| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| G Plewe, G Noelken, U Krause, J Beyer, E del Poz. Suppression of growth hormone and somatomedin C by long-acting somatostatin analog SMS 201-995 in type I diabetes mellitus. Hormone research. vol 27. issue 1. 1987-09-30. PMID:2887504. |
in addition to dietary measures and conventional insulin therapy, the patients received a subcutaneous dose of 50 micrograms sms three times daily for 3 days. |
1987-09-30 |
2023-08-11 |
Not clear |
| G Plewe, G Noelken, U Krause, J Beyer, E del Poz. Suppression of growth hormone and somatomedin C by long-acting somatostatin analog SMS 201-995 in type I diabetes mellitus. Hormone research. vol 27. issue 1. 1987-09-30. PMID:2887504. |
dampening of glucose oscillations and counterregulatory mechanisms, and reduction of insulin dosage by sms may enable a better control of unstable diabetes. |
1987-09-30 |
2023-08-11 |
Not clear |
| W Creutzfeldt, B Lembcke, U R Fölsch, S Schleser, I Koo. Effect of somatostatin analogue (SMS 201-995, Sandostatin) on pancreatic secretion in humans. The American journal of medicine. vol 82. issue 5B. 1987-07-13. PMID:2884879. |
the release of pancreatic polypeptide by a solid test meal is abolished by administration of 25 micrograms of sms, the release of gastric inhibitory polypeptide is nearly completely suppressed, the response of insulin and c-peptide are significantly lowered, and the gastrin response is only slightly reduced. |
1987-07-13 |
2023-08-11 |
human |
| J A Olsen, F B Loud, J Christianse. Inhibition of meal stimulated gastric acid secretion by an octapeptide somatostatin analogue SMS 201-995. Gut. vol 28. issue 4. 1987-07-09. PMID:2884171. |
pl-gastrin was significantly decreased during infusion of 10 pmol/kg/h of sms 201-995 and insulin was significantly inhibited during infusion of 50 pmol/kg/h. |
1987-07-09 |
2023-08-11 |
human |
| R Horikawa, K Takano, N Hizuka, K Asakawa, T Shibasaki, A Masuda, K Shizum. Effect of a single administration of somatostatin analogue (SMS 201-995) on GH, TSH and insulin secretion in patients with acromegaly. Endocrinologia japonica. vol 33. issue 6. 1987-06-26. PMID:2884093. |
effect of a single administration of somatostatin analogue (sms 201-995) on gh, tsh and insulin secretion in patients with acromegaly. |
1987-06-26 |
2023-08-11 |
Not clear |
| S D Chernausek, D C Beach, W Banach, M A Sperlin. Characteristics of hepatic receptors for somatomedin-C/insulin-like growth factor I and insulin in the developing human. The Journal of clinical endocrinology and metabolism. vol 64. issue 4. 1987-04-16. PMID:2950128. |
insulin and the somatomedins (sms) are putative regulators of cell proliferation and metabolism in the fetus. |
1987-04-16 |
2023-08-11 |
human |
| H S Fuessl, J Domin, S R Bloo. Oral absorption of the somatostatin analogue SMS 201-995: theoretical and practical implications. Clinical science (London, England : 1979). vol 72. issue 2. 1987-04-01. PMID:2880692. |
biological activity of absorbed sms was shown by significant and lasting suppression of plasma insulin concentrations, resulting in significant hyperglycaemia at 90 and 120 min compared with the control study. |
1987-04-01 |
2023-08-11 |
human |
| L Cantalamessa, A Catania, M Baldini, A Orsatt. Improvement of diabetes after treatment with somatostatin analogue SMS 201-995 in an acromegalic patient. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 18. issue 11. 1987-02-18. PMID:2878866. |
conversely, addition of sms 201-995 to insulin treatment led to normalization of blood glucose. |
1987-02-18 |
2023-08-11 |
human |
| R R Davies, M Miller, S J Turner, T H Goodship, D B Cook, M Watson, A McGill, H Orskov, K G Alberti, D G Johnsto. Effects of somatostatin analogue SMS 201-995 in normal man. Clinical endocrinology. vol 24. issue 6. 1987-02-05. PMID:2878747. |
insulin levels were suppressed following sms 201-995 and the response to meals was inhibited. |
1987-02-05 |
2023-08-11 |
human |
| J Takemura, Y N Kwok, J C Brow. Comparison of the effect of somatostatin and an analogue, SMS 201-995, on gastrin and insulin secretion from isolated perfused rat stomach and pancreas. The American journal of medicine. vol 81. issue 6B. 1987-02-04. PMID:2879449. |
comparison of the effect of somatostatin and an analogue, sms 201-995, on gastrin and insulin secretion from isolated perfused rat stomach and pancreas. |
1987-02-04 |
2023-08-11 |
rat |
| J Takemura, Y N Kwok, J C Brow. Comparison of the effect of somatostatin and an analogue, SMS 201-995, on gastrin and insulin secretion from isolated perfused rat stomach and pancreas. The American journal of medicine. vol 81. issue 6B. 1987-02-04. PMID:2879449. |
