| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Corti, A De Gasperi, G Oppizzi, E Pannacciulli, A Cristalli, G Fantini, E Mazza, M Prosperi, A Rocchini, D Sabbadini, C Savi, A Scaiola, S Vai, F Romani, L DeCarlis, G F Rondinar. Somatomedin C (IGF I) plasma levels after orthotopic liver transplantation (OLT) in end-stage cirrhotic patients. Transplant international : official journal of the European Society for Organ Transplantation. vol 5 Suppl 1. 2003-12-23. PMID:14621770. |
insulin-like growth factors [igf i and ii or somatomedins (sms)] are polypeptides chemically and biologically correlated with insulin. |
2003-12-23 |
2023-08-12 |
Not clear |
| A Corti, A De Gasperi, G Oppizzi, E Pannacciulli, A Cristalli, G Fantini, E Mazza, M Prosperi, A Rocchini, D Sabbadini, C Savi, A Scaiola, S Vai, F Romani, L DeCarlis, G F Rondinar. Somatomedin C (IGF I) plasma levels after orthotopic liver transplantation (OLT) in end-stage cirrhotic patients. Transplant international : official journal of the European Society for Organ Transplantation. vol 5 Suppl 1. 2003-12-23. PMID:14621770. |
synthesis of sms is regulated by gh, insulin, thyroxine and nutrition (caloric and protein intake, and nitrogen balance). |
2003-12-23 |
2023-08-12 |
Not clear |
| A Corti, A De Gasperi, G Oppizzi, E Pannacciulli, A Cristalli, G Fantini, E Mazza, M Prosperi, A Rocchini, D Sabbadini, C Savi, A Scaiola, S Vai, F Romani, L DeCarlis, G F Rondinar. Somatomedin C (IGF I) plasma levels after orthotopic liver transplantation (OLT) in end-stage cirrhotic patients. Transplant international : official journal of the European Society for Organ Transplantation. vol 5 Suppl 1. 2003-12-23. PMID:14621770. |
the biological properties of sms are related to their structural homology with insulin, and can be summarized as follows: a. insulin-like activity (glucose oxidation, lipogenesis, glycogen synthesis, inhibition of lipolysis and glycogenolysis); b. sulphation activity (incorporation of sulphate and leucine into glycosaminglycans of the cartilage); c. stimulation of fibroblast multiplication; d. amplification of other hormone activities (gh); e. complementary anabolic activity with insulin. |
2003-12-23 |
2023-08-12 |
Not clear |
| Alexander Stark, Rolf Mentlei. Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells. Regulatory peptides. vol 108. issue 2-3. 2003-04-10. PMID:12220732. |
in accordance, the sst1- or sst2-selective non-peptide agonists l-797591 or l-054522 and peptide agonist octreotide (sms 201995; sst2, sst3, and sst5 selective) potently inhibited glp-1-induced insulin secretion whereas the sst3-selective agonist l-796778 showed little effect. |
2003-04-10 |
2023-08-12 |
rat |
| Y S Yun, H C Lee, C S Park, K H Chang, C H Cho, Y D Song, S K Lim, K R Kim, K B Hu. Effects of long-acting somatostatin analogue (Sandostatin) on manifest diabetic ketoacidosis. Journal of diabetes and its complications. vol 13. issue 5-6. 2000-05-19. PMID:10765004. |
to examine the additive effect of octreotide, the synthetic long-acting somatostatin analogue sms 201-995, to conventional treatment of manifest dka, we compared the correction time of acidosis, ketonuria, and hyperglycemia of patients treated with an intravenous infusion of low-dose insulin (4 units per hour) plus subcutaneous injection of octreotide (50 microg every 6 hours) by low-dose insulin alone. |
2000-05-19 |
2023-08-12 |
Not clear |
| I B Hirsch, D D'Alessio, L Eng, C Davis, A Lernmark, A Chai. Severe insulin resistance in a patient with type 1 diabetes and stiff-man syndrome treated with insulin lispro. Diabetes research and clinical practice. vol 41. issue 3. 1999-02-02. PMID:9829349. |
in summary, we describe the first patient with type 1 diabetes, sms, and severe insulin resistance. |
1999-02-02 |
2023-08-12 |
Not clear |
| N Pørksen, S R Munn, J L Steers, J D Veldhuis, P C Butle. Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass. The American journal of physiology. vol 270. issue 6 Pt 1. 1996-09-26. PMID:8764190. |
in contrast, sms decreased insulin pulse mass in the postabsorptive (84 +/- 28 vs. 214 +/- 73 pmol/pulse, sms vs. sal, p < 0.05) and fed states (676 +/- 143 vs. 913 +/- 183 pmol/pulse, sms vs. sal, p < 0.05). |
1996-09-26 |
2023-08-12 |
Not clear |
| N Pørksen, S R Munn, J L Steers, J D Veldhuis, P C Butle. Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass. The American journal of physiology. vol 270. issue 6 Pt 1. 1996-09-26. PMID:8764190. |
in the postabsorptive state, sms decreased insulin clearance by approximately 50% (0.32 +/- 0.04 vs. 0.60 +/- 0.09 l/min, p < 0.05), but after glucose ingestion, insulin clearance was comparable during sms or sal (0.72 +/- 0.04 vs. 0.80 +/- 0.08 l/min, p = 0.4). |
1996-09-26 |
2023-08-12 |
Not clear |
| N Pørksen, S R Munn, J L Steers, J D Veldhuis, P C Butle. Effects of somatostatin on pulsatile insulin secretion: elective inhibition of insulin burst mass. The American journal of physiology. vol 270. issue 6 Pt 1. 1996-09-26. PMID:8764190. |
