hub genes and related mechanisms affecting the progression of gastric cancer. Biotechnology & genetic engineering reviews. 2023-05-27. PMID:37243583. |
twelve hub genes were screened by cytoscape, including cholecystokinin b receptor (cckbr), collagen type i alpha 1 (col1a1), col1a2, col2a1, col6a3, col11a1, matrix metallopeptidase 1 (mmp1), mmp3, mmp7, mmp10, tissue inhibitor of matrix metalloprotease 1 (timp1) and secreted phosphoprotein 1 (spp1). |
2023-05-27 |
2023-08-14 |
Not clear |
| Jiawei Yin, Xiaoli Xie, Yanchun Quan, Zhiqiang Wang, Shu Liu, Quanping Su, Fengyuan Che, Lijuan Wan. RNA-seq analysis reveals candidate genes associated with proliferation, invasion, and migration in BCL11A knockdown B-NHL cell lines. Annals of hematology. 2023-05-06. PMID:37148312. |
rna sequencing (rna-seq) and kegg pathway analysis demonstrated that bcl11a-targeted genes were significantly enriched in the pi3k/akt signaling pathway, focal adhesion, and extracellular matrix (ecm)-receptor interaction (including col4a1, col4a2, fn1, spp1), and spp1 was the most significantly downregulated gene. |
2023-05-06 |
2023-08-14 |
Not clear |
| Chen Li, Yi-Hong Qia. Inflammation-dependent activation of NCOA2 associates with p300 and c-MYC/Max heterodimer to transactivate RUNX2-AS1 and mediate RUNX2 downstream bone differentiation genes in the pathology of septic nonunion. Cytokine. vol 158. 2022-08-14. PMID:35964415. |
overexpression or knockdown of runx2-as1 in vitro could inhibit or induce, respectively, the expression of runx2 and runx2-downstream target genes, including alpl (alkaline phosphatase), col1a1 (collagen type i alpha 1 chain), ibsp (integrin binding sialoprotein), mmp13 (matrix metallopeptidases), and spp1 (secreted phosphoprotein 1), which are involved in bone differentiation. |
2022-08-14 |
2023-08-14 |
Not clear |
| Toshihisa Komor. Whole Aspect of Runx2 Functions in Skeletal Development. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628587. |
in endochondral ossification, runx2 induces chondrocyte maturation, enhances chondrocyte proliferation through indian hedgehog (ihh) induction, and induces the expression of vascular endothelial growth factor a (vegfa), secreted phosphoprotein 1 (spp1), integrin-binding sialoprotein (ibsp), and matrix metallopeptidase 13 (mmp13) in the terminal hypertrophic chondrocytes. |
2022-05-28 |
2023-08-13 |
mouse |
| Toshihisa Komor. Whole Aspect of Runx2 Functions in Skeletal Development. International journal of molecular sciences. vol 23. issue 10. 2022-05-28. PMID:35628587. |
in immature osteoblasts, runx2 regulates the expression of bone matrix protein genes, including col1a1, col1a2, spp1, ibsp, and bone gamma carboxyglutamate protein (bglap)/bglap2, and induces osteoblast maturation. |
2022-05-28 |
2023-08-13 |
mouse |
| Ashley Yim, Christian Smith, Amanda M Brow. Osteopontin/secreted phosphoprotein-1 harnesses glial-, immune-, and neuronal cell ligand-receptor interactions to sense and regulate acute and chronic neuroinflammation. Immunological reviews. 2022-04-22. PMID:35451082. |
osteopontin (opn) also known by its official gene designation secreted phosphoprotein-1 (spp1) is a fascinating, multifunctional protein expressed in a number of cell types that functions not only in intercellular communication, but also in the extracellular matrix (ecm). |
2022-04-22 |
2023-08-13 |
Not clear |
