| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Yang, Chun Xiao, Kang Liu, Liping Song, Yonggang Zhang, Birong Don. Silencing of long noncoding INHBA antisense RNA1 suppresses proliferation, migration, and extracellular matrix deposition in human hypertrophic scar fibroblasts via regulating microRNA-141-3p/myeloid cell leukemia 1 axis. Bioengineered. vol 12. issue 1. 2021-11-10. PMID:33977869. |
long noncoding rnas (lncrnas) play vital roles in the progression of hypertrophic scar (hs). |
2021-11-10 |
2023-08-13 |
human |
| Abhishek Roy, Zarna Pathak, Hemant Kuma. Strategies to neutralize RhoA/ROCK pathway after spinal cord injury. Experimental neurology. vol 343. 2021-11-09. PMID:34166685. |
hypertrophic scarring, insignificant intrinsic axon-growth activity, and axon-growth inhibitory molecules such as myelin inhibitors and scar inhibitors constitute a significant hindrance to spinal cord repair. |
2021-11-09 |
2023-08-13 |
Not clear |
| Seung Yeol Lee, So Young Joo, Yoon Soo Cho, Gi Yeun Hur, Cheong Hoon Se. Effect of extracorporeal shock wave therapy for burn scar regeneration: A prospective, randomized, double-blinded study. Burns : journal of the International Society for Burn Injuries. vol 47. issue 4. 2021-11-08. PMID:32917473. |
this study aimed to investigate the regeneration effect of extracorporeal shock wave therapy (eswt) on hypertrophic scar regeneration using objective measurements. |
2021-11-08 |
2023-08-13 |
Not clear |
| Yan Zhi, Hong Wang, Bin Huang, Gang Yan, Long-Zong Yan, Wei Zhang, Jia Zhan. Panax Notoginseng Saponins suppresses TRPM7 via the PI3K/AKT pathway to inhibit hypertrophic scar formation in vitro. Burns : journal of the International Society for Burn Injuries. vol 47. issue 4. 2021-11-08. PMID:33143990. |
panax notoginseng saponins suppresses trpm7 via the pi3k/akt pathway to inhibit hypertrophic scar formation in vitro. |
2021-11-08 |
2023-08-13 |
Not clear |
| Yan Zhi, Hong Wang, Bin Huang, Gang Yan, Long-Zong Yan, Wei Zhang, Jia Zhan. Panax Notoginseng Saponins suppresses TRPM7 via the PI3K/AKT pathway to inhibit hypertrophic scar formation in vitro. Burns : journal of the International Society for Burn Injuries. vol 47. issue 4. 2021-11-08. PMID:33143990. |
hypertrophic scar (hs) formation, a type of dermal fibroproliferative condition, is a frequent complication in wound healing resulting from burns, severe trauma, and surgical procedures. |
2021-11-08 |
2023-08-13 |
Not clear |
| Yan Zhi, Hong Wang, Bin Huang, Gang Yan, Long-Zong Yan, Wei Zhang, Jia Zhan. Panax Notoginseng Saponins suppresses TRPM7 via the PI3K/AKT pathway to inhibit hypertrophic scar formation in vitro. Burns : journal of the International Society for Burn Injuries. vol 47. issue 4. 2021-11-08. PMID:33143990. |
hence, this study was intended to interrogate anti-apoptosis and anti-fibrosis effects of pns on the hypertrophic scar fibroblasts (hsfs) during hs formation and assess the involvement of trpm7 and pi3k/akt signaling pathway. |
2021-11-08 |
2023-08-13 |
Not clear |
| Chaoyi Zhong, Qingwen Nong, Wenyu Feng, Yugu Pan, Yajun Wu, Xianmin Zeng, Hanwen Li, Xueran Zhong, Feicui Li, Zhiwei Luan, Xing Huang, Kai Luo, Daen Liu, Jun Ya. Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway. Burns : journal of the International Society for Burn Injuries. vol 47. issue 1. 2021-11-08. PMID:33279335. |
hypertrophic scar (hs) is a pathological scar that often occurs in burn patients. |
2021-11-08 |
2023-08-13 |
Not clear |
| Chaoyi Zhong, Qingwen Nong, Wenyu Feng, Yugu Pan, Yajun Wu, Xianmin Zeng, Hanwen Li, Xueran Zhong, Feicui Li, Zhiwei Luan, Xing Huang, Kai Luo, Daen Liu, Jun Ya. Polyphyllin VII induces fibroblasts apoptosis via the ERK/JNK pathway. Burns : journal of the International Society for Burn Injuries. vol 47. issue 1. 2021-11-08. PMID:33279335. |
in the present study, we demonstrate that pp7 exerts a significant inhibitory effect on hypertrophic scar fibroblasts (hsfs) in vitro. |
2021-11-08 |
2023-08-13 |
Not clear |
| Ningdan Ma, Jie Lua. Letter to the Editor: Comment on Suga, et al. Scar Assessment After Breast Reconstruction: Risk Factors for Hypertrophy and Hyperpigmentation in Asian Patients (Ann Plast Surg. 2020;85:229-232). Annals of plastic surgery. vol 87. issue 5. 2021-11-08. PMID:33883443. |
scar assessment after breast reconstruction: risk factors for hypertrophy and hyperpigmentation in asian patients (ann plast surg. |
2021-11-08 |
2023-08-13 |
Not clear |
| David S Ruppert, Mahmoud M Mohammed, Mohamed M Ibrahim, Emilio O Bachtiar, Kevin Erning, Kayvan Ansari, Jeffrey I Everitt, David Brown, Bruce Klitzman, William Koshut, Ken Gall, Howard Levinso. Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 6. 2021-11-08. PMID:34129714. |
is a major problem affecting over 80 million people worldwide annually, many of whom suffer from debilitating hypertrophic scar contractures. |
