| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gaurav Majumdar, Amit Kumar Trivedi, Neelu Jain Gupta, Vinod Kuma. Circadian synchronization determines critical day length for seasonal responses. Physiology & behavior. vol 147. 2016-02-23. PMID:25957913. |
to investigate this, we measured expression levels of genes implicated in the photoperiod-induced changes in reproduction (eya3, tsh beta, dio2, dio3, gnrh and gnih) and metabolism (sirt1, hmgcr, fasn and ppar alpha) in photosensitive redheaded buntings subjected to light-dark cycles of varying period lengths (t-photocycles). |
2016-02-23 |
2023-08-13 |
Not clear |
| Pan Guo, Huifeng Pi, Shangcheng Xu, Lei Zhang, Yuming Li, Min Li, Zhengwang Cao, Li Tian, Jia Xie, Renyan Li, Mindi He, Yonghui Lu, Chuan Liu, Weixia Duan, Zhengping Yu, Zhou Zho. Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicological sciences : an official journal of the Society of Toxicology. vol 142. issue 1. 2015-07-20. PMID:25159133. |
consistent with this finding, cd exposure was associated with decreased sirtuin 1 (sirt1) protein expression and activity, thus promoted acetylation of pgc-1 alpha, a key enzyme involved in mitochondrial biogenesis and function, although cd did not disrupt the interaction between sirt1 and pgc-1 alpha. |
2015-07-20 |
2023-08-13 |
Not clear |
| Pan Guo, Huifeng Pi, Shangcheng Xu, Lei Zhang, Yuming Li, Min Li, Zhengwang Cao, Li Tian, Jia Xie, Renyan Li, Mindi He, Yonghui Lu, Chuan Liu, Weixia Duan, Zhengping Yu, Zhou Zho. Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicological sciences : an official journal of the Society of Toxicology. vol 142. issue 1. 2015-07-20. PMID:25159133. |
moreover, sirtinol and sirt1 sirna each blocked the melatonin-mediated elevation in mitochondrial function by inhibiting sirt1/ pgc-1 alpha signaling. |
2015-07-20 |
2023-08-13 |
Not clear |
| Pan Guo, Huifeng Pi, Shangcheng Xu, Lei Zhang, Yuming Li, Min Li, Zhengwang Cao, Li Tian, Jia Xie, Renyan Li, Mindi He, Yonghui Lu, Chuan Liu, Weixia Duan, Zhengping Yu, Zhou Zho. Melatonin Improves mitochondrial function by promoting MT1/SIRT1/PGC-1 alpha-dependent mitochondrial biogenesis in cadmium-induced hepatotoxicity in vitro. Toxicological sciences : an official journal of the Society of Toxicology. vol 142. issue 1. 2015-07-20. PMID:25159133. |
in summary, our results indicate that sirt1 plays an essential role in the ability of moderate melatonin to stimulate pgc-1 alpha and improve mitochondrial biogenesis and function at least partially through melatonin receptors in cadmium-induced hepatotoxicity. |
2015-07-20 |
2023-08-13 |
Not clear |
| Guangwei Liu, Yujing Bi, Lixiang Xue, Yan Zhang, Hui Yang, Xi Chen, Yun Lu, Zhengguo Zhang, Huanrong Liu, Xiao Wang, Ruoning Wang, Yiwei Chu, Ruifu Yan. Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1. Proceedings of the National Academy of Sciences of the United States of America. vol 112. issue 9. 2015-05-08. PMID:25730867. |
beyond this finding, sirt1 signaled through a hypoxia-inducible factor-1 alpha (hif1α)-dependent pathway, orchestrating the reciprocal th1 and t(reg) lineage commitment through dc-derived il-12 and tgf-β1. |
2015-05-08 |
2023-08-13 |
Not clear |
| E M Choi, K S Suh, S Y Rhee, Y S Ki. Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis. Free radical research. vol 48. issue 7. 2015-03-30. PMID:24628445. |
furthermore, sciadopitysin treatment increased the levels of sirtuin 1 (sirt1), peroxisome proliferator-activated receptor gamma coactivator 1 alpha (pgc-1α), nuclear respiratory factor 1 (nrf-1), and mitochondrial transcription factor a (tfam). |
2015-03-30 |
2023-08-12 |
Not clear |