| Yanqing Wu, Peng Duan, Yujiao Wen, Jin Zhang, Xiaoli Wang, Juan Dong, Qiang Zhao, Shenglei Feng, Chunyu Lv, Yang Guo, Satoshi H Namekawa, Shuiqiao Yua. UHRF1 establishes crosstalk between somatic and germ cells in male reproduction. Cell death & disease. vol 13. issue 4. 2022-04-20. PMID:35440090. |
rna sequencing and whole genome bisulfite sequencing (wgbs) revealed that many extracellular matrix (ecm)-related genes (e.g., timp1, trf, and spp1) appeared upregulated with the dna hypomethylation status in uhrf1-deficient scs. |
2022-04-20 |
2023-08-13 |
mouse |
| Mihaela Chivu-Economescu, Laura G Necula, Lilia Matei, Denisa Dragu, Coralia Bleotu, Andrei Sorop, Vlad Herlea, Simona Dima, Irinel Popescu, Carmen C Diacon. Collagen Family and Other Matrix Remodeling Proteins Identified by Bioinformatics Analysis as Hub Genes Involved in Gastric Cancer Progression and Prognosis. International journal of molecular sciences. vol 23. issue 6. 2022-03-25. PMID:35328635. |
ppi network analysis and mcode plug-in pointed out nine upregulated hub genes coding for proteins from the collagen family (col12a1, col5a2, and col10a1) or involved in the assembly (bgn) or degradation of collagens (cthrc1), and also associated with cell adhesion (thbs2 and spp1) and extracellular matrix degradation (fap, sulf1). |
2022-03-25 |
2023-08-13 |
Not clear |
| Majid Mehravar, Fatemeh Ghaemimanesh, Ensieh M Poursan. Alternative polyadenylation mechanism links secreted phosphoprotein 1 gene to glioblastoma. Cancer biomarkers : section A of Disease markers. 2022-03-11. PMID:35275520. |
secreted phosphoprotein 1 (spp1), also known as osteopontin (opn), is a multifunctional protein expressed in diverse normal tissues, and functionally is involved in cellular matrix and signaling processes. |
2022-03-11 |
2023-08-13 |
Not clear |
| Qi Yang, Hongman Zhang, Ting Wei, Anqi Lin, Yueqin Sun, Peng Luo, Jian Zhan. Single-Cell RNA Sequencing Reveals the Heterogeneity of Tumor-Associated Macrophage in Non-Small Cell Lung Cancer and Differences Between Sexes. Frontiers in immunology. vol 12. 2021-11-23. PMID:34804043. |
in terms of the differentially expressed genes, the complement gene c1qc and the matrix remodeling relevant genes fn1 and spp1 were differentially expressed in the tams between sexes, of which the male upregulated spp1 showed the potential as an ideal target for adjuvant immunotherapy and improving the efficacy of immunotherapy. |
2021-11-23 |
2023-08-13 |
Not clear |
| Avery C Kramer, David W Erikson, Bryan A McLendon, Heewon Seo, Kanako Hayashi, Thomas E Spencer, Fuller W Bazer, Robert C Burghardt, Greg A Johnso. SPP1 expression in the mouse uterus and placenta: implications for implantation†. Biology of reproduction. vol 105. issue 4. 2021-11-18. PMID:34165144. |
secreted phosphoprotein 1 (spp1, also known as osteopontin) binds integrins to mediate cell-cell and cell-extracellular matrix communication to promote cell adhesion, migration, and differentiation. |
2021-11-18 |
2023-08-13 |
mouse |
| Tina D Tremaine, Ali A Fouladi-Nasht. Steroid regulation of secreted phosphoprotein 1 (SPP1) expression in ovine endometrium. Reproduction, fertility, and development. vol 33. issue 4. 2021-11-04. PMID:33541520. |
secreted phosphoprotein 1 (spp1) is an extracellular matrix glycoprotein that is highly expressed at the maternal-fetal interface and is a critical mediator of embryo implantation. |
2021-11-04 |
2023-08-13 |
Not clear |
