| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Pezawas, A Meyer-Lindenberg, A L Goldman, B A Verchinski, G Chen, B S Kolachana, M F Egan, V S Mattay, A R Hariri, D R Weinberge. Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Molecular psychiatry. vol 13. issue 7. 2008-08-13. PMID:18347599. |
these data provide in vivo evidence of biologic epistasis between slc6a4 and bdnf in the human brain by identifying a neural mechanism linking serotonergic and neurotrophic signaling on the neural systems level, and have implications for personalized treatment planning in depression. |
2008-08-13 |
2023-08-12 |
mouse |
| Pilar A Saiz, Maria P Garcia-Portilla, Celso Arango, Blanca Morales, Maria-Teresa Bascaran, Sara Martinez-Barrondo, Gerardo Florez, Emilio Sotomayor, Begoña Paredes, Cesar Alvarez, Gema San Narciso, Eduardo Carreño, Igor Bombin, Victoria Alvarez, Eliecer Coto, Juan M Fernandez, Manuel Bousoño, Julio Bobe. Association study between obsessive-compulsive disorder and serotonergic candidate genes. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 3. 2008-07-02. PMID:18191318. |
the purpose of this study is to investigate the association between four serotonergic polymorphisms (stin2 vntr and 5-httlpr of the slc6a4 gene, and a-1438g (rs6311) and t102c (rs6313) of the htr2a gene) and ocd. |
2008-07-02 |
2023-08-12 |
Not clear |
| L van den Berg, M Vos-Loohuis, M B H Schilder, B A van Oost, H A W Hazewinkel, C M Wade, E K Karlsson, K Lindblad-Toh, A E Liinamo, P A J Leegwate. Evaluation of the serotonergic genes htr1A, htr1B, htr2A, and slc6A4 in aggressive behavior of golden retriever dogs. Behavior genetics. vol 38. issue 1. 2008-07-01. PMID:18066658. |
evaluation of the serotonergic genes htr1a, htr1b, htr2a, and slc6a4 in aggressive behavior of golden retriever dogs. |
2008-07-01 |
2023-08-12 |
Not clear |
| Gabi Koller, Peter Zill, Thomas Skoruppa, Brigitta Bondy, Ulrich W Preuss, Michael Soyk. Low level of harm avoidance is associated with serotonin transporter functional haplotype in alcohol-dependent individuals. Psychiatric genetics. vol 18. issue 2. 2008-04-28. PMID:18349696. |
the serotonin transporter gene (slc6a4) encodes a trans-membrane protein (5-htt) that plays an important role in regulating serotonergic neurotransmission, which is known to be involved in many psychiatric disorders. |
2008-04-28 |
2023-08-12 |
Not clear |
| François Dubé, Pascal Amireaul. Local serotonergic signaling in mammalian follicles, oocytes and early embryos. Life sciences. vol 81. issue 25-26. 2008-02-15. PMID:18023821. |
additional serotonergic players, including the 5-ht transporter (sert or slc6a4) expressed in oocytes and embryos, and the 5-ht-producing enzyme tryptophan hydroxylase-1 (tph1) expressed in cumulus cells, now make up a complete and autonomous local serotonergic network. |
2008-02-15 |
2023-08-12 |
mouse |
| Michael Camilleri, Christopher N Andrews, Adil E Bharucha, Paula J Carlson, Irene Ferber, Debra Stephens, Thomas C Smyrk, Raul Urrutia, Jeroen Aerssens, Leen Thielemans, Hinrich Göhlmann, Ilse van den Wyngaert, Bernard Couli. Alterations in expression of p11 and SERT in mucosal biopsy specimens of patients with irritable bowel syndrome. Gastroenterology. vol 132. issue 1. 2007-03-14. PMID:17241856. |
two proteins that influence the function of serotonin and serotonergic receptors are serotonin transporter protein (sert or soluble carrier protein, slc6a4) and p11 (s-100a10, or calpactin i light chain). |
2007-03-14 |
2023-08-12 |
Not clear |
| L van den Berg, L Kwant, M S Hestand, B A van Oost, P A J Leegwate. Structure and variation of three canine genes involved in serotonin binding and transport: the serotonin receptor 1A gene (htr1A), serotonin receptor 2A gene (htr2A), and serotonin transporter gene (slc6A4). The Journal of heredity. vol 96. issue 7. 2006-10-31. PMID:16251523. |
here, we describe the characterization of three genes of the canine serotonergic system: the serotonin receptor 1a and 2a gene (htr1a and htr2a) and the serotonin transporter gene (slc6a4). |
2006-10-31 |
2023-08-12 |
dog |
| J B Fan, P Skla. Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. Molecular psychiatry. vol 10. issue 10. 2005-12-23. PMID:15940296. |
the serotonin transporter gene (slc6a4) is a candidate gene for schizophrenia based on serotonin transporter's crucial role in serotonergic neurotransmission. |
2005-12-23 |
2023-08-12 |
human |
| b' Pascal Amireault, Fran\\xc3\\xa7ois Dub\\xc3\\xa. Serotonin and its antidepressant-sensitive transport in mouse cumulus-oocyte complexes and early embryos. Biology of reproduction. vol 73. issue 2. 2005-11-08. PMID:15858217.' |
to clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-ht itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (tph1); and the 5-ht-specific transporter (slc6a4) required for modulating its cellular effects. |
2005-11-08 |
2023-08-12 |
mouse |
| H Sunny Sun, Hui-Chung Wang, Te-Jen Lai, Tso-Jen Wang, Chih-Ming L. Sequence variants and haplotype analysis of serotonin transporter gene and association with bipolar affective disorder in Taiwan. Pharmacogenetics. vol 14. issue 3. 2004-10-25. PMID:15167705. |
serotonin transporter (slc6a4) is responsible for serotonin re-uptake into presynaptic terminals, thus fine-tuning brain serotonergic neurotransmission. |
2004-10-25 |
2023-08-12 |
Not clear |
| A Frisch, B Finkel, E Michaelovsky, M Sigal, N Laor, R Weizma. A rare short allele of the serotonin transporter promoter region (5-HTTLPR) found in an aggressive schizophrenic patient of Jewish Libyan origin. Psychiatric genetics. vol 10. issue 4. 2001-08-09. PMID:11324943. |
the serotonin transporter gene (slc6a4), which plays a key role in the serotonergic pathway in the brain, is a candidate for mediating genetic susceptibility to various psychiatric disorders. |
2001-08-09 |
2023-08-12 |
human |