All Relations between sod1 and lumbar

Publication Sentence Publish Date Extraction Date Species
Ermanna Turano, Federica Virla, Ilaria Scambi, Sylwia Dabrowska, Oluwamolakun Bankole, Raffaella Mariott. Adipose mesenchymal stem cells-derived extracellular vesicles exert their preferential action in damaged central sites of SOD1 mice rather than peripherally. European journal of histochemistry : EJH. vol 68. issue 3. 2024-07-04. PMID:38963135. repeated intranasal administrations of high doses of asc-evs were able to ameliorate motor performance of injected sod1(g93a) mice at the early stage of the disease and produce a significant improvement at the end-stage in the lumbar mns rescue. 2024-07-04 2024-07-10 mouse
Jing Yang, Cheng Xin, Jia Huo, Xin Li, Hui Dong, Qi Liu, Rui Li, Yaling Li. Rab Geranylgeranyltransferase Subunit Beta as a Potential Indicator to Assess the Progression of Amyotrophic Lateral Sclerosis. Brain sciences. vol 13. issue 11. 2023-11-25. PMID:38002490. in our previous studies, we found that the expression of rabggtase (low rabggtb expression and no change in rabggta) is lower in the lumbar and thoracic regions of spinal cord motoneurons in sod1g93a mice compared with wt (wild-type) mice groups, and upregulation of rabggtb promoted prenylation modification of rab7, which promoted autophagy to protect neurons by degrading sod1. 2023-11-25 2023-11-28 mouse
Jin Gao, Mingchen Jiang, Danilo Erricolo, Richard L Magin, Gerardo Morfini, Thomas Royston, Andrew C Larson, Weiguo L. Identifying potential imaging markers for diffusion property changes in a mouse model of amyotrophic lateral sclerosis: Application of the continuous time random walk model to ultrahigh b-value diffusion-weighted MR images of spinal cord tissue. NMR in biomedicine. 2023-09-18. PMID:37721118. the diffusion data were acquired in situ from the lumbar level of spinal cords of wild-type and age-matched transgenic sod1 2023-09-18 2023-10-07 mouse
Akiko Yamamuro-Tanabe, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshiok. Schwann cell derived-peroxiredoxin protects motor neurons against hydrogen peroxide-induced cell death in mouse motor neuron cell line NSC-34. Journal of pharmacological sciences. vol 153. issue 2. 2023-08-28. PMID:37640472. we found that the expression of prdx1 mrna was markedly downregulated in the lumbar spinal cord of the superoxide dismutase 1 (sod1) 2023-08-28 2023-09-07 mouse
Akiko Yamamuro-Tanabe, Yurika Mukai, Wataru Kojima, Siyuan Zheng, Naoko Matsumoto, Shoho Takada, Mao Mizuhara, Yasuhiro Kosuge, Yuki Ishimaru, Yasuhiro Yoshiok. An Increase in Peroxiredoxin 6 Expression Induces Neurotoxic A1 Astrocytes in the Lumbar Spinal Cord of Amyotrophic Lateral Sclerosis Mice Model. Neurochemical research. 2023-08-09. PMID:37556038. in this study, we observed that the expression of peroxiredoxin 6 (prdx6), a member of the peroxiredoxin family, was markedly upregulated in astrocytes of the lumbar spinal cord of sod1 2023-08-09 2023-08-16 mouse
Xiaojiao Xu, Qiu Yang, Zheyi Liu, Rong Zhang, Hang Yu, Manli Wang, Sheng Chen, Guowang Xu, Yaping Shao, Weidong L. Integrative analysis of metabolomics and proteomics unravels purine metabolism disorder in the SOD1 Neurobiology of disease. 2023-03-31. PMID:37001614. utilizing liquid chromatography-mass spectrometry-based metabolomics, we analyzed the metabolites levels of plasma, lumbar spinal cord, and motor cortex from sod1 2023-03-31 2023-08-14 Not clear
