All Relations between slc6a4 and serotonergic

Publication Sentence Publish Date Extraction Date Species
Sylvana I S Rendeiro de Noronha, Lauro Angelo Gonçalves de Moraes, James E Hassell, Christopher E Stamper, Mathew R Arnold, Jared D Heinze, Christine L Foxx, Margaret M Lieb, Kristin E Cler, Bree L Karns, Sophia Jaekel, Kelsey M Loupy, Fernanda C S Silva, Deoclécio Alves Chianca-Jr, Christopher A Lowry, Rodrigo Cunha de Meneze. High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats. Biological research. vol 57. issue 1. 2024-05-05. PMID:38705984. here we conducted a nine-week hfd protocol in male rats, followed by an analysis of the gut microbiome diversity and community composition, brainstem serotonergic gene expression (tph2, htr1a, and slc6a4), and anxiety-related defensive behavioral responses. 2024-05-05 2024-05-08 rat
Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. 2022-10-22 2023-08-14 Not clear
Osama Y Alshogran, Laith N Al-Eitan, Shoroq M Altawalbeh, Hatem A Ama. Association of DRD4 exon III and 5-HTTLPR VNTR genetic polymorphisms with psychiatric symptoms in hemodialysis patients. PloS one. vol 16. issue 3. 2021-10-13. PMID:33784353. given that the dopaminergic and serotonergic pathways are involved in the etiology of psychiatric disease, this study evaluated the genetic association of dopamine d4 receptor (drd4) and serotonin transporter (slc6a4) genes with psychiatric symptom susceptibility among hd patients. 2021-10-13 2023-08-13 Not clear
M A Schiele, P Zwanzger, K Schwarte, V Arolt, B T Baune, K Domschk. Serotonin Transporter Gene Promoter Hypomethylation as a Predictor of Antidepressant Treatment Response in Major Depression: A Replication Study. The international journal of neuropsychopharmacology. vol 24. issue 3. 2021-10-06. PMID:33125470. in mdd, lower slc6a4 promoter methylation has been suggested to predict impaired response to serotonergic antidepressants. 2021-10-06 2023-08-13 Not clear
Irmak Sah, Emel Hulya Yukseloglu, Nese Kocabasoglu, Burcu Bayoglu, Emre Cirakoglu, Mujgan Cengi. The effects of 5-HTTLPR/rs25531 serotonin transporter gene polymorphisms on antisocial personality disorder among criminals in a sample of the Turkish population. Molecular biology reports. vol 48. issue 1. 2021-05-25. PMID:33452587. it has been determined by previous studies that aspd may have a genetic origin and the human serotonin transporter gene (slc6a4) is one of the two serotonergic genes expected to be associated with this disorder. 2021-05-25 2023-08-13 human
David A Nielsen, Huiqiong Deng, Michelle A Patriquin, Mark J Harding, John Oldham, Ramiro Salas, J Christopher Fowler, B Christopher Frue. Association of TPH1 and serotonin transporter genotypes with treatment response for suicidal ideation: a preliminary study. European archives of psychiatry and clinical neuroscience. vol 270. issue 5. 2021-04-05. PMID:30923939. variants in three genes coding for components of the serotonergic system, the tryptophan hydroxylase 1 (tph1) rs1799913, serotonin transporter (slc6a4) 5-httlpr, and serotonin receptor 2a (htr2a) rs6311, were evaluated for association with suicidal ideation (si) and with recovery from si in a psychiatric inpatient population. 2021-04-05 2023-08-13 Not clear
Shu-Yue Qu, Xiao-Yue Li, Xia Heng, Yi-Yu Qi, Ping-Yuan Ge, Sai-Jia Ni, Zeng-Ying Yao, Rui Guo, Nian-Yun Yang, Yi Cao, Qi-Chun Zhang, Hua-Xu Zh. Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics. Frontiers in pharmacology. vol 12. 2021-03-23. PMID:33746756. grin2b, drd, prkca, htr, maoa, slc6a4, grin2a, and cacna1a are implicated in inhibition of depressive symptoms through modulating tryptophan metabolism, serotonergic and dopaminergic synaptic activities, camp signaling pathway, and calcium signaling pathway. 2021-03-23 2023-08-13 mouse
Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). 2021-01-04 2023-08-13 rat
Natalia Chmielewska, Janusz Szyndler, Piotr Maciejak, Adam Płaźni. Epigenetic mechanisms of stress and depression. Psychiatria polska. vol 53. issue 6. 2020-12-10. PMID:32017826. early and adult stress exposure is believed to have an association with epigenetic alteration of genes involved in mood regulation, for example, genes involved in the regulation of the hpa axis activity (nr3c1) or responsible for the serotonergic neurotransmission (slc6a4). 2020-12-10 2023-08-13 Not clear
Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). 2020-09-14 2023-08-13 mouse
Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Rosanne Freak-Poli, Richard Saffery, Joanne Rya. Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression. BMC psychiatry. vol 18. issue 1. 2019-06-25. PMID:30180828. disrupted serotonergic signaling is often a feature of depression and the role of the serotonin transporter gene (slc6a4), responsible for serotonin re-uptake, has received much attention in this regard. 2019-06-25 2023-08-13 Not clear
