| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M K McLeod, P Kothary, M Warnock, A Fukuuchi, A M Tuter. Mechanisms of somatostatin action in RINm5F cells in culture: preliminary evidence for possible altered G protein function. The Journal of surgical research. vol 53. issue 5. 1992-12-04. PMID:1359194. |
to study the effects of sms on insulin secretion, conditioned media were sampled after 24 hr. |
1992-12-04 |
2023-08-11 |
rat |
| M K McLeod, P Kothary, M Warnock, A Fukuuchi, A M Tuter. Mechanisms of somatostatin action in RINm5F cells in culture: preliminary evidence for possible altered G protein function. The Journal of surgical research. vol 53. issue 5. 1992-12-04. PMID:1359194. |
there was a significant decrease in the secretion of insulin and intracellular camp levels in response to 50 nm sms. |
1992-12-04 |
2023-08-11 |
rat |
| M K McLeod, P Kothary, M Warnock, A Fukuuchi, A M Tuter. Mechanisms of somatostatin action in RINm5F cells in culture: preliminary evidence for possible altered G protein function. The Journal of surgical research. vol 53. issue 5. 1992-12-04. PMID:1359194. |
we conclude that the inhibition of insulin secretion by sms is associated with an attenuation of camp formation. |
1992-12-04 |
2023-08-11 |
rat |
| H S Fuessl, J M Burrin, G Williams, T E Adrian, S R Bloo. The effect of a long-acting somatostatin analogue (SMS 201-995) on intermediary metabolism and gut hormones after a test meal in normal subjects. Alimentary pharmacology & therapeutics. vol 1. issue 4. 1992-03-05. PMID:2979676. |
however, sms 201-995 impairs carbohydrate tolerance, probably due to inhibition of insulin secretion. |
1992-03-05 |
2023-08-11 |
human |
| P Diem, R P Robertso. Preventive effects of octreotide (SMS 201-995) on diabetic ketogenesis during insulin withdrawal. British journal of clinical pharmacology. vol 32. issue 5. 1991-12-30. PMID:1954071. |
preventive effects of octreotide (sms 201-995) on diabetic ketogenesis during insulin withdrawal. |
1991-12-30 |
2023-08-11 |
Not clear |
| C Santos, P P García-Luna, D Acosta, A Pumar, J L Pereira, I Gavilán, F Cuberta, F García de Pesquera, R Astorg. [Trials of acute treatment with SMS 201-995 in acromegalics]. Revista clinica espanola. vol 189. issue 3. 1991-12-05. PMID:1947381. |
inspire of the reducing effect that sms has on insulin levels, its influence on the blood sugar profile is scare. |
1991-12-05 |
2023-08-11 |
Not clear |
| M C Pagliacci, R Tognellini, F Grignani, I Nicolett. Inhibition of human breast cancer cell (MCF-7) growth in vitro by the somatostatin analog SMS 201-995: effects on cell cycle parameters and apoptotic cell death. Endocrinology. vol 129. issue 5. 1991-12-02. PMID:1935786. |
sms 201-995 significantly reduced the mcf-7 cell growth induced by serum, estradiol, insulin, and insulin-like growth factor-i in both short term and long term experiments. |
1991-12-02 |
2023-08-11 |
human |
| b' M Zamaklar, N Ribarac-Stepi\\xc4\\x87, N Lali\\xc4\\x87, M Devecerski, S Damjanovi\\xc4\\x87, P Djordjevi\\xc4\\x8. [The effect of somatostatin on specific binding of insulin to receptors in patients with non-insulin dependent diabetes]. Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka. issue 41. 1991-11-20. PMID:1680775.' |
tests were performed of the effects of the somatostatin (sms) upon the concentration of insulin, glucagon and sth, as well as of the effects of sms upon the specific binding of the insulin to the receptors. |
1991-11-20 |
2023-08-11 |
human |
| b' M Zamaklar, N Ribarac-Stepi\\xc4\\x87, N Lali\\xc4\\x87, M Devecerski, S Damjanovi\\xc4\\x87, P Djordjevi\\xc4\\x8. [The effect of somatostatin on specific binding of insulin to receptors in patients with non-insulin dependent diabetes]. Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka. issue 41. 1991-11-20. PMID:1680775.' |
in the group of healthy volunteers, a considerable decrease of insulin took place six hours after the administration of sth, and the decrease of the glucagon was especially marked, tending to increase again after six hours, while the specific binding of the insulin to the receptors, and the number of receptors were decreased six hours following the administration of the sms when compared with the placebo, and without tending to reach the previous levels until 3 a.m. (03 h). |
1991-11-20 |
2023-08-11 |
human |
| b' M Zamaklar, N Ribarac-Stepi\\xc4\\x87, N Lali\\xc4\\x87, M Devecerski, S Damjanovi\\xc4\\x87, P Djordjevi\\xc4\\x8. [The effect of somatostatin on specific binding of insulin to receptors in patients with non-insulin dependent diabetes]. Glas. Srpska akademija nauka i umetnosti. Odeljenje medicinskih nauka. issue 41. 1991-11-20. PMID:1680775.' |
in insulin-independent diabetics, the sms leads to a considerable drop of concentrations of insulin, glucagon, sth and to a specific binding of the insulin. |
1991-11-20 |
2023-08-11 |
human |
| S L Shumak, L D Grossman, E Chew, V Kozousek, S R George, W Singer, A G Harris, B Zinma. Growth hormone suppression and nonproliferative diabetic retinopathy: a preliminary feasibility study. Clinical and investigative medicine. Medecine clinique et experimentale. vol 13. issue 5. 1991-03-04. PMID:2276223. |
