| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Werner, Y Koch, F Baldino, I Goze. Steroid regulation of somatostatin mRNA in the rat hypothalamus. The Journal of biological chemistry. vol 263. issue 16. 1988-06-29. PMID:2897361. |
in contrast, there was no significant change in cerebral cortex somatostatin mrna levels after gonadectomy. |
1988-06-29 |
2023-08-11 |
rat |
| O P Rorsta. Evidence for the presence of dihydro (reduced) somatostatin-14 in the guinea pig brain. Peptides. vol 8. issue 5. 1988-03-02. PMID:2893359. |
the proportion of the [h2]somatostatin peak in five brain regions, the hypothalamus, amygdala, cerebral cortex, brainstem and cerebellum, ranged from 6 to 20% of total sli. |
1988-03-02 |
2023-08-11 |
Not clear |
| G W Arendash, W J Millard, A J Dunn, E M Meye. Long-term neuropathological and neurochemical effects of nucleus basalis lesions in the rat. Science (New York, N.Y.). vol 238. issue 4829. 1987-12-09. PMID:2890210. |
bilateral lesions of the nucleus basalis magnocellularis increased somatostatin and neuropeptide y in the cortex of the rat by at least 138 and 284 percent, respectively, suggesting a functional interaction between cholinergic and peptidergic neurons that may differ from that in alzheimer's disease. |
1987-12-09 |
2023-08-11 |
rat |
| F R Sharp, M F Gonzalez, S M Saga. Fetal frontal cortex transplanted to injured motor/sensory cortex of adult rats. II. VIP-, somatostatin-, and NPY-immunoreactive neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 7. issue 10. 1987-11-23. PMID:2889809. |
fetal frontal cortex transplants that survived 2-9 months in cavities in adult rat motor/sensory cortex were processed for vasoactive intestinal polypeptide (vip), somatostatin 14 (ss), and neuropeptide y (npy) immunocytochemistry, and nadph-diaphorase (nadph-d) histochemistry. |
1987-11-23 |
2023-08-11 |
rat |
| G Jeffery, J G Parnavela. Early visual deafferentation of the cortex results in an asymmetry of somatostatin labelled cells. Experimental brain research. vol 67. issue 3. 1987-11-18. PMID:2888682. |
early visual deafferentation of the cortex results in an asymmetry of somatostatin labelled cells. |
1987-11-18 |
2023-08-11 |
rat |
| G Jeffery, J G Parnavela. Early visual deafferentation of the cortex results in an asymmetry of somatostatin labelled cells. Experimental brain research. vol 67. issue 3. 1987-11-18. PMID:2888682. |
because the uncrossed retinal projection is so small in the rodent, this manipulation substantially reduces the visual innervation of the cortex ipsilateral to the remaining eye, and is correlated here with an asymmetry in the number of somatostatin positive cells. |
1987-11-18 |
2023-08-11 |
rat |
| C A Whitford, J M Candy, C R Snell, B H Hirst, A E Oakley, M Johnson, J E Thompso. Autoradiographic visualization of binding sites for [3H]somatostatin in the rat brain. European journal of pharmacology. vol 138. issue 3. 1987-10-09. PMID:2887442. |
the distribution of binding sites using 0.7 nm [3h]somatostatin confirmed that previously described for iodinated tyrosyl analogues of somatostatin, with highest densities of sites in the cerebral cortex (particularly in laminae iii-v), amygdala, lateral septal nucleus, hippocampus and claustrum. |
1987-10-09 |
2023-08-11 |
rat |
| H Chneiweiss, P Bertrand, J Epelbaum, C Kordon, J Glowinski, J Premont, A Enjalber. Somatostatin receptors on cortical neurones and adenohypophysis: comparison between specific binding and adenylate cyclase inhibition. European journal of pharmacology. vol 138. issue 2. 1987-09-25. PMID:2887438. |
primary cultures of mouse embryonic neurones from the cerebral cortex and rat pituitary membranes were used to identify and characterize further the somatostatin receptors coupled to an adenylate cyclase and to compare these receptors with specific binding sites for a non-reducible somatostatin analog. |
1987-09-25 |
2023-08-11 |
mouse |
| V Chan-Pala. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. The Journal of comparative neurology. vol 260. issue 2. 1987-09-15. PMID:2886516. |
somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide y neurons, and effects in alzheimer-type dementia. |
1987-09-15 |
2023-08-11 |
human |
| V Chan-Pala. Somatostatin immunoreactive neurons in the human hippocampus and cortex shown by immunogold/silver intensification on vibratome sections: coexistence with neuropeptide Y neurons, and effects in Alzheimer-type dementia. The Journal of comparative neurology. vol 260. issue 2. 1987-09-15. PMID:2886516. |
