| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi Yu, Ruilin Guo, Jie Ling, Chenjia Xu, Minglu Ma, Xiaojuan Dong, Jing Wu, Ting Huan. SIRT1 Activation Suppresses Corneal Endothelial-Mesenchymal Transition via the TGF-β/Smad2/3 Pathway. Current issues in molecular biology. vol 46. issue 12. 2024-12-27. PMID:39727955. |
moreover, rsv-activated sirt1 downregulated the expression levels of alpha smooth muscle actin (α-sma), vimentin, and snail and upregulated the expression levels of e-cadherin and na |
2024-12-27 |
2024-12-29 |
human |
| Yijun Wu, Jingfang Xiong, Gaofeng Chen, Yihui Liu, Changqing Zhao, Zhaolin Zhang, Hong X. Oxymatrine relieves non-alcoholic fatty liver disease by promoting the sirtuin 1/adenosine 5'-monophosphate-activated protein kinase pathway and peroxisome proliferator activated receptor alpha-mediated hepatic fatty acid oxidation. European journal of pharmacology. 2024-12-05. PMID:39637931. |
peroxisome proliferator activated receptor alpha (pparα), sirtuin 1 (sirt1)/adenosine 5'-monophosphate-activated protein kinase (ampk) pathway- and fatty acid oxidation (acyl-coa oxidase 1 and carnitine palmitoyltransferase 1a)-associated proteins were measured both in vivo and in vitro. |
2024-12-05 |
2024-12-08 |
rat |
| Xiaosha Wang, Layla Frühn, Panpan Li, Xin Shi, Nini Wang, Yuan Feng, Julia Prinz, Hanhan Liu, Verena Prokosc. Comparative proteomic analysis of regenerative mechanisms in mouse retina to identify markers for neuro-regeneration in glaucoma. Scientific reports. vol 14. issue 1. 2024-10-04. PMID:39366989. |
common interactors comprising e1a binding protein p300 (ep300), creb binding protein (cbp), calcium/calmodulin dependent protein kinase ii alpha (camkiiα) and sirtuin 1 (sirt1) were found in both reg-p14 and reg-li retinas. |
2024-10-04 |
2024-10-07 |
mouse |
| Nevine Fathy, Merna A Labib, Reham M Essam, Noha A El-Boghdad. The Interplay between MiR-134/BDNF and LKB1/AMPK/SIRT1 Accentuates the Antidepressant Efficacy of Empagliflozin in Ovariectomized Rats. ACS chemical neuroscience. 2024-10-01. PMID:39350330. |
empa also dwindled ovx-induced changes of hippocampal p-lkb1/lkb1, p-ampk/ampk, sirt1, and inflammatory markers (nuclear factor-kappa-b, interleukin-1 beta, interleukin-6, and tumor necrosis factor alpha). |
2024-10-01 |
2024-10-03 |
rat |
| Maryam Owjfard, Zahra Rahimian, Farzaneh Karimi, Afshin Borhani-Haghighi, Arashk Mallahzade. A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke. Heliyon. vol 10. issue 14. 2024-07-31. PMID:39082038. |
sirt1 activation by resveratrol triggers the deacetylation and activation of downstream targets like peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (pgc-1α) and forkhead box protein o (foxo), regulating mitochondrial biogenesis, antioxidant defense, and cellular stress response. |
2024-07-31 |
2024-08-02 |
Not clear |
| Ahmed A Sedik, Dalia T Hussein, Khaled Fathy, Noha A Mowaa. Neuroprotective and cognitive enhancing effects of herbecetin against thioacetamide induced hepatic encephalopathy in rats via upregulation of AMPK and SIRT1 signaling pathways. Scientific reports. vol 14. issue 1. 2024-05-18. PMID:38762495. |
herbacetin reduced brain levels of malodialdeyde, glutamine synthetase (gs), tumor necrosis factor- alpha (tnf-α), interleukin 1 b (il-1β), annexin v, and increased brain gsh, sirtuin 1 (sirt1), and amp-activated kinase (ampk) expression levels. |
2024-05-18 |
2024-05-27 |
rat |
| Hongbao Xu, Xiaona Song, Xiaoru Zhang, Guangrui Wang, Xiaoling Cheng, Ling Zhang, Zirou Wang, Ran Li, Chongyi Ai, Xinxing Wang, Lingling Pu, Zhaoli Chen, Weili Li. SIRT1 regulates mitochondrial fission to alleviate high altitude hypoxia inducedcardiac dysfunction in rats via the PGC-1α-DRP1/FIS1/MFF pathway. Apoptosis : an international journal on programmed cell death. 2024-04-27. PMID:38678130. |
