| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P Wilms, M Bäh. Reactive changes in the adult rat superior colliculus after deafferentation. Restorative neurology and neuroscience. vol 9. issue 1. 2012-10-02. PMID:21551831. |
after 1 day to 1 year the contralateral sc was sectioned sagitally and examined with antibodies directed against vimentin and glial fibrillary acidic protein (gfap) to label astrocytes, myelin basic protein (mbp) to detect oligodendrocytes, ox-42 to stain microglia and smi-31 to determine degeneration of afferent retinal ganglion cell axons. |
2012-10-02 |
2023-08-12 |
rat |
| P Wilms, M Bäh. Reactive changes in the adult rat superior colliculus after deafferentation. Restorative neurology and neuroscience. vol 9. issue 1. 2012-10-02. PMID:21551831. |
microglia activation occurred as soon as 2 days after optic nerve transection in the anterior part of the sc. |
2012-10-02 |
2023-08-12 |
rat |
| P Wilms, M Bäh. Reactive changes in the adult rat superior colliculus after deafferentation. Restorative neurology and neuroscience. vol 9. issue 1. 2012-10-02. PMID:21551831. |
after 4 days, a homogeneous distribution of activated microglia was seen in the whole sc. |
2012-10-02 |
2023-08-12 |
rat |
| P Wilms, M Bäh. Reactive changes in the adult rat superior colliculus after deafferentation. Restorative neurology and neuroscience. vol 9. issue 1. 2012-10-02. PMID:21551831. |
activated microglia might be involved in triggering regional changes in an anterior-posterior graded fashion in the deafferented sc. |
2012-10-02 |
2023-08-12 |
rat |
| Hiroyuki Okada, Yoshifumi Iwamaru, Shigeo Fukuda, Takashi Yokoyama, Shirou Mohr. Detection of disease-associated prion protein in the optic nerve and the adrenal gland of cattle with bovine spongiform encephalopathy by using highly sensitive immunolabeling procedures. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. vol 60. issue 4. 2012-05-07. PMID:22260993. |
in the optic nerve, the dual immunofluorescent technique showed that the granular prp(sc) was occasionally detected in the astrocytes, microglia, and myelin sheath adjacent to the axon. |
2012-05-07 |
2023-08-12 |
cattle |
| Jacob I Ayers, Charles R Schutt, Ronald A Shikiya, Adriano Aguzzi, Anthony E Kincaid, Jason C Bart. The strain-encoded relationship between PrP replication, stability and processing in neurons is predictive of the incubation period of disease. PLoS pathogens. vol 7. issue 3. 2011-07-05. PMID:21437239. |
in the cns, the short incubation period strains were characterized by the accumulation of n-terminally truncated prp(sc) in the soma of neurons, astrocytes and microglia in contrast to long incubation period strains where prp(sc) did not accumulate to detectable levels in the soma of neurons but was detected in glia similar to short incubation period strains. |
2011-07-05 |
2023-08-12 |
Not clear |
| Jan Kranich, Nike Julia Krautler, Jeppe Falsig, Boris Ballmer, Shulei Li, Gregor Hutter, Petra Schwarz, Rita Moos, Christian Julius, Gino Miele, Adriano Aguzz. Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner. The Journal of experimental medicine. vol 207. issue 10. 2011-01-10. PMID:20837697. |
because mfge8 receptors are expressed by microglia and depletion of microglia increases prp(sc) accumulation in organotypic cerebellar slices, we conclude that engulfment of apoptotic bodies by microglia may be an important pathway of prion clearance controlled by astrocyte-borne mfge8. |
2011-01-10 |
2023-08-12 |
mouse |
| Martina M Hughes, Robert H Field, V Hugh Perry, Carol L Murray, Colm Cunningha. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation. Glia. vol 58. issue 16. 2011-01-06. PMID:20878768. |
despite the phagocytic machinery available to microglia the aberrant amyloid proteins produced during alzheimer's and prion disease, amyloid-β and prp(sc), are inefficiently cleared. |
2011-01-06 |
2023-08-12 |
Not clear |
| Martina M Hughes, Robert H Field, V Hugh Perry, Carol L Murray, Colm Cunningha. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation. Glia. vol 58. issue 16. 2011-01-06. PMID:20878768. |
these data indicate that microglia in the prion-diseased brain are capable of phagocytosis per se, but show limited efficacy in removing prp(sc) even upon marked escalation of cns inflammation. |
2011-01-06 |
2023-08-12 |
Not clear |
| James B Stanton, Donald P Knowles, Douglas R Call, Bruce A Mathison, Timothy V Baszle. Limited transcriptional response of ovine microglia to prion accumulation. Biochemical and biophysical research communications. vol 386. issue 2. 2009-07-27. PMID:19523453. |
to further define the molecular changes associated with prp(sc) accumulation in cultured cells, the transcriptional profile of prp(sc)-accumulating primary ovine microglia was compared to the profile of prp(sc)-lacking microglia using the affymetrix bovine genome array. |
2009-07-27 |
2023-08-12 |
cattle |
| James B Stanton, Donald P Knowles, Douglas R Call, Bruce A Mathison, Timothy V Baszle. Limited transcriptional response of ovine microglia to prion accumulation. Biochemical and biophysical research communications. vol 386. issue 2. 2009-07-27. PMID:19523453. |