| Priyatansh Gurha, Tiannan Wang, Ashley H Larimore, Yassine Sassi, Cei Abreu-Goodger, Maricela O Ramirez, Anilkumar K Reddy, Stefan Engelhardt, George E Taffet, Xander H T Wehrens, Mark L Entman, Antony Rodrigue. microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription. PloS one. vol 8. issue 9. 2014-07-18. PMID:24086656. |
mechanistically, mir-22 postranscriptionally inhibits peroxisome proliferator-activated receptor gamma coactivator 1 alpha (pgc-1α), pparα and sirtuin 1 (sirt1) expression via a synergistic circuit, which may account for deleterious actions of unchecked mir-22 expression on the heart. |
2014-07-18 |
2023-08-12 |
mouse |
| Cheng Luo, Yan Li, Liang Yang, Zhihui Feng, Yuan Li, Jiangang Long, Jiankang Li. A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology. vol 14. issue 5. 2014-05-16. PMID:24026667. |
the results showed that subacute treatment with low dose of acrolein induces the following events compared to the control cells: cell senescence demonstrated by increases in the activity of β-galactosidase, the higher expression of p53 and p21, decreases in dna synthesis, sirt1 expression, and telomere length; oxidative stress occurred as the increases in the production of reactive oxygen species, dna damage, and protein oxidation; and mitochondrial dysfunction shown as decreases in the mitochondrial membrane potential, mitochondrial biogenesis regulator pgc-1 alpha and mitochondria complex i, ii, iii, and v. these results suggest that acrolein may accelerate aging through the mechanism of increasing oxidative stress and mitochondrial dysfunction. |
2014-05-16 |
2023-08-12 |
human |
| Elaine Vieira, Laura Marroquí, Ana Lucia C Figueroa, Beatriz Merino, Rebeca Fernandez-Ruiz, Angel Nadal, Thomas P Burris, Ramon Gomis, Ivan Quesad. Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. PloS one. vol 8. issue 7. 2014-03-05. PMID:23936124. |
high glucose inhibited key genes controlled by ampk such as nampt, sirt1 and pgc-1 alpha in alphatc1-9 cells (p<0.05). |
2014-03-05 |
2023-08-12 |
mouse |
| Elaine Vieira, Laura Marroquí, Ana Lucia C Figueroa, Beatriz Merino, Rebeca Fernandez-Ruiz, Angel Nadal, Thomas P Burris, Ramon Gomis, Ivan Quesad. Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells. PloS one. vol 8. issue 7. 2014-03-05. PMID:23936124. |
nampt inhibition decreased sirt1, pgc-1 alpha and rev-erb alpha mrna expression (p<0.01) and glucagon release (p<0.05). |
2014-03-05 |
2023-08-12 |
mouse |
| Veena Theendakara, Alexander Patent, Clare A Peters Libeu, Brittany Philpot, Sonia Flores, Olivier Descamps, Karen S Poksay, Qiang Zhang, Gabriellee Cailing, Matthew Hart, Varghese John, Rammohan V Rao, Dale E Bredese. Neuroprotective Sirtuin ratio reversed by ApoE4. Proceedings of the National Academy of Sciences of the United States of America. vol 110. issue 45. 2013-12-31. PMID:24145446. |
here we show that, although both apoe3 and apoe4 associate with app with nanomolar affinities, only apoe4 significantly (i) reduces the ratio of soluble amyloid precursor protein alpha (sappα) to aβ; (ii) reduces sirtuin t1 (sirt1) expression, resulting in markedly differing ratios of neuroprotective sirt1 to neurotoxic sirt2; (iii) triggers tau phosphorylation and app phosphorylation; and (iv) induces programmed cell death. |
2013-12-31 |
2023-08-12 |
Not clear |
| Marcin Buler, Sanna-Mari Aatsinki, Réka Skoumal, Jukka Hakkol. Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function. Biochemical pharmacology. vol 82. issue 12. 2012-01-09. PMID:21933665. |
in this study we have investigated the effect of two major regulators of hepatic energy homeostasis, the transcriptional coactivator, peroxisome proliferator-activated receptor γ coactivator 1 alpha (pgc-1α) and the nad-dependent deacetylase protein, sirtuin 1 (sirt1) on pxr expression and function. |
2012-01-09 |
2023-08-12 |
mouse |
