| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C S Reigstad, D R Linden, J H Szurszewski, J L Sonnenburg, G Farrugia, P C Kashya. Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 28. issue 9. 2018-02-12. PMID:27072889. |
these data suggest that correlated expression of slc6a4 and htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut. |
2018-02-12 |
2023-08-13 |
mouse |
| Elisa M Trucco, Brian M Hicks, Sandra Villafuerte, Joel T Nigg, Margit Burmeister, Robert A Zucke. Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use. Journal of abnormal psychology. vol 125. issue 4. 2017-03-09. PMID:26845260. |
polymorphisms across serotonergic (slc6a4, 5-httlpr), dopaminergic (drd4, u-vntr), noradrenergic (slc6a2, rs36021), and gabaergic (gabra2, rs279858; gabra6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems. |
2017-03-09 |
2023-08-13 |
Not clear |
| Yun-Ai Su, Ji-Tao Li, Wen-Ji Dai, Xue-Mei Liao, Li-Cai Dong, Tian-Lan Lu, Chad Bousman, Tian-Mei S. Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment. International clinical psychopharmacology. vol 31. issue 3. 2016-12-22. PMID:26745768. |
the aim of this study was to investigate the relationship between genotypic variation in six candidate serotonergic genes (adcy9, htr1b, gnb3, htr2a, tph2, slc6a4) and depressive and anxiety symptom severity trajectories as well as remission following escitalopram treatment. |
2016-12-22 |
2023-08-13 |
Not clear |
| Rosario Montirosso, Livio Provenzi, Monica Fumagalli, Ida Sirgiovanni, Roberto Giorda, Uberto Pozzoli, Silvana Beri, Giorgia Menozzi, Ed Tronick, Francesco Morandi, Fabio Mosca, Renato Borgatt. Serotonin Transporter Gene (SLC6A4) Methylation Associates With Neonatal Intensive Care Unit Stay and 3-Month-Old Temperament in Preterm Infants. Child development. vol 87. issue 1. 2016-12-13. PMID:26822441. |
results suggested that in preterm infants nicu-related stress might be associated with alterations of serotonergic tone as a consequence of slc6a4 methylation, which in turn, might associate with temperamental difficulties assessed at 3 months of age. |
2016-12-13 |
2023-08-13 |
Not clear |
| Karlene T Barrett, Ryan T Dosumu-Johnson, J Andrew Daubenspeck, Rachael D Brust, Vasileios Kreouzis, Jun Chul Kim, Aihua Li, Susan M Dymecki, Eugene E Natti. Partial Raphe Dysfunction in Neurotransmission Is Sufficient to Increase Mortality after Anoxic Exposures in Mice at a Critical Period in Postnatal Development. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 14. 2016-08-15. PMID:27053202. |
we studied autoresuscitation in two transgenic mouse models in which exocytic neurotransmitter release was impaired via conditional expression of the light chain from tetanus toxin (tox) in raphe neurons expressing serotonergic bacterial artificial chromosome drivers pet1 or slc6a4. |
2016-08-15 |
2023-08-13 |
mouse |
| Daniel R Taub, Joshua Pag. Molecular Signatures of Natural Selection for Polymorphic Genes of the Human Dopaminergic and Serotonergic Systems: A Review. Frontiers in psychology. vol 7. 2016-07-04. PMID:27375535. |
in spite of speculation in the literature about selection on these genes, current evidence from population genomic analyses supports selectively neutral processes, such as genetic drift and population dynamics, as the principal drivers of recent evolution in dopaminergic and serotonergic genes other than slc6a4. |
2016-07-04 |
2023-08-13 |
human |
| Isabelle E Bauer, David P Graham, Jair C Soares, David A Nielse. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. vol 16. issue 11. 2016-06-29. PMID:26265436. |
current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (tph2) and the serotonin transporter (slc6a4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline. |
