| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Avula, A Rand, J L Black, D J O'Kan. Simultaneous genotyping of multiple polymorphisms in human serotonin transporter gene and detection of novel allelic variants. Translational psychiatry. vol 1. 2013-04-04. PMID:22832606. |
the serotonin transporter, called slc6a4, sert or 5-htt, modulates neurotransmission by removal of serotonin from the synapse of serotonergic neurons, facilitating serotonin reuptake into the presynaptic terminus. |
2013-04-04 |
2023-08-12 |
human |
| Daniela Zuccarello, Marco Ghezzi, Manuel Pengo, Monica Forzan, Anna Chiara Frigo, Alberto Ferlin, Carlo Forest. No difference in 5-HTTLPR and Stin2 polymorphisms frequency between premature ejaculation patients and controls. The journal of sexual medicine. vol 9. issue 6. 2012-10-10. PMID:22489680. |
recently, genetic polymorphisms located on slc6a4 gene codifying for 5-ht transporter (5-htt or serotonin transporter [sert]), the major regulator of serotonergic neurotransmission, have been linked with the pathogenesis of pe and associated with the clinical response to therapy with contrasting results. |
2012-10-10 |
2023-08-12 |
Not clear |
| Gabor Varga, Anna Szekely, Peter Antal, Peter Sarkozy, Zsofia Nemoda, Zsolt Demetrovics, Maria Sasvari-Szekel. Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 3. 2012-10-05. PMID:22259185. |
here we report an association study of both dopaminergic (comt rs4680, drd4 48 bp vntr, drd2/ankk1 rs1800497) and serotonergic (htr1a rs6925, htr1b rs13212041, slc6a4 5-httlpr) gene polymorphisms and trait impulsivity assessed with the barratt impulsiveness scale (bis-11) in a sample of 687 caucasian young adults. |
2012-10-05 |
2023-08-12 |
Not clear |
| Yuka Abe, Takeshi Suganuma, Masakazu Ishii, Gou Yamamoto, Tomohiko Gunji, Glenn T Clark, Tetsuhiko Tachikawa, Yuji Kiuchi, Yoshimasa Igarashi, Kazuyoshi Bab. Association of genetic, psychological and behavioral factors with sleep bruxism in a Japanese population. Journal of sleep research. vol 21. issue 3. 2012-10-04. PMID:22545912. |
in addition, 13 polymorphisms in four genes related to serotonergic neurotransmission (slc6a4, htr1a, htr2a and htr2c) were genotyped. |
2012-10-04 |
2023-08-12 |
human |
| Pilar A Saiz, Paz García-Portilla, Begoña Paredes, Paul Corcoran, Celso Arango, Blanca Morales, Emilio Sotomayor, Victoria Alvarez, Eliecer Coto, Gerardo Flórez, María-Teresa Bascaran, Manuel Bousoño, Julio Bobe. Role of serotonergic-related systems in suicidal behavior: Data from a case-control association study. Progress in neuro-psychopharmacology & biological psychiatry. vol 35. issue 6. 2011-11-29. PMID:21575667. |
to investigate whether functional polymorphisms directly (htr2a and slc6a4 genes) or indirectly (il-1 gene complex, apoe and ace genes) related with serotonergic neurotransmission were associated with suicidal behavior. |
2011-11-29 |
2023-08-12 |
Not clear |
| Judit Lazary, Gabriella Juhasz, Laszlo Hunyady, Gyorgy Bagd. Personalized medicine can pave the way for the safe use of CB₁ receptor antagonists. Trends in pharmacological sciences. vol 32. issue 5. 2011-09-07. PMID:21497918. |
we summarize endocannabinoid signaling in pathways related to anxiety and depression, identify the serotonergic system as the most likely candidate to mediate the side effects of cb₁ receptor antagonists, and propose that poloymorphisms in cnr1, slc6a4 and certain cyp 450 enzymes could help to identify individuals who may benefit from treatment with cb₁ receptor antagonist without psychiatric side effects. |
2011-09-07 |
2023-08-12 |
Not clear |
| Dennis L Murphy, Pablo R Moy. Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21439906. |
considering its primary importance in the regulation and function of the entire serotonergic system (as evidenced by the consequences of sert-mediated reuptake inhibition by sris like fluoxetine in humans and of genetically engineered changes in mice and rats), it seems likely that slc6a4 and sert will remain areas of high interest in our field's attempts to better understand and treat 5-ht-related disorders. |
