| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Damien D Pearse, Johana Bastidas, Sarah S Izabel, Mousumi Ghos. Schwann Cell Transplantation Subdues the Pro-Inflammatory Innate Immune Cell Response after Spinal Cord Injury. International journal of molecular sciences. vol 19. issue 9. 2018-12-11. PMID:30154346. |
multicolor flow cytometry and immunohistochemical analysis of specific phenotypic markers of pro- and anti-inflammatory microglia and macrophages as well as cytokines at 1 week after sc transplantation was employed. |
2018-12-11 |
2023-08-13 |
rat |
| Binbin Wang, Bingbing Fan, Qijun Dai, Xingguo Xu, Peipei Jiang, Lin Zhu, Haifeng Dai, Zhigang Yao, Zhongling Xu, Xiaojuan Li. Fascin-1 Contributes to Neuropathic Pain by Promoting Inflammation in Rat Spinal Cord. Neurochemical research. vol 43. issue 2. 2018-08-16. PMID:29052088. |
the increased fascin-1 widely expressed in drg, however, it localized predominantly in microglia, seldom in neuron, and hardly in astrocyte in the sc. |
2018-08-16 |
2023-08-13 |
rat |
| b' Mirjana Nacka-Aleksi\\xc4\\x87, Marija Stojanovi\\xc4\\x87, Lidija Simi\\xc4\\x87, Biljana Bufan, Jelena Kotur-Stevuljevi\\xc4\\x87, Zorica Stoji\\xc4\\x87-Vukani\\xc4\\x87, Mirjana Dimitrijevi\\xc4\\x87, Slavica Ra\\xc5\\xbei\\xc4\\x87, Gordana Leposavi\\xc4\\x8. Sex as a determinant of age-related changes in rat spinal cord inflammation-oxidation state. Biogerontology. vol 18. issue 5. 2018-07-10. PMID:28825141.' |
with age, rat sc microglia became sensitized ("primed"), while sc tissue shifted towards mild inflammatory state, with increased levels of proinflammatory il-1β (key marker of microglial systemic inflammation-induced neurotoxicity), which was more prominent in males. |
2018-07-10 |
2023-08-13 |
human |
| Ting Zhang, Kai Sun, Wen Shen, Le Qi, Wei Yin, Li-Wei Wan. SOCS1 regulates neuropathic pain by inhibiting neuronal sensitization and glial activation in mouse spinal cord. Brain research bulletin. vol 124. 2017-10-26. PMID:27233783. |
on the contrary, overexpression of socs1 in the sc reversed cci-induced pain behavioral, activation of neurons, astrocytes, microglia, and the expression of proinflammatory cytokines including tumor necrosis factor α (tnf-α), interleukin 1β (il-1β) and il-6. |
2017-10-26 |
2023-08-13 |
mouse |
| Valentina Villa, Stefano Thellung, Alessandro Corsaro, Federica Novelli, Bruno Tasso, Luca Colucci-D'Amato, Elena Gatta, Michele Tonelli, Tullio Flori. Celecoxib Inhibits Prion Protein 90-231-Mediated Pro-inflammatory Responses in Microglial Cells. Molecular neurobiology. vol 53. issue 1. 2016-11-02. PMID:25404089. |
we report that the prion protein fragment encompassing amino acids 90-231 (prp90-231), a model of the neurotoxic activity of the pathogenic prion protein (prp(sc)), causes activation of both primary microglia cultures and n9 microglial cells in vitro. |
2016-11-02 |
2023-08-13 |
Not clear |
| Qi Shi, Kang Xiao, Bao-Yun Zhang, Xiao-Mei Zhang, Li-Na Chen, Cao Chen, Chen Gao, Xiao-Ping Don. Successive passaging of the scrapie strains, ME7-ha and 139A-ha, generated by the interspecies transmission of mouse-adapted strains into hamsters markedly shortens the incubation times, but maintains their molecular and pathological properties. International journal of molecular medicine. vol 35. issue 4. 2015-12-01. PMID:25683243. |
neuropathological assays revealed comparable spongiform degeneration and microglia proliferation in the brain tissues from the infected mice and hamsters, but markedly more plaque-like deposits of prp(sc) and more severe astrogliosis in the brains of the hamster. |
2015-12-01 |
2023-08-13 |
mouse |
| Marina S Hernandes, Luiz R G Britt. Inflammatory responses in the rat superior colliculus after eye enucleation. Brain research bulletin. vol 101. 2014-11-04. PMID:24333190. |
in this study, immunoblotting and immunostaining assays revealed increased expression of astrocyte and microglia markers in the rat superior colliculus (sc) between 1 and 15 days after contralateral enucleation. |
2014-11-04 |
2023-08-12 |
rat |
| Joseph M Herndon, Aram B Cholanians, Serrine S Lau, Terrence J Monk. Glial cell response to 3,4-(+/-)-methylenedioxymethamphetamine and its metabolites. Toxicological sciences : an official journal of the Society of Toxicology. vol 138. issue 1. 2014-10-14. PMID:24299738. |
rats were treated with mda (20mg/kg, sc) followed by ex vivo biopsy culture to determine the activation of quiescent microglia. |
2014-10-14 |
2023-08-12 |
rat |
| Wu-Ling Xie, Qi Shi, Jin Zhang, Bao-Yun Zhang, Han-Shi Gong, Yan Guo, Shao-Bin Wang, Yin Xu, Ke Wang, Cao Chen, Yong Liu, Xiao-Ping Don. Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23526370. |
however, the detailed regional distribution between microglia and prp(sc) deposition has not been presented, and investigation of fractalkine signaling which is involved in the regulation of activation of microglia in prion disease is not well documented. |
2014-06-23 |
2023-08-12 |
rat |