the effects of a somatostatin analogue, sms 201-995, and somatostatin-14 on gastrin and insulin release from the isolated perfused rat stomach and pancreas were studied. |
1987-02-04 |
2023-08-11 |
rat |
| J Takemura, Y N Kwok, J C Brow. Comparison of the effect of somatostatin and an analogue, SMS 201-995, on gastrin and insulin secretion from isolated perfused rat stomach and pancreas. The American journal of medicine. vol 81. issue 6B. 1987-02-04. PMID:2879449. |
in the presence of 10 mm arginine plus glucose at a concentration of either 8.8 or 17.6 mm, insulin secretion was reduced by both sms 201-995 and somatostatin-14 to levels obtained with glucose alone. |
1987-02-04 |
2023-08-11 |
rat |
| J Takemura, Y N Kwok, J C Brow. Comparison of the effect of somatostatin and an analogue, SMS 201-995, on gastrin and insulin secretion from isolated perfused rat stomach and pancreas. The American journal of medicine. vol 81. issue 6B. 1987-02-04. PMID:2879449. |
however, when gastric inhibitory polypeptide (10 ng/ml) in the presence of 8.8 mm glucose was used to stimulate insulin release, somatostatin-14 completely inhibited the insulinotropic action of gastric inhibitory polypeptide while sms 201-995 was without effect. |
1987-02-04 |
2023-08-11 |
rat |
| D G Johnston, R R Davies, K G Alberti, M Miller, S J Turner, M Watson, H Orsko. Effects of SMS 201-995 on intermediary metabolism and endocrine status in normal and diabetic humans. The American journal of medicine. vol 81. issue 6B. 1987-02-04. PMID:2879452. |
postprandial circulating glucose and insulin levels the following day were unaffected by sms 201-995, and no side effects were observed. |
1987-02-04 |
2023-08-11 |
human |
| D G Johnston, R R Davies, K G Alberti, M Miller, S J Turner, M Watson, H Orsko. Effects of SMS 201-995 on intermediary metabolism and endocrine status in normal and diabetic humans. The American journal of medicine. vol 81. issue 6B. 1987-02-04. PMID:2879452. |
in type i diabetic patients receiving a variable rate insulin infusion overnight to maintain normoglycemia, sms 201-995 (50 micrograms) administered at 11 p.m. decreased insulin requirements for two to three hours after injection. |
1987-02-04 |
2023-08-11 |
human |
| G J Bruining, A N Bosschaart, R S Aarsen, S W Lamberts, P J Sauer, E Del Poz. Normalization of glucose homeostasis by a long-acting somatostatin analog SMS 201-995 in a newborn with nesidioblastosis. Acta endocrinologica. Supplementum. vol 279. 1986-11-25. PMID:2877536. |
intravenous infusion of a long acting somatostatin analog, sms 201-995, at a dosage gradually increasing from 2 to 50 micrograms/24 hr, was accompanied by a dramatic fall in circulating insulin levels. |
1986-11-25 |
2023-08-11 |
Not clear |
| M S Rios, I Navascues, J Saban, A Ordoñez, F Sevilla, E Del Poz. Somatostatin analog SMS 201-995 and insulin needs in insulin-dependent diabetic patients studied by means of an artificial pancreas. The Journal of clinical endocrinology and metabolism. vol 63. issue 5. 1986-11-19. PMID:2876005. |
somatostatin analog sms 201-995 and insulin needs in insulin-dependent diabetic patients studied by means of an artificial pancreas. |
1986-11-19 |
2023-08-11 |
Not clear |
| M S Rios, I Navascues, J Saban, A Ordoñez, F Sevilla, E Del Poz. Somatostatin analog SMS 201-995 and insulin needs in insulin-dependent diabetic patients studied by means of an artificial pancreas. The Journal of clinical endocrinology and metabolism. vol 63. issue 5. 1986-11-19. PMID:2876005. |
sms 201-995 is a new somatostatin analog which is 10-60 times more potent and specific than somatostatin as an inhibitor of gh and insulin release. |
1986-11-19 |
2023-08-11 |
Not clear |
| M S Rios, I Navascues, J Saban, A Ordoñez, F Sevilla, E Del Poz. Somatostatin analog SMS 201-995 and insulin needs in insulin-dependent diabetic patients studied by means of an artificial pancreas. The Journal of clinical endocrinology and metabolism. vol 63. issue 5. 1986-11-19. PMID:2876005. |
in conclusion, the somatostatin analog sms 201-995 has a potential value as an adjunct to insulin in the management of idd patients. |
1986-11-19 |
2023-08-11 |
Not clear |
| J Wahren, L S Eriksso. The influence of a long-acting somatostatin analogue on splanchnic haemodynamics and metabolism in healthy subjects and patients with liver cirrhosis. Scandinavian journal of gastroenterology. Supplement. vol 119. 1986-11-17. PMID:2876492. |
insulin and glucagon levels fell markedly in response to sms administration, and the blood concentration and splanchnic output of glucose decreased transiently. |
1986-11-17 |
2023-08-11 |
human |