Sonali N Reisinger, Thomas Wanek, Oliver Langer, Daniela D Polla. PET imaging of the mouse brain reveals a dynamic regulation of SERT density in a chronic stress model. Translational psychiatry. vol 9. issue 1. 2019-06-10. PMID:30745564. the serotonin transporter (sert, slc6a4) plays an important role in the regulation of serotonergic neurotransmission and its aberrant expression has been linked to several psychiatric conditions. 2019-06-10 2023-08-13 mouse
Maria Teresa Plana, Teresa Torres, Natalia Rodríguez, Daniel Boloc, Patricia Gassó, Elena Moreno, Amalia Lafuente, Josefina Castro-Fornieles, Sergi Mas, Luisa Lazar. Genetic variability in the serotoninergic system and age of onset in anorexia nervosa and obsessive-compulsive disorder. Psychiatry research. vol 271. 2019-04-23. PMID:30554102. following on from previous work by our group where we showed that early onset anorexia nervosa (an) and obsessive-compulsive disorder (ocd) shared a common genetic background, the aim of the present study is to assess genetic pleiotropy related to the serotonergic system (slc6a4, 5htr2a, 5htr2c, tph2, slc18a1), in a common phenotype such as very-early age of onset. 2019-04-23 2023-08-13 Not clear
H Palma-Gudiel, V Peralta, M Deuschle, V Navarro, L Fañaná. Epigenetics-by-sex interaction for somatization conferred by methylation at the promoter region of SLC6A4 gene. Progress in neuro-psychopharmacology & biological psychiatry. vol 89. 2019-03-25. PMID:30201454. the serotonin transporter (sert), encoded by slc6a4 gene, has received major attention due to its crucial role in serotonergic transmission. 2019-03-25 2023-08-13 Not clear
J H Piel, T A Lett, C Wackerhagen, M M Plichta, S Mohnke, O Grimm, N Romanczuk-Seiferth, F Degenhardt, H Tost, S Witt, M Nöthen, M Rietschel, A Heinz, A Meyer-Lindenberg, H Walter, S Er. The effect of 5-HTTLPR and a serotonergic multi-marker score on amygdala, prefrontal and anterior cingulate cortex reactivity and habituation in a large, healthy fMRI cohort. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 3. 2019-01-29. PMID:29358097. a suggested intermediate phenotype of mdd is emotion recognition: the 5-httlpr polymorphism of slc6a4 as well as other serotonergic genes have been associated with amygdala and prefrontal function during emotion recognition. 2019-01-29 2023-08-13 human
J Waider, S Popp, M D Lange, R Kern, J F Kolter, J Kobler, N C Donner, K R Lowe, J H Malzbender, C J Brazell, M R Arnold, B Aboagye, A Schmitt-Böhrer, C A Lowry, H C Pape, K P Lesc. Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Translational psychiatry. vol 7. issue 10. 2018-06-14. PMID:28972592. functional assessment of c-fos after associated foot shock, electrophysiological recordings of gabaergic synaptic transmission, differential expression of the slc6a4 gene in serotonergic neurons were combined with locomotor and anxiety-like measurements in different contextual settings. 2018-06-14 2023-08-13 mouse
James H Fox, James E Hassell, Philip H Siebler, Mathew R Arnold, Andrew K Lamb, David G Smith, Heidi E W Day, Tessa M Smith, Emma M Simmerman, Alexander A Outzen, Kaley S Holmes, Christopher J Brazell, Christopher A Lowr. Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm. Brain, behavior, and immunity. vol 66. 2018-06-06. PMID:28888667. rats were euthanized on day 11 and brain tissue was sectioned for analysis of mrna expression for genes important in control of brain serotonergic signaling, including tph2, htr1a, slc6a4, and slc22a3, throughout the brainstem dorsal and median raphe nuclei. 2018-06-06 2023-08-13 mouse
Xiaoxue Gao, Jinting Liu, Pingyuan Gong, Junhui Wang, Wan Fang, Hongming Yan, Lusha Zhu, Xiaolin Zho. Identifying new susceptibility genes on dopaminergic and serotonergic pathways for the framing effect in decision-making. Social cognitive and affective neuroscience. vol 12. issue 9. 2018-05-24. PMID:28431168. this effect has been found to be modulated by the serotonin transporter gene (slc6a4) and the catechol-o-methyltransferase gene (comt) polymorphisms, which are on the dopaminergic and serotonergic pathways and which are associated with affective processing. 2018-05-24 2023-08-13 human
C S Reigstad, D R Linden, J H Szurszewski, J L Sonnenburg, G Farrugia, P C Kashya. Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 28. issue 9. 2018-02-12. PMID:27072889. among the 10 pairwise comparisons conducted between five serotonergic transcripts, tph1, chga, maoa, slc6a4, and htr4, we found a strong, positive correlation between colonic expression of slc6a4 and htr4 across different colonization states and sexes. 2018-02-12 2023-08-13 mouse
C S Reigstad, D R Linden, J H Szurszewski, J L Sonnenburg, G Farrugia, P C Kashya. Correlated gene expression encoding serotonin (5-HT) receptor 4 and 5-HT transporter in proximal colonic segments of mice across different colonization states and sexes. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 28. issue 9. 2018-02-12. PMID:27072889. these data suggest that correlated expression of slc6a4 and htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut. 2018-02-12 2023-08-13 mouse