| Destiny N Johns, Caroline G Lucas, Caroline A Pfeiffer, Paula R Chen, Ashley E Meyer, Shelbi D Perry, Lee D Spate, Raissa F Cecil, Melissa A Fudge, Melissa S Samuel, Christine M Spinka, Hongyu Liu, Matthew C Lucy, Kevin D Wells, Randall S Prather, Thomas E Spencer, Rodney D Geiser. Conceptus interferon gamma is essential for establishment of pregnancy in the pig. Biology of reproduction. 2021-10-05. PMID:34608481. |
the endometrial stromal extracellular matrix was altered in the ifng-/- embryo pregnancies and there was an increased endometrial mrna levels for collagen xvii (col17a1), matrilin 1 (matn1), secreted phosphoprotein 1 (spp1) and cysteine-rich secretory protein 3 (crisp3), which are involved with repair and remodeling of the extracellular matrix. |
2021-10-05 |
2023-08-13 |
Not clear |
| Yifeng Luo, Hui Yi, Xinyan Huang, Gengpeng Lin, Yukun Kuang, Yubiao Guo, Canmao Xi. Inhibition of macrophage migration inhibitory factor (MIF) as a therapeutic target in bleomycin-induced pulmonary fibrosis rats. American journal of physiology. Lung cellular and molecular physiology. vol 321. issue 1. 2021-10-04. PMID:33881353. |
the results showed that mif inhibition attenuated lung injury and extracellular matrix deposition; significantly reduced the levels of cytokines including transforming growth factor-β1 (tgf-β1), tumor necrosis factor-α (tnf-α), interleukin-17 (il-17), hydroxyproline (hyp), fibroblast growth factor 23 (fgf23), and secreted phosphoprotein 1 (spp1); and inhibited the expression of cd68, f4/80, and α-smooth muscle actin (α-sma) protein. |
2021-10-04 |
2023-08-13 |
rat |
| Xiao-Liang Xu, Hui Liu, Ying Zhang, Su-Xin Zhang, Zhong Chen, Yang Bao, Tian-Ke L. SPP1 and FN1 are significant gene biomarkers of tongue squamous cell carcinoma. Oncology letters. vol 22. issue 4. 2021-08-31. PMID:34457068. |
the top 11 candidate hub genes were acquired, namely plasminogen activator urokinase (plau), signal transducer and activator of transcription 1, c-x-c motif chemokine ligand 12, matrix metallopeptidase (mmp) 13, secreted phosphoprotein 1 (spp1), periostin, mmp1, mmp3, fibronectin 1 (fn1), serpin family e member 1 and snail family transcriptional repressor 2. |
2021-08-31 |
2023-08-13 |
Not clear |
| Zhikai Lin, Cristina Nica, Anton Sculean, Maria B Asparuhov. Positive Effects of Three-Dimensional Collagen-Based Matrices on the Behavior of Osteoprogenitors. Frontiers in bioengineering and biotechnology. vol 9. 2021-08-10. PMID:34368101. |
in contrast to genes encoding the bone matrix proteins collagen type i (col1a1) and osteopontin (spp1) induced by all matrices, the expression of the osteogenic differentiation markers runx2, alpl, dlx5, ibsp, bglap2, and phex was significantly increased in cells grown on hadm and ccm only. |
2021-08-10 |
2023-08-13 |
Not clear |
| Michael P Whyte, S Deepak Amalnath, William H McAlister, Marc D McKee, Deborah J Veis, Margaret Huskey, Shenghui Duan, Vinieth N Bijanki, Suhas Alur, Steven Mum. Hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of DMP1 encoding dentin matrix protein 1 and SPP1 encoding osteopontin: The first digenic SIBLING protein osteopathy? Bone. vol 132. 2021-06-17. PMID:31843680. |
hypophosphatemic osteosclerosis, hyperostosis, and enthesopathy associated with novel homozygous mutations of dmp1 encoding dentin matrix protein 1 and spp1 encoding osteopontin: the first digenic sibling protein osteopathy? |
2021-06-17 |
2023-08-13 |
Not clear |