| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Christopher Q Rogers, Joanne M Ajmo, Min Yo. Adiponectin and alcoholic fatty liver disease. IUBMB life. vol 60. issue 12. 2009-02-10. PMID:18709650. |
chronic ethanol exposure is thought to cause enhanced hepatic lipogenesis and impaired fatty acid oxidation by inhibiting key hepatic transcriptional regulators such as amp-activated kinase (ampk), sirtuin 1 (sirt1), ppar-gamma coactivator alpha (pgc-1alpha), peroxisome proliferator-activated receptor alpha (pparalpha), and sterol regulatory element-binding protein 1 (srebp-1). |
2009-02-10 |
2023-08-12 |
human |
| Joan Oliva, Barbara A French, Jun Li, Fawzia Bardag-Gorce, Paul Fu, Samuel W Frenc. Sirt1 is involved in energy metabolism: the role of chronic ethanol feeding and resveratrol. Experimental and molecular pathology. vol 85. issue 3. 2008-12-17. PMID:18793633. |
the expression of sirt1 and pgc1 alpha was increased by ethanol but not when naringin or resveratrol was fed with ethanol. |
2008-12-17 |
2023-08-12 |
rat |
| Joanne M Ajmo, Xiaomei Liang, Christopher Q Rogers, Brandi Pennock, Min Yo. Resveratrol alleviates alcoholic fatty liver in mice. American journal of physiology. Gastrointestinal and liver physiology. vol 295. issue 4. 2008-11-26. PMID:18755807. |
the resveratrol-mediated increase in activities of sirt1 and ampk was associated with suppression of sterol regulatory element binding protein 1 (srebp-1) and activation of peroxisome proliferator-activated receptor gamma coactivator alpha (pgc-1alpha). |
2008-11-26 |
2023-08-12 |
mouse |
| Joseph T Rodgers, Carles Lerin, Zachary Gerhart-Hines, Pere Puigserve. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS letters. vol 582. issue 1. 2008-03-12. PMID:18036349. |
metabolic adaptations through the pgc-1 alpha and sirt1 pathways. |
2008-03-12 |
2023-08-12 |
Not clear |
| Joseph T Rodgers, Carles Lerin, Zachary Gerhart-Hines, Pere Puigserve. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. FEBS letters. vol 582. issue 1. 2008-03-12. PMID:18036349. |
thus, understanding the pgc-1 alpha and sirt1 pathways might have important implications for comprehending metabolic and age-associated diseases. |
2008-03-12 |
2023-08-12 |
Not clear |
| Li Qiang, Hong Wang, Stephen R Farme. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Molecular and cellular biology. vol 27. issue 13. 2007-08-09. PMID:17452443. |
adiponectin secretion is regulated by sirt1 and the endoplasmic reticulum oxidoreductase ero1-l alpha. |
2007-08-09 |
2023-08-12 |
Not clear |
| Li Qiang, Hong Wang, Stephen R Farme. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Molecular and cellular biology. vol 27. issue 13. 2007-08-09. PMID:17452443. |
in this report, we demonstrate that the endoplasmic reticulum (er) oxidoreductase ero1-l alpha and effectors modulating peroxisome proliferator-activated receptor gamma (ppar gamma) and sirt1 activities regulate secretion of adiponectin from 3t3-l1 adipocytes. |
2007-08-09 |
2023-08-12 |
Not clear |
| Li Qiang, Hong Wang, Stephen R Farme. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Molecular and cellular biology. vol 27. issue 13. 2007-08-09. PMID:17452443. |
specifically, adiponectin secretion and ero1-l alpha expression are induced during the early phase of adipogenesis but are then down-regulated during the terminal phase, coincident with an increased expression of sirt1. |
2007-08-09 |
2023-08-12 |
Not clear |
| Li Qiang, Hong Wang, Stephen R Farme. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Molecular and cellular biology. vol 27. issue 13. 2007-08-09. PMID:17452443. |
suppression of sirt1 or activation of ppar gamma enhances ero1-l alpha expression and stimulates secretion of high-molecular-weight complexes of adiponectin in mature adipocytes. |
2007-08-09 |
2023-08-12 |
Not clear |
| Li Qiang, Hong Wang, Stephen R Farme. Adiponectin secretion is regulated by SIRT1 and the endoplasmic reticulum oxidoreductase Ero1-L alpha. Molecular and cellular biology. vol 27. issue 13. 2007-08-09. PMID:17452443. |
moreover, ectopic expression of ero1-l alpha in ero1-l alpha-deficient 3t3 fibroblasts stimulates the secretion of adiponectin following their conversion into adipocytes and prevents the suppression of adiponectin secretion in response to activation of sirt1 by exposure to resveratrol. |
2007-08-09 |
2023-08-12 |
Not clear |
| Liping Qiao, Jianhua Sha. SIRT1 regulates adiponectin gene expression through Foxo1-C/enhancer-binding protein alpha transcriptional complex. The Journal of biological chemistry. vol 281. issue 52. 2007-02-12. PMID:17090532. |
sirt1 regulates adiponectin gene expression through foxo1-c/enhancer-binding protein alpha transcriptional complex. |
2007-02-12 |
2023-08-12 |
mouse |
| Shino Nemoto, Maria M Fergusson, Toren Finke. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. The Journal of biological chemistry. vol 280. issue 16. 2005-06-23. PMID:15716268. |
sirt1 functionally interacts with the metabolic regulator and transcriptional coactivator pgc-1{alpha}. |
2005-06-23 |
2023-08-12 |
Not clear |
| Yoshiyuki Horio, Shin Hisahara, Jun Sakamot. [Functional analysis of SIR2]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 122 Suppl. 2004-02-27. PMID:14727515. |
we found that sir2 alpha (sirt1) was highly expressed during embryogenesis. |
2004-02-27 |
2023-08-12 |
mouse |