2011-07-25 |
2023-08-12 |
human |
| Javier Contreras, Sandra Hernández, Paulina Quezada, Albana Dassori, Consuelo Walss-Bass, Michael Escamilla, Henriette Ravento. Association of serotonin transporter promoter gene polymorphism (5-HTTLPR) with depression in Costa Rican schizophrenic patients. Journal of neurogenetics. vol 24. issue 2. 2011-01-27. PMID:20397838. |
the serotonin transporter protein regulates serotonergic signaling at synapses and is encoded by a single gene (slc6a4; locus link id: 6532), located at 17q11.1-q12 with two polymorphic variants (the short and the long allele). |
2011-01-27 |
2023-08-12 |
human |
| Carolina Blaya, Giovanni A Salum, Priya Moorjani, Ana Carolina Seganfredo, Elizeth Heldt, Sandra Leistner-Segal, Jordan W Smoller, Gisele Gus Manfr. Panic disorder and serotonergic genes (SLC6A4, HTR1A and HTR2A): Association and interaction with childhood trauma and parenting. Neuroscience letters. vol 485. issue 1. 2011-01-04. PMID:20817074. |
panic disorder and serotonergic genes (slc6a4, htr1a and htr2a): association and interaction with childhood trauma and parenting. |
2011-01-04 |
2023-08-12 |
Not clear |
| Athanasios Papathanasopoulos, Michael Camilleri, Paula J Carlson, Adrian Vella, Sara J Linker Nord, Duane D Burton, Suwebatu T Odunsi, Alan R Zinsmeiste. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. Obesity (Silver Spring, Md.). vol 18. issue 6. 2010-09-20. PMID:19876010. |
genes controlling adrenergic and serotonergic mechanisms (adra2a, gnb3, and slc6a4) affect gastric emptying (ge), volume (gv), and satiation. |
2010-09-20 |
2023-08-12 |
human |
| Nader Perroud, Elizabeth Neidhart, Brice Petit, Monique Vessaz, Térèse Laforge, Céline Relecom, Romano La Harpe, Alain Malafosse, Michel Guippon. Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 4. 2010-09-03. PMID:20052688. |
tryptophan hydroxylase (tph), the rate limiting enzyme of serotonin biosynthesis and the serotonin transporter (slc6a4), involved in the reuptake of serotonin from the synaptic gap, play major role in serotonergic signaling. |
2010-09-03 |
2023-08-12 |
human |
| Luis F Garcia, Anton Aluja, Joan Fibla, Lara Cuevas, Oscar Garcí. Incremental effect for antisocial personality disorder genetic risk combining 5-HTTLPR and 5-HTTVNTR polymorphisms. Psychiatry research. vol 177. issue 1-2. 2010-06-22. PMID:20363030. |
as the serotonin transporter gene (slc6a4 or 5-htt) is a key regulator of central serotonergic activity, several association studies between antisocial personality disorder (apd) and the slc6a4 polymorphisms have been conducted in the last decade. |
2010-06-22 |
2023-08-12 |
human |
| Gabriella Juhasz, Darragh Downey, Neal Hinvest, Emma Thomas, Diana Chase, Zoltan G Toth, Kathryn Lloyd-Williams, Krisztina Mekli, Hazel Platt, Antony Payton, Gyorgy Bagdy, Rebecca Elliott, J F William Deakin, Ian M Anderso. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043001. |
we tested the hypothesis that variations in serotonergic genes (tph2, tph1, slc6a4, htr1a), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. |
2010-06-21 |
2023-08-12 |
human |
| Shaoyong Su, Jinying Zhao, J Douglas Bremner, Andrew H Miller, Weining Tang, Mark Bouzyk, Harold Snieder, Olga Novik, Nadeem Afzal, Jack Goldberg, Viola Vaccarin. Serotonin transporter gene, depressive symptoms, and interleukin-6. Circulation. Cardiovascular genetics. vol 2. issue 6. 2010-03-01. PMID:20031642. |
we explored the relationship of genetic variants of the serotonin transporter gene slc6a4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma interleukin-6 (il-6) levels. |
2010-03-01 |
2023-08-12 |
Not clear |
