| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shaojun Liu, Jing Chen, Jian Shi, Wenyi Zhou, Li Wang, Weilun Fang, Yun Zhong, Xiaohui Chen, Yanfang Chen, Abdelkarim Sabri, Shiming Li. M1-like macrophage-derived exosomes suppress angiogenesis and exacerbate cardiac dysfunction in a myocardial infarction microenvironment. Basic research in cardiology. vol 115. issue 2. 2020-12-22. PMID:32112145. |
mir-155 was transferred to endothelial cells (ecs), leading to the inhibition of angiogenesis and cardiac dysfunction by downregulating its novel target genes, including rac family small gtpase 1 (rac1), p21 (rac1)-activated kinase 2 (pak2), sirtuin 1 (sirt1), and protein kinase amp-activated catalytic subunit alpha 2 (ampkα2). |
2020-12-22 |
2023-08-13 |
Not clear |
| Shangwen Pan, Yan Wu, Lei Pei, Shengnan Li, Limin Song, Haifa Xia, Yaxin Wang, Yuan Yu, Xiaobo Yang, Huaqing Shu, Jiancheng Zhang, Shiying Yuan, You Shan. BML-111 Reduces Neuroinflammation and Cognitive Impairment in Mice With Sepsis via the SIRT1/NF-κB Signaling Pathway. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30186119. |
some of the other surviving mice were killed at 24 h after surgery to assess synaptic damage (psd95 and synapsin1), markers of inflammation [tumor necrosis factor alpha (tnf-α) and interleukin (il)-1β], cytoplasmic p65, nuclear p65, ac- nf-κb and sirt1. |
2020-10-01 |
2023-08-13 |
mouse |
| Li Liu, Youde Jiang, Jena J Steinl. Epac1 and Glycyrrhizin Both Inhibit HMGB1 Levels to Reduce Diabetes-Induced Neuronal and Vascular Damage in the Mouse Retina. Journal of clinical medicine. vol 8. issue 6. 2020-10-01. PMID:31159195. |
we also investigated whether epac1 and glycyrrhizin work synergistically to reduce the retinal inflammatory mediators, tumor necrosis factor alpha (tnfα) and interleukin-1-beta (il1β), as well as sirtuin 1 (sirt1) levels. |
2020-10-01 |
2023-08-13 |
mouse |
| Ann-Yae Na, Eun-Ju Yang, Ju Mi Jeon, Sung Hwan Ki, Kyung-Sik Song, Sangkyu Le. Protective Effect of Isoliquiritigenin against Ethanol-Induced Hepatic Steatosis by Regulating the SIRT1-AMPK Pathway. Toxicological research. vol 34. issue 1. 2020-09-30. PMID:29371998. |
lipid accumulation was assayed by oil red o staining, and the expression of sirtuin1 (sirt1), sterol regulatory element-binding protein-1c (srebp-1c), amp-activated protein kinase (ampk), and peroxisome proliferator-activated receptor alpha (pparα) was studied by western blotting. |
2020-09-30 |
2023-08-13 |
Not clear |
| Dan-Dan Huang, Xiao-Hong Wei, Hong-Na Mu, Chun-Shui Pan, Quan Li, Bai-He Hu, Xin Chang, Li Yan, Jing-Yu Fan, Yu-Ying Liu, Jian-Yuan Luo, Jing-Yan Ha. Total Salvianolic Acid Injection Prevents Ischemia/Reperfusion-Induced Myocardial Injury Via Antioxidant Mechanism Involving Mitochondrial Respiratory Chain Through the Upregulation of Sirtuin1 and Sirtuin3. Shock (Augusta, Ga.). vol 51. issue 6. 2020-06-25. PMID:29863652. |
moreover, tsi protected heart from oxidative insults, such as elevation of myeloperoxidase, malondialdehyde, hydrogen peroxide, ros, as well as attenuated i/r-elicited downregulation of sirt1, sirt3, nadh dehydrogenase [ubiquinone] 1 alpha subcomplex 10 (ndufa10), succinate dehydrogenase complex, subunit a, flavoprotein variant (sdha), and restoring mitochondrial respiratory chain complexes activity. |
2020-06-25 |
2023-08-13 |
rat |
| Yang Yang, Yimin Jia, Qinwei Sun, Haibo Dong, Ruqian Zha. White light emitting diode induces autophagy in hippocampal neuron cells through GSK-3-mediated GR and RORα pathways. Aging. vol 11. issue 6. 2020-05-20. PMID:30923260. |
concurrently, the rhythmic pattern of clock-related gene expression was disrupted, which was associated with augmented expression of sirt1, ampk and retinoid-related orphan receptor alpha (rorα). |
2020-05-20 |
2023-08-13 |
Not clear |