| Sokrates Stein, Christine Lohmann, Christoph Handschin, Elin Stenfeldt, Jan Borén, Thomas F Lüscher, Christian M Matte. ApoE-/- PGC-1α-/- mice display reduced IL-18 levels and do not develop enhanced atherosclerosis. PloS one. vol 5. issue 10. 2011-03-07. PMID:21042583. |
the pparγ coactivator 1 alpha (ppargc1a or pgc-1α) was identified as an important transcriptional cofactor of pparγ and is activated by sirt1. |
2011-03-07 |
2023-08-12 |
mouse |
| Qihuang Jin, Fang Zhang, Tingting Yan, Zhen Liu, Chunxi Wang, Xinjian Ge, Qiwei Zha. C/EBPalpha regulates SIRT1 expression during adipogenesis. Cell research. vol 20. issue 4. 2010-07-08. PMID:20157332. |
in this study, we show that both sirt1 protein and mrna levels were increased along with ccaat/enhancer-binding protein alpha (c/ebpalpha) during adipocyte differentiation. |
2010-07-08 |
2023-08-12 |
Not clear |
| Shweta Rane, Minzhen He, Danish Sayed, Lin Yan, Dorothy Vatner, Maha Abdellati. An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cellular signalling. vol 22. issue 7. 2010-06-10. PMID:20193759. |
we have recently reported that downregulation of mir-199a-5p is necessary and sufficient for inducing upregulation of its targets, including hypoxia-inducible factor-1 alpha (hif-1 alpha) and sirt1, during hypoxia preconditioning (hpc). |
2010-06-10 |
2023-08-12 |
Not clear |
| Shweta Rane, Minzhen He, Danish Sayed, Lin Yan, Dorothy Vatner, Maha Abdellati. An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cellular signalling. vol 22. issue 7. 2010-06-10. PMID:20193759. |
our present study shows that overexpression of a constitutively active akt (caakt) induced 70% reduction in mir-199a-5p and was associated with a robust increase in hif-1 alpha (10+/-2 fold) and sirt1 (4+/-0.8 fold) that was reversed by overexpression of mir-199a-5p. |
2010-06-10 |
2023-08-12 |
Not clear |
| Shweta Rane, Minzhen He, Danish Sayed, Lin Yan, Dorothy Vatner, Maha Abdellati. An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p. Cellular signalling. vol 22. issue 7. 2010-06-10. PMID:20193759. |
accordingly, we predicted that beta ar would antagonize akt-induced, mir-199a-5p-dependent, upregulation of hif-1 alpha and sirt1. |
2010-06-10 |
2023-08-12 |
Not clear |
| Tomomi Asaba, Takayoshi Suzuki, Rie Ueda, Hiroki Tsumoto, Hidehiko Nakagawa, Naoki Miyat. Inhibition of human sirtuins by in situ generation of an acetylated lysine-ADP-ribose conjugate. Journal of the American Chemical Society. vol 131. issue 20. 2009-07-01. PMID:19413317. |
among the compounds thus designed and synthesized, we found that 2k, which contains an ethoxycarbonyl group at the alpha position to the acetamide of acetylated lysine substrate analogue 1, showed potent inhibitory activity in an in vitro assay using recombinant sirt1, with high selectivity over sirt2 and sirt3. |
2009-07-01 |
2023-08-12 |
human |
| Elhadji M Dioum, Rui Chen, Matthew S Alexander, Quiyang Zhang, Richard T Hogg, Robert D Gerard, Joseph A Garci. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science (New York, N.Y.). vol 324. issue 5932. 2009-06-16. PMID:19498162. |
we demonstrate that sirtuin 1 (sirt1), a redox-sensing deacetylase, selectively stimulates activity of the transcription factor hypoxia-inducible factor 2 alpha (hif-2alpha) during hypoxia. |
2009-06-16 |
2023-08-12 |
mouse |
| Aparna Purushotham, Thaddeus T Schug, Qing Xu, Sailesh Surapureddi, Xiumei Guo, Xiaoling L. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell metabolism. vol 9. issue 4. 2009-06-15. PMID:19356714. |
here we demonstrate that hepatic sirt1 regulates lipid homeostasis by positively regulating peroxisome proliferators-activated receptor alpha (pparalpha), a nuclear receptor that mediates the adaptive response to fasting and starvation. |
2009-06-15 |
2023-08-12 |
mouse |