| Sandra Dehning, Norbert Müller, Judith Matz, Andreas Bender, Irina Kerle, Jens Benninghoff, Richard Musil, Ilja Spellmann, Brigitta Bondy, Hans-Juergen Möller, Michael Riedel, Peter Zil. A genetic variant of HTR2C may play a role in the manifestation of Tourette syndrome. Psychiatric genetics. vol 20. issue 1. 2010-02-24. PMID:20010450. |
as neuroimaging studies allude to dopaminergic and serotonergic dysfunction in gts and serotonin as an important factor for dopamine release, genotyping of common polymorphisms in the serotonergic receptor (htr1a: c-1019g; htr2a: t102c, his452tyr, a-1438g; htr2c: c-759t, g-697c) and transporter genes (slc6a4) was carried out in 87 patients with gts, compared with 311 matched controls. |
2010-02-24 |
2023-08-12 |
Not clear |
| A Schmitt, J Benninghoff, R Moessner, M Rizzi, E Paizanis, C Doenitz, S Gross, M Hermann, A Gritti, L Lanfumey, S Fritzen, A Reif, M Hamon, D L Murphy, A Vescovi, K-P Lesc. Adult neurogenesis in serotonin transporter deficient mice. Journal of neural transmission (Vienna, Austria : 1996). vol 114. issue 9. 2009-11-27. PMID:17510734. |
the 5-ht transporter (5-htt, slc6a4) mediates high-affinity reuptake of 5-ht into presynaptic terminals and thereby fine-tunes serotonergic neurotransmission. |
2009-11-27 |
2023-08-12 |
mouse |
| A Heck, R Lieb, A Ellgas, H Pfister, S Lucae, D Roeske, B Pütz, B Müller-Myhsok, M Uhr, F Holsboer, M Isin. Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking. Genes, brain, and behavior. vol 8. issue 4. 2009-09-11. PMID:19566713. |
to overcome this limitation, we performed an extended genetic association study analyzing 17 serotonergic (slc6a4, htr1a, htr1b, htr2a, htr2c, htr3a, htr6, maoa, tph1, tph2) and dopaminergic genes (slc6a3, drd2, drd3, drd4, comt, maoa, th, dbh), which have been previously reported to be implicated with personality traits. |
2009-09-11 |
2023-08-12 |
Not clear |
| Dennis L Murphy, Meredith A Fox, Kiara R Timpano, Pablo R Moya, Renee Ren-Patterson, Anne M Andrews, Andrew Holmes, Klaus-Peter Lesch, Jens R Wendlan. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems. Neuropharmacology. vol 55. issue 6. 2009-04-14. PMID:18824000. |
these include examples of the consequences that result from direct serotonergic gene manipulation (gene deletion or overexpression) in mice and other species; an evaluation of some phenotypes related to functional human serotonergic gene variants, particularly in slc6a4, the serotonin transporter gene; and finally, a consideration of the pharmacogenomics of serotonergic drugs with respect to both their therapeutic actions and side effects. |
2009-04-14 |
2023-08-12 |
mouse |
| Pilar A Saiz, Maria P García-Portilla, Begoña Paredes, Celso Arango, Blanca Morales, Victoria Alvarez, Eliecer Coto, Maria-Teresa Bascaran, Manuel Bousoño, Julio Bobe. Association between the A-1438G polymorphism of the serotonin 2A receptor gene and nonimpulsive suicide attempts. Psychiatric genetics. vol 18. issue 5. 2008-11-14. PMID:18797395. |
to investigate the association between four serotonergic polymorphisms [a-1438g (rs6311) and t102c (rs6313) of the serotonin 2a receptor gene, and stin2 vntr and 5-httlpr of the slc6a4 gene] and suicidal behavior. |
2008-11-14 |
2023-08-12 |
Not clear |
| Gerardo Florez, Pilar Saiz, Paz Garcia-Portilla, Sandra Alvarez, Luis Nogueíras, Blanca Morales, Victoria Alvarez, Eliecer Coto, Julio Bobe. Association between the Stin2 VNTR polymorphism of the serotonin transporter gene and treatment outcome in alcohol-dependent patients. Alcohol and alcoholism (Oxford, Oxfordshire). vol 43. issue 5. 2008-11-07. PMID:18552399. |
the aim of this study was to investigate the potential association between functional polymorphisms of dopaminergic [dopamine receptor d2 (drd2), dopamine receptor d3 (drd3) and dopamine transporter (slc6a3)] and serotonergic [serotonin 2a receptor (htr2a) and serotonin transporter (slc6a4)] genes and treatment outcome in alcohol-dependent patients. |
2008-11-07 |
2023-08-12 |
Not clear |