| Wu-Ling Xie, Qi Shi, Jin Zhang, Bao-Yun Zhang, Han-Shi Gong, Yan Guo, Shao-Bin Wang, Yin Xu, Ke Wang, Cao Chen, Yong Liu, Xiao-Ping Don. Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23526370. |
under the dynamic analysis on hallmarks of activation of microglia, a time-dependent increase of iba1 and cd68 was detected, accompanied by accumulation of prp(sc) and progression of neurodegenerative symptoms. |
2014-06-23 |
2023-08-12 |
rat |
| Wu-Ling Xie, Qi Shi, Jin Zhang, Bao-Yun Zhang, Han-Shi Gong, Yan Guo, Shao-Bin Wang, Yin Xu, Ke Wang, Cao Chen, Yong Liu, Xiao-Ping Don. Abnormal activation of microglia accompanied with disrupted CX3CR1/CX3CL1 pathway in the brains of the hamsters infected with scrapie agent 263K. Journal of molecular neuroscience : MN. vol 51. issue 3. 2014-06-23. PMID:23526370. |
with serial brain sections and double staining of iba1 and prp(sc), we observed that the microglia distributed around prp(sc) deposits in 263k-infected hamsters' brains, proposing prp(sc) phagocytosis. |
2014-06-23 |
2023-08-12 |
rat |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
using a prp(sc)-specific elisa we discovered a monocationic phenyl-furan-benzimidazole (db772), which has previously demonstrated anti-pestiviral activity and represents a chemical category previously untested for anti-prion activity, that inhibited prp(sc) accumulation and prion infectivity in primary sheep microglial cell cultures (prnp 136vv/154rr/171qq) and rov9 cultures (vrq-ovinized rk13 cells). |
2013-05-28 |
2023-08-12 |
Not clear |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
the anti-prp(sc) selectivity index in cell culture was approximately 4.6 in microglia and 5.5 in rov9 cells. |
2013-05-28 |
2023-08-12 |
Not clear |
| James B Stanton, David A Schneider, Kelcey D Dinkel, Bethany F Balmer, Timothy V Baszler, Bruce A Mathison, David W Boykin, Arvind Kuma. Discovery of a novel, monocationic, small-molecule inhibitor of scrapie prion accumulation in cultured sheep microglia and Rov cells. PloS one. vol 7. issue 11. 2013-05-28. PMID:23226483. |
the results describe a new chemical category that inhibits ovine prp(sc) accumulation in primary sheep microglia and rov9 cells, and can be used for future studies into the treatment and mechanism of prion diseases. |
2013-05-28 |
2023-08-12 |
Not clear |
| Stephanie A Schittone, Kalen R Dionne, Kenneth L Tyler, Penny Clark. Activation of innate immune responses in the central nervous system during reovirus myelitis. Journal of virology. vol 86. issue 15. 2012-11-21. PMID:22623770. |
reovirus infection of the murine spinal cord (sc) was used as a model system to investigate innate immune responses during viral myelitis, including the activation of glia (microglia and astrocytes) and interferon (ifn) signaling and increased expression of inflammatory mediators. |
2012-11-21 |
2023-08-12 |
mouse |
| Chiara Rigato, Nina Swinnen, Roeland Buckinx, Isabelle Couillin, Jean-Marie Mangin, Jean-Michel Rigo, Pascal Legendre, Hervé Le Corron. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 34. 2012-11-19. PMID:22915101. |
microglia are known to invade the mammalian spinal cord (sc) at an early embryonic stage. |
2012-11-19 |
2023-08-12 |
mouse |
| Chiara Rigato, Nina Swinnen, Roeland Buckinx, Isabelle Couillin, Jean-Marie Mangin, Jean-Michel Rigo, Pascal Legendre, Hervé Le Corron. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 34. 2012-11-19. PMID:22915101. |
by performing patch-clamp recordings in situ using a whole-mouse embryonic sc preparation, we show here that embryonic microglia already express functional p2x7r. |
2012-11-19 |
2023-08-12 |
mouse |
| Chiara Rigato, Nina Swinnen, Roeland Buckinx, Isabelle Couillin, Jean-Marie Mangin, Jean-Michel Rigo, Pascal Legendre, Hervé Le Corron. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 34. 2012-11-19. PMID:22915101. |
more important, we found that proliferation of embryonic sc microglia, but not their activation state, depends almost entirely on p2x7r by comparing wild-type and p2x7r-/- embryos. |
2012-11-19 |
2023-08-12 |
mouse |
| Chiara Rigato, Nina Swinnen, Roeland Buckinx, Isabelle Couillin, Jean-Marie Mangin, Jean-Michel Rigo, Pascal Legendre, Hervé Le Corron. Microglia proliferation is controlled by P2X7 receptors in a Pannexin-1-independent manner during early embryonic spinal cord invasion. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 32. issue 34. 2012-11-19. PMID:22915101. |
these results reveal a developmental role of p2x7r by controlling embryonic sc microglia proliferation at a critical developmental state in the sc of mouse embryos. |
2012-11-19 |
2023-08-12 |
mouse |
| Jong Kil Lee, Edward H Schuchman, Hee Kyung Jin, Jae-sung Ba. Soluble CCL5 derived from bone marrow-derived mesenchymal stem cells and activated by amyloid β ameliorates Alzheimer's disease in mice by recruiting bone marrow-induced microglia immune responses. Stem cells (Dayton, Ohio). vol 30. issue 7. 2012-10-19. PMID:22570192. |
these results suggest that the beneficial effects observed in ad mice after intracerebral sc transplantation may be explained by alternative microglia activation. |
2012-10-19 |
2023-08-12 |
mouse |