after eight weeks of sms 201-995 administration, 24-hour integrated plasma growth hormone concentrations had declined by 47.0 +/- 9.3% of pretreatment values (p less than 0.01), and insulin requirements fell from 40.7 +/- 6.7 units per day to 32.2 +/- 6.9 units per day (p less than 0.01). |
1991-03-04 |
2023-08-11 |
human |
| R Arnol. Therapeutic strategies in the management of endocrine GEP tumours. European journal of clinical investigation. vol 20 Suppl 1. 1991-02-13. PMID:1702388. |
a similarly effective drug to prevent hypoglycaemia due to uncontrolled insulin release from insulinomas is not available since neither sms nor diazoxide are effective in every insulinoma patient. |
1991-02-13 |
2023-08-11 |
Not clear |
| S E Kahn, L J Klaff, M W Schwartz, J C Beard, R N Bergman, G J Taborsky, D Port. Treatment with a somatostatin analog decreases pancreatic B-cell and whole body sensitivity to glucose. The Journal of clinical endocrinology and metabolism. vol 71. issue 4. 1990-10-23. PMID:2205630. |
to determine the specific alteration in b-cell function caused by a somatostatin analog in man and to determine the effect of the induced insulin deficiency on insulin action, we administered octreotide (sms 201-995; 50 micrograms twice daily) to nine healthy male subjects, aged 24-35 yr. b-cell function was assessed by measuring the acute insulin response (air) to glucose (airglucose) at fasting glucose and to arginine (airarg) at glucose concentrations of fasting, approximately 14 and more than 28 mm after 2 (n = 7) and 8 days (n = 9) of octreotide. |
1990-10-23 |
2023-08-11 |
human |
| M Krempf, S Ranganathan, J P Remy, B Charbonnel, J Guillo. Effect of long-acting somatostatin analog (SMS 201-995) on high glomerular filtration rate in insulin dependent diabetic patients. International journal of clinical pharmacology, therapy, and toxicology. vol 28. issue 7. 1990-09-21. PMID:2387655. |
effect of long-acting somatostatin analog (sms 201-995) on high glomerular filtration rate in insulin dependent diabetic patients. |
1990-09-21 |
2023-08-11 |
human |
| A B Foot, K Davidson, J A Edge, J A Wass, D B Dunge. The growth hormone releasing hormone (GHRH) response to a mixed meal is blunted in young adults with insulin-dependent diabetes mellitus whereas the somatostatin response is normal. Clinical endocrinology. vol 32. issue 2. 1990-07-11. PMID:1971774. |
these results indicate that glucose and insulin may play a role in the regulation of ghrh release following a mixed meal but circulating levels of ghrh and sms are unlikely to be relevant to the abnormal regulation of gh in iddm. |
1990-07-11 |
2023-08-11 |
human |
| J Halse, A G Harris, A Kvistborg, O Kjartansson, E Hanssen, O Smiseth, O Djøsland, G Hass, J Jervel. A randomized study of SMS 201-995 versus bromocriptine treatment in acromegaly: clinical and biochemical effects. The Journal of clinical endocrinology and metabolism. vol 70. issue 5. 1990-06-14. PMID:2186055. |
gastrointestinal glucose absorption was delayed, and insulin secretion suppressed during treatment with sms 201-995. |
1990-06-14 |
2023-08-11 |
Not clear |
| T Mitsukawa, J Takemura, J Asai, M Nakazato, K Kangawa, H Matsuo, S Matsukur. Islet amyloid polypeptide response to glucose, insulin, and somatostatin analogue administration. Diabetes. vol 39. issue 5. 1990-06-05. PMID:1970540. |
pretreatment with sms 201-995 completely abolished iapp and insulin secretion to intravenous glucose injection. |
1990-06-05 |
2023-08-11 |
human |
| C Camisa, G E Schacht, T M O'Dorisio, R F Maceyk. Treatment of psoriasis with chronic subcutaneous administration of somatostatin analog 201-995 (sandostatin). II. Effect on pancreatic and thyroid hormone. Cleveland Clinic journal of medicine. vol 57. issue 1. 1990-04-04. PMID:2407389. |
the purposes of the study were to determine: (1) levels of insulin, glucose, glucagon, pancreatic polypeptide (pp), and sms 201-995 after a subcutaneous injection of sms 201-995 and ingestion of a standardized meal; (2) nocturnal (0200 h) thyroid stimulating hormone (tsh) levels before, during, and after treatment; and (3) the pharmacokinetics of sms 201-995. |
1990-04-04 |
2023-08-11 |
Not clear |
| C Camisa, G E Schacht, T M O'Dorisio, R F Maceyk. Treatment of psoriasis with chronic subcutaneous administration of somatostatin analog 201-995 (sandostatin). II. Effect on pancreatic and thyroid hormone. Cleveland Clinic journal of medicine. vol 57. issue 1. 1990-04-04. PMID:2407389. |
after chronic administration of sms 201-995, insulin was suppressed with resultant mild carbohydrate intolerance that persisted throughout the treatment course. |
1990-04-04 |
2023-08-11 |
Not clear |
| E J Mozell, E A Woltering, T M O'Dorisio, B E Phillipson, J Fletcher, W S Fletcher, B Howe, D Hill, D Rhe. Adult onset nesidioblastosis: response of glucose, insulin, and secondary peptides to therapy with Sandostatin. The American journal of gastroenterology. vol 85. issue 2. 1990-03-14. PMID:2405644. |
insulin:glucose ratios decreased during sms therapy. |
1990-03-14 |
2023-08-11 |
Not clear |