| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L L Shi, M Z Liu, Z Y Jiang, X T Yu, J Q Li, G H Gu. [Research advances on pharmacological interventions for hypertrophic scar]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 12. 2023-01-03. PMID:36594149. |
hypertrophic scar is an abnormal fibrous proliferative disease that occurs after deep cutaneous injury, which not only affects aesthetics and function but also has negative psychological effects on the patients. |
2023-01-03 |
2023-08-14 |
Not clear |
| L L Shi, M Z Liu, Z Y Jiang, X T Yu, J Q Li, G H Gu. [Research advances on pharmacological interventions for hypertrophic scar]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 12. 2023-01-03. PMID:36594149. |
however, the mechanism of hypertrophic scar formation has not been fully elucidated, and its clinical treatment is complex with a high rate of recurrence and no radicle cure. |
2023-01-03 |
2023-08-14 |
Not clear |
| L L Shi, M Z Liu, Z Y Jiang, X T Yu, J Q Li, G H Gu. [Research advances on pharmacological interventions for hypertrophic scar]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 12. 2023-01-03. PMID:36594149. |
intervention based on molecular targets will likely be the future direction for the prevention and treatment of hypertrophic scar. |
2023-01-03 |
2023-08-14 |
Not clear |
| L L Shi, M Z Liu, Z Y Jiang, X T Yu, J Q Li, G H Gu. [Research advances on pharmacological interventions for hypertrophic scar]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns. vol 38. issue 12. 2023-01-03. PMID:36594149. |
in this article, we review the specific roles and mechanisms of drug-targeted interventions in hypertrophic scar formation, including general drugs, cytokines, immunomodulators, herbal extracts, exosomes, and nanomaterials, in the context of advances in both basic and clinical research at home and abroad. |
2023-01-03 |
2023-08-14 |
Not clear |
| Shiyi Li, Jinxiu Yang, Jiachen Sun, Minliang Che. Adipose-Derived Mesenchymal Stem Cells Alleviate Hypertrophic Scar by Inhibiting Bioactivity and Inducing Apoptosis in Hypertrophic Scar Fibroblasts. Cells. vol 11. issue 24. 2022-12-23. PMID:36552789. |
adipose-derived mesenchymal stem cells alleviate hypertrophic scar by inhibiting bioactivity and inducing apoptosis in hypertrophic scar fibroblasts. |
2022-12-23 |
2023-08-14 |
Not clear |
| Yanxia Zhu, Qi Jiang, Zhaokui Jin, Danyang Chen, Qingqing Xu, Jinchun Chen, Yue Zeng, Shengqiang Chen, Qianjun H. Two-Dimensional Mg Advanced healthcare materials. 2022-12-22. PMID:36546774. |
two-dimensional mg unexpected temporal and spatial extension of inflammation in severely burned patients frequently causes cellular apoptosis, wound deepening, and serious fibroplasia, leading to the difficulty of wound healing and the formation of hypertrophic scar. |
2022-12-22 |
2023-08-14 |
Not clear |
| Zhi-Bo Zhang, Zhu-Liang Zhou, Fu-Xi Xing, Yong Li, Xing-Chen Sun, Yu-Ting Zhao, Xiang-Zhou Zhang, Ji-Song Li. Analysis of Energy and Density in Treating Hypertrophic Scar After Burn in Children with CO The international journal of lower extremity wounds. 2022-12-20. PMID:36536604. |
analysis of energy and density in treating hypertrophic scar after burn in children with co |
2022-12-20 |
2023-08-14 |
Not clear |
| Xianglong Meng, Xinxin Gao, Kai Shi, Jingchun Zhao, Xiuhang Zhang, Xin Zhou, Xianjun Liu, Jiaao Y. Interferon-α2b-Induced RARRES3 Upregulation Inhibits Hypertrophic Scar Fibroblasts' Proliferation and Migration Through Wnt/β-Catenin Pathway Suppression. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2022-12-15. PMID:36520614. |
interferon-α2b-induced rarres3 upregulation inhibits hypertrophic scar fibroblasts' proliferation and migration through wnt/β-catenin pathway suppression. |
2022-12-15 |
2023-08-14 |
Not clear |
| Xianglong Meng, Xinxin Gao, Kai Shi, Jingchun Zhao, Xiuhang Zhang, Xin Zhou, Xianjun Liu, Jiaao Y. Interferon-α2b-Induced RARRES3 Upregulation Inhibits Hypertrophic Scar Fibroblasts' Proliferation and Migration Through Wnt/β-Catenin Pathway Suppression. Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research. 2022-12-15. PMID:36520614. |
hypertrophic scar (hs) is a severe skin fibrotic disorder with unclear pathogenesis. |
2022-12-15 |
2023-08-14 |
Not clear |
| Kai Wu, Fang Ma, Jiangyong Shen, Hui Zhang, Yu Wan, Xi He, Anning Yang, Jiantuan Xiong, Yun Jiao, Zhigang Bai, Shengchao Ma, Yideng Jiang, Huiping Zhang, Yinju Ha. LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar. Acta biochimica et biophysica Sinica. vol 54. issue 12. 2022-12-14. PMID:36514215. |
lncrna fpasl suppresses fibroblast proliferation through its dna methylation via dnmt3b in hypertrophic scar. |