2016-06-29 |
2023-08-13 |
Not clear |
| Moe Igari, Hao-Wei Shen, Yoko Hagino, Setsu Fukushima, Yoshiyuki Kasahara, Klaus-Peter Lesch, Dennis L Murphy, Frank Scott Hall, George R Uhl, Kazutaka Ikeda, Nobuo Yaegashi, Ichiro Sor. Attenuated methamphetamine-induced locomotor sensitization in serotonin transporter knockout mice is restored by serotonin 1B receptor antagonist treatment. Behavioural pharmacology. vol 26. issue 1-2. 2015-09-03. PMID:25485646. |
the present experiments examined serotonergic roles in meth-induced locomotor sensitization by assessing: (a) the effect of serotonin transporter (sert; slc6a4) knockout (ko) on meth-induced locomotor sensitization; (b) extracellular monoamine levels in meth-treated animals as determined by in-vivo microdialysis; and (c) effects of serotonin (5-ht) receptor antagonists on meth-induced behavioral sensitization, with focus on effects of the 5-ht1b receptor antagonist sb 216641 and a comparison with the 5-ht2 receptor antagonist ketanserin. |
2015-09-03 |
2023-08-13 |
mouse |
| Senka Sabolovic Rudman, Maja Mustapic, Vesna Kosec, Nela Pivac, Franjo Rudman, Dorotea Muck-Sele. Serotonin risk factors for the development of hypertension in pregnancy. Archives of gynecology and obstetrics. vol 291. issue 4. 2015-07-01. PMID:25223859. |
to determine platelet serotonin (5-ht) concentrations and genotype and allele frequencies of serotonergic type 2a receptor gene (htr2a) and 5-ht transporter gene (slc6a4) in women with pre-eclampsia, gestational hypertension without proteinuria (pih) and in control normotensive pregnant women. |
2015-07-01 |
2023-08-13 |
Not clear |
| Sarah Wilker, Thomas Elbert, Iris-Tatjana Kolass. The downside of strong emotional memories: how human memory-related genes influence the risk for posttraumatic stress disorder--a selective review. Neurobiology of learning and memory. vol 112. 2015-02-09. PMID:24012801. |
here, we focus on genes involved in noradrenergic (adra2b), serotonergic (slc6a4), and dopaminergic signaling (comt) as well as in the molecular cascades of memory formation (prkca and wwc1). |
2015-02-09 |
2023-08-12 |
human |
| Alonzo Whyte, Tammy Jessen, Seth Varney, Ana M D Carneir. Serotonin transporter and integrin beta 3 genes interact to modulate serotonin uptake in mouse brain. Neurochemistry international. vol 73. 2015-02-02. PMID:24083985. |
convergent evidence from genetic analyses of human subjects has implicated the integrin β3 subunit gene (itgb3) as a modulator of serotonergic systems via genetic interactions with the 5-ht transporter gene (slc6a4, sert). |
2015-02-02 |
2023-08-12 |
mouse |
| Xiong Zhang, Xing Cheng, Yan-Bing Hu, Jun-Mei Lai, Hui You, Pei-Long Hu, Ming Zou, Jian-Hong Zh. Serotonin transporter polymorphic region 5-HTTLPR modulates risk for Parkinson's disease. Neurobiology of aging. vol 35. issue 8. 2014-12-08. PMID:24684793. |
taken together, our data provide novel insight in support that the slc6a4 polymorphisms, particularly 5-httlpr, and the serotonergic system are associated with pd etiology. |
2014-12-08 |
2023-08-12 |
Not clear |
| Johanna Nyffeler, Susanne Walitza, Elise Bobrowski, Ronnie Gundelfinger, Edna Grünblat. Association study in siblings and case-controls of serotonin- and oxytocin-related genes with high functioning autism. Journal of molecular psychiatry. vol 2. issue 1. 2014-11-21. PMID:25408912. |
the serotonergic and oxytocinergic systems are of interest in autism for several reasons: (i) both systems are implicated in social behavior, and abnormal levels of serotonin and oxytocin have been found in people with asd; (ii) treatment with selective serotonin reuptake inhibitors and oxytocin can yield improvements; and (iii) previous association studies have linked the serotonin transporter (sert; slc6a4), serotonin receptor 2a (htr2a), and oxytocin receptor (oxtr) genes with asd. |