Jacques Durand, Anton Filipchu. Electrical and Morphological Properties of Developing Motoneurons in Postnatal Mice and Early Abnormalities in SOD1 Transgenic Mice. Advances in neurobiology. vol 28. 2022-09-06. PMID:36066832. in this chapter, we review electrical and morphological properties of lumbar motoneurons during postnatal development in wild-type (wt) and transgenic superoxide dismutase 1 (sod1) mice, models of amyotrophic lateral sclerosis. 2022-09-06 2023-08-14 mouse
Tomasz Jankowiak, Marcin Cholewiński, Marcin Bączy. Differential effects of invasive anodal trans-spinal direct current stimulation on monosynaptic EPSPs, Ia afferents excitability, and motoneuron intrinsic properties between SOD1 G93A and WT mice. Neuroscience. 2022-07-06. PMID:35792195. in this study, we have applied 15-minute tsdcs to the lumbar segments of presymptomatic sod1 and wildtype (wt) mice and explored its impact on mn passive membrane properties, epsp amplitude, and ia afferent activity. 2022-07-06 2023-08-14 mouse
Masaaki Yoshikawa, Chihiro Ishikawa, Haiyan Li, Takashi Kudo, Dai Shiba, Masaki Shirakawa, Masafumi Murtani, Satoru Takahashi, Shin Aizawa, Takashi Shig. Comparing effects of microgravity and amyotrophic lateral sclerosis in the mouse ventral lumbar spinal cord. Molecular and cellular neurosciences. 2022-06-06. PMID:35660087. in this study, to elucidate the motor system that is affected by each condition, we investigated the effects of mg and the human sod1 als mutation on gene expression in various cell types of the mouse ventral lumbar spinal cord, which is rich in motor neurons innervating the lower limb. 2022-06-06 2023-08-14 mouse
Tetsuya Asano, Haruko Nakamura, Yuko Kawamoto, Mikiko Tada, Yayoi Kimura, Hiroshi Takano, Ryoji Yao, Hiroya Saito, Takuya Ikeda, Hiroyasu Komiya, Shun Kubota, Shunta Hashiguchi, Keita Takahashi, Misako Kunii, Kenichi Tanaka, Yoshio Goshima, Fumio Nakamura, Hideyuki Takeuchi, Hiroshi Doi, Fumiaki Tanak. Inhibition of Crmp1 phosphorylation at Ser522 ameliorates motor function and neuronal pathology in amyotrophic lateral sclerosis model mice. eNeuro. 2022-05-06. PMID:35523582. using a comprehensive phosphoproteomic approach, we have identified elevated phosphorylation of collapsin response mediator protein 1 (crmp1) at serine 522 in the lumbar spinal cord of als model mice overexpressing a human superoxide dismutase mutant (sod1 2022-05-06 2023-08-13 mouse
Masaaki Yoshikawa, Shin Aizawa, Ronald W Oppenheim, Carol Milliga. Neurovascular unit pathology is observed very early in disease progression in the mutant SOD1 Experimental neurology. 2022-04-19. PMID:35439439. here we examine changes in morphology of neurovascular units, associated gene and protein expression in the lumbar spinal cord of sod1 2022-04-19 2023-08-13 mouse
Michael MacLean, Raquel López-Díez, Carolina Vasquez, Paul F Gugger, Ann Marie Schmid. Neuronal-glial communication perturbations in murine SOD1 Communications biology. vol 5. issue 1. 2022-03-01. PMID:35228715. to interrogate cell-intrinsic and inter-cell type perturbations in als, single-nucleus rna sequencing was performed on the lumbar spinal cord in the murine als model sod1 2022-03-01 2023-08-13 Not clear
Masaharu Tanaka, Kengo Homma, Aki Soejim. Histopathological changes of the spinal cord and motor neuron dynamics in SOD1 Tg mice. Journal of toxicologic pathology. vol 35. issue 1. 2022-02-28. PMID:35221507. we analyzed the histopathological changes and the number of motor neurons (mns) in the lumbar spinal cord of cu/zn superoxide dismutase transgenic (sod1 2022-02-28 2023-08-13 mouse