2022-12-14 |
2023-08-14 |
Not clear |
| Kai Wu, Fang Ma, Jiangyong Shen, Hui Zhang, Yu Wan, Xi He, Anning Yang, Jiantuan Xiong, Yun Jiao, Zhigang Bai, Shengchao Ma, Yideng Jiang, Huiping Zhang, Yinju Ha. LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar. Acta biochimica et biophysica Sinica. vol 54. issue 12. 2022-12-14. PMID:36514215. |
however, the molecular mechanisms of specific lncrnas in the context of hypertrophic scar remain largely unclear. |
2022-12-14 |
2023-08-14 |
Not clear |
| Kai Wu, Fang Ma, Jiangyong Shen, Hui Zhang, Yu Wan, Xi He, Anning Yang, Jiantuan Xiong, Yun Jiao, Zhigang Bai, Shengchao Ma, Yideng Jiang, Huiping Zhang, Yinju Ha. LncRNA FPASL suppresses fibroblast proliferation through its DNA methylation via DNMT3b in hypertrophic scar. Acta biochimica et biophysica Sinica. vol 54. issue 12. 2022-12-14. PMID:36514215. |
using go annotation enrichment analysis along with azc (a specific inhibitor of dna methylation), we identify that dna methylation is responsible for downregulating fpasl in hypertrophic scar. |
2022-12-14 |
2023-08-14 |
Not clear |
| Nazihah Bakhtyar, Saeid Amini-Nik, Marc G Jeschk. OMICS Approaches Evaluating Keloid and Hypertrophic Scars. International journal of inflammation. vol 2022. 2022-12-09. PMID:36483731. |
abnormal scar formation during wound healing can result in keloid and hypertrophic scars, which is a major global health challenge. |
2022-12-09 |
2023-08-14 |
Not clear |
| So Young Joo, Yoon Soo Cho, Ji Won Yoo, Yi Hyun Kim, Rachael Sabangan, Seung Yeol Lee, Cheong Hoon Se. Clinical Utility of the Portable Pressure-Measuring Device for Compression Garment Pressure Measurement on Hypertrophic Scars by Burn Injury during Compression Therapy. Journal of clinical medicine. vol 11. issue 22. 2022-11-26. PMID:36431220. |
sixty-five participants (aged 20~70 years) with partial- or full-thickness burns, vancouver scar scale score of ≥4, and a hypertrophic scar of ≥4 cm × 4 cm were enrolled. |
2022-11-26 |
2023-08-14 |
human |
| Joe E Mouawad, Jonathan Heywood, Milton B Armstrong, Adeyemi Ogunleye, Carol Feghali-Bostwic. Low Baseline Expression of Fibrotic Genes in an Ex Vivo Human Skin Model is a Potential Indicator of Excessive Skin Scarring. Plastic and reconstructive surgery. Global open. vol 10. issue 11. 2022-11-17. PMID:36389611. |
the variability of wound healing and subsequent scar formation across patients makes it virtually impossible to predict if a patient's surgery will result in excessive fibrosis and scarring, possibly amounting to keloids or hypertrophic scars. |
2022-11-17 |
2023-08-14 |
human |
| Jacky Edward. Hypertrophic scar management. British journal of nursing (Mark Allen Publishing). vol 31. issue 20. 2022-11-12. PMID:36370406. |
hypertrophic scar management. |
2022-11-12 |
2023-08-14 |
Not clear |
| Jacky Edward. Hypertrophic scar management. British journal of nursing (Mark Allen Publishing). vol 31. issue 20. 2022-11-12. PMID:36370406. |
it is more efficient to prevent hypertrophic scars than treat them; early diagnosis of a problem scar can considerably impact the overall outcome. |
2022-11-12 |
2023-08-14 |
Not clear |
| Jiayi Yin, Shiming Zhang, Chao Yang, Yan Wang, Bing Shi, Qian Zheng, Ni Zeng, Hanyao Huan. Mechanotransduction in skin wound healing and scar formation: Potential therapeutic targets for controlling hypertrophic scarring. Frontiers in immunology. vol 13. 2022-11-03. PMID:36325354. |
mechanotransduction in skin wound healing and scar formation: potential therapeutic targets for controlling hypertrophic scarring. |
2022-11-03 |
2023-08-14 |
Not clear |
| Daqin Chen, Qiannan Li, Huimin Zhang, Fang Kou, Qiang Li, Chunming Lyu, Hai We. Traditional Chinese medicine for hypertrophic scars-A review of the therapeutic methods and potential effects. Frontiers in pharmacology. vol 13. 2022-10-27. PMID:36299876. |
hypertrophic scar (hs) is a typical pathological response during skin injury, which can lead to pain, itching, and contracture in patients and even affect their physical and mental health. |
2022-10-27 |
2023-08-14 |
Not clear |
| Jian Zhang, Yan Li, Jiaqi Liu, Fu Han, Jihong Shi, Gaofeng Wu, Kejia Wang, Kuo Shen, Ming Zhao, Xiaowen Gao, Chenyang Tian, Yunchuan Wang, Ke Tao, Dahai H. Adiponectin ameliorates hypertrophic scar by inhibiting Yes-associated protein transcription through SIRT1-mediated deacetylation of C/EBPβ and histone H3. iScience. vol 25. issue 10. 2022-10-24. PMID:36274941. |
adiponectin ameliorates hypertrophic scar by inhibiting yes-associated protein transcription through sirt1-mediated deacetylation of c/ebpβ and histone h3. |
2022-10-24 |
2023-08-14 |
Not clear |