the distribution of somatostatin immunoreactive neurons and fibers parallels the distribution of neuropeptide y (npy) neurons and fibers in the hippocampus and cerebral cortex to a remarkable extent. |
1987-09-15 |
2023-08-11 |
human |
| M F Beal, M F Mazurek, J B Marti. A comparison of somatostatin and neuropeptide Y distribution in monkey brain. Brain research. vol 405. issue 2. 1987-06-08. PMID:3567602. |
the high levels in cerebral cortex and basal ganglia suggest that somatostatin and neuropeptide y may play a role both in cognition and in normal motor function. |
1987-06-08 |
2023-08-11 |
human |
| J C Reubi, A Probst, R Cortés, J M Palacio. Distinct topographical localisation of two somatostatin receptor subpopulations in the human cortex. Brain research. vol 406. issue 1-2. 1987-06-05. PMID:2882820. |
distinct topographical localisation of two somatostatin receptor subpopulations in the human cortex. |
1987-06-05 |
2023-08-11 |
human |
| J C Reubi, A Probst, R Cortés, J M Palacio. Distinct topographical localisation of two somatostatin receptor subpopulations in the human cortex. Brain research. vol 406. issue 1-2. 1987-06-05. PMID:2882820. |
the use of two different radioligands, [125i]leu8, d-tryp22,tyr25-somatostatin-28 and the stable somatostatin octapeptide analog [125i]204-090, d-phe-cys[125i]tyr-d-trp-lys-thr-cys-thr(ol), allowed to differentiate between two somatostatin receptor subpopulations in the human cortex. |
1987-06-05 |
2023-08-11 |
human |
| W Bondareff, C Q Mountjoy, M Roth, M N Rossor, L L Iversen, G P Reynold. Age and histopathologic heterogeneity in Alzheimer's disease. Evidence for subtypes. Archives of general psychiatry. vol 44. issue 5. 1987-05-29. PMID:2883954. |
the ad-2 cases were associated with less choline acetyltransferase activity, smaller concentrations of somatostatin and norepinephrine, and more plaques and tangles in the cerebral cortex. |
1987-05-29 |
2023-08-11 |
Not clear |
| R McCarty, L M Plunket. Quantitative autoradiographic analysis of somatostatin binding sites in discrete areas of rat forebrain. Brain research bulletin. vol 18. issue 1. 1987-05-04. PMID:2881615. |
highest concentrations of somatostatin binding sites (fmol/mg protein) were found in the claustrum (151), basolateral nucleus of the amygdala (90), deep layers of the cerebral cortex (61), lateral olfactory nuclei (58), ca1 and ca2 areas of hippocampus (57), medial and lateral septal nuclei (54), and the medial habenula (44). |
1987-05-04 |
2023-08-11 |
rat |
| R J Boakes, J A Cour. Failure of carbachol to influence the release of somatostatin from slices of rat cerebral cortex. Brain research. vol 397. issue 1. 1987-02-27. PMID:2879603. |
failure of carbachol to influence the release of somatostatin from slices of rat cerebral cortex. |
1987-02-27 |
2023-08-11 |
rat |
| M F Beal, J B Marti. Neuropeptides in neurological disease. Annals of neurology. vol 20. issue 5. 1986-12-24. PMID:2947536. |
the reduced cortical concentrations of somatostatin and neuropeptide y in ad cerebral cortex may reflect a loss of neurons or terminals in which these two peptides are co-localized. |
1986-12-24 |
2023-08-11 |
Not clear |
| D Dawbarn, M N Rossor, C Q Mountjoy, M Roth, P C Emso. Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type. Neuroscience letters. vol 70. issue 1. 1986-12-17. PMID:2877420. |
decreased somatostatin immunoreactivity but not neuropeptide y immunoreactivity in cerebral cortex in senile dementia of alzheimer type. |
1986-12-17 |
2023-08-11 |
Not clear |
| D M Mann, P O Yate. Neurotransmitter deficits in Alzheimer's disease and in other dementing disorders. Human neurobiology. vol 5. issue 3. 1986-12-09. PMID:2876973. |
within the cortex, somatostatin containing neurones and the large pyramidal cells, presumed to use glutamate/aspartate as transmitters, are the most severely damaged cells. |
1986-12-09 |
2023-08-11 |
Not clear |
| J Pless, W Bauer, U Briner, W Doepfner, P Marbach, R Maurer, T J Petcher, J C Reubi, J Vondersche. Chemistry and pharmacology of SMS 201-995, a long-acting octapeptide analogue of somatostatin. Scandinavian journal of gastroenterology. Supplement. vol 119. 1986-11-17. PMID:2876507. |
the compound has been shown to inhibit growth of transplantable insulinomas in hamsters and to label selectively a subset of somatostatin receptors in the rat cortex. |
1986-11-17 |
2023-08-11 |
human |