additionally, hh exposure triggers aberrant expression of mitochondrial fission-regulated proteins, with a decrease in pparγ coactivator 1 alpha (pgc-1α) and mitochondrial fission factor (mff) and an increase in mitochondrial fission 1 (fis1) and dynamin-related protein 1 (drp1), all of which are mitigated by sirt1 upregulation. |
2024-04-27 |
2024-04-30 |
rat |
| Monalisa Parija, Surya Prakash, B Madhu Krishna, Sanghamitra Dash, Sandip K Mishr. SIRT1 mediates breast cancer development and tumorigenesis controlled by estrogen-related receptor β. Breast cancer (Tokyo, Japan). 2024-02-29. PMID:38421553. |
sirt1 is a well-known target gene of the estrogen receptor alpha (er alpha) and is closely related to er alpha deacetylation. |
2024-02-29 |
2024-03-02 |
Not clear |
| Jae-Sung Kim, Jeong-Yeon Seo, Kyeong-Rok Kang, HyangI Lim, Do Kyung Kim, Hong Sung Chu. Metformin Attenuates Manganese-Induced Oxidative Stress in N27-A Dopaminergic Neuronal Cells. Biological & pharmaceutical bulletin. vol 47. issue 2. 2024-02-28. PMID:38417906. |
metformin (0.5 mm) significantly attenuated the decrease in sirtuin-1 (sirt1) and peroxisome proliferator activated receptor gamma coactivator-1 alpha levels, which were increased by mn (0.4 mm). |
2024-02-28 |
2024-03-02 |
Not clear |
| Zhuo An, Congcong Xie, Hui Lu, Shusong Wang, Xiujia Zhang, Wenbo Yu, Xiaoli Guo, Zehao Liu, Dandan Shang, Xueying Wan. Mitochondrial Morphology and Function Abnormality in Ovarian Granulosa Cells of Patients with Diminished Ovarian Reserve. Reproductive sciences (Thousand Oaks, Calif.). 2024-01-31. PMID:38294667. |
additionally, the silent information regulator 1 (sirt1)/phospho-amp-activated protein kinase (p-ampk)-peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (pgc-1α) pathway expression was decreased, which was speculated to be associated with the decreased mitochondrial mass in the dor group. |
2024-01-31 |
2024-02-02 |
Not clear |
| Soroosh Mozaffaritabar, Erika Koltai, Lei Zhou, Zoltan Bori, Attila Kolonics, Sylwester Kujach, Yaodong Gu, Atsuko Koike, Anita Boros, Zsolt Radá. PGC-1α activation boosts exercise-dependent cellular response in the skeletal muscle. Journal of physiology and biochemistry. 2024-01-23. PMID:38261146. |
the pgc-1α overexpressed animals exhibited higher levels of fibronectin type iii domain-containing protein 5 (fndc5), 5' adenosine monophosphate-activated protein kinase alpha (ampk-α), the mammalian target of rapamycin (mtor), sirtuin 1 (sirt1), lon protease homolog 1 (lonp1), citrate synthase (cs), succinate dehydrogenase complex flavoprotein subunit a (sdha), mitofusin-1 (mfn1), endothelial nitric oxide synthase (enos), hormone-sensitive lipase (hsl), adipose triglyceride lipase (atgl), g protein-coupled receptor 41 (gpr41), and phosphatidylcholine cytidylyltransferase 2 (pcyt2), and lower levels of sirtuin 3 (sirt3) compared to wild-type animals. |
2024-01-23 |
2024-01-25 |
mouse |
| Haira Guedes Lúcio, Mariana Grancieri, Oscar David Medina Martinez, Renata Celi Lopes Toledo, Cícero Beserra de Menezes, Neuza Maria Brunoro Costa, Valéria Aparecida Vieira Queiroz, Bárbara Pereira da Silva, Hércia Stampini Duarte Martin. Dry heat whole Sorghum BRS 305 flour modulate satiety and improves antioxidant response in brain of Wistar rats fed with high-fat high-fructose diet. Food research international (Ottawa, Ont.). vol 173. issue Pt 1. 2023-10-07. PMID:37803565. |
brs305 sorghum consumption improved gene expression of sirtuin-1 (sirt1) in adipose tissue, and in the brain increased heat shock protein 72 (hsp72), erythroid-derived nuclear factor 2 (nrf2), peroxisome proliferator-activated receptor alpha (pparα), superoxide dismutase (sod) and catalase activity compared to hfhf. |