| Hai Xiao, Xinyue Qin, Jinping Wan, Rong L. Pharmacological Targets and the Biological Mechanisms of Formononetin for Alzheimer's Disease: A Network Analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2020-01-16. PMID:31175839. |
results seven key target genes for formononetin in the treatment of patients with ad were identified, including estrogen receptor alpha (esr1), peroxisome proliferator-activated receptor gamma (pparg), tumor protein p53 (tp53), sirtuin 1 (sirt1), tumor necrosis factor (tnf), cytochrome p450 19a1 (cyp19a1), and nuclear factor (erythroid-derived 2)-like 2 (nfe2l2). |
2020-01-16 |
2023-08-13 |
Not clear |
| Sihua Jin, Lei Yang, Xinfeng Fan, Minghui Wu, Yuan Xu, Xianzen Chen, Zhiqiang Lin, Zhaoyu Gen. Effect of divergence in residual feed intake on expression of lipid metabolism-related genes in the liver of meat-type ducks1. Journal of animal science. vol 97. issue 9. 2019-12-13. PMID:31325379. |
relative expressions of key genes, namely sirtuin 1 (sirt1), forkhead box o1 (foxo1), peroxisome proliferator-activated receptor gamma (pparγ), sterol regulatory element-binding transcription factor 1c (srebp-1c), fas cell surface death receptor (fas), acetyl-coa carboxylase alpha (acc), carnitine palmitoyltransferase 1a (cpt1a), and acyl-coa oxidase 1 (acox1), were then determined in the hrfi and lrfi ducks by quantitative pcr. |
2019-12-13 |
2023-08-13 |
Not clear |
| Xiao-Xiao Li, Xin-Yi Lu, Shi-Jie Zhang, Amy P Chiu, Lilian H Lo, David A Largaespada, Qu-Bo Chen, Vincent W Ken. Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 111. 2019-06-13. PMID:30576936. |
this protective effect might be associated with sts induced activation of sirtuin 1 (sirt1)/protein kinase amp-activated catalytic subunit alpha 1 (prkaa1) pathways. |
2019-06-13 |
2023-08-13 |
mouse |
| Jie Qin, Yan Liu, Yongkui Lu, Meiling Liu, Manli Li, Juan Li, Lijuan W. Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression. Scientific reports. vol 7. issue 1. 2019-05-20. PMID:28878214. |
hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating sirt1 expression. |
2019-05-20 |
2023-08-13 |
human |
| Yiyang Zhang, Yingshu Li, Jinfeng Li, Biao Li, Yingzhi Chong, Guoying Zheng, Shufeng Sun, Fumin Fen. SIRT1 alleviates isoniazid-induced hepatocyte injury by reducing histone acetylation in the IL-6 promoter region. International immunopharmacology. vol 67. 2019-05-09. PMID:30578970. |
we found that compared with the blank control group, expression of sirt1 was decreased in the isoniazid group and that expression of nf-κb p65 was increased, leading to an increase of the expression of inflammatory cytokines interleukin-6 (il-6) and tumour necrosis factor alpha (tnf-α). |
2019-05-09 |
2023-08-13 |
Not clear |
| Mijung Lee, Jae-Jun Ban, Jin-Young Chung, Wooseok Im, Manho Ki. Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation. PloS one. vol 13. issue 5. 2018-08-01. PMID:29742127. |
sirt1 is a deacetylase of the sirtuin family and deacetylates proteins including the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (pgc-1α) which is associated with mitochondrial respiration and biogenesis. |
2018-08-01 |
2023-08-13 |
mouse |
| Qi Wu, Yulan Wang, Mingping Qian, Yongxia Qiao, Shaowu Zou, Changqiang Chen, Xiao Zhang, Yan Chen, Yinghui Zhao, Guoqing Zhu, Yuxin Chen, Fenyong Sun, Jiayi Wang, Qiuhui Pa. Sirt1 suppresses Wnt/βCatenin signaling in liver cancer cells by targeting βCatenin in a PKAα-dependent manner. Cellular signalling. vol 37. 2018-05-22. PMID:28583374. |
mechanistically, sirt1 expression elevates phosphorylation of the alpha subunit of protein kinase a (pkaα), and this event is essential for sirt1-induced phosphorylation of βcatenin. |
2018-05-22 |
2023-08-13 |
mouse |
| Ya-Nan Shu, Li-Hua Dong, Han Li, Qian-Qian Pei, Sui-Bing Miao, Fan Zhang, Dan-Dan Zhang, Rong Chen, Ya-Juan Yin, Yan-Ling Lin, Zhen-Ying Xue, Pin Lv, Xiao-Li Xie, Li-Li Zhao, Xi Nie, Peng Chen, Mei Ha. CKII-SIRT1-SM22α loop evokes a self-limited inflammatory response in vascular smooth muscle cells. Cardiovascular research. vol 113. issue 10. 2018-05-21. PMID:28419207. |