the array analysis revealed only 19 upregulated genes and 30 downregulated genes in prp(sc)-accumulating microglia. |
2009-07-27 |
2023-08-12 |
cattle |
| James B Stanton, Donald P Knowles, Douglas R Call, Bruce A Mathison, Timothy V Baszle. Limited transcriptional response of ovine microglia to prion accumulation. Biochemical and biophysical research communications. vol 386. issue 2. 2009-07-27. PMID:19523453. |
the results support the hypothesis that chronic prp(sc) accumulation in cultured microglia results in a limited transcriptional response. |
2009-07-27 |
2023-08-12 |
cattle |
| Yasuyuki Kihara, Keisuke Yanagida, Kayo Masago, Yoshihiro Kita, Daisuke Hishikawa, Hideo Shindou, Satoshi Ishii, Takao Shimiz. Platelet-activating factor production in the spinal cord of experimental allergic encephalomyelitis mice via the group IVA cytosolic phospholipase A2-lyso-PAFAT axis. Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 7. 2008-12-24. PMID:18802104. |
these data suggest that paf accumulation in the sc of eae mice is profoundly dependent on the group iva cytosolic pla(2)/lysopafat axis present in the infiltrating macrophages and activated microglia. |
2008-12-24 |
2023-08-12 |
mouse |
| James B Stanton, Donald P Knowles, Katherine I O'Rourke, Lynn M Herrmann-Hoesing, Bruce A Mathison, Timothy V Baszle. Small-ruminant lentivirus enhances PrPSc accumulation in cultured sheep microglial cells. Journal of virology. vol 82. issue 20. 2008-10-14. PMID:18684809. |
the results demonstrate the in vitro utility of prp(sc)-permissive sheep microglial cells in investigating the biology of natural prion diseases and show that small-ruminant lentiviruses enhance prion conversion in cultured sheep microglia. |
2008-10-14 |
2023-08-12 |
Not clear |
| James B Stanton, Donald P Knowles, Katherine I O'Rourke, Lynn M Herrmann-Hoesing, Bruce A Mathison, Timothy V Baszle. Small-ruminant lentivirus enhances PrPSc accumulation in cultured sheep microglial cells. Journal of virology. vol 82. issue 20. 2008-10-14. PMID:18684809. |
primary microglia coinfected with a small-ruminant lentivirus (caprine arthritis encephalitis virus-cork strain) and prp(sc) demonstrated an approximately twofold increase in prp(sc) accumulation compared to that of primary microglia infected with prp(sc) alone. |
2008-10-14 |
2023-08-12 |
Not clear |
| Jeppe Falsig, Christian Julius, Ilan Margalith, Petra Schwarz, Frank L Heppner, Adriano Aguzz. A versatile prion replication assay in organotypic brain slices. Nature neuroscience. vol 11. issue 1. 2008-04-11. PMID:18066056. |
pharmacogenetic ablation of microglia from posca slices led to a 15-fold increase in prion titers and prp(sc) concentrations over those in microglia-containing slices, as well as an increase in susceptibility to infection. |
2008-04-11 |
2023-08-12 |
mouse |
| Sabine Gilch, Frank Schmitz, Yasmine Aguib, Claudia Kehler, Sigrid Bülow, Stefan Bauer, Elisabeth Kremmer, Hermann M Schätz. CpG and LPS can interfere negatively with prion clearance in macrophage and microglial cells. The FEBS journal. vol 274. issue 22. 2008-01-29. PMID:17944938. |
for this purpose, we challenged the macrophage cell line j774, the microglial cell line bv-2 and primary bone marrow-derived macrophages in a resting or stimulated state with various prion strains, and monitored the uptake and clearance of prp(sc). |
2008-01-29 |
2023-08-12 |
Not clear |
| Delphine Boche, Colm Cunningham, Fabian Docagne, Helen Scott, V Hugh Perr. TGFbeta1 regulates the inflammatory response during chronic neurodegeneration. Neurobiology of disease. vol 22. issue 3. 2006-08-24. PMID:16510291. |
the investigation of the role of tgfbeta1 during a time course disease shows that its expression is correlated with (i) the onset of behavioral abnormalities, (ii) increased activated microglia, (iii) thickening of the basement membrane, and (iv) is associated with increased prp(sc) deposition. |
2006-08-24 |
2023-08-12 |
Not clear |
| Bhisham Chera, Kurt E Schaecher, Anne Rocchini, Syed Z Imam, Eric A Sribnick, Swapan K Ray, Syed F Ali, Naren L Bani. Immunofluorescent labeling of increased calpain expression and neuronal death in the spinal cord of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice. Brain research. vol 1006. issue 2. 2004-06-07. PMID:15051518. |
there was an increase in calpain expression in microglia, astrocytes, and neurons in the sc of mptp-treated mice at 1 and 7 days, as compared to controls. |
2004-06-07 |
2023-08-12 |
mouse |
| Dianna L Hynds, Nagarathnamma Rangappa, Julia Ter Beest, Diane M Snow, Alexander G Rabchevsk. Microglia enhance dorsal root ganglion outgrowth in Schwann cell cultures. Glia. vol 46. issue 2. 2004-05-28. PMID:15042588. |
rat drg explants were grown on monolayers consisting of either sc, microglia, sc exposed to microglia-conditioned medium (mcm), or co-cultures with different relative concentrations of microglia. |
2004-05-28 |
2023-08-12 |
rat |