2023-10-07 |
2023-10-15 |
rat |
| Qiannan Ren, Qiming Sun, Junfen F. Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease. Autophagy. 2023-09-13. PMID:37700498. |
acox1: acyl-coa oxidase 1; adh5: alcohol dehydrogenase 5 (class iii), chi polypeptide; adipoq: adiponectin, c1q and collagen domain containing; atg: autophagy related; becn1: beclin 1; crtc2: creb regulated transcription coactivator 2; er: endoplasmic reticulum; f2rl1: f2r like trypsin receptor 1; fa: fatty acid; foxo1: forkhead box o1; glp1r: glucagon like peptide 1 receptor; grk2: g protein-coupled receptor kinase 2; gtpase: guanosine triphosphatase; hfd: high-fat diet; hscs: hepatic stellate cells; htra2: htra serine peptidase 2; irgm: immunity related gtpase m; kd: knockdown; kdm6b: lysine demethylase 6b; ko: knockout; lamp2: lysosomal associated membrane protein 2; lap: lc3-associated phagocytosis; lds: lipid droplets; li ko: liver-specific knockout; lsecs: liver sinusoidal endothelial cells; map1lc3/lc3: microtubule associated protein 1 light chain 3; map3k5: mitogen-activated protein kinase kinase kinase 5; med1: mediator complex subunit 1; mtor: mechanistic target of rapamycin kinase; mtorc1: mechanistic target of rapamycin complex 1; nafld: non-alcoholic fatty liver disease; nash: non-alcoholic steatohepatitis; nfe2l2: nfe2 like bzip transcription factor 2; nos3: nitric oxide synthase 3; nr1h3: nuclear receptor subfamily 1 group h member 3; oa: oleic acid; oe: overexpression; osbpl8: oxysterol binding protein like 8; pa: palmitic acid; rubcnl: rubicon like autophagy enhancer; plin2: perilipin 2; plin3: perilipin 3; ppara: peroxisome proliferator activated receptor alpha; prkaa2/ampk: protein kinase amp-activated catalytic subunit alpha 2; rab: member ras oncogene family; rptor: regulatory associated protein of mtor complex 1; scd: stearoyl-coa desaturase; sirt1: sirtuin 1; sirt3: sirtuin 3; snare: soluble n-ethylmaleimide-sensitive factor attachment protein receptor; sqstm1/p62: sequestosome 1; srebf1: sterol regulatory element binding transcription factor 1;srebf2: sterol regulatory element binding transcription factor 2; sting1: stimulator of interferon response cgamp interactor 1; stx17: syntaxin 17; tags: triacylglycerols; tfeb: transcription factor eb; tp53/p53: tumor protein p53; ulk1: unc-51 like autophagy activating kinase 1; vmp1: vacuole membrane protein 1. |
2023-09-13 |
2023-10-07 |
Not clear |
| Ya-Nan Ma, Xuemei Jiang, Wei Tang, Peipei Son. Influence of intermittent fasting on autophagy in the liver. Bioscience trends. 2023-09-04. PMID:37661370. |
if affects hepatic autophagy through multiple interacting pathways and molecular mechanisms, including adenosine monophosphate (amp)-activated protein kinase (ampk), mammalian target of rapamycin (mtor), silent mating-type information regulatory 2 homolog-1 (sirt1), peroxisomal proliferator-activated receptor alpha (pparα) and farnesoid x receptor (fxr), as well as signaling pathways and molecular mechanisms such as glucagon and fibroblast growth factor 21 (fgf21). |
2023-09-04 |
2023-09-07 |
Not clear |
| Xiaotong Su, Linglin Lai, Xu Li, Wenna Li, Zhentao Mo, Yiqi Li, Lu Xiao, Wenjun Wang, Feng Wan. DMC (2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone) enhances exercise tolerance via the AMPK-SIRT1-PGC-1α pathway in mice fed a high-fat diet. Phytotherapy research : PTR. 2023-06-14. PMID:37314083. |