sirtuin 1 (sirt1) inhibits nuclear factor kappa b (nf-κb) activity in response to the inflammatory cytokine tumour necrosis factor alpha (tnf-α). |
2018-05-21 |
2023-08-13 |
Not clear |
| Jian Sun, Enshuang Guo, Jiankun Yang, Yan Yang, Shenpei Liu, Jifa Hu, Xiaojing Jiang, Olaf Dirsch, Uta Dahmen, Wei Dong, Anding Li. Carbon monoxide ameliorates hepatic ischemia/reperfusion injury via sirtuin 1-mediated deacetylation of high-mobility group box 1 in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 23. issue 4. 2017-11-03. PMID:28133883. |
in vitro, corm-2 reduced hypoxia/reoxygenation-induced hmgb1 translocation and release, these inhibitions were blocked by sirt1 inhibition using ex527 or sirt1 small interfering rna both in alpha mouse liver 12 cells and raw264.7 macrophages. |
2017-11-03 |
2023-08-13 |
mouse |
| Ying Shao, Chuan Lv, Can Wu, Yuehong Zhou, Qiuyue Wan. Mir-217 promotes inflammation and fibrosis in high glucose cultured rat glomerular mesangial cells via Sirt1/HIF-1α signaling pathway. Diabetes/metabolism research and reviews. vol 32. issue 6. 2017-10-06. PMID:26891083. |
sirt1 suppresses activation of hypoxia-inducible factor-1 alpha (hif-1α), with mircrorna-217 (mir-217) being closely related to sirt1. |
2017-10-06 |
2023-08-13 |
rat |
| Li-Li Wen, Chien-Yu Lin, Hsiu-Chu Chou, Chih-Cheng Chang, Hau-Yin Lo, Shu-Hui Jua. Perfluorooctanesulfonate Mediates Renal Tubular Cell Apoptosis through PPARgamma Inactivation. PloS one. vol 11. issue 5. 2017-07-10. PMID:27171144. |
pfos reduced the protein interaction between pparγ and pparγ coactivator-1 alpha (pgc1α) by pparγ deacetylation through sirt1 upregulation, of which the binding of pparγ and pgc1α to a peroxisome proliferator response element (ppre) in the promoter regions of these antioxidative enzymes was alleviated in the chip assay. |
2017-07-10 |
2023-08-13 |
mouse |
| Xiaohui Xu, Ni Zheng, Zhaoni Chen, Wansu Huang, Tao Liang, Hai Kuan. Puerarin, isolated from Pueraria lobata (Willd.), protects against diabetic nephropathy by attenuating oxidative stress. Gene. vol 591. issue 2. 2017-01-27. PMID:27317894. |
meanwhile, the silent information regulator 1 (sirt1), forkhead box protein o1 (foxo1) and alpha subunit of peroxisome proliferators-activated receptor-gamma coactivator-1 (pgc-1α) expressions were significantly up-regulated at protein level by pr administration in renal cortex. |
2017-01-27 |
2023-08-13 |
mouse |
| Jinbong Park, Yong-Deok Jeon, Hye-Lin Kim, Dae-Seung Kim, Yo-Han Han, Yunu Jung, Dong-Hyun Youn, JongWook Kang, Daeyeon Yoon, Mi-Young Jeong, Jong-Hyun Lee, Seung-Heon Hong, Junhee Lee, Jae-Young U. Veratri Nigri Rhizoma et Radix (Veratrum nigrum L.) and Its Constituent Jervine Prevent Adipogenesis via Activation of the LKB1-AMPKα-ACC Axis In Vivo and In Vitro. Evidence-based complementary and alternative medicine : eCAM. vol 2016. 2016-05-04. PMID:27143989. |
the levels of peroxisome proliferator-activated receptor gamma (pparγ), ccaat-enhancer-binding protein alpha (c/ebpα), adipocyte fatty-acid-binding protein (ap2), adiponectin, resistin, and lipin1 were suppressed by vn, while sirt1 was upregulated. |
2016-05-04 |
2023-08-13 |
mouse |
| M Tan, C Tang, Y Zhang, Y Cheng, L Cai, X Chen, Y Gao, Y Deng, M Pa. SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids. Free radical research. vol 49. issue 8. 2016-04-18. PMID:25789761. |
consistent with this finding, gcdca was found to decrease sirt1 protein expression and activity, thus promoting the deacetylation of peroxisome proliferator-activated receptor gamma, coactivator 1 alpha (pgc-1α), a key enzyme involved in mitochondrial biogenesis and function. |
2016-04-18 |
2023-08-13 |
Not clear |