Natalia Nowicka, Kamila Szymańska, Judyta Juranek, Kamila Zglejc-Waszak, Agnieszka Korytko, Michał Załęcki, Małgorzata Chmielewska-Krzesińska, Krzysztof Wąsowicz, Joanna Wojtkiewic. The Involvement of RAGE and Its Ligands during Progression of ALS in SOD1 G93A Transgenic Mice. International journal of molecular sciences. vol 23. issue 4. 2022-02-26. PMID:35216298. here, we demonstrated the expression of rage and its ligands during the progression of the disease in the transgenic sod1 g93a mouse lumbar spinal cord. 2022-02-26 2023-08-13 mouse
Xiaojiao Xu, Jingjing Zhang, Song Li, Murad Al-Nusaif, Qinming Zhou, Sheng Chen, Weidong L. Bone Marrow Stromal Cell Antigen 2: Is a Potential Neuroinflammation Biomarker of SOD1 Frontiers in neuroscience. vol 15. 2022-02-24. PMID:35197819. in the present study, we attempted to elucidate the genetic basis of neuroinflammation in als by comparing the transcriptomic profile of the anterior horns of the lumbar spinal cord (ahlsc) between sod1 2022-02-24 2023-08-13 Not clear
Lei Zhu, Fan Hu, Cheng Li, Caixiang Zhang, Ruiwen Hang, Renshi X. Perilipin 4 Protein: an Impending Target for Amyotrophic Lateral Sclerosis. Molecular neurobiology. vol 58. issue 4. 2021-10-27. PMID:33242187. therefore, we observed and analyzed the alteration of perilipin 4 (plin 4) distribution in the anterior horns (ah); the central canals (cc) and its surrounding gray matter; the posterior horns (ph); and the anterior, lateral, and posterior funiculus (af, lf, and pf) of the cervical, thoracic, and lumbar segments, as well as the alteration of plin 4 expression in the entire spinal cords at the pre-onset, onset, and progression stages of tg(sod1*g93a)1gur (tg) mice and the same period of wild-type(wt) by fluorescent immunohistochemistry, the western blot, and the image analysis. 2021-10-27 2023-08-13 mouse
Julia Post, Vanessa Kogel, Anja Schaffrath, Philipp Lohmann, N Jon Shah, Karl-Josef Langen, Dieter Willbold, Antje Willuweit, Janine Kutzsch. A Novel Anti-Inflammatory d-Peptide Inhibits Disease Phenotype Progression in an ALS Mouse Model. Molecules (Basel, Switzerland). vol 26. issue 6. 2021-05-12. PMID:33805709. rd2rd2 treatment in sod1*g93a mice resulted not only in a reduction of activated astrocytes and microglia in both the brain stem and lumbar spinal cord, but also in a rescue of neurons in the motor cortex. 2021-05-12 2023-08-13 mouse
Matthew J Fogarty, Erica W H Mu, Nickolas A Lavidis, Peter G Noakes, Mark C Bellingha. Size-Dependent Vulnerability of Lumbar Motor Neuron Dendritic Degeneration in SOD1 Anatomical record (Hoboken, N.J. : 2007). vol 303. issue 5. 2021-02-16. PMID:31509351. size-dependent vulnerability of lumbar motor neuron dendritic degeneration in sod1 the motor neuron (mn) soma surface area is correlated with motor unit type. 2021-02-16 2023-08-13 Not clear
Matthew J Fogarty, Erica W H Mu, Nickolas A Lavidis, Peter G Noakes, Mark C Bellingha. Size-Dependent Vulnerability of Lumbar Motor Neuron Dendritic Degeneration in SOD1 Anatomical record (Hoboken, N.J. : 2007). vol 303. issue 5. 2021-02-16. PMID:31509351. we used a golgi-cox impregnation protocol to examine soma size-dependent changes in the dendritic morphology of lumbar mns in sod1 2021-02-16 2023-08-13 Not clear
Roberta Bonafede, Ermanna Turano, Ilaria Scambi, Alice Busato, Pietro Bontempi, Federica Virla, Lorenzo Schiaffino, Pasquina Marzola, Bruno Bonetti, Raffaella Mariott. ASC-Exosomes Ameliorate the Disease Progression in SOD1(G93A) Murine Model Underlining Their Potential Therapeutic Use in Human ALS. International journal of molecular sciences. vol 21. issue 10. 2021-02-16. PMID:32455791. our results demonstrated that repeated administration of asc-exosomes improved the motor performance; protected lumbar motoneurons, the neuromuscular junction, and muscle; and decreased the glial cells activation in treated sod1(g93a) mice. 2021-02-16 2023-08-13 mouse