further, dmc alone or combined with exercise could restore normal tissue morphology, reduce fatigue-associated markers, and boost whole-body metabolism and the protein expression of phospho-amp-activated protein kinase alpha/total-amp-activated protein kinase alpha (ampk), sirtuin-1 (sirt1), peroxisome-proliferator-activated receptor gamma coactivator 1alpha (pgc-1α), and peroxisome proliferator-activated receptor alpha in the muscle and adipose tissues of hfd-fed mice. |
2023-06-14 |
2023-08-14 |
mouse |
| Lijun Xu, Xiaoyun Sun, Brian Griffiths, Ludmilla Voloboueva, Alex Valdes, Miles Dobrenski, Jeong-Jin Min, Creed M Star. Sexual Dimorphism in Brain Sirtuin-1 and m6A Methylated Sirtuin-1 mRNA, and in Protection with Post-Injury Anti-miR-200c treatment, after Experimental Stroke in Aged Mice. Aging and disease. vol 14. issue 3. 2023-05-16. PMID:37191419. |
mice were subjected to 1hr of transient middle cerebral artery occlusion (mcao) and assessed for post-injury expression of mir-200c, sirt1 protein and mrna, n6-methyladenosine (m6a) methylated sirt1 mrna, atp, cytochrome c oxidase activity, tumor necrosis factor alpha (tnfα), interleukin-6 (il-6), infarct volume and motor function. |
2023-05-16 |
2023-08-14 |
mouse |
| Ioanna Ioannou, Angeliki Chatziantoniou, Constantinos Drenios, Panayiota Christodoulou, Malamati Kourti, Apostolos Zaravino. Signatures of Co-Deregulated Genes and Their Transcriptional Regulators in Kidney Cancers. International journal of molecular sciences. vol 24. issue 7. 2023-04-13. PMID:37047552. |
differential expression and upstream regulators, including transcription factors [myc proto-oncogene (myc), ccaat enhancer binding protein delta (cebpd), rela proto-oncogene, nf-kb subunit (rela), zinc finger miz-type containing 1 (zmiz1), negative elongation factor complex member e (nelfe) and kruppel-like factor 4 (klf4)] and protein kinases [casein kinase 2 alpha 1 (csnk2a1), mitogen-activated protein kinases 1 (mapk1) and 14 (mapk14), sirtuin 1 (sirt1), cyclin dependent kinases 1 (cdk1) and 4 (cdk4), homeodomain interacting protein kinase 2 (hipk2) and extracellular signal-regulated kinases 1 and 2 (erk1/2)], were computed using the characteristic direction, as well as geo2enrichr and x2k, respectively, and further subjected to go and kegg pathways enrichment analyses. |
2023-04-13 |
2023-08-14 |
Not clear |
| Shiyi Kan, Caixia Pi, Li Zhang, Daimo Guo, Zhixing Niu, Yang Liu, Mengmeng Duan, Xiahua Pu, Mingru Bai, Chenchen Zhou, Demao Zhang, Jing Xi. FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway. Cell communication and signaling : CCS. vol 21. issue 1. 2023-03-14. PMID:36915160. |
we then revealed that fgf19-mediated mitochondrial biogenesis and fusion required the binding of fgf19 to the membrane receptor, fgfr4, and the activation of amp-activated protein kinase alpha (ampkα)/peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (pgc-1α)/sirtuin 1 (sirt1) axis. |
2023-03-14 |
2023-08-14 |
Not clear |
| Hanna Artsi, Einav Cohen-Kfir, Ron Shahar, Noga Kalish-Achrai, Natan Lishinsky, Rivka Dresner-Polla. SIRT1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/Sv female mice. Frontiers in endocrinology. vol 13. 2022-12-26. PMID:36568088. |
sirt1 haplo-insufficiency results in reduced cortical bone thickness, increased porosity and decreased estrogen receptor alpha in bone in adult 129/sv female mice. |
2022-12-26 |
2023-08-14 |
mouse |
| Qingxia Huang, Tingting Lou, Jing Lu, Manying Wang, Xuenan Chen, Linyuan Xue, Xiaolei Tang, Wenxiu Qi, Zepeng Zhang, Hang Su, Wenqi Jin, Chenxu Jing, Daqing Zhao, Liwei Sun, Xiangyan L. Major ginsenosides from Journal of ginseng research. vol 46. issue 6. 2022-10-31. PMID:36312736. |
sirtuin 1 (sirt1) can deacetylate peroxisome proliferator-activated receptor gamma coactivator 1 alpha (pgc-1α) to promote mitochondrial biosynthesis. |
2022-10-31 |
2023-08-14 |
Not clear |