2021-11-08 |
2023-08-13 |
mouse |
| David S Ruppert, Mahmoud M Mohammed, Mohamed M Ibrahim, Emilio O Bachtiar, Kevin Erning, Kayvan Ansari, Jeffrey I Everitt, David Brown, Bruce Klitzman, William Koshut, Ken Gall, Howard Levinso. Poly(lactide-co-ε-caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. vol 29. issue 6. 2021-11-08. PMID:34129714. |
the results of this study have brought us closer towards developing an alternative technology that supports skin grafts with the potential to investigate long-term hypertrophic scar contractures. |
2021-11-08 |
2023-08-13 |
mouse |
| Zhiyou Chen, Zong Chen, Ran Pang, Zhiru Wei, Han Zhang, Wenhui Liu, Guangshuai L. The effect of botulinum toxin injection dose on the appearance of surgical scar. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34211099. |
early postoperative injection of botulinum toxin type a (btxa) can reduce surgical scar hypertrophy. |
2021-11-08 |
2023-08-13 |
Not clear |
| Hui Song Cui, So Young Joo, Yoon Soo Cho, Ji Heon Park, Yu Mi Ro, June-Bum Kim, Cheong Hoon Se. Effect of extracorporeal shock wave therapy on keratinocytes derived from human hypertrophic scars. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34453089. |
keratinocytes derived from hypertrophic scar tissue were cultured and expression of proliferation markers (keratin 5 and 14), activation markers (keratin 6 and 17), differentiation markers (keratin 1, 10, and involucrin), apoptosis factors (bax, bcl2, and caspase 14), and proliferation/differentiation regulators (p21 and p27) was investigated to compared with that of those in keratinocytes derived from normal skin tissue. |
2021-11-08 |
2023-08-13 |
human |
| Longxiang Tu, Zunwen Lin, Qin Huang, Dewu Li. USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar-Derived Fibroblasts by Deubiquitinating TGF-βR1 In Vitro. Plastic and reconstructive surgery. vol 148. issue 5. 2021-11-08. PMID:34546211. |
hypertrophic scar is a fibroproliferative disorder caused by skin injury. |
2021-11-08 |
2023-08-13 |
Not clear |
| Longxiang Tu, Zunwen Lin, Qin Huang, Dewu Li. USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar-Derived Fibroblasts by Deubiquitinating TGF-βR1 In Vitro. Plastic and reconstructive surgery. vol 148. issue 5. 2021-11-08. PMID:34546211. |
the incidence of hypertrophic scar following trauma or burns is 40 to 70 percent or 70 percent, respectively. |
2021-11-08 |
2023-08-13 |
Not clear |
| Longxiang Tu, Zunwen Lin, Qin Huang, Dewu Li. USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar-Derived Fibroblasts by Deubiquitinating TGF-βR1 In Vitro. Plastic and reconstructive surgery. vol 148. issue 5. 2021-11-08. PMID:34546211. |
it has been shown that transforming growth factor (tgf) β1/smad signaling plays a crucial role in hypertrophic scar, and that usp15 can regulate the activity of tgfβ1/smad signaling to affect the progression of the disease. |
2021-11-08 |
2023-08-13 |
Not clear |
| Longxiang Tu, Zunwen Lin, Qin Huang, Dewu Li. USP15 Enhances the Proliferation, Migration, and Collagen Deposition of Hypertrophic Scar-Derived Fibroblasts by Deubiquitinating TGF-βR1 In Vitro. Plastic and reconstructive surgery. vol 148. issue 5. 2021-11-08. PMID:34546211. |
however, the underlying mechanism of usp15 in hypertrophic scar remains unclear. |
2021-11-08 |
2023-08-13 |
Not clear |
| Xingwang Deng, Fang Zhao, Dan Zhao, Qing Zhang, Yongzhao Zhu, Qian Chen, Lijuan Qiang, Nan Xie, Jiaxiang Ma, Xiaoliang Pan, Yinsheng Wu, Lifeng Guan, Yan Xi. Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. International wound journal. 2021-11-08. PMID:34749441. |
oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. |
2021-11-08 |
2023-08-13 |
human |
| Xingwang Deng, Fang Zhao, Dan Zhao, Qing Zhang, Yongzhao Zhu, Qian Chen, Lijuan Qiang, Nan Xie, Jiaxiang Ma, Xiaoliang Pan, Yinsheng Wu, Lifeng Guan, Yan Xi. Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. International wound journal. 2021-11-08. PMID:34749441. |
we hypothesised that oxymatrine may promote hypertrophic scar repair by inhibiting fibroblast autophagy. |
2021-11-08 |
2023-08-13 |
human |
| Xingwang Deng, Fang Zhao, Dan Zhao, Qing Zhang, Yongzhao Zhu, Qian Chen, Lijuan Qiang, Nan Xie, Jiaxiang Ma, Xiaoliang Pan, Yinsheng Wu, Lifeng Guan, Yan Xi. Oxymatrine promotes hypertrophic scar repair through reduced human scar fibroblast viability, collagen and induced apoptosis via autophagy inhibition. International wound journal. 2021-11-08. PMID:34749441. |
in vivo studies showed that inhibition of autophagy by oxymatrine promoted scar repair, resulting in a significantly improved final outcome of the hypertrophic scars, a smaller scar area, decreased epidermal and dermal thickness, and a significant downregulation of ck10, p63, collagen i, α-sma, and tgf-β1. |
2021-11-08 |
2023-08-13 |
human |