sms appeared to alter insulin clearance through modulation of insulin pulse amplitude, because in the postabsorptive state clearance was closely correlated to the pulse amplitude (r = + 0.87, p < 0.0001). |
1996-09-26 |
2023-08-12 |
Not clear |
| M Breidert, T Pinzer, J Wildbrett, S R Bornstein, M Hanefel. Long-term effect of octreotide in acromegaly on insulin resistance. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 27. issue 5. 1995-09-21. PMID:7642173. |
the glucosal disposal rate on average (insulin infusion rate 40 mu/m2/min) was not significantly changed following sms treatment (mclbm before 3.60 +/- 0.38, after 3.95 +/- 0.41 mg/kg lbm/min). |
1995-09-21 |
2023-08-12 |
Not clear |
| M Breidert, T Pinzer, J Wildbrett, S R Bornstein, M Hanefel. Long-term effect of octreotide in acromegaly on insulin resistance. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 27. issue 5. 1995-09-21. PMID:7642173. |
additionally there was no significant difference of serum basal insulin levels (0.19 +/- 0.01 vs. 0.23 +/- 0.06 nmol/l) as well as basal c-peptide levels (0.79 +/- 0.07 vs. 0.47 +/- 0.04 nmol/l) before and with sms treatment. |
1995-09-21 |
2023-08-12 |
Not clear |
| M Bayraktar, A Usman, Z Kora. Effect of the new somatostatin analogue SMS 201-995 on exogenously used insulin. The Clinical investigator. vol 72. issue 9. 1995-03-16. PMID:7849444. |
effect of the new somatostatin analogue sms 201-995 on exogenously used insulin. |
1995-03-16 |
2023-08-12 |
human |
| M Bayraktar, A Usman, Z Kora. Effect of the new somatostatin analogue SMS 201-995 on exogenously used insulin. The Clinical investigator. vol 72. issue 9. 1995-03-16. PMID:7849444. |
the effect of the somatostatin analogue sms 201-995 on exogenously infused insulin was observed in ten healthy volunteers. |
1995-03-16 |
2023-08-12 |
human |
| M Bayraktar, A Usman, Z Kora. Effect of the new somatostatin analogue SMS 201-995 on exogenously used insulin. The Clinical investigator. vol 72. issue 9. 1995-03-16. PMID:7849444. |
each subject was infused with saline throughout the study and insulin at a rate of 40 mu/kg per hour between 60-160 min of the study (step a) or sms 201-995 in a 75 micrograms iv bolus following at a rate of 75 micrograms/h for 160 min and insulin at the same rate and duration (step b). |
1995-03-16 |
2023-08-12 |
human |
| M Bayraktar, A Usman, Z Kora. Effect of the new somatostatin analogue SMS 201-995 on exogenously used insulin. The Clinical investigator. vol 72. issue 9. 1995-03-16. PMID:7849444. |
blood glucose levels decreased markedly throughout the infusion of insulin with or without sms 201-995. |
1995-03-16 |
2023-08-12 |
human |
| M Bayraktar, A Usman, Z Kora. Effect of the new somatostatin analogue SMS 201-995 on exogenously used insulin. The Clinical investigator. vol 72. issue 9. 1995-03-16. PMID:7849444. |
these results show that sms 201-995 increases the level of exogenously infused insulin. |
1995-03-16 |
2023-08-12 |
human |
| B Mallet, B Vialettes, S Haroche, P Escoffier, P Gastaut, J P Taubert, P Vagu. Stabilization of severe proliferative diabetic retinopathy by long-term treatment with SMS 201-995. Diabete & metabolisme. vol 18. issue 6. 1993-05-03. PMID:1297600. |
sms 201-995 was injected subcutaneously with a continuous pump system at a dose of 400 micrograms/d into 4 insulin dependent diabetic patients suffering from proliferative diabetic retinopathy progressing despite a pan-photocoagulation. |
1993-05-03 |
2023-08-11 |
Not clear |
| K Kusuhara, M Kusunoki, T Okamoto, Y Sakanoue, J Utsunomiy. Reduction of the effluent volume in high-output ileostomy patients by a somatostatin analogue, SMS 201-995. International journal of colorectal disease. vol 7. issue 4. 1993-04-08. PMID:1293241. |
there were no significant changes in the plasma levels of glucagon, c peptide, insulin, renin or aldosterone with sms 201-995 therapy. |
1993-04-08 |
2023-08-11 |
Not clear |
| C B Verchere, Y N Kwok, J C Brow. Inhibitory actions of a somatostatin analog SMS 201-995 on endocrine secretion from the isolated perfused stomach and pancreas of the rat. Pharmacology. vol 46. issue 1. 1993-03-12. PMID:8094569. |
in this study, the effect of sms on the secretion of immunoreactive insulin, gastrin and gastric somatostatin was examined in the rat using in situ vascularly perfused organ preparations. |
1993-03-12 |
2023-08-12 |
rat |
| C B Verchere, Y N Kwok, J C Brow. Inhibitory actions of a somatostatin analog SMS 201-995 on endocrine secretion from the isolated perfused stomach and pancreas of the rat. Pharmacology. vol 46. issue 1. 1993-03-12. PMID:8094569. |
in the perfused pancreas both ss-14 (6.1 x 10(-9) mol/l) and sms (9.4 x 10(-9) mol/l) inhibited the gip (2 x 10(-9) mol/l) or acetylcholine (1 x 10(-6) mol/l), but not 17.8 x 10(-9) mol/l glucose-stimulated insulin secretion. |
1993-03-12 |
2023-08-12 |
rat |