2014-11-21 |
2023-08-13 |
Not clear |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Raffaella Calati, Florence Gressier, Martina Balestri, Alessandro Serrett. Genetic modulation of borderline personality disorder: systematic review and meta-analysis. Journal of psychiatric research. vol 47. issue 10. 2014-04-04. PMID:23810197. |
meta-analyses were performed for three serotonergic polymorphisms: two common polymorphisms of the serotonin transporter gene (slc6a4), the promoter insertion/deletion (5-httlpr) and the intron 2 vntr (stin2 vntr), and the rs1800532 (a218c) polymorphism of the tryptophan hydroxylase 1 gene (tph1), all showing no association. |
2014-04-04 |
2023-08-12 |
Not clear |
| Sebastiaan Engelborghs, Kristel Sleegers, Stefan Van der Mussele, Nathalie Le Bastard, Nathalie Brouwers, Christine Van Broeckhoven, Peter Paul De Dey. Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 1. 2013-12-27. PMID:23334703. |
a prospective, longitudinal study was set up to investigate possible genetic associations of behavioral and psychological signs and symptoms of dementia (bpsd) in alzheimer's disease (ad) with two candidate genes in the serotonergic neurotransmitter pathway: serotonin transporter (slc6a4) and brain-specific tryptophan hydroxylase (tph2). |
2013-12-27 |
2023-08-12 |
Not clear |
| Jae-Won Kim, Hyo-Sang Ahn, Ja-Hyun Baik, Bong-June Yoo. Administration of clomipramine to neonatal mice alters stress response behavior and serotonergic gene expressions in adult mice. Journal of psychopharmacology (Oxford, England). vol 27. issue 2. 2013-09-30. PMID:22992375. |
an analysis of the expression of serotonergic genes after exposure to social defeat stress revealed small but significant changes in the expression of 5-ht1a receptor gene (htr1a) and 5-htt gene (slc6a4) in the mice treated with clomipramine compared with the mice injected with saline. |
2013-09-30 |
2023-08-12 |
mouse |
| Pilar A Saiz, Sara Martínez-Barrondo, María P García-Portilla, Paul Corcoran, Blanca Morales, María-Teresa Bascaran, Begoña Paredes, Victoria Alvarez, Eliecer Coto, Juan M Fernández, Manuel Bousoño, Julio Bobe. Role of serotonergic polymorphisms in the clinical severity of the panic disorder. Revista de psiquiatria y salud mental. vol 2. issue 1. 2013-07-25. PMID:23034196. |
to investigate the association between three serotonergic polymorphisms (a-1438g [rs6311] of the htr2a gene, stin2 vntr and 5-httlpr of the slc6a4 gene) and the severity of panic and depression symptomatology among mental health outpatients with diagnosis of panic disorder (pd). |
2013-07-25 |
2023-08-12 |
Not clear |
| Abigail G Schindler, Daniel I Messinger, Jeffrey S Smith, Haripriya Shankar, Richard M Gustin, Selena S Schattauer, Julia C Lemos, Nicholas W Chavkin, Catherine E Hagan, John F Neumaier, Charles Chavki. Stress produces aversion and potentiates cocaine reward by releasing endogenous dynorphins in the ventral striatum to locally stimulate serotonin reuptake. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 49. 2013-04-11. PMID:23223282. |
activation of the dynorphin/κ-opioid receptor (kor) system by repeated stress exposure or agonist treatment produces place aversion, social avoidance, and reinstatement of extinguished cocaine place preference behaviors by stimulation of p38α mapk, which subsequently causes the translocation of the serotonin transporter (sert, slc6a4) to the synaptic terminals of serotonergic neurons. |
2013-04-11 |